Difference between revisions of "Piericidin"

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Piericidin

Description

Piericidin C₂₅H₃₇NO₄ is an antibiotic (isolated from Streptomyces mobaraensis) showing similarity with ubiquinone structure which has a potent and competitive inhibitory effect of CI (it competes with endogenous and partially with exogenous Q for binding sites). CI inhibitors have been divided (1) depending of the site of action (functional classification): quinone antagonists (e.g. piericidin A, first site), semiquinone antagonists (piericidin A, second site; piericidin B; rotenone and quinol antagonists (myxothiazol; stigmatellin), and (2) depending on their effect on ROS production: inducing ROS production (e.g. rotenone, piericidin A, Rolliniastatin-1 and -2) and preventing ROS production (e.g. stigmatellin, capsaicin, mucidin and coenzyme Q2). In plants, pieridicin A inhibits photosystem II.

Reference: Jeng 1968 Biochemistry, Degli 1998 Biochim Biophys Acta, Fato 2009 Biochim Biophys Acta

MitoPedia topics: Inhibitor

Piericidin A

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 {{MitoPedia
-|description='''Piericidin''' C<sub>25</sub>H<sub>37</sub>NO<sub>4</sub> is an antibiotic (isolated from ''Streptomyces mobaraensis'') showing similarity with ubiquinone structure which has a potent and competitive inhibitory effect of [[Complex I |CI]] (it competes with endogenous and partially with exogenous Q for binding sites). CI inhibitors have been divided (1) depending of the site of action (functional classification): quinone antagonists (e.g. piericidin A, first site), semiquinone antagonists (piericidin A, second site; piericidin B; [[Rotenone| rotenone]] and quinol antagonists (myxothiazol; stigmatellin), and (2) depending on their effect on ROS production: inducing ROS production (e.g. rotenone, piericidin A, Rolliniastatin-1 and -2) and preventing ROS production (e.g. stigmatellin, capsaicin, mucidin and coenzyme Q2). In plants, pieridicin A inhibits photosystem II.
+|description='''Piericidin''' C<sub>25</sub>H<sub>37</sub>NO<sub>4</sub> is an antibiotic (isolated from ''Streptomyces mobaraensis'') showing similarity with ubiquinone structure which has a potent and competitive inhibitory effect of [[Complex I |CI]] (it competes with endogenous and partially with exogenous Q for binding sites). CI inhibitors have been divided (''1'') depending of the site of action (functional classification): quinone antagonists (e.g. piericidin A, first site), semiquinone antagonists (piericidin A, second site; piericidin B; [[Rotenone| rotenone]] and quinol antagonists (myxothiazol; stigmatellin), and (''2'') depending on their effect on ROS production: inducing ROS production (e.g. rotenone, piericidin A, Rolliniastatin-1 and -2) and preventing ROS production (e.g. stigmatellin, capsaicin, mucidin and coenzyme Q2). In plants, pieridicin A inhibits photosystem II.
 |info=[[Jeng 1968 Biochemistry]], [[Degli 1998 Biochim Biophys Acta]], [[Fato 2009 Biochim Biophys Acta]]
 }}