Difference between revisions of "Pathway control ratio"
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Careful selection of the reference state, ''J''<sub>ref</sub>, is required, for which some guidelines may be provided without the possibility to formulate general rules. ''FCR'' are best defined by taking ''J''<sub>ref</sub> as the maximum flux (e.g. [[Additive effect of convergent CI+II electron flow|CI+II]]<sub>''[[ETS|E]]''</sub>), such that flux in various other respiratory states, ''J<sub>i</sub>'', smaller or equal to ''J''<sub>ref</sub>. However, this is not generally possible with ''SCR''. For instance, the CI/CII substrate control ratio (at constant coupling state) may be larger or smaller than 1.0, depending on the mitochondrial source and various mitochondrial injuries. The CII-respiration may be selected preferentially as ''J''<sub>ref</sub>, is mitochondria with variable CI-related injuries are studied. | Careful selection of the reference state, ''J''<sub>ref</sub>, is required, for which some guidelines may be provided without the possibility to formulate general rules. ''FCR'' are best defined by taking ''J''<sub>ref</sub> as the maximum flux (e.g. [[Additive effect of convergent CI+II electron flow|CI+II]]<sub>''[[ETS|E]]''</sub>), such that flux in various other respiratory states, ''J<sub>i</sub>'', smaller or equal to ''J''<sub>ref</sub>. However, this is not generally possible with ''SCR''. For instance, the CI/CII substrate control ratio (at constant coupling state) may be larger or smaller than 1.0, depending on the mitochondrial source and various mitochondrial injuries. The CII-respiration may be selected preferentially as ''J''<sub>ref</sub>, is mitochondria with variable CI-related injuries are studied. | ||
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Revision as of 18:58, 17 February 2012
- high-resolution terminology - matching measurements at high-resolution
Pathway control ratio
Description
Substrate control ratios, SCR, are flux control ratios, FCR, at a constant mitochondrial coupling state. Whereas there are only three well-defined coupling states of mitochondrial respiration, L, P, E (LEAK, OXPHOS, ETS), numerous substrate states are possible.
Careful selection of the reference state, Jref, is required, for which some guidelines may be provided without the possibility to formulate general rules. FCR are best defined by taking Jref as the maximum flux (e.g. CI+IIE), such that flux in various other respiratory states, Ji, smaller or equal to Jref. However, this is not generally possible with SCR. For instance, the CI/CII substrate control ratio (at constant coupling state) may be larger or smaller than 1.0, depending on the mitochondrial source and various mitochondrial injuries. The CII-respiration may be selected preferentially as Jref, is mitochondria with variable CI-related injuries are studied.
Abbreviation: SCR
Reference: Gnaiger 2009 Int J Biochem Cell Biol; List of respiratory states
MitoPedia methods:
Respirometry
MitoPedia topics: "Respiratory state" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property.
Respiratory state"Respiratory state" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property.
