Difference between revisions of "OctPM pathway control state"
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Revision as of 10:29, 8 November 2016
- high-resolution terminology - matching measurements at high-resolution
OctPM pathway control state
Description
OctPM: Octanoylcarnitine & Pyruvate & Malate.
MitoPathway control: FAO&CI
SUIT protocol: SUIT_FNSGp(PGM)01 - SUIT RP1, SUIT_FNSGp(PGM)02 - SUIT RP1
This substrate combination supports CI-linked flux which is typically higher than FAO capacity. In SUIT-RP1, PMOct is induced after PM(E), to evaluate any additive effect of adding Oct. In SUIT-RP2, FAO OXPHOS capacity is measured first, testing for the effect of increasing malate concentration (compare malate control state, M alone), and pyruvate is added to compare FAO as the background state with CI&FAO as the reference state.
Abbreviation: PMOct
Reference: MiPNet21.06 SUIT reference protocol
MitoPedia concepts:
Respiratory state,
SUIT state
OctPM(L)
OctPM(P)
- SUIT_FNSGp(PGM)02_4P: 1D 2Oct 3Mtit&Mc (&McNADH) 4P 5G 6S 7U 8Gp 9Rot 10Ama 11Tm 12Azd
OctPM(E)
- SUIT_FNSGp(PGM)01_4Oct: 1PM 2D&Dc (&DcNADH) 3U 4Oct 5G 6S 7Rot 8Gp 9Ama 10Tm 11Azd
