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...appears that normalisation of altered Kv1.5 channel, an oxygen sensing ion channel and fulfillment of oxygen demand by myocardium might offer a new strategy f

..., Hool LC (2016) The role of the L-type Ca²⁺ channel in altered metabolic activity in a murine model of hypertrophic cardiomyopathy. JACC: Basic to T

...er BM, Hekimi S, Culmsee C, Eckert GP, Dolga AM (2020) SK channel-mediated metabolic escape to glycolysis inhibits ferroptosis and supports stress resistance in ...oxins. Our findings shed light on metabolic mechanisms promoted through SK channel activation through mitohormesis, which enhances neuronal resilience against

...n C, Hool L (2016) The L-type Ca²⁺ channel facilitates abnormal metabolic activity in the cTnI-G203S mouse model of hypertrophic cardiomyopathy. J Ph ...y be effective in reducing the cardiomyopathy by normalising mitochondrial metabolic activity.

...iferation. This study identifies a Kv1.3-mediated mechanism underlying the metabolic regulation of proliferation, which may provide a therapeutic target for dis

|title=Boutilier RG (2001) Mechanisms of metabolic defense against hypoxia in hibernating frogs. Respir Physiol 128:365-77. ...tation initiates a generalised suppression of ion channel densities and/or channel leak activities. The net result is that cell membrane permeabilities are re

|title=Very long chain ceramides interfere with C16 ceramide-induced channel formation: rheostatic control of apoptosis. .../sub>-channel formation in vivo. This interplay between different ceramide metabolic enzymes and their products adds a new dimension to the complexity of mitoch

...ors, which may have therapeutic potential in ischaemia reperfusion injury, metabolic syndrome and some cancers7-9.

...ecova R, Halasova E, Pokusa M (2024) The impact of ATP-sensitive potassium channel modulation on mitochondria in a Parkinson's disease model using SH-SY5Y cel ...H-SY5Y cells. Our results offer valuable insights into the significance of metabolic differences between differentiated and non-differentiated SH-SY5Y cells, pa

...Y, Kong Q, Li J, Xin Y, Wu W, Tang X, Liu X (2023) Voltage-dependent anion channel 1 (VDAC1) overexpression alleviates cardiac fibroblast activation in cardia ...ed to reduced long-chain fatty acid (LCFA) uptake. Voltage-dependent anion channel 1 (VDAC1), the main gatekeeper of the outer mitochondrial membrane (OMM), s

...ffset age-associated mitochondrial deficiency with reduced K_ATP channel activity. Diabetes 65:2700-10. ...ce, but not humans, are able to successfully compensate for age-associated metabolic dysfunction by adjusting their β cell glucose sensitivity, and highlight a

...es. The present results indicate a novel therapeutic strategy for managing metabolic diseases and improving exercise endurance. |keywords=PGC-1α, TRPV-1, High-fat diet-induced metabolic disorders, Exercise capacity

...ensitise mitochondria to mPTP opening. Thus, cellular metabolic fluxes and metabolic environment dictate mitochondrial functional response to Ca²⁺ ov

...ed in ischemic or late-stage failing hearts. The mechanism regulating this metabolic switch remains poorly understood. Here, we report that loss of PHD2/3, the ...ial infarction, Prolyl hydroxylase domain protein, Voltage-dependent anion channel

...erstand how cytoskeletal disruption in the absence of dystrophin may cause metabolic dysfunctions in skeletal muscle.

...nd energetics of these respiratory components are summarized and also some metabolic engineering of C. glutamicum to produce valuable chemicals are described re

...der anoxic conditions and with glycolytic inhibitors showed that anaerobic metabolic processes contribute from 30 to 40% to the overall heat production rate. Si

...stem, controlling local AMP and ADP concentrations and forming [[metabolic channel]]s. Since substrate-level phosphorylation is involved in the TCA-cycle, the

|title=[[File:LeeHK.jpg|left|90px]] The metabolic syndrome (MetS) - dysmitochondrial syndrome and mitochondrial disruptors. [ ...docrine disrupting chemicals (EDCs), persistent organic pollutants (POPs), metabolic disrupting chemicals (MDCs).

...the content of adenine nucleotides and creatine phosphate against decrease metabolic acidosis and growth of glucose [4]. ...on the functioning of mitochondria, and in particular, on work of mitoKATP channel.

...xercise, suggesting that ''in vivo'' activation of voltage-dependent anion channel (VDAC)/adenine nucleotide translocase (ANT) can support mitochondrial ADP t

...lucose-stimulated insulin secretion and was corrected by sulfonylurea KATP channel inhibitor administration. Collectively, these data are consistent with a ro

...approaches revealed that RNF207 interacts with the voltage-dependent anion channel (VDAC), which is considered to be a key regulator of mitochondria function,

|title=Krumschnabel G, Biasi C, Schwarzbaum PJ, Wieser W (1996) Membrane-metabolic coupling and ion homeostasis in anoxia-tolerant and anoxia-intolerant hepat |keywords=sodium pump, rubidium uptake, potassium efflux, channel arrest, ion homeostasis

...ic dilation and preconditioning-like mitochondrial ATP-sensitive potassium channel activation. Furthermore, oxidative post-translational modification by gluta

...s in the incubation buffer or culture medium. The physiologically relevant metabolic H⁺ flux, however, must not be confused with ECAR. ...odules |O2k signal]]: The [[O2k-pH ISE-Module]] is operated through the pX channel of the O2k, with electric potential (volt [V]) as the primary and raw signa

...5 KO on this process. In summary, TRPC5 deletion in the CeA alleviated the metabolic deterioration of mice fed a HFD, and these phenotypic improvements were cor

|Lecture – Erich Gnaiger: Mitochondrial metabolic structure, respiratory capacity and respiratory control |Patricia Rojo (Caceres, ES): Molecular partakers of the mitochondrial TIM22 channel

...a supercomplex consisting of MtCK, ATP-Synthasome, voltage dependent anion channel associated with tubulin βII which restricts permeability of the mitochondr

...ndrial functionality reaching tissue levels that can affect enzyme and ion channel activities, and impact energy metabolism pathways and cellular homeostasis.

...ge through its interaction with the outer membrane voltage-dependent anion channel (VDAC). Based on this model, we predicted that disrupting microtubule archi

...onally, Complex V (CV) ATP hydrolytic activity can be measured with the pH channel. These measurements of Complex I-V activities are specific as demonstrated

...ndrial functionality reaching tissue levels that can affect enzyme and ion channel activities, and impact energy metabolism pathways and cellular homeostasis.

...activation in adult mice leads to a shortened lifespan, growth deficit and metabolic alterations indicative of impaired energy balance. Dietary Mg²⁺

...ciated with the binding of cytoskeletal tubulin to voltage dependent anion channel (VDAC) in the mitochondrial outer membrane. In cardiomyocytes VDAC is proba

|title=Imran I, Hillert MH, Klein J (2015) Early metabolic responses to lithium/pilocarpine-induced status epilepticus in rat brain. J ...ution. Similarly, administration of pregabalin (100 mg/kg i.p.), a calcium channel ligand, 15 min prior to pilocarpine strongly attenuated parameters of membr

...AC1 deletion in yeast affects mitochondrial DNA maintenance and promotes a metabolic rewiring towards fatty acids biosynthesis. ...elle functionality. To overcome this condition, Δpor1 undergoes a complete metabolic rewiring that does not involve the activation of the retrograde response, a

...thway that are linked to reducing-equivalents, suggesting that TB47 causes metabolic redox stress. In mouse infection models, a TB47 monotherapy was not bacteri

...l functionality and can reach tissue levels that can affect enzyme and ion channel activities and impact energy metabolism pathways and cellular homeostasis.

:::::* O2: Oxygen channel only. :::::* O2 & Amp: Oxygen and amperometric channel.

...iration rates upon treatment with serum albumin and HCO3- were analysed by metabolic tracing of 13C-labelled substrates and respirometry studies, respectively. ...The increase in ATP seemed not to be dependent on the sperm-specific Ca2+ channel CatSper. Finally, we demonstrated that neither HCO3- nor serum albumin stim

...skeleton in cardiac cells are necessary prerequisites for highly organized metabolic networks characteristic of adult cardiomyocytes.

:::: For the oxygen channel, X=O₂, ''c''_O2 is the oxygen concentration [nmol/mL = ...tion]], ''c''_X [µM = nmol/mL]. The signal of the potentiometric channel, however, is primarily expressed logarithmically as pX=-log(''c''<sub>X</su

...tics develops for the first time the explicit link between thermodynamics, metabolic control, bioenergetics and clinical applications. ...eyr JHS, Cornish-Bowden A (Stellenbosch, Marseille) How should we quantify metabolic regulation? p 91.

|style="width: 60em"|'''Hong Kyu Lee''' (Seoul, KR) The metabolic syndrome and mitochondrial function - towards an international mtDNA cybrid ...tz DS, Ilkayeva O, Newgard CB, Muoio DM (US) Mitochondrial dysfunction and metabolic inflexibility in models of aging and diet-induced obesity.

...odules |O2k signal]]: The [[O2k-pH ISE-Module]] is operated through the pX channel of the O2k, with electric potential (volt [V]) as the primary and raw signa ...units [pmol·s^-1·mL^-1]]. The physiologically relevant metabolic proton flux, therefore, must not be confused with ECAR.

...||[[Schiffer 2013 Abstract MiP2013|Dietary inorganic nitrate reduces basal metabolic rate in man]]||A1-09 Oral ..., London, CA||[[Staples 2013 Abstract MiP2013| Mechanisms of mitochondrial metabolic depression in hibernation]]||A2-03 Oral

...ly specialized subject but with a very practical aspect (diagnostic tools, metabolic adaptations following therapeutic interventions, etc.). The atmosphere was ...[Sadler Daniel|Daniel Sadler]]''': ''Early life exercise training counters metabolic perturbations imparted by low parental cardiorespiratory fitness.''

...eds electrons into CII. In reality, dehydrogenases of fatty acid oxidation channel electrons to the coenzyme Q-junction but not through CII. The ambiguities s ...from the organ to the cell. In: Ichai, C., Quintard, H., Orban, JC. (eds) Metabolic Disorders and Critically Ill Patients. '''Springer''', Cham. - [[Quintard 2

...ical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states an ...The mitochondrial acylome emerges: proteomics, regulation by Sirtuins, and metabolic and disease implications. Cell Metab 27:497-512. - [[Carrico 2018 Cell Meta

...ur-Farraj P, Stassart RM, Fledrich R (2023) Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration. [[Sundaram_2023_Cell_Metab|»B |'''"Liver [mitochondria] (...) adapt to metabolic challenges by increasing FAO-derived mitochondrial respiration in OBES [obe

...ical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states an ...The mitochondrial acylome emerges: proteomics, regulation by Sirtuins, and metabolic and disease implications. Cell Metab 27:497-512. - [[Carrico 2018 Cell Meta

...eds electrons into CII. In reality, dehydrogenases of fatty acid oxidation channel electrons to the Q-junction but not through CII. The ambiguities surroundin :::: '''1.29. Ref 73''' Intlekofer AM, Finley LWS (2019) Metabolic signatures of cancer cells and stem cells. '''Nat Metab''' 1:177-88. - [[In