Difference between revisions of "Respiratory complexes"
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|abbr=C<sub>''i''</sub> | |abbr=C<sub>''i''</sub> | ||
|description='''Respiratory complexes''' are membrane-bound enzymes consisting of several subunits which are involved in energy transduction of the [[respiratory system]]. The different localizations and functions of the respiratory complexes explain the architecture of the respiratory system. Respiratory complexes of the [[electron transfer system]] tansfer electrons to reduce oxygen to water in aerobic respiration, whereas the respiratory complex [[ATP synthase]] (C<sub>V</sub>) is part of the [[phosphorylation system]]. Proton translocation couples the electron transfer system to the phosphorylation system. Membrane-spanning respiratory complexes function as proton pumps (in most mitochondria C<sub>I</sub>, C<sub>III</sub>, C<sub>IV</sub> and C<sub>V</sub>; in yeast mitochondria C<sub>III</sub>, C<sub>IV</sub> and C<sub>V</sub>). Respiratory complexes bound to one side of the inner mt-membrane and C<sub>I</sub> transfer electrons to the [[Q-junction]] which separates upstream and downstream segments of the electron transfer system. Electron transfer complexes localized to the inner face of the inner mt-membrane are C<sub>II</sub> and C<sub>ETF</sub>, and a respiratory complex localized to the outer face of the inner mt-membrane is C<sub>GpDH</sub>. | |description='''Respiratory complexes''' are membrane-bound enzymes consisting of several subunits which are involved in energy transduction of the [[respiratory system]]. The different localizations and functions of the respiratory complexes explain the architecture of the respiratory system. Respiratory complexes of the [[electron transfer system]] tansfer electrons to reduce oxygen to water in aerobic respiration, whereas the respiratory complex [[ATP synthase]] (C<sub>V</sub>) is part of the [[phosphorylation system]]. Proton translocation couples the electron transfer system to the phosphorylation system. Membrane-spanning respiratory complexes function as proton pumps (in most mitochondria C<sub>I</sub>, C<sub>III</sub>, C<sub>IV</sub> and C<sub>V</sub>; in yeast mitochondria C<sub>III</sub>, C<sub>IV</sub> and C<sub>V</sub>). Respiratory complexes bound to one side of the inner mt-membrane and C<sub>I</sub> transfer electrons to the [[Q-junction]] which separates upstream and downstream segments of the electron transfer system. Electron transfer complexes localized to the inner face of the inner mt-membrane are C<sub>II</sub> and C<sub>ETF</sub>, and a respiratory complex localized to the outer face of the inner mt-membrane is C<sub>GpDH</sub>. The 'primary complexes' (CI to CIV)comprise the machinery for transfer of electrons from NADH and succinate to oxygen as described in an extensive series of publications by the laboratory of Hatefi (see [[Hatefi 1962 J Biol Chem-XLII]]). Secondary complexes (supercomplexes) and their activities have been described to be stable at repeated freezing, thawing, dilution, centrifugation, and storage at -2O °C. The activity of [[supercomplex]]es is representative of electron transfer function in intact mitochondria activated by appropriate substrate combinations. | ||
|info=[[Gnaiger 2012 MitoPathways]] | |info=[[Gnaiger 2012 MitoPathways]] | ||
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Revision as of 05:25, 29 June 2014
- high-resolution terminology - matching measurements at high-resolution
Respiratory complexes
Description
Respiratory complexes are membrane-bound enzymes consisting of several subunits which are involved in energy transduction of the respiratory system. The different localizations and functions of the respiratory complexes explain the architecture of the respiratory system. Respiratory complexes of the electron transfer system tansfer electrons to reduce oxygen to water in aerobic respiration, whereas the respiratory complex ATP synthase (CV) is part of the phosphorylation system. Proton translocation couples the electron transfer system to the phosphorylation system. Membrane-spanning respiratory complexes function as proton pumps (in most mitochondria CI, CIII, CIV and CV; in yeast mitochondria CIII, CIV and CV). Respiratory complexes bound to one side of the inner mt-membrane and CI transfer electrons to the Q-junction which separates upstream and downstream segments of the electron transfer system. Electron transfer complexes localized to the inner face of the inner mt-membrane are CII and CETF, and a respiratory complex localized to the outer face of the inner mt-membrane is CGpDH. The 'primary complexes' (CI to CIV)comprise the machinery for transfer of electrons from NADH and succinate to oxygen as described in an extensive series of publications by the laboratory of Hatefi (see Hatefi 1962 J Biol Chem-XLII). Secondary complexes (supercomplexes) and their activities have been described to be stable at repeated freezing, thawing, dilution, centrifugation, and storage at -2O °C. The activity of supercomplexes is representative of electron transfer function in intact mitochondria activated by appropriate substrate combinations.
Abbreviation: Ci
Reference: Gnaiger 2012 MitoPathways
MitoPedia topics: Enzyme
