Quoilin 2012 Biochem Biophys Res Commun
» [[Has info::PMID: 22659746]]
Was written by::Quoilin C, Was written by::Mouithys-Mickalad A, Was written by::Duranteau J, Was written by::Gallez B, Was written by::Hoebeke M (Was published in year::2012) Was published in journal::Biochem Biophys Res Commun
Abstract: [[has abstract::To study the mechanism of oxygen regulation in inflammation-induced acute kidney injury, we investigate the effects of a bacterial endotoxin (lipopolysaccharide, LPS) on the basal respiration of proximal tubular epithelial cells (HK-2) both by high-resolution respirometry and electron spin resonance spectroscopy. These two complementary methods have shown that HK-2 cells exhibit a decreased oxygen consumption rate when treated with LPS. Surprisingly, this cellular respiration alteration persists even after the stress factor was removed. We suggested that this irreversible decrease in renal oxygen consumption after LPS challenge is related to a pathologic metabolic down-regulation such as a lack of oxygen utilization by cells.]] • Keywords: has publicationkeywords::Endotoxin, has publicationkeywords::HK-2 cells, has publicationkeywords::Basal respiration, has publicationkeywords::LPS
• O2k-Network Lab: Was published by MiPNetLab::BE Liege Votion DM
Labels:
Tissue;cell: tissue and cell::Endothelial;epithelial;mesothelial cell Preparation: Preparation::Intact cells
Regulation: Topic::Flux control, Topic::Oxygen kinetics Coupling state: Coupling states::ROUTINE
HRR: Instrument and method::Oxygraph-2k
