PGMS-pathway control state: Difference between revisions
(Created page with "{{MitoPedia |abbr=PGMS |description=left|200px|PGMS '''PGMS''': Pyruvate & Glutamate & Malate & Succinate. '''MitoPathway control:''' CI&II 2...") |
No edit summary |
||
| Line 6: | Line 6: | ||
2-oxoglutarate is produced through the citric acid cycle from citrate by isocitrate dehydrogenase, from oxaloacetate and glutamate by the transaminase, and from glutamate by the glutamate dehydrogenase. If the 2-oxoglutarate carrier does not outcompete these sources of 2-oxoglutarate, then the TCA cycle operates in full circle with external pyruvate&malate&glutamate&succinate | 2-oxoglutarate is produced through the citric acid cycle from citrate by isocitrate dehydrogenase, from oxaloacetate and glutamate by the transaminase, and from glutamate by the glutamate dehydrogenase. If the 2-oxoglutarate carrier does not outcompete these sources of 2-oxoglutarate, then the TCA cycle operates in full circle with external pyruvate&malate&glutamate&succinate | ||
|info=[[Gnaiger 2014 MitoPathways |Gnaiger 2014 MitoPathways - Chapter 5.6]] | |info=[[Gnaiger 2014 MitoPathways |Gnaiger 2014 MitoPathways - Chapter 5.6]] | ||
}} | }} | ||
{{MitoPedia concepts}} | {{MitoPedia concepts | ||
|mitopedia concept=SUIT state | |||
}} | |||
{{MitoPedia methods}} | {{MitoPedia methods}} | ||
{{MitoPedia O2k and high-resolution respirometry | {{MitoPedia O2k and high-resolution respirometry}} | ||
}} | |||
{{MitoPedia topics}} | {{MitoPedia topics}} | ||
== PGMS(L) == | == PGMS(L) == | ||
Revision as of 16:18, 13 May 2016
- high-resolution terminology - matching measurements at high-resolution
PGMS-pathway control state
Description
PGMS: Pyruvate & Glutamate & Malate & Succinate.
MitoPathway control: CI&II
2-oxoglutarate is produced through the citric acid cycle from citrate by isocitrate dehydrogenase, from oxaloacetate and glutamate by the transaminase, and from glutamate by the glutamate dehydrogenase. If the 2-oxoglutarate carrier does not outcompete these sources of 2-oxoglutarate, then the TCA cycle operates in full circle with external pyruvate&malate&glutamate&succinate
Abbreviation: PGMS
Reference: Gnaiger 2014 MitoPathways - Chapter 5.6
MitoPedia concepts:
SUIT state
PGMS(L)
PGMS(P)
PGMS(E)
Discussion
Recent studies showed that CII- and CI&II-linked OXPHOS capacity is inhibited by 2 mM malate concentrations as applied in most SUIT protocols. This inhibition is less pronounced at 0.5 mM malate
