Ryu 2014 Cell Metab: Difference between revisions
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{{Publication | {{Publication | ||
|title=Ryu D, Jo YS, Lo Sasso G, Stein S, Zhang H, Perino A, Lee JU, Zeviani M, Romand R, Hottiger MO, Schoonjans K, Auwerx J (2014) A SIRT7-dependent acetylation switch of GABPฮฒ1 controls mitochondrial function. Cell Metab 20:856-69. | |title=Ryu D, Jo YS, Lo Sasso G, Stein S, Zhang H, Perino A, Lee JU, Zeviani M, Romand R, Hottiger MO, Schoonjans K, Auwerx J (2014) A SIRT7-dependent acetylation switch of GABPฮฒ1 controls mitochondrial function. Cell Metab 20:856-69. | ||
|info=[http://www.ncbi.nlm.nih.gov/pubmed/25200183 PMID: 25200183] | |info=[http://www.ncbi.nlm.nih.gov/pubmed/25200183 PMID: 25200183 Open access] | ||
|authors=Ryu D, Jo YS, Lo Sasso G, Stein S, Zhang H, Perino A, Lee JU, Zeviani M, Romand R, Hottiger MO, Schoonjans K, Auwerx J | |authors=Ryu D, Jo YS, Lo Sasso G, Stein S, Zhang H, Perino A, Lee JU, Zeviani M, Romand R, Hottiger MO, Schoonjans K, Auwerx J | ||
|year=2014 | |year=2014 | ||
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{{Labeling | {{Labeling | ||
|area=Respiration, mtDNA;mt-genetics, nDNA;cell genetics | |area=Respiration, mtDNA;mt-genetics, nDNA;cell genetics, Genetic knockout;overexpression | ||
|tissues=Heart, Liver, Lung;gill | |organism=Mouse | ||
|couplingstates=OXPHOS | |tissues=Heart, Nervous system, Liver, Lung;gill | ||
|preparations=Homogenate | |||
|couplingstates=LEAK, OXPHOS | |||
|substratestates=CI, CII, CIV, CI&II, Other combinations, ROX | |substratestates=CI, CII, CIV, CI&II, Other combinations, ROX | ||
|instruments=Oxygraph-2k | |instruments=Oxygraph-2k | ||
|additional= | |additional=2016-09 | ||
}} | }} |
Revision as of 15:03, 26 September 2016
Ryu D, Jo YS, Lo Sasso G, Stein S, Zhang H, Perino A, Lee JU, Zeviani M, Romand R, Hottiger MO, Schoonjans K, Auwerx J (2014) A SIRT7-dependent acetylation switch of GABPฮฒ1 controls mitochondrial function. Cell Metab 20:856-69. |
Ryu D, Jo YS, Lo Sasso G, Stein S, Zhang H, Perino A, Lee JU, Zeviani M, Romand R, Hottiger MO, Schoonjans K, Auwerx J (2014) Cell Metab
Abstract: Mitochondrial activity is controlled by proteins encoded by both nuclear and mitochondrial DNA. Here, we identify Sirt7 as a crucial regulator of mitochondrial homeostasis. Sirt7 deficiency in mice induces multisystemic mitochondrial dysfunction, which is reflected by increased blood lactate levels, reduced exercise performance, cardiac dysfunction, hepatic microvesicular steatosis, and age-related hearing loss. This link between SIRT7 and mitochondrial function is translatable in humans, where SIRT7 overexpression rescues the mitochondrial functional defect in fibroblasts with a mutation in NDUFSI. These wide-ranging effects of SIRT7 on mitochondrial homeostasis are the consequence of the deacetylation of distinct lysine residues located in the hetero- and homodimerization domains of GABPฮฒ1, a master regulator of nuclear-encoded mitochondrial genes. SIRT7-mediated deacetylation of GABPฮฒ1 facilitates complex formation with GABPฮฑ and the transcriptional activation of the GABPฮฑ/GABPฮฒ heterotetramer. Altogether, these data suggest that SIRT7 is a dynamic nuclear regulator of mitochondrial function through its impact on GABPฮฒ1 function.
Copyright ยฉ 2014 Elsevier Inc. All rights reserved.
โข O2k-Network Lab: CH Lausanne Auwerx J
Labels: MiParea: Respiration, mtDNA;mt-genetics, nDNA;cell genetics, Genetic knockout;overexpression
Organism: Mouse
Tissue;cell: Heart, Nervous system, Liver, Lung;gill
Preparation: Homogenate
Coupling state: LEAK, OXPHOS
HRR: Oxygraph-2k
2016-09