high-resolution terminology - matching measurements at high-resolution

OXPHOS capacity

Description

OXPHOS capacity P is the respiratory capacity of mitochondria in the ADP-activated state of oxidative phosphorylation, at saturating concentrations of ADP and inorganic phosphate (which may not be the case in State 3), oxygen, and defined reduced CHNO-fuel substrates.

Abbreviation: P

Reference: BEC 2020.1, Gnaiger 2020 BEC MitoPathways, Gnaiger 2009 Int J Biochem Cell Biol

Coupled energy cycles of oxidative phosphorylation stimulated by saturating concentrations of ADP and inorganic phosphate. 2[H] indicates the reduced hydrogen equivalents of CHO substrates (NS) and electron transfer to oxygen. H⁺_out are protons pumped out of the matrix phase to the positive P-phase. Proton flow to the negative matrix phase (H⁺_in) drives the phosphorylation of ADP to ATP. The capacity of the phosphorylation system may contribute to the limitation of flux. Proton leaks dissipate energy of translocated protons from the positive P-phase to the negative N-phase. Measurement of OXPHOS capacity is possible in mt-preparations supported by an ET-pathway competent substrate state, exemplifed as the NS-pathway (CI&II-linked substrate supply) (Gnaiger 2020 BEC MitoPathways).

OXPHOS P and State 3

Gnaiger E (2020) OXPHOS P and State 3. Mitochondr Physiol Network (2016-07-15) last update 2020-11-08.

Oroboros (2020) MiPNet

Abstract: OXPHOS capacity P is the respiratory capacity of mitochondria in the ADP-activated state of oxidative phosphorylation, at saturating concentrations of ADP (which may not be the case in State 3), inorganic phosphate, oxygen, and defined reduced substrates. Since OXPHOS is partially coupled, intrinsic uncoupling and dyscoupling contribute to the control of flux in the OXPHOS state. Oxygen consumption P in the OXPHOS state, therefore, is partitioned into the net OXPHOS capacity P-L strictly coupled to phosphorylation P», and nonphosphorylating LEAK respiration L_P, compensating for proton leaks, slip and cation cycling: P = P-L+L_P. It is frequently assumed that LEAK respiration L, as measured in the LEAK-state, overestimates the LEAK component of respiration L_P, as measured in the OXPHOS state, particularly if the protonmotive force is not adjusted to equivalent levels in L and L_P. However, if the LEAK component increases with enzyme turnover during P, the low enzyme turnover during L may counteract the effect of the higher pmF. OXPHOS capacity is expressed (1) per mt-marker (O₂ flux per mt-protein, CS, etc); if ET capacity E is used as a functional mitochondrial marker, then OXPHOS capacity is expressed as the OXPHOS-control ratio (P/E flux control ratio). (2) OXPHOS capacity is expressed per tissue or cell mass, integrating mt-quantity (density) and mt-quality (O₂ flux). (3) OXPHOS capacity is expressed per cell (O₂ flow), which then is a function of mt-density, mt-quality, and cell size. If conditions for measurement and expression of respiration vary, explicit symbols are used, expressing OXPHOS capacity as oxygen flux in state P, J_O₂P or as oxygen flow in state P, I_O₂P. If these conditions are defined and remain consistent within a given context, then the simple symbol P for respiratory rate can be used to substitute the more explicit expression for respiratory activity.

• O2k-Network Lab: AT Innsbruck Gnaiger E

References

Keywords

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The Blue Book 2020
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OXPHOS-, ROUTINE-, ET-, and LEAK states; respiratory capacities (P, R, E, L) corrected for residual oxygen consumption Rox.
4-compartmental OXPHOS model. (1) ET capacity E of the noncoupled electron transfer system ETS. OXPHOS capacity P is partitioned into (2) the dissipative LEAK component L, and (3) ADP-stimulated P-L net OXPHOS capacity. (4) If P-L is kinetically limited by a low capacity of the phosphorylation system to utilize the protonmotive force pmF, then the apparent E-P excess capacity is available to drive coupled processes other than phosphorylation P» (ADP to ATP) without competing with P».
(P-L)/P is the OXPHOS P-L control efficiency. The biochemical coupling efficiency is independent of kinetic control by the phosphorylation system when expressed as the E-L coupling efficiency, (E-L)/E. (E-P)/E is the kinetic E-P control efficiency.

Bioblast links: Coupling control - >>>>>>> - Click on [Expand] or [Collapse] - >>>>>>>

1. Mitochondrial and cellular respiratory rates in coupling-control states

» Baseline state

Respiratory rate	Defining relations
OXPHOS capacity	P = P´-Rox	mt-preparations
ROUTINE respiration	R = R´-Rox	living cells
ET capacity	E = E´-Rox	» Level flow
		» Noncoupled respiration - Uncoupler
LEAK respiration	L = L´-Rox	» Static head
		» LEAK state with ATP
		» LEAK state with oligomycin
		» LEAK state without adenylates
Residual oxygen consumption Rox	L = L´-Rox

Chance and Williams nomenclature: respiratory states

» State 1 —» State 2 —» State 3 —» State 4 —» State 5

2. Flux control ratios related to coupling in mt-preparations and living cells

» Flux control ratio

» Coupling-control ratio

» Coupling-control protocol

FCR	Definition
L/P coupling-control ratio	L/P	» Respiratory acceptor control ratio, RCR = P/L
L/R coupling-control ratio	L/R
L/E coupling-control ratio	L/E	» Uncoupling-control ratio, UCR = E/L (ambiguous)
P/E control ratio	P/E
R/E control ratio	R/E	» Uncoupling-control ratio, UCR = E/L
net P/E control ratio	(P-L)/E
net R/E control ratio	(R-L)/E

3. Net, excess, and reserve capacities of respiration

Respiratory net rate	Definition	Icon
P-L net OXPHOS capacity	P-L
R-L net ROUTINE capacity	R-L
E-L net ET capacity	E-L
E-P excess capacity	E-P
E-R reserve capacity	E-R

4. Flux control efficiencies related to coupling-control ratios

» Flux control efficiency j_Z-Y

» Background state

» Reference state

» Metabolic control variable

Coupling-control efficiency		Definition		Canonical term
P-L control efficiency	j_P-L	= (P-L)/P	= 1-L/P	P-L OXPHOS-flux control efficiency
R-L control efficiency	j_R-L	= (R-L)/R	= 1-L/R	R-L ROUTINE-flux control efficiency
E-L coupling efficiency	j_E-L	= (E-L)/E	= 1-L/E	E-L ET-coupling efficiency » Biochemical coupling efficiency
E-P control efficiency	j_E-P	= (E-P)/E	= 1-P/E	E-P ET-excess flux control efficiency
E-R control efficiency	j_E-R	= (E-R)/E	= 1-R/E	E-R ET-reserve flux control efficiency

5. General

» Basal respiration

» Cell ergometry

» Dyscoupled respiration

» Dyscoupling

» Electron leak

» Electron-transfer-pathway state

» Hyphenation

» Oxidative phosphorylation

» Oxygen flow

» Oxygen flux

» Permeabilized cells

» Phosphorylation system

» Proton leak

» Proton slip

» Respiratory state

» Uncoupling

» List of publications: OXPHOS

Sort in ascending/descending order by a click on one of the small symbols in squares below.
Default sorting: chronological. Empty fields appear first in ascending order.

	Year	Reference	Coupling	Pathway	Preparation	Organism	Tissue;cell
Liu 2024 Cell Death Dis	2024	Liu JC, Zhao XY, Wu ML, Shi YF, Huang ZP, Fang LP, Zhu C, Peng X, Shi ZL, Lan LJ, Ji WL, Luo L, Feng L, Zhang ZL, Xu DE, Li S, Qin ZH, Sun YY, Schachner M, Ma QH (2024) GPR50 regulates neuronal development as a mitophagy receptor. Cell Death Dis 15:591. https://doi.org/10.1038/s41419-024-06978-y	ET LEAK OXPHOS	N S CIV NS ROX	Homogenate	Mouse	Nervous system
Fernandez-Tocino 2024 Basic Res Cardiol	2024	Fernández-Tocino M, Pun-Garcia A, Gómez M, Clemente-Moragón A, Oliver E, Villena-Gutierrez R, Trigo-Anca S, Díaz-Guerra A, Sanz-Rosa D, Prados B, Del Campo L, Andrés V, Fuster V, de la Pompa JL, Cádiz L, Ibañez B (2024) β3-Adrenergic receptor overexpression in cardiomyocytes preconditions mitochondria to withstand ischemia-reperfusion injury. Basic Res Cardiol [Epub ahead of print]. https://doi.org/10.1007/s00395-024-01072-y	ET LEAK OXPHOS	N ROX	Isolated mitochondria	Mouse	Heart
Kahl 2024 J Hepatol	2024	Kahl S, Straßburger K, Pacini G, Trinks N, Pafili K, Mastrototaro L, Dewidar B, Sarabhai T, Trenkamp S, Esposito I, Schlensak M, Granderath FA, Roden M (2024) Dysglycemia and liver lipid content determine the relationship of insulin resistance with hepatic OXPHOS capacity in obesity. J Hepatol [Epub ahead of print]. https://doi.org/10.1016/j.jhep.2024.08.012	OXPHOS ET LEAK	F N S ROX	Permeabilized tissue	Human	Liver
Kolb 2024 Biochemistry	2024	Kolb AJ, Corridon P, Ullah M, Pfaffenberger ZJ, Xu WM, Winfree S, Sandoval RH, Hato T, Witzmann FA, Mohallem R, Franco J, Aryal UK, Atkinson SJ, Basile DP, Bacallao RL (2024) Sulfotransferase 1C2 increases mitochondrial respiration by converting mitochondrial membrane cholesterol to cholesterol sulfate. Biochemistry [Epub ahead of print]. https://doi.org/10.1021/acs.biochem.3c00344	LEAK OXPHOS	N S NS	Isolated mitochondria	Rat	Kidney
Jardon 2024 Gut Microbes	2024	Jardon KM, Goossens GH, Most J, Galazzo G, Venema K, Penders J, Blaak EE (2024) Examination of sex-specific interactions between gut microbiota and host metabolism after 12-week combined polyphenol supplementation in individuals with overweight or obesity. Gut Microbes 16:2392875. https://doi.org/10.1080/19490976.2024.2392875	ET LEAK OXPHOS	N NS	Permeabilized tissue	Human	Skeletal muscle
Perry 2024 JCI Insight	2024	Perry CE, Halawani SM, Mukherjee S, Ngaba LV, Lieu M, Lee WD, Davis JG, Adzika GK, Bebenek AN, Bazianos DD, Chen B, Mercado-Ayon E, Flatley LP, Suryawanshi AP, Ho I, Rabinowitz JD, Serai SD, Biko DM, Tamaroff J, DeDio A, Wade K, Lin KY, Livingston DJ, McCormack SE, Lynch DR, Baur JA (2024) NAD⁺ precursors prolong survival and improve cardiac phenotypes in a mouse model of Friedreich's Ataxia. JCI Insight 9:e177152. https://doi.org/10.1172/jci.insight.177152	LEAK OXPHOS	F N S CIV	Isolated mitochondria	Mouse	Heart
Puighermanal 2024 Nat Commun	2024	Puighermanal E, Luna-Sánchez M, Gella A, van der Walt G, Urpi A, Royo M, Tena-Morraja P, Appiah I, de Donato MH, Menardy F, Bianchi P, Esteve-Codina A, Rodríguez-Pascau L, Vergara C, Gómez-Pallarès M, Marsicano G, Bellocchio L, Martinell M, Sanz E, Jurado S, Soriano FX, Pizcueta P, Quintana A (2024) Cannabidiol ameliorates mitochondrial disease via PPARγ activation in preclinical models. Nat Commun 15:7730. https://doi.org/10.1038/s41467-024-51884-8	LEAK OXPHOS	N S	Isolated mitochondria	Mouse	Nervous system
Balnis 2024 Sci Adv	2024	Balnis J, Tufts A, Jackson EL, Drake LA, Singer DV, Lacomis D, Lee CG, Elias JA, Doles JD, Maher LJ 3rd, Jen A, Coon JJ, Jourd'heuil D, Singer HA, Vincent CE, Jaitovich A (2024) Succinate dehydrogenase-complex II regulates skeletal muscle cellular respiration and contractility but not muscle mass in genetically induced pulmonary emphysema. Sci Adv [Epub ahead of print]. https://doi.org/10.1126/sciadv.ado8549	ET LEAK OXPHOS	N S NS	Permeabilized tissue	Mouse	Skeletal muscle
Li 2024 Sci Rep	2024	Li J, Zhang S, Li C, Zhang X, Shan Y, Zhang Z, Bo H, Zhang Y (2024) Endurance exercise-induced histone methylation modification involved in skeletal muscle fiber type transition and mitochondrial biogenesis. Sci Rep 14:21154. https://doi.org/10.1038/s41598-024-72088-6	LEAK OXPHOS	N	Isolated mitochondria	Rat	Skeletal muscle
Lavorato 2024 JCI Insight	2024	Lavorato M, Iadarola D, Remes C, Kaur P, Broxton C, Mathew ND, Xiao R, Seiler C, Nakamaru-Ogiso E, Anderson VE, Falk MJ (2024) dldhcri3 zebrafish exhibited altered mitochondrial ultrastructure, morphology and dysfunction partially rescued by probucol or thiamine. JCI Insight [Epub ahead of print]. https://doi.org/10.1172/jci.insight.178973	ET LEAK ROUTINE OXPHOS	N S NS ROX CIV	Homogenate	Zebrafish
Cardoso 2024 MitoFit FAO	2024	Cardoso LHD, Cecatto C, Ozola M, Korzh S, Zvejniece L, Gukalova B, Doerrier C, Dambrova M, Makrecka-Kuka M, Gnaiger E, Liepinsh E (2024) Fatty acid β-oxidation in brain mitochondria: Insights from high-resolution respirometry in mouse, rat and Drosophila brain, ischemia and aging models. MitoFit Preprints 2023.10. https://doi.org/10.26124/mitofit:2023-0010.v2	OXPHOS ET	F N S Gp	Homogenate	Mouse Rat Drosophila	Heart Nervous system Kidney
Shabalina 2024 Biochim Biophys Acta Bioenerg	2024	Shabalina IG, Jiménez B, Sousa-Filho CPB, Cannon B, Nedergaard J (2024) In isolated brown adipose tissue mitochondria UCP1 is not essential for nor involved in the uncoupling effects of the classical uncouplers FCCP and DNP. Biochim Biophys Acta Bioenerg [Epub ahead of print]. https://doi.org/10.1016/j.bbabio.2024.149516	ET LEAK OXPHOS	F N	Isolated mitochondria	Mouse	Fat
Doan 2024 Nat Cardiovasc Res	2024	Doan KV, Luongo TS, Ts'olo TT, Lee WD, Frederick DW, Mukherjee S, Adzika GK, Perry CE, Gaspar RB, Walker N, Blair MC, Bye N, Davis JG, Holman CD, Chu Q, Wang L, Rabinowitz JD, Kelly DP, Cappola TP, Margulies KB, Baur JA (2024) Cardiac NAD⁺ depletion in mice promotes hypertrophic cardiomyopathy and arrhythmias prior to impaired bioenergetics. Nat Cardiovasc Res [Epub ahead of print]. https://doi.org/10.1038/s44161-024-00542-9	LEAK OXPHOS	F N S CIV	Homogenate Isolated mitochondria	Mouse	Heart
Shirakawa 2024 Sci Rep	2024	Shirakawa R, Nakajima T, Yoshimura A, Kawahara Y, Orito C, Yamane M, Handa H, Takada S, Furihata T, Fukushima A, Ishimori N, Nakagawa M, Yokota I, Sabe H, Hashino S, Kinugawa S, Yokota T (2024) Author Correction: Enhanced mitochondrial oxidative metabolism in peripheral blood mononuclear cells is associated with fatty liver in obese young adults. Sci Rep 14:6786. https://doi.org/10.1038/s41598-024-57171-2. Erratum for: Sci Rep. 2023 13:5203. https://doi.org/10.1038/s41598-023-32549-w	LEAK OXPHOS ET		Permeabilized cells	Human	Blood cells
Meszaros 2024 Transpl Int	2024	Meszaros AT, Weissenbacher A, Schartner M, Egelseer-Bruendl T, Hermann M, Unterweger J, Mittelberger C, Reyer BA, Hofmann J, Zelger BG, Hautz T, Resch T, Margreiter C, Maglione M, Komlódi T, Ulmer H, Cardini B, Troppmair J, Öfner D, Gnaiger E, Schneeberger S, Oberhuber R (2024) The predictive value of graft viability and bioenergetics testing towards the outcome in liver transplantation. Transpl Int 37:12380. https://doi.org/10.3389/ti.2024.12380	LEAK OXPHOS ET	N S NS F ROX	Homogenate	Human	Liver
Jacovetti 2024 Mol Metab	2024	Jacovetti C, Donnelly C, Menoud V, Suleiman M, Cosentino C, Sobel J, Wu K, Bouzakri K, Marchetti P, Guay C, Kayser B, Regazzi R (2024) The mitochondrial tRNA-derived fragment, mt-tRF-Leu^TAA, couples mitochondrial metabolism to insulin secretion. Mol Metab 84:101955. https://doi.org/10.1016/j.molmet.2024.101955	LEAK OXPHOS	N S NS ROX	Permeabilized cells	Rat	Islet cell;pancreas;thymus
Hu 2024 Ecotoxicol Environ Saf	2024	Hu R, Fan W, Li S, Zhang G, Zang L, Qin L, Li R, Chen R, Zhang L, Gu W, Zhang Y, Rajagopalan S, Sun Q, Liu C (2024) PM_2.5-induced cellular senescence drives brown adipose tissue impairment in middle-aged mice. Ecotoxicol Environ Saf 278:116423. https://doi.org/10.1016/j.ecoenv.2024.116423	LEAK OXPHOS ET	N S CIV NS ROX	Homogenate	Mouse	Fat
Jiang 2024 Nat Metab	2024	Jiang S, Yuan T, Rosenberger FA, Mourier A, Dragano NRV, Kremer LS, Rubalcava-Gracia D, Hansen FM, Borg M, Mennuni M, Filograna R, Alsina D, Misic J, Koolmeister C, Papadea P, de Angelis MH, Ren L, Andersson O, Unger A, Bergbrede T, Di Lucrezia R, Wibom R, Zierath JR, Krook A, Giavalisco P, Mann M, Larsson NG (2024) Inhibition of mammalian mtDNA transcription acts paradoxically to reverse diet-induced hepatosteatosis and obesity. Nat Metab [Epub ahead of print]. https://doi.org/10.1038/s42255-024-01038-3	LEAK OXPHOS ET	F N S Gp Other combinations	Isolated mitochondria	Mouse	Liver
Gnaiger 2024 MitoFit	2024	Gnaiger E (2024) Addressing the ambiguity crisis in bioenergetics and thermodynamics. MitoFit Preprints 2024.3. https://doi.org/10.26124/mitofit:2024-0003	LEAK OXPHOS ET	NS
Davis 2024 BEC	2024	Davis MS, Barrett MR, Bayly WM, Bolinger A (2024) Effect of selected fluorophores on equine skeletal muscle mitochondrial respiration. Bioenerg Commun 2024.2. https://doi.org/10.26124/bec:2024-0002	LEAK OXPHOS	N S	Isolated mitochondria	Horse	Skeletal muscle
Ciccone 2024 J Exp Biol	2024	Ciccone C, Kante F, Folkow LP, Hazlerigg DG, West AC, Wood SH (2024) Circadian coupling of mitochondria in a deep-diving mammal. J Exp Biol 227:jeb24699. https://doi.org/10.1242/jeb.246990	LEAK ROUTINE OXPHOS ET	N S NS	Permeabilized cells Intact cells	Other mammals	Fibroblast
Mahapatra 2024 J Gerontol A Biol Sci Med Sci	2024	Mahapatra G, Gao Z, Bateman JR 3rd, Lockhart SN, Bergstrom J, Piloso JE, Craft S, Molina AJA (2024) Peripheral blood cells from older adults exhibit sex-associated differences in mitochondrial function. J Gerontol A Biol Sci Med Sci [Epub ahead of print]. https://doi.org/10.1093/gerona/glae098	ROUTINE OXPHOS ET	F N Gp CIV NS Other combinations ROX	Permeabilized cells Intact cells	Human	Blood cells
Queiroz 2024 Ecotoxicol Environ Saf	2024	Queiroz MIC, Lazaro CM, Dos Santos LMB, Rentz T, Virgilio-da-Silva JV, Moraes-Vieira PMM, Cunha FAS, Santos JCC, Vercesi AE, Leite ACR, Oliveira HCF (2024) In vivo chronic exposure to inorganic mercury worsens hypercholesterolemia, oxidative stress and atherosclerosis in the LDL receptor knockout mice. Ecotoxicol Environ Saf 275:116254. https://doi.org/10.1016/j.ecoenv.2024.116254	LEAK OXPHOS ET	N	Isolated mitochondria	Mouse	Liver
Natsui 2024 Physiol Rep	2024	Natsui H, Watanabe M, Yokota T, Tsuneta S, Fumoto Y, Handa H, Shouji M, Koya J, Nishino K, Tatsuta D, Koizumi T, Kadosaka T, Nakao M, Koya T, Temma T, Ito YM, Kanako HC, Hatanaka Y, Yasushige S, Wakasa S, Miura S, Masuda T, Nishioka N, Naraoka S, Ochi K, Kudo T, Ishikawa T, Anzai T (2024) Influence of epicardial adipose tissue inflammation and adipocyte size on postoperative atrial fibrillation in patients after cardiovascular surgery. Physiol Rep 12:e15957. https://doi.org/10.14814/phy2.15957	LEAK OXPHOS ET	F N NS	Permeabilized tissue	Human	Fat
Hunter-Manseau 2024 Insect Sci	2024	Hunter-Manseau F, Cormier SB, Strang R, Pichaud N (2024) Fasting as a precursor to high-fat diet enhances mitochondrial resilience in Drosophila melanogaster. Insect Sci [Epub ahead of print]. https://doi.org/10.1111/1744-7917.13355	LEAK OXPHOS ET	N S Gp NS Other combinations ROX	Permeabilized tissue	Drosophila
Tsouka 2024 Commun Med (Lond)	2024	Tsouka S, Kumar P, Seubnooch P, Freiburghaus K, St-Pierre M, Dufour JF, Masoodi M (2024) Transcriptomics-driven metabolic pathway analysis reveals similar alterations in lipid metabolism in mouse MASH model and human. Commun Med (Lond) 4:39. https://doi.org/10.1038/s43856-024-00465-3	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Mouse	Liver
Kim 2024 J Exerc Rehabil	2024	Kim TW, Park SS, Kim SH, Kim MK, Shin MS, Kim SH (2024) Exercise before pregnancy exerts protective effect on prenatal stress-induced impairment of memory, neurogenesis, and mitochondrial function in offspring. J Exerc Rehabil 20:2-10. https://doi.org/10.12965/jer.2448068.034	LEAK OXPHOS	N NS		Mouse	Nervous system
Cefis 2024 Acta Physiol (Oxf)	2024	Cefis M, Dargegen M, Marcangeli V, Taherkhani S, Dulac M, Leduc-Gaudet JP, Mayaki D, Hussain SNA, Gouspillou G (2024) MFN2 overexpression in skeletal muscles of young and old mice causes a mild hypertrophy without altering mitochondrial respiration and H₂O₂ emission. Acta Physiol (Oxf) [Epub ahead of print]. https://doi.org/10.1111/apha.14119	LEAK OXPHOS	N NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Donnelly 2024 Redox Biol	2024	Donnelly C, Komlódi T, Cecatto C, Cardoso LHD, Compagnion A-C, Matera A, Tavernari D, Campiche O, Paolicelli RC, Zanou N, Kayser B, Gnaiger E, Place N (2024) Functional hypoxia reduces mitochondrial calcium uptake. Redox Biol 71:103037. https://doi.org/10.1016/j.redox.2024.103037	LEAK OXPHOS ET	N S NS ROX	Intact organism Isolated mitochondria Intact cells	Human Mouse	Heart Skeletal muscle
Cazares-Preciado 2024 BMJ Open Diabetes Res Care	2024	Cázares-Preciado JA, López-Arredondo A, Cruz-Cardenas JA, Luévano-Martínez LA, García-Rivas G, Prado-Garcia H, Brunck MEG (2024) Metabolic features of neutrophilic differentiation of HL-60 cells in hyperglycemic environments. BMJ Open Diabetes Res Care 12:e004181. https://doi.org/10.1136/bmjdrc-2024-004181	LEAK ROUTINE OXPHOS	ROX	Intact cells	Human	Blood cells
Xiao 2024 Sci Adv	2024	Xiao L, Yin Y, Sun Z, Liu J, Jia Y, Yang L, Mao Y, Peng S, Xie Z, Fang L, Li J, Xie X, Gan Z (2024) AMPK phosphorylation of FNIP1 (S220) controls mitochondrial function and muscle fuel utilization during exercise. Sci Adv 10:eadj2752. https://doi.org/10.1126/sciadv.adj2752	LEAK OXPHOS	N S	Permeabilized tissue	Mouse	Skeletal muscle
Hu 2024 Front Endocrinol (Lausanne)	2024	Hu Y, Fang B, Tian X, Wang H, Tian X, Yu F, Li T, Yang Z, Shi R (2024) Passive exercise is an effective alternative to HRT for restoring OVX induced mitochondrial dysfunction in skeletal muscle. Front Endocrinol (Lausanne) 15:1356312. https://doi.org/10.3389/fendo.2024.1356312	LEAK OXPHOS	N S CIV NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Opperdoes 2024 BMC Genomics	2024	Opperdoes FR, Záhonová K, Škodová-Sveráková I, Bučková B, Chmelová Ľ, Lukeš J, Yurchenko V (2024) In silico prediction of the metabolism of Blastocrithidia nonstop, a trypanosomatid with non-canonical genetic code. BMC Genomics 25:184. https://doi.org/10.1186/s12864-024-10094-8	LEAK OXPHOS ET ROUTINE	S	Isolated mitochondria Intact cells	Protists
Al-Sabri 2024 Sci Rep	2024	Al-Sabri MH, Ammar N, Korzh S, Alsehli AM, Hosseini K, Fredriksson R, Mwinyi J, Williams MJ, Boukhatmi H, Schiöth HB (2024) Fluvastatin-induced myofibrillar damage is associated with elevated ROS, and impaired fatty acid oxidation, and is preceded by mitochondrial morphological changes. https://doi.org/10.1038/s41598-024-53446-w	LEAK OXPHOS ET	F N S Gp NS ROX	Permeabilized tissue	Drosophila	Skeletal muscle
Fitzgerald 2024 J Cachexia Sarcopenia Muscle	2024	Fitzgerald LF, Lackey J, Moussa A, Shah SV, Castellanos AM, Khan S, Schonk M, Thome T, Salyers ZR, Jakkidi N, Kim K, Yang Q, Hepple RT, Ryan TE (2024) Chronic aryl hydrocarbon receptor activity impairs muscle mitochondrial function with tobacco smoking. https://doi.org/10.1002/jcsm.13439	LEAK OXPHOS	N CIV NS ROX	Permeabilized tissue Isolated mitochondria	Mouse	Skeletal muscle
Qiao 2024 J Sport Health Sci	2024	Qiao YS, Blackwell TL, Cawthon PM, Coen PM, Cummings SR, Distefano G, Farsijani S, Forman DE, Goodpaster BH, Kritchevsky SB, Mau T, Toledo FGS, Newman AB, Glynn NW (2024) Associations of accelerometry-measured and self-reported physical activity and sedentary behavior with skeletal muscle energetics: The Study of Muscle, Mobility and Aging (SOMMA). https://doi.org/10.1016/j.jshs.2024.02.001	LEAK OXPHOS	N NS	Permeabilized tissue	Human	Skeletal muscle
Ravasz 2024 Sci Rep	2024	Ravasz D, Bui D, Nazarian S, Pallag G, Karnok N, Roberts J, Marzullo BP, Tennant DA, Greenwood B, Kitayev A, Hill C, Komlódi T, Doerrier C, Cunatova K, Fernandez-Vizarra E, Gnaiger E, Kiebish Michael A, Raska A, Kolev K, Czumbel B, Narain NR, Seyfried TN, Chinopoulos C (2024) Residual Complex I activity and amphidirectional Complex II operation support glutamate catabolism through mtSLP in anoxia. Sci Rep 14:1729. https://doi.org/10.1038/s41598-024-51365-4	OXPHOS	N S	Isolated mitochondria	Mouse	Heart Liver
Balmaceda 2024 Biochim Biophys Acta Mol Basis Dis	2024	Balmaceda V, Komlodi T, Szibor M, Gnaiger E, Moore AL, Fernandez-Vizarra E, Viscomi C (2024) The striking differences in the bioenergetics of brain and liver mitochondria are enhanced in mitochondrial disease. Biochim Biophys Acta Mol Basis Dis 1870:167033. https://doi.org/10.1016/j.bbadis.2024.167033	LEAK OXPHOS ET	N S NS	Isolated mitochondria	Mouse	Nervous system Liver
Patil 2024 J Exp Biol	2024	Patil YN, Gnaiger E, Landry AP, Leno ZJ, Hand SC (2024) OXPHOS capacity is diminished and the phosphorylation system inhibited during diapause in an extremophile, embryos of Artemia franciscana. J Exp Biol 227:jeb.245828. https://doi.org/10.1242/jeb.245828	LEAK OXPHOS ET	F N S NS	Homogenate Isolated mitochondria	Artemia
Lee 2024 ACS Nano	2024	Lee CH, Wallace DC, Burke PJ (2024) Super-resolution imaging of voltages in the interior of individual, vital mitochondria. ACS Nano 18:1345−56. https://doi.org/10.1021/acsnano.3c02768	LEAK OXPHOS ET		Isolated mitochondria
Abegg 2024 Toxicol Lett	2024	Abegg VF, Panajatovic MV, Mancuso RV, Allard JA, Duthaler U, Odermatt A, Krähenbühl S, Bouitbir J (2024) Mechanisms of hepatocellular toxicity associated with the components of St. John's Wort extract hypericin and hyperforin in HepG2 and HepaRG cells. https://doi.org/10.1016/j.toxlet.2024.01.008	LEAK ROUTINE OXPHOS ET	N S DQ CIV ROX	Permeabilized cells Intact cells	Human	Liver
Visker 2024 Exp Physiol	2024	Visker JR, Leszczynski EC, Wellette-Hunsucker AG, McPeek AC, Quinn MA, Kim SH, Bazil JN, Ferguson DP (2024) Postnatal growth restriction alters myocardial mitochondrial energetics in mice. https://doi.org/10.1113/ep091304	LEAK OXPHOS	F N S NS	Isolated mitochondria	Mouse	Heart
Dong 2024 Nat Commun	2024	Dong J, Chen L, Ye F, Tang J, Liu B, Lin J, Zhou PH, Lu B, Wu M, Lu JH, He JJ, Engelender S, Meng Q, Song Z, He H (2024) Mic19 depletion impairs endoplasmic reticulum-mitochondrial contacts and mitochondrial lipid metabolism and triggers liver disease. https://doi.org/10.1038/s41467-023-44057-6	LEAK OXPHOS ET	N S CIV NS	Homogenate	Mouse	Liver
Noerregaard 2024 J Physiol	2024	Noerregaard LB, Hansen CC, Wickham KA, Moeller S, Olsen K, Ehlers T, Bangsbo J, Hellsten Y (2024) Exercise training alters skeletal muscle microvascular endothelial cell properties in recent postmenopausal females. J Physiol [Epub ahead of print]. https://doi.org/10.1113/jp286269	LEAK OXPHOS ROUTINE	N S NS	Permeabilized cells Intact cells	Human	Skeletal muscle Endothelial;epithelial;mesothelial cell
Wilburn 2024 Sci Rep	2024	Wilburn D, Miserlis D, Fletcher E, Papoutsi E, Ismaeel A, Bradley C, Ring A, Wilkinson T, Smith RS, Ferrer L, Haynatzki G, Monteleone P, Banerjee S, Brisbois E, Bohannon WT, Koutakis P (2024) Skeletal muscle desmin alterations following revascularization in peripheral artery disease claudicants. Sci Rep 14:12609. https://doi.org/10.1038/s41598-024-63626-3	LEAK OXPHOS	N S DQ CIV NS ROX	Permeabilized tissue	Human	Skeletal muscle
Morishita 2024 Biol Pharm Bull	2024	Morishita R, Onishi A, Oya M, Karashima H, Mori M, Kawatani Y, Kamei N, Takeda-Morishita M (2024) Effect of orally ingested water containing H2-filled ultrafine bubbles (UFBs) on ethanol-induced oxidative stress in rats. Biol Pharm Bull 47:1106-12. https://doi.org/10.1248/bpb.b24-00034	ET LEAK OXPHOS	N S NS ROX	Homogenate	Rat	Liver
Wang 2024 Adv Sci (Weinh)	2024	Wang H, Stevens T, Lu J, Roberts A, Van't Land C, Muzumdar R, Gong Z, Vockley J, Prochownik EV (2024) Body-wide inactivation of the Myc-like Mlx transcription factor network accelerates aging and increases the lifetime cancer incidence. Adv Sci (Weinh) [Epub ahead of print]. https://doi.org/10.1002/advs.202401593	LEAK OXPHOS	F N S NS	Isolated mitochondria	Mouse	Fat Skeletal muscle Liver
Buescher 2024 Acta Physiol (Oxf)	2024	Buescher FM, Schmitz MT, Frett T, Kramme J, de Boni L, Elmenhorst EM, Mulder E, Moestl S, Heusser K, Frings-Meuthen P, Jordan J, Rittweger J, Pesta D (2024) Effects of 30 days bed rest and exercise countermeasures on PBMC bioenergetics. Acta Physiol (Oxf) 240(3):e14102. https://doi.org/10.1111/apha.14102	ET LEAK ROUTINE OXPHOS	N NS	Permeabilized cells Intact cells	Human	Blood cells
Zhao 2024 J Adv Res	2024	Zhao Y, Lu Z, Zhang H, Wang L, Sun F, Li Q, Cao T, Wang B, Ma H, You M, Zhou Q, Wei X, Li L, Liao Y, Yan Z, Liu D, Gao P, Zhu Z (2024) Sodium-glucose exchanger 2 inhibitor canagliflozin promotes mitochondrial metabolism and alleviates salt-induced cardiac hypertrophy via preserving SIRT3 expression. J Adv Res [Epub ahead of print]. https://doi.org/10.1016/j.jare.2024.04.030	ET LEAK OXPHOS	F N S NS ROX	Isolated mitochondria	Mouse	Heart
Dulac 2024 J Physiol	2024	Dulac M, Hajj-Boutros G, Sonjak V, Faust A, Hussain SNA, Chevalier S, Dionne IJ, Morais JA, Gouspillou G (2024) A multimodal exercise countermeasure prevents the negative impact of head-down tilt bed rest on muscle volume and mitochondrial health in older adults. J Physiol [Epub ahead of print]. https://doi.org/10.1113/jp285897	LEAK OXPHOS	F N NS ROX	Permeabilized tissue	Human	Skeletal muscle
Li 2024 Cell Res	2024	Li M, Wang Y, Wei X, Cai WF, Wu J, Zhu M, Wang Y, Liu YH, Xiong J, Qu Q, Chen Y, Tian X, Yao L, Xie R, Li X, Chen S, Huang X, Zhang C, Xie C, Wu Y, Xu Z, Zhang B, Jiang B, Wang ZC, Li Q, Li G, Lin SY, Yu L, Piao HL, Deng X, Han J, Zhang CS, Lin SC (2024) AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine. Cell Res [Epub ahead of print]. https://doi.org/10.1038/s41422-024-00985-6	ET LEAK OXPHOS	N NS	Permeabilized tissue	Mouse	Skeletal muscle
Holwerda 2024 J Cachexia Sarcopenia Muscle	2024	Holwerda AM, Dirks ML, Barbeau PA, Goessens J, Gijsen A, van Loon LJC, Holloway GP (2024) Mitochondrial bioenergetics are not associated with myofibrillar protein synthesis rates. J Cachexia Sarcopenia Muscle [Epub ahead of print]. https://doi.org/10.1002/jcsm.13532	LEAK OXPHOS	N S NS	Permeabilized tissue	Human Mouse	Skeletal muscle
Alanova 2024 Acta Physiol (Oxf)	2024	Alanova P, Alan L, Opletalova B, Bohuslavova R, Abaffy P, Matejkova K, Holzerova K, Benak D, Kaludercic N, Menabo R, Di Lisa F, Ostadal B, Kolar F, Pavlinkova G (2024) HIF-1α limits myocardial infarction by promoting mitophagy in mouse hearts adapted to chronic hypoxia. Acta Physiol (Oxf) [Epub ahead of print]. https://doi.org/10.1111/apha.14202	ET LEAK OXPHOS	F N S CIV NS	Isolated mitochondria	Mouse	Heart
Artman 2024 J Equine Vet Sci	2024	Artman JL, Wesolowski LT, Semanchik PL, Isles JK, Norton SA, White-Springer SH (2024) Local and systemic responses to repeated gluteal muscle microbiopsies in mature sedentary horses. J Equine Vet Sci 136:105070. https://doi.org/10.1016/j.jevs.2024.105070	ET LEAK OXPHOS	N S NS ROX	Permeabilized tissue	Horse	Skeletal muscle
Coulson 2024 J Exp Biol	2024	Coulson SZ, Guglielmo CG, Staples JF (2024) Migration increases mitochondrial oxidative capacity without increasing reactive oxygen species emission in a songbird. J Exp Biol 227:jeb246849. https://doi.org/10.1242/jeb.246849	LEAK OXPHOS	F N S CIV	Isolated mitochondria	Birds	Skeletal muscle
Westerlund 2024 Heliyon	2024	Westerlund E, Marelsson SE, Karlsson M, Sjövall F, Chamkha I, Åsander Frostner E, Lundgren J, Fellman V, Eklund EA, Steding-Ehrenborg K, Darin N, Paul G, Hansson MJ, Ehinger JK, Elmér E (2024) Correlation of mitochondrial respiration in platelets, peripheral blood mononuclear cells and muscle fibers. Heliyon 10:e26745. https://doi.org/10.1016/j.heliyon.2024.e26745	ET LEAK ROUTINE OXPHOS	N S CIV NS ROX	Permeabilized cells Permeabilized tissue Intact cells	Human	Skeletal muscle Blood cells Platelet
Leo 2024 MitoFit	2024	Leo E, Rychtarova L, Garcia-Souza LF, Åsander Frostner E, Elmér E, Gnaiger E (2024) High-resolution respirometry in a small-volume chamber. MitoFit Preprints 2024.4.v2. https://doi.org/10.26124/mitofit:2024-0004.v2	ET LEAK ROUTINE OXPHOS	F N S Gp CIV NS Other combinations ROX	Permeabilized cells Homogenate Isolated mitochondria Intact cells	Human Mouse	Heart Nervous system Blood cells HUVEC Platelet
Wang 2024 J Biomed Sci	2024	Wang V, Tseng KY, Kuo TT, Huang EY, Lan KL, Chen ZR, Ma KH, Greig NH, Jung J, Choi HI, Olson L, Hoffer BJ, Chen YH (2024) Attenuating mitochondrial dysfunction and morphological disruption with PT320 delays dopamine degeneration in MitoPark mice. J Biomed Sci 31:38. https://doi.org/10.1186/s12929-024-01025-6	ET LEAK OXPHOS	N S CIV NS ROX	Homogenate	Mouse	Nervous system
Xu 2024 Sci Adv	2024	Xu G, Quan S, Schell J, Gao Y, Varmazyad M, Sreenivas P, Cruz D, Jiang H, Pan M, Han X, Palavicini JP, Zhao P, Sun X, Marchant ED, Rasmussen BB, Li G, Katsumura S, Morita M, Munkácsy E, Horikoshi N, Chocron ES, Gius D (2024) Mitochondrial ACSS1-K635 acetylation knock-in mice exhibit altered metabolism, cell senescence, and nonalcoholic fatty liver disease. Sci Adv 10:eadj5942. https://doi.org/10.1126/sciadv.adj5942	ET LEAK OXPHOS	F N ROX		Mouse	Liver
Navarro 2024 Exp Gerontol	2024	Navarro CDC, Francisco A, Costa EFD, Dalla Costa AP, Sartori MR, Bizerra PFV, Salgado AR, Figueira TR, Vercesi AE, Castilho RF (2024) Aging-dependent mitochondrial bioenergetic impairment in the skeletal muscle of NNT-deficient mice. Exp Gerontol 193:112465. https://doi.org/10.1016/j.exger.2024.112465	ET LEAK OXPHOS	N S CIV ROX	Permeabilized tissue	Mouse	Skeletal muscle
Magri 2024 Cell Death Discov	2024	Magrì A, Lipari CLR, Caccamo A, Battiato G, Conti Nibali S, De Pinto V, Guarino F, Messina A (2024) AAV-mediated upregulation of VDAC1 rescues the mitochondrial respiration and sirtuins expression in a SOD1 mouse model of inherited ALS. Cell Death Discov 10:178. https://doi.org/10.1038/s41420-024-01949-w	ET LEAK OXPHOS	N S NS ROX	Homogenate	Mouse	Nervous system
Doerrier 2024 Free Radic Biol Med	2024	Doerrier C, Gama-Perez P, Pesta D, Distefano G, Soendergaard SD, Maise Chroeis K, Gonzalez-Franquesa A, Goodpaster BH, Prats C, Sales-Pardo M, Guimera R, Coen PM, Gnaiger E, Larsen S, Garcia-Roves PM (2024) Harmonization of experimental procedures to assess mitochondrial respiration in human permeabilized skeletal muscle fibers. Free Radic Biol Med 223:384-97. https://doi.org/10.1016/j.freeradbiomed.2024.07.039	ET LEAK OXPHOS	N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Liepinsh 2024 Br J Pharmacol	2024	Liepinsh E, Zvejniece L, Clemensson L, Ozola M, Vavers E, Cirule H, Korzh S, Skuja S, Groma V, Briviba M, Grinberga S, Liu W, Olszewski P, Gentreau M, Fredriksson R, Dambrova M, Schiöth HB (2024) Hydroxymethylglutaryl-CoA reductase activity is essential for mitochondrial β-oxidation of fatty acids to prevent lethal accumulation of long-chain acylcarnitines in the mouse liver. Br J Pharmacol [Epub ahead of print]. https://doi.org/10.1111/bph.16363	ET LEAK OXPHOS	F N S NS ROX	Homogenate	Mouse	Liver
Cardoso 2024 BEC	2024	Cardoso LHD, Gnaiger E (2024) OXPHOS coupling and uncoupling. Bioenerg Commun 2024.5. https://doi.org/10.26124/bec.2024-0005	LEAK OXPHOS ET
Zhang 2024 Cell Metab	2024	Zhang Y, Higgins CB, Tica S, Adams JA, Sun J, Kelly SC, Zong X, Dietzen DJ, Pietka T, Ballentine SJ, Shriver L, Patti G, Cao Y, DeBosch BJ (2024) Hierarchical tricarboxylic acid cycle regulation by hepatocyte arginase 2 links the urea cycle to oxidative metabolism. Cell Metab [Epub ahead of print]. https://doi.org/10.1016/j.cmet.2024.07.007	ET LEAK OXPHOS	N NS		Mouse	Liver
Thome 2024 JCI Insight	2024	Thome T, Vugman NA, Stone LE, Wimberly K, Scali ST, Ryan TE (2024) A tryptophan-derived uremic metabolite-Ahr-Pdk4 axis governs skeletal muscle mitochondrial energetics in chronic kidney disease. JCI Insight [Epub ahead of print]. https://doi.org/10.1172/jci.insight.178372	LEAK OXPHOS	F N	Permeabilized tissue Isolated mitochondria	Human Mouse	Skeletal muscle
Garcia-Poyatos 2024 Dev Cell	2024	García-Poyatos C, Arora P, Calvo E, Marques IJ, Kirschke N, Galardi-Castilla M, Lembke C, Meer M, Fernández-Montes P, Ernst A, Haberthür D, Hlushchuk R, Vázquez J, Vermathen P, Enríquez JA, Mercader N (2024) Cox7a1 controls skeletal muscle physiology and heart regeneration through complex IV dimerization. Dev Cell [Epub ahead of print]. https://doi.org/10.1016/j.devcel.2024.04.012	LEAK OXPHOS	N S CIV NS ROX	Isolated mitochondria	Zebrafish	Skeletal muscle
Lhuissier 2024 iScience	2024	Lhuissier C, Desquiret-Dumas V, Girona A, Alban J, Faure J, Cassereau J, Codron P, Lenaers G, Baris OR, Gueguen N, Chevrollier A (2024) Mitochondrial F0F1-ATP synthase governs the induction of mitochondrial fission. iScience 27:109808. https://doi.org/10.1016/j.isci.2024.109808	LEAK ROUTINE OXPHOS ET	N NS ROX	Permeabilized cells Intact cells	Mouse	Fibroblast
Sorby-Adams 2024 Redox Biol	2024	Sorby-Adams A, Prime TA, Miljkovic JL, Prag HA, Krieg T, Murphy MP (2024) A model of mitochondrial superoxide production during ischaemia-reperfusion injury for therapeutic development and mechanistic understanding. Redox Biol 72:103161. https://doi.org/10.1016/j.redox.2024.103161	LEAK OXPHOS ET	S Other combinations	Isolated mitochondria	Rat	Heart
Bellar 2023 Clin Transl Med	2023	Bellar A, Welch N, Dasarathy J, Attaway A, Musich R, Kumar A, Sekar J, Mishra S, Sandlers Y, Streem D, Nagy LE, Dasarathy S (2023) Peripheral blood mononuclear cell mitochondrial dysfunction in acute alcohol-associated hepatitis. https://doi.org/10.1002/ctm2.1276	LEAK ROUTINE OXPHOS ET	N S CIV NS ROX	Permeabilized cells Intact cells	Human	Blood cells
Czyzowska 2023 Redox Biol	2023	Czyżowska A, Brown J, Xu H, Sataranatarajan K, Kinter M, Tyrell VJ, O'Donnell VB, Van Remmen H (2023) Elevated phospholipid hydroperoxide glutathione peroxidase (GPX4) expression modulates oxylipin formation and inhibits age-related skeletal muscle atrophy and weakness. https://doi.org/10.1016/j.redox.2023.102761	LEAK OXPHOS	N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Kienzle 2023 BMC Biol	2023	Kienzle L, Bettinazzi S, Choquette T, Brunet M, Khorami HH, Jacques JF, Moreau M, Roucou X, Landry CR, Angers A, Breton S (2023) A small protein coded within the mitochondrial canonical gene nd4 regulates mitochondrial bioenergetics. https://doi.org/10.1186/s12915-023-01609-y	LEAK ROUTINE OXPHOS ET	N CIV NS ROX	Permeabilized cells Intact cells	Human	HEK HeLa
Horcas-Nieto 2023 Biochim Biophys Acta Mol Basis Dis	2023	Horcas-Nieto JM, Versloot CJ, Langelaar-Makkinje M, Gerding A, Blokzijl T, Koster MH, Baanstra M, Martini IA, Coppes RP, Bourdon C, van Ijzendoorn SCD, Kim P, Bandsma RHJ, Bakker BM (2023) Organoids as a model to study intestinal and liver dysfunction in severe malnutrition. https://doi.org/10.1016/j.bbadis.2022.166635	LEAK ET OXPHOS	F		Mouse	Liver Other cell lines
Szulik 2023 Basic Res Cardiol	2023	Szulik MW, Valdez S, Walsh M, Davis K, Bia R, Horiuchi E, O'Very S, Laxman AK, Sandaklie-Nicolova L, Eberhardt DR, Durrant JR, Sheikh H, Hickenlooper S, Creed M, Brady C, Miller M, Wang L, Garcia-Llana J, Tracy C, Drakos SG, Funai K, Chaudhuri D, Boudina S, Franklin S (2023) SMYD1a protects the heart from ischemic injury by regulating OPA1-mediated cristae remodeling and supercomplex formation. https://doi.org/10.1007/s00395-023-00991-6	LEAK OXPHOS ET	N NS	Isolated mitochondria	Mouse	Heart
Moellering 2023 Arthritis Res Ther	2023	Moellering DR, Smith-Johnston K, Kelley C, Sammy MJ, Benedict J, Brock G, Johnson J, Baskin KK, Jarjour WN, Belury MA, Reiser PJ, Nagareddy PR, Hanaoka BY (2023) Association between skeletal muscle mitochondrial dysfunction and insulin resistance in patients with rheumatoid arthritis: a case-control study. https://doi.org/10.1186/s13075-023-03065-z	LEAK OXPHOS ET	F N CIV ROX	Permeabilized tissue	Human	Skeletal muscle
Kankuri 2023 Exp Mol Med	2023	Kankuri E, Finckenberg P, Leinonen J, Tarkia M, Björk S, Purhonen J, Kallijärvi J, Kankainen M, Soliymani R, Lalowski M, Mervaala E (2023) Altered acylcarnitine metabolism and inflexible mitochondrial fuel utilization characterize the loss of neonatal myocardial regeneration capacity. https://doi.org/10.1038/s12276-023-00967-5	LEAK OXPHOS	F N S NS ROX	Isolated mitochondria	Mouse	Heart
Giovarelli 2023 Mol Med	2023	Giovarelli M, Serati A, Zecchini S, Guelfi F, Clementi E, Mandò C (2023) Cryopreserved placental biopsies maintain mitochondrial activity for high-resolution respirometry. https://doi.org/10.1186/s10020-023-00645-2	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue	Human	Genital
Airik 2023 Antioxidants (Basel)	2023	Airik M, Arbore H, Childs E, Huynh AB, Phua YL, Chen CW, Aird K, Bharathi S, Zhang B, Conlon P, Kmoch S, Kidd K, Bleyer AJ, Vockley J, Goetzman E, Wipf P, Airik R (2023) Mitochondrial ROS triggers KIN pathogenesis in FAN1-deficient kidneys. https://doi.org/10.3390/antiox12040900	OXPHOS ET LEAK	N S NS	Isolated mitochondria	Human	Kidney
Gemmink 2023 Mol Metab	2023	Gemmink A, Daemen S, Wefers J, Hansen J, van Moorsel D, Astuti P, Jorgensen JA, Kornips E, Schaart G, Hoeks J, Schrauwen P, Hesselink MKC (2023) Twenty-four hour rhythmicity in mitochondrial network connectivity and mitochondrial respiration; a study in human skeletal muscle biopsies of young lean and older individuals with obesity. https://doi.org/10.1016/j.molmet.2023.101727	LEAK OXPHOS ET	F N NS	Permeabilized tissue	Human	Skeletal muscle
Scandalis 2023 JAMA Cardiol	2023	Scandalis L, Kitzman DW, Nicklas BJ, Lyles M, Brubaker P, Nelson MB, Gordon M, Stone J, Bergstrom J, Neufer PD, Gnaiger E, Molina AJA (2023) Skeletal muscle mitochondrial respiration and exercise intolerance in patients with heart failure with preserved ejection fraction. JAMA Cardiol 8:575–84. https://doi.org/10.1001/jamacardio.2023.0957	OXPHOS ET LEAK	N NS ROX S	Permeabilized tissue	Human	Skeletal muscle
Horvath 2023 Antioxidants (Basel)	2023	Horváth T, Sándor L, Baráth B, Donka T, Baráth B, Mohácsi Á, Jász KD, Hartmann P, Boros M (2023) Methane admixture protects liver mitochondria and improves graft function after static cold storage and reperfusion. Antioxidants (Basel) 12:271. https://doi.org/10.3390/antiox12020271	LEAK OXPHOS	N NS ROX	Homogenate	Rat	Liver
Hoogstraten 2023 Arch Toxicol	2023	Hoogstraten CA, Jacobs MME, de Boer G, van de Wal MAE, Koopman WJH, Smeitink JAM, Russel FGM, Schirris TJJ (2023) Metabolic impact of genetic and chemical ADP/ATP carrier inhibition in renal proximal tubule epithelial cells. https://doi.org/10.1007/s00204-023-03510-7	LEAK OXPHOS	N	Isolated mitochondria	Human	Kidney
Leduc-Gaudet 2023 Nat Commun	2023	Leduc-Gaudet JP, Franco-Romero A, Cefis M, Moamer A, Broering FE, Milan G, Sartori R, Chaffer TJ, Dulac M, Marcangeli V, Mayaki D, Huck L, Shams A, Morais JA, Duchesne E, Lochmuller H, Sandri M, Hussain SNA, Gouspillou G (2023) MYTHO is a novel regulator of skeletal muscle autophagy and integrity. https://doi.org/10.1038/s41467-023-36817-1	LEAK OXPHOS	N NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Silaidos 2023 Geroscience	2023	Silaidos CV, Reutzel M, Wachter L, Dieter F, Ludin N, Blum WF, Wudy SA, Matura S, Pilatus U, Hattingen E, Pantel J, Eckert GP (2023) Age-related changes in energy metabolism in peripheral mononuclear blood cells (PBMCs) and the brains of cognitively healthy seniors. https://doi.org/10.1007/s11357-023-00810-9	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Human	Blood cells
Nollet 2023 Eur Heart J	2023	Nollet EE, Duursma I, Rozenbaum A, Eggelbusch M, Wüst RCI, Schoonvelde SAC, Michels M, Jansen M, van der Wel NN, Bedi KC, Margulies KB, Nirschl J, Kuster DWD, van der Velden J (2023) Mitochondrial dysfunction in human hypertrophic cardiomyopathy is linked to cardiomyocyte architecture disruption and corrected by improving NADH-driven mitochondrial respiration. https://doi.org/10.1093/eurheartj/ehad028	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Human	Heart
Stampley 2023 Physiol Rep	2023	Stampley JE, Cho E, Wang H, Theall B, Johannsen NM, Spielmann G, Irving BA (2023) Impact of maximal exercise on immune cell mobilization and bioenergetics. https://doi.org/10.14814/phy2.15753	LEAK ROUTINE OXPHOS ET	N NS ROX	Permeabilized cells Intact cells	Human	Blood cells
Mancilla 2023 Physiol Rep	2023	Mancilla R, Pava-Mejia D, van Polanen N, de Wit V, Bergman M, Grevendonk L, Jorgensen J, Kornips E, Hoeks J, Hesselink MKC, Schrauwen-Hinderling VB (2023) Invasive and noninvasive markers of human skeletal muscle mitochondrial function. https://doi.org/10.14814/phy2.15734	LEAK OXPHOS ET	F N NS	Permeabilized tissue	Human	Skeletal muscle
Davis 2023 MitoFit	2023	Davis MS, Barrett MR, Bayly WM, Bolinger A (2023) Effect of selected fluorophores on equine skeletal muscle mitochondrial respiration. MitoFit Preprints 2023.5. https://doi.org/10.26124/mitofit:2023-0005 — 2024-04-25 published in Bioenerg Commun 2024.2.	LEAK OXPHOS	N S	Isolated mitochondria	Horse	Skeletal muscle
Bellissimo 2023 Exp Physiol	2023	Bellissimo CA, Castellani LN, Finch MS, Murugathasan M, Gandhi S, Sweeney G, Abdul-Sater AA, MacPherson REK, Perry CGR (2023) Memory impairment in the D2.mdx mouse model of Duchenne muscular dystrophy is prevented by the adiponectin receptor agonist ALY688. https://doi.org/10.1113/ep091274	LEAK OXPHOS	N	Permeabilized cells	Mouse	Nervous system
Wang 2023 Nature	2023	Wang D, Townsend LK, DesOrmeaux GJ, Frangos SM, Batchuluun B, Dumont L, Kuhre RE, Ahmadi E, Hu S, Rebalka IA, Gautam J, Jabile MJT, Pileggi CA, Rehal S, Desjardins EM, Tsakiridis EE, Lally JSV, Juracic ES, Tupling AR, Gerstein HC, Paré G, Tsakiridis T, Harper ME, Hawke TJ, Speakman JR, Blondin DP, Holloway GP, Jørgensen SB, Steinberg GR (2023) GDF15 promotes weight loss by enhancing energy expenditure in muscle. https://doi.org/10.1038/s41586-023-06249-4	LEAK OXPHOS	N NS	Permeabilized tissue Intact cells Isolated mitochondria	Mouse	Skeletal muscle
Golomb 2023 Sci Rep	2023	Golomb BA, Sanchez Baez R, Schilling JM, Dhanani M, Fannon MJ, Berg BK, Miller BJ, Taub PR, Patel HH (2023) Mitochondrial impairment but not peripheral inflammation predicts greater Gulf War illness severity. https://doi.org/10.1038/s41598-023-35896-w	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Fletcher 2023 Transl Res	2023	Fletcher E, Miserlis D, Sorokolet K, Wilburn D, Bradley C, Papoutsi E, Wilkinson T, Ring A, Ferrer L, Haynatzki G, Smith RS, Bohannon WT, Koutakis P (2023) Diet-induced obesity augments ischemic myopathy and functional decline in a murine model of peripheral artery disease. https://doi.org/10.1016/j.trsl.2023.05.002	LEAK OXPHOS	N S DQ CIV NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Mayayo-Vallverdu 2023 Redox Biol	2023	Mayayo-Vallverdú C, López de Heredia M, Prat E, González L, Espino Guarch M, Vilches C, Muñoz L, Asensi MA, Serra C, Llebaria A, Casado M, Artuch R, Garrabou G, Garcia-Roves PM, Pallardó FV, Nunes V (2023) The antioxidant l-Ergothioneine prevents cystine lithiasis in the Slc7a9^-/- mouse model of cystinuria. https://doi.org/10.1016/j.redox.2023.102801	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Kidney
Dewidar 2023 EBioMedicine	2023	Dewidar B, Mastrototaro L, Englisch C, Ress C, Granata C, Rohbeck E, Pesta D, Heilmann G, Wolkersdorfer M, Esposito I, Reina Do Fundo M, Zivehe F, Yavas A, Roden M (2023) Alterations of hepatic energy metabolism in murine models of obesity, diabetes and fatty liver diseases. https://doi.org/10.1016/j.ebiom.2023.104714	LEAK OXPHOS ET	F N NS ROX	Permeabilized tissue	Mouse	Skeletal muscle Liver
Steffen 2023 J Exp Biol	2023	Steffen JBM, Sokolov EP, Bock C, Sokolova IM (2023) Combined effects of salinity and intermittent hypoxia on mitochondrial capacity and reactive oxygen species efflux in the Pacific oyster, Crassostrea gigas. https://doi.org/10.1242/jeb.246164	LEAK OXPHOS ET	N CIV NS ROX	Isolated mitochondria	Molluscs	Lung;gill
Frangos 2023 J Biol Chem	2023	Frangos SM, DesOrmeaux GJ, Holloway GP (2023) Acidosis attenuates CPT-I supported bioenergetics as a potential mechanism limiting lipid oxidation. https://doi.org/10.1016/j.jbc.2023.105079	LEAK OXPHOS	F N S NS	Permeabilized tissue Isolated mitochondria	Mouse	Skeletal muscle
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Mioc 2023 Molecules	2023	Mioc M, Mioc A, Racoviceanu R, Ghiulai R, Prodea A, Milan A, Barbu Tudoran L, Oprean C, Ivan V, Șoica C (2023) The antimelanoma biological assessment of triterpenic acid functionalized gold nanoparticles. https://doi.org/10.3390/molecules28010421	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Endothelial;epithelial;mesothelial cell
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Dominguez-Lopez 2023 Neuropharmacology	2023	Dominguez-Lopez S, Ahn B, Sataranatarajan K, Ranjit R, Premkumar P, Van Remmen H, Beckstead MJ (2023) Long-term methamphetamine self-administration increases mesolimbic mitochondrial oxygen consumption and decreases striatal glutathione. https://doi.org/10.1016/j.neuropharm.2023.109436	LEAK OXPHOS	N S CIV NS ROX	Permeabilized tissue	Mouse	Nervous system
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Sathiaseelan 2023 J Gerontol A Biol Sci Med Sci	2023	Sathiaseelan R, Ahn B, Stout MB, Logan S, Wanagat J, Van M Nguyen H, Hord NG, Vandiver AR, Selvarani R, Ranjit R, Yarbrough H, Masingale A, Miller BF, Wolf RF, Austad SN, Richardson A (2023) A genetically heterogeneous rat model with divergent mitochondrial genomes. https://doi.org/10.1093/gerona/glad056	LEAK OXPHOS	N S CIV NS ROX	Permeabilized tissue	Rat	Skeletal muscle
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Garcia-Roche 2023 PLoS One	2023	García-Roche M, Talmón D, Cañibe G, Astessiano AL, Mendoza A, Cassina A, Quijano C, Carriquiry M (2023) Hepatic metabolism of grazing cows of two Holstein strains under two feeding strategies with different levels of pasture inclusion. https://doi.org/10.1371/journal.pone.0290551	LEAK OXPHOS ET	F N S NS ROX	Intact cells	Bovines	Liver
Zvejniece 2023 Biomed Pharmacother	2023	Zvejniece L, Svalbe B, Vavers E, Ozola M, Grinberga S, Gukalova B, Sevostjanovs E, Liepinsh E, Dambrova M (2023) Decreased long-chain acylcarnitine content increases mitochondrial coupling efficiency and prevents ischemia-induced brain damage in rats.	LEAK OXPHOS	N S CIV NS ROX	Isolated mitochondria	Rat
Ismaeel 2023 Physiol Rep	2023	Ismaeel A, Valentino TR, Burke B, Goh J, Saliu TP, Albathi F, Owen A, McCarthy JJ, Wen Y (2023) Acetate and succinate benefit host muscle energetics as exercise-associated post-biotics. https://doi.org/10.14814/phy2.15848	LEAK OXPHOS ET	N S NS ROX	Homogenate	Mouse	Skeletal muscle
Jiang 2023 Sci Rep	2023	Jiang N, Wang Z, Guo X, Peng Z, He Y, Wang Q, Wu H, Cui Y (2023) Hepatic Runx1t1 improves body fat index after endurance exercise in obese mice. https://doi.org/10.1038/s41598-023-46302-w	LEAK OXPHOS		Isolated mitochondria	Mouse	Liver
Kutschka 2023 Basic Res Cardiol	2023	Kutschka I, Bertero E, Wasmus C, Xiao K, Yang L, Chen X, Oshima Y, Fischer M, Erk M, Arslan B, Alhasan L, Grosser D, Ermer KJ, Nickel A, Kohlhaas M, Eberl H, Rebs S, Streckfuss-Bömeke K, Schmitz W, Rehling P, Thum T, Higuchi T, Rabinowitz J, Maack C, Dudek J (2023) Activation of the integrated stress response rewires cardiac metabolism in Barth syndrome. https://doi.org/10.1007/s00395-023-01017-x	LEAK OXPHOS ET	F N	Isolated mitochondria	Mouse	Heart
Zhang 2023 Nat Commun	2023	Zhang Y, Fan Y, Hu H, Zhang X, Wang Z, Wu Z, Wang L, Yu X, Song X, Xiang P, Zhang X, Wang T, Tan S, Li C, Gao L, Liang X, Li S, Li N, Yue X, Ma C (2023) ZHX2 emerges as a negative regulator of mitochondrial oxidative phosphorylation during acute liver injury. https://doi.org/10.1038/s41467-023-43439-0	LEAK OXPHOS ET	N S NS ROX	Intact cells	Mouse	Liver
Santos-Silva 2023 Transl Psychiatry	2023	Santos-Silva T, Hazar Ülgen D, Lopes CFB, Guimarães FS, Alberici LC, Sandi C, Gomes FV (2023) Transcriptomic analysis reveals mitochondrial pathways associated with distinct adolescent behavioral phenotypes and stress response. https://doi.org/10.1038/s41398-023-02648-3	LEAK OXPHOS ET	N	Permeabilized cells	Rat	Nervous system
Bodis 2023 Diabetes Obes Metab	2023	Bódis K, Breuer S, Crepzia-Pevzner A, Zaharia OP, Schön M, Saatmann N, Altenhofen D, Springer C, Szendroedi J, Wagner R, Al-Hasani H, Roden M, Pesta D, Chadt A (2023) Impact of physical fitness and exercise training on subcutaneous adipose tissue beiging markers in humans with and without diabetes and a high-fat diet-fed mouse model. https://doi.org/10.1111/dom.15322	LEAK OXPHOS ET	F N NS		Mouse	Fat
Batterson 2023 Physiol Rep	2023	Batterson PM, McGowan EM, Borowik AK, Kinter MT, Miller BF, Newsom SA, Robinson MM (2023) High-fat diet increases electron transfer flavoprotein synthesis and lipid respiration in skeletal muscle during exercise training in female mice. https://doi.org/10.14814/phy2.15840	LEAK OXPHOS ET	F N S Gp NS ROX	Isolated mitochondria	Mouse	Skeletal muscle
Sundaram 2023 Cell Metab	2023	Sundaram VK, Schütza V, Schröter NH, Backhaus A, Bilsing A, Joneck L, Seelbach A, Mutschler C, Gomez-Sanchez JA, Schäffner E, Sánchez EE, Akkermann D, Paul C, Schwagarus N, Müller S, Odle A, Childs G, Ewers D, Kungl T, Sitte M, Salinas G, Sereda MW, Nave KA, Schwab MH, Ost M, Arthur-Farraj P, Stassart RM, Fledrich R (2023) Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration. https://doi.org/10.1016/j.cmet.2023.10.017	LEAK OXPHOS ET	N S NS ROX	Intact cells	Mouse	Nervous system
Liu 2023 Pharmacol Res	2023	Liu S, Yue S, Guo Y, Han JY, Wang H (2023) Sorafenib induces cardiotoxicity through RBM20-mediated alternative splicing of sarcomeric and mitochondrial genes. https://doi.org/10.1016/j.phrs.2023.107017	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Rat	Heart
Wen 2023 PLoS One	2023	Wen W, Guo C, Chen Z, Yang D, Zhu D, Jing Q, Zheng L, Sun C, Tang C (2023) Regular exercise attenuates alcoholic myopathy in zebrafish by modulating mitochondrial homeostasis. https://doi.org/10.1371/journal.pone.0294700	LEAK ET OXPHOS	N S NS ROX	Intact cells	Zebrafish	Skeletal muscle
Pereyra 2023 Am J Physiol Gastrointest Liver Physiol	2023	Pereyra AS, McLaughlin KL, Buddo KA, Ellis JM (2023) Medium-chain fatty acid oxidation is independent of L-carnitine in liver and kidney but not in heart and skeletal muscle. https://doi.org/10.1152/ajpgi.00105.2023	LEAK ROUTINE OXPHOS	F N	Homogenate	Mouse	Heart Skeletal muscle Liver Kidney
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Harmsen 2023 J Physiol	2023	Harmsen JF, Kotte M, Habets I, Bosschee F, Frenken K, Jorgensen JA, de Kam S, Moonen-Kornips E, Cissen J, Doligkeit D, van de Weijer T, Erazo-Tapia E, Buitinga M, Hoeks J, Schrauwen P (2023) Exercise training modifies skeletal muscle clock gene expression but not 24-hour rhythmicity in substrate metabolism of men with insulin resistance. https://doi.org/10.1113/jp285523	LEAK OXPHOS ET	F N NS	Permeabilized tissue	Human	Skeletal muscle
Noone 2023 J Physiol	2023	Noone J, Damiot A, Kenny H, Chery I, Zahariev A, Normand S, Crampes F, de Glisezinski I, Rochfort KD, Laurens C, Bareille MP, Simon C, Bergouignan A, Blanc S, O'Gorman DJ (2023) The impact of 60 days of -6° head down tilt bed rest on mitochondrial content, respiration and regulators of mitochondrial dynamics. https://doi.org/10.1113/jp284734	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue	Human	Skeletal muscle
Sharma 2023 Biosci Biotechnol Biochem	2023	Sharma S, Zhang X, Azhar G, Patyal P, Verma A, Kc G, Wei JY (2023) Valine improves mitochondrial function and protects against oxidative stress. https://doi.org/10.1093/bbb/zbad169	LEAK ROUTINE OXPHOS ET	N S CIV ROX	Permeabilized cells Intact cells	Mouse	Skeletal muscle
Curtabbi 2023 Redox Biol	2023	Curtabbi A, Guarás A, Cabrera-Alarcón JL, Rivero M, Calvo E, Rosa-Moreno M, Vázquez J, Medina M, Enríquez JA (2023) Regulation of respiratory complex I assembly by FMN cofactor targeting. https://doi.org/10.1016/j.redox.2023.103001	OXPHOS	CIV N S	Permeabilized cells Isolated mitochondria	Mouse	Fibroblast Kidney
Dabrowska 2023 Int J Mol Sci	2023	Dabrowska A, Zajac M, Bednarczyk P, Lukasiak A (2023) Effect of quercetin on mitoBK_Ca channel and mitochondrial function in human bronchial epithelial cells exposed to particulate matter. Int J Mol Sci 24:638. https://doi.org/10.3390/ijms24010638	LEAK ROUTINE OXPHOS ET	S ROX	Permeabilized cells Intact cells	Human	Lung;gill Endothelial;epithelial;mesothelial cell
Verma 2023 Int J Mol Sci	2023	Verma A, Azhar G, Zhang X, Patyal P, Kc G, Sharma S, Che Y, Wei JY (2023) P. gingivalis-LPS induces mitochondrial dysfunction mediated by neuroinflammation through oxidative stress. Int J Mol Sci 24:950. https://doi.org/10.3390/ijms24020950	LEAK ROUTINE OXPHOS ET	N S CIV ROX	Permeabilized cells Intact cells	Human	Endothelial;epithelial;mesothelial cell
Glombik 2023 Int J Mol Sci	2023	Glombik K, Kukla-Bartoszek M, Curzytek K, Detka J, Basta-Kaim A, Budziszewska B (2023) The effects of prenatal dexamethasone exposure on brain metabolic homeostasis in adulthood: implications for depression. Int J Mol Sci 24:1156. https://doi.org/10.3390/ijms24021156	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Rat	Nervous system
Mousa 2023 Cell Rep	2023	Mousa MG, Vuppaladhadiam L, Kelly MO, Pietka T, Ek S, Shen KC, Meyer GA, Finck BN, Brookheart RT (2023) Site-1 protease inhibits mitochondrial respiration by controlling the TGF-β target gene Mss51. Cell Rep 42:112336. https://doi.org/10.1016/j.celrep.2023.112336	LEAK OXPHOS ET	N NS	Permeabilized tissue	Mouse	Skeletal muscle
Kim 2023 Nat Commun	2023	Kim Y, Li C, Gu C, Fang Y, Tycksen E, Puri A, Pietka TA, Sivapackiam J, Kidd K, Park SJ, Johnson BG, Kmoch S, Duffield JS, Bleyer AJ, Jackrel ME, Urano F, Sharma V, Lindahl M, Chen YM (2023) MANF stimulates autophagy and restores mitochondrial homeostasis to treat autosomal dominant tubulointerstitial kidney disease in mice. Nat Commun 14:6493. https://doi.org/10.1038/s41467-023-42154-0	LEAK OXPHOS ET	N NS	Permeabilized cells	Mouse	Kidney
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Pharaoh 2023 Geroscience	2023	Pharaoh G, Kamat V, Kannan S, Stuppard RS, Whitson J, Martín-Pérez M, Qian WJ, MacCoss MJ, Villén J, Rabinovitch P, Campbell MD, Sweet IR, Marcinek DJ (2023) The mitochondrially targeted peptide elamipretide (SS-31) improves ADP sensitivity in aged mitochondria by increasing uptake through the adenine nucleotide translocator (ANT). https://doi.org/10.1007/s11357-023-00861-y	LEAK OXPHOS	N S NS ROX	Permeabilized tissue Isolated mitochondria	Mouse	Skeletal muscle
Awad-Igbaria 2023 J Transl Med	2023	Awad-Igbaria Y, Ferreira N, Keadan A, Sakas R, Edelman D, Shamir A, Francous-Soustiel J, Palzur E (2023) HBO treatment enhances motor function and modulates pain development after sciatic nerve injury via protection the mitochondrial function. https://doi.org/10.1186/s12967-023-04414-x	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Rat	Nervous system
Krause 2023 J Transl Med	2023	Krause J, Nickel A, Madsen A, Aitken-Buck HM, Stoter AMS, Schrapers J, Ojeda F, Geiger K, Kern M, Kohlhaas M, Bertero E, Hofmockel P, Hübner F, Assum I, Heinig M, Müller C, Hansen A, Krause T, Park DD, Just S, Aïssi D, Börnigen D, Lindner D, Friedrich N, Alhussini K, Bening C, Schnabel RB, Karakas M, Iacoviello L, Salomaa V, Linneberg A, Tunstall-Pedoe H, Kuulasmaa K, Kirchhof P, Blankenberg S, Christ T, Eschenhagen T, Lamberts RR, Maack C, Stenzig J, Zeller T (2023) An arrhythmogenic metabolite in atrial fibrillation. https://doi.org/10.1186/s12967-023-04420-z	LEAK OXPHOS	F N NS	Isolated mitochondria Intact cells	Human	Heart
Arias-Reyes 2023 MitoFit	2023	Arias-Reyes C, Aliaga-Raduán F, Pinto-Aparicio R, Joseph V, Soliz J (2023) Mitochondrial plasticity in the retrosplenial cortex enhances ATP synthesis during acclimatization to hypoxia in mice but not in rats. MitoFit Preprints 2023.6. https://doi.org/10.26124/mitofit:2023-0006	LEAK OXPHOS ET	N S NS	Permeabilized tissue	Mouse Rat	Nervous system
Sadri 2023 Function (Oxf)	2023	Sadri S, Zhang X, Audi SH, Cowley AW Jr, Dash RK (2023) Computational modeling of substrate-dependent mitochondrial respiration and bioenergetics in the heart and kidney cortex and outer medulla. Function (Oxf) 4:zqad038. https://doi.org/10.1093/function/zqad038	OXPHOS	N S NS		Rat	Heart Kidney
Morales-Rubio 2023 Sci Rep	2023	Morales-Rubio R, Bernal-Ramírez J, Rubio-Infante N, Luévano-Martínez LA, Ríos A, Escalante BA, García-Rivas G, Rodríguez González J (2023) Cellular shortening and calcium dynamics are improved by noisy stimulus in a model of cardiomyopathy. https://doi.org/10.1038/s41598-023-41611-6	LEAK OXPHOS ET	S CIV	Permeabilized cells	Mouse	Heart
Thompson 2023 Geroscience	2023	Thompson SD, Barrett KL, Rugel CL, Redmond R, Rudofski A, Kurian J, Curtin JL, Dayanidhi S, Lavasani M (2023) Sex-specific preservation of neuromuscular function and metabolism following systemic transplantation of multipotent adult stem cells in a murine model of progeria. https://doi.org/10.1007/s11357-023-00892-5	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Ling 2023 EBioMedicine	2023	Ling C, Versloot CJ, Arvidsson Kvissberg ME, Hu G, Swain N, Horcas-Nieto JM, Miraglia E, Thind MK, Farooqui A, Gerding A, van Eunen K, Koster MH, Kloosterhuis NJ, Chi L, ChenMi Y, Langelaar-Makkinje M, Bourdon C, Swann J, Smit M, de Bruin A, Youssef SA, Feenstra M, van Dijk TH, Thedieck K, Jonker JW, Kim PK, Bakker BM, Bandsma RHJ (2023) Rebalancing of mitochondrial homeostasis through an NAD⁺-SIRT1 pathway preserves intestinal barrier function in severe malnutrition. https://doi.org/10.1016/j.ebiom.2023.104809	LEAK OXPHOS ET	N	Permeabilized tissue	Mouse
Boykov 2023 Sci Rep	2023	Boykov IN, Montgomery MM, Hagen JT, Aruleba RT, McLaughlin KL, Coalson HS, Nelson MA, Pereyra AS, Ellis JM, Zeczycki TN, Vohra NA, Tan SF, Cabot MC, Fisher-Wellman KH (2023) Pan-tissue mitochondrial phenotyping reveals lower OXPHOS expression and function across cancer types. https://doi.org/10.1038/s41598-023-43963-5	LEAK OXPHOS ET	F N S NS	Permeabilized tissue	Mouse	Heart Endothelial;epithelial;mesothelial cell
Menail 2023 FASEB J	2023	Menail HA, Cormier SB, Léger A, Robichaud S, Hebert-Chatelain E, Lamarre SG, Pichaud N (2023) Age-related flexibility of energetic metabolism in the honey bee Apis mellifera. https://doi.org/10.1096/fj.202300654r	LEAK OXPHOS ET	N S Gp CIV NS ROX	Permeabilized tissue	Hexapods
Deschemin 2023 Sci Rep	2023	Deschemin JC, Ransy C, Bouillaud F, Chung S, Galy B, Peyssonnaux C, Vaulont S (2023) Hepcidin deficiency in mice impairs white adipose tissue browning possibly due to a defect in de novo adipogenesis. https://doi.org/10.1038/s41598-023-39305-0	LEAK OXPHOS ET	S	Homogenate	Mouse	Fat
Sadri 2023 Arch Biochem Biophys	2023	Sadri S, Tomar N, Yang C, Audi SH, Cowley AW Jr, Dash RK (2023) Effects of ROS pathway inhibitors and NADH and FADH₂ linked substrates on mitochondrial bioenergetics and ROS emission in the heart and kidney cortex and outer medulla. Arch Biochem Biophys 744:109690. https://doi.org/10.1016/j.abb.2023.109690	OXPHOS	N S		Rat	Heart Kidney
Bowering 2023 Front Physiol	2023	Bowering LR, McArley TJ, Devaux JBL, Hickey AJR, Herbert NA (2023) Metabolic resilience of the Australasian snapper (Chrysophrys auratus) to marine heatwaves and hypoxia. https://doi.org/10.3389/fphys.2023.1215442	LEAK OXPHOS ET	N NS CIV ROX	Permeabilized tissue	Fishes	Heart
Rodriguez 2023 BEC	2023	Rodríguez E, Bettinazzi S, Inwongwan S, Camus MF, Lane N (2023) Harmonizing protocols to measure Drosophila respiratory function in mitochondrial preparations. Bioenerg Commun 2023.3. https://doi.org/10.26124/bec:2023-0003	LEAK OXPHOS ET	N S Gp ROX	Permeabilized tissue Homogenate	Drosophila
Noone 2023 Cell Signal	2023	Noone J, Rochfort KD, O'Sullivan F, O'Gorman DJ (2023) SIRT4 is a regulator of human skeletal muscle fatty acid metabolism influencing inner and outer mitochondrial membrane-mediated fusion. https://doi.org/10.1016/j.cellsig.2023.110931	LEAK OXPHOS	F N ROX	Permeabilized cells	Human	Skeletal muscle
Nijholt 2023 Sci Rep	2023	Nijholt KT, Sánchez-Aguilera PI, Mahmoud B, Gerding A, Wolters JC, Wolters AHG, Giepmans BNG, Silljé HHW, de Boer RA, Bakker BM, Westenbrink BD (2023) A Kinase Interacting Protein 1 regulates mitochondrial protein levels in energy metabolism and promotes mitochondrial turnover after exercise. https://doi.org/10.1038/s41598-023-45961-z	LEAK OXPHOS ET	F N	Isolated mitochondria	Mouse	Heart
Mazaki 2023 Cell Commun Signal	2023	Mazaki Y, Handa H, Fumoto Y, Horinouchi T, Onodera Y (2023) LRRK2 is involved in the chemotaxis of neutrophils and differentiated HL-60 cells, and the inhibition of LRRK2 kinase activity increases fMLP-induced chemotactic activity. https://doi.org/10.1186/s12964-023-01305-y	LEAK OXPHOS	N NS	Permeabilized cells	Human	Blood cells
Cossin-Sevrin 2022 J Exp Biol	2022	Cossin-Sevrin N, Hsu BY, Marciau C, Viblanc VA, Ruuskanen S, Stier A (2022) Effect of prenatal glucocorticoids and thyroid hormones on developmental plasticity of mitochondrial aerobic metabolism, growth and survival: an experimental test in wild great tits. https://doi.org/10.1242/jeb.243414	LEAK OXPHOS	N NS	Intact cells	Birds	Blood cells
Munro 2022 Mitochondrion	2022	Munro D, Rodríguez E, Blier PU (2022) The longest-lived metazoan, Arctica islandica, exhibits high mitochondrial H₂O₂ removal capacities. https://doi.org/10.1016/j.mito.2022.11.005	LEAK OXPHOS	N CIV	Isolated mitochondria	Molluscs	Lung;gill Endothelial;epithelial;mesothelial cell
Loughland 2022 J Exp Biol	2022	Loughland I, Lau GY, Jolly J, Seebacher F (2022) Rates of warming impact oxidative stress in zebrafish (Danio rerio).	LEAK OXPHOS ET	N NS	Isolated mitochondria	Zebrafish	Skeletal muscle
Bikman 2022 Eur J Clin Nutr	2022	Bikman BT, Shimy KJ, Apovian CM, Yu S, Saito ER, Walton CM, Ebbeling CB, Ludwig DS (2022) A high-carbohydrate diet lowers the rate of adipose tissue mitochondrial respiration. https://doi.org/10.1038/s41430-022-01097-3	LEAK OXPHOS ET	N NS	Permeabilized cells	Human	Fat
Pruuchova 2022 Antioxidants (Basel)	2022	Průchová P, Gotvaldová K, Smolková K, Alán L, Holendová B, Tauber J, Galkin A, Ježek P, Jabůrek M (2022) Antioxidant role and cardiolipin remodeling by redox-activated mitochondrial Ca²⁺-independent phospholipase A_2γ in the brain.	LEAK OXPHOS	N NS	Isolated mitochondria	Mouse	Nervous system
Xu 2022 Nat Commun	2022	Xu Z, Fu T, Guo Q, Zhou D, Sun W, Zhou Z, Chen X, Zhang J, Liu L, Xiao L, Yin Y, Jia Y, Pang E, Chen Y, Pan X, Fang L, Zhu MS, Fei W, Lu B, Gan Z (2022) Disuse-associated loss of the protease LONP1 in muscle impairs mitochondrial function and causes reduced skeletal muscle mass and strength. https://doi.org/10.1038/s41467-022-28557-5	LEAK OXPHOS ET	N S ROX	Isolated mitochondria	Mouse	Skeletal muscle
Gomez 2022 Nutrients	2022	Gómez Rodríguez A, Talamonti E, Naudi A, Kalinovich AV, Pauter AM, Barja G, Bengtsson T, Jacobsson A, Pamplona R, Shabalina IG (2022) Elovl2-ablation leads to mitochondrial membrane fatty acid remodeling and reduced efficiency in mouse liver mitochondria. https://doi.org/10.3390/nu14030559	LEAK OXPHOS ET	N	Isolated mitochondria	Mouse	Liver
Graham 2022 Physiol Rep	2022	Graham ZA, DeBerry JJ, Cardozo CP, Bamman MM (2022) SS-31 does not prevent or reduce muscle atrophy 7 days after a 65 kdyne contusion spinal cord injury in young male mice. https://doi.org/10.14814/phy2.15266	LEAK OXPHOS ET	N ROX	Permeabilized tissue	Mouse	Skeletal muscle
Pedersen 2022 Nat Commun	2022	Pedersen JS, Rygg MO, Chrøis K, Sustarsic EG, Gerhart-Hines Z, Wever Albrechtsen NJ, Serizawa RR, Kristiansen VB, Basse AL, Boilesen AEB, Olsen BH, Hansen T, Gluud LL, Madsbad S, Larsen S, Bendtsen F, Dela F (2022) Influence of NAFLD and bariatric surgery on hepatic and adipose tissue mitochondrial biogenesis and respiration. Nat Commun 13:2931. https://doi.org/10.1038/s41467-022-30629-5	LEAK OXPHOS ET	F N S CIV NS	Permeabilized tissue	Human	Liver Fat
Lee 2022 Hum Mol Genet	2022	Lee RG, Balasubramaniam S, Stentenbach M, Kralj T, McCubbin T, Padman B, Smith J, Riley LG, Priyadarshi A, Peng L, Nuske MR, Webster R, Peacock K, Roberts P, Stark Z, Lemire G, Ito YA; Care4Rare Canada Consortium, Boycott KM, Geraghty MT, van Klinken JB, Ferdinandusse S, Zhou Y, Walsh R, Marcellin E, Thorburn DR, Rosciolli T, Fletcher J, Rackham O, Vaz FM, Reid GE, Filipovska A (2022) Deleterious variants in CRLS1 lead to cardiolipin deficiency and cause an autosomal recessive multi-system mitochondrial disease. https://doi.org/10.1093/hmg/ddac040	LEAK OXPHOS	N CIV ROX	Permeabilized cells	Human	Fibroblast
Copperi 2022 Commun Biol	2022	Copperi F, Schleis I, Roumain M, Muccioli GG, Casola S, Klingenspor M, Pfeifer A, Gnad T (2022) EBI2 is a negative modulator of brown adipose tissue energy expenditure in mice and human brown adipocytes. https://doi.org/10.1038/s42003-022-03201-6	LEAK OXPHOS ET	N	Intact cells	Mouse	Fat
Leibold 2022 PLoS One	2022	Leibold S, Bagivalu Lakshminarasimha A, Gremse F, Hammerschmidt M, Michel M (2022) Long-term obesogenic diet leads to metabolic phenotypes which are not exacerbated by catch-up growth in zebrafish. https://doi.org/10.1371/journal.pone.0267933	LEAK OXPHOS ET	N ROX	Isolated mitochondria	Zebrafish
Hadanny 2022 Sports Med Open	2022	Hadanny A, Hachmo Y, Rozali D, Catalogna M, Yaakobi E, Sova M, Gattegno H, Abu Hamed R, Lang E, Polak N, Friedman M, Finci S, Zemel Y, Bechor Y, Gal N, Efrati S (2022) Effects of hyperbaric oxygen therapy on mitochondrial respiration and physical performance in middle-aged athletes: a blinded, randomized controlled trial.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Crislip 2022 Biomolecules	2022	Crislip GR, Wohlgemuth SE, Wolff CA, Gutierrez-Monreal MA, Douglas CM, Ebrahimi E, Cheng KY, Masten SH, Barral D, Bryant AJ, Esser KA, Gumz ML (2022) Apparent absence of BMAL1-dependent skeletal muscle-kidney cross talk in mice. https://doi.org/10.3390/biom12020261	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Mouse	Kidney
Yoval-Sanchez 2022 Redox Biol	2022	Yoval-Sánchez B, Ansari F, James J, Niatsetskaya Z, Sosunov S, Filipenko P, Tikhonova IG, Ten V, Wittig I, Rafikov R, Galkin A (2022) Redox-dependent loss of flavin by mitochondria complex I is different in brain and heart. https://doi.org/10.1016/j.redox.2022.102258	LEAK OXPHOS	NS	Isolated mitochondria	Mouse	Heart Nervous system
Napso 2022 Acta Physiol (Oxf)	2022	Napso T, Lean SC, Lu M, Mort EJ, Desforges M, Moghimi A, Bartels B, El-Bacha T, Fowden AL, Camm EJ, Sferruzzi-Perri AN (2022) Diet-induced maternal obesity impacts feto-placental growth and induces sex-specific alterations in placental morphology, mitochondrial bioenergetics, dynamics, lipid metabolism and oxidative stress in mice. https://doi.org/10.1111/apha.13795	LEAK OXPHOS ET	F N S CIV NS ROX	Permeabilized tissue	Mouse	Genital
Olesen 2022 Metabol Open	2022	Olesen K, Moruzzi N, Bulatovic I, Folmes C, Jeon R, Felldin U, Terzic A, Simonson OE, Le Blanc K, Österholm C, Berggren PO, Schiffer T, Rodin S, Tilevik A, Grinnemo KH (2022) Diversity of respiratory parameters and metabolic adaptation to low oxygen tension in mesenchymal stromal cells. https://doi.org/10.1016/j.metop.2022.100167	LEAK OXPHOS	N S NS ROX	Permeabilized cells	Human	Other cell lines
Gschwind 2022 Ann Clin Transl Neurol	2022	Gschwind M, Garcia Segarra N, Schaller A, Bolognini R, Nuoffer JM, Hourez R, Deprez M, Lhermitte B, Maeder P, Tran C, Kuntzer T (2022) Early-onset leukoencephalomyelopathy due to a biallelic NDUFV1 variant in a mid-forties patient. https://doi.org/10.1002/acn3.51556	LEAK OXPHOS	N S CIV	Homogenate	Human	Skeletal muscle Fibroblast
Yin 2022 J Exp Med	2022	Yin Y, Xu D, Mao Y, Xiao L, Sun Z, Liu J, Zhou D, Xu Z, Liu L, Fu T, Ding C, Guo Q, Sun W, Zhou Z, Yang L, Jia Y, Chen X, Gan Z (2022) FNIP1 regulates adipocyte browning and systemic glucose homeostasis in mice by shaping intracellular calcium dynamics. https://doi.org/10.1084/jem.20212491	LEAK OXPHOS	F N S ROX	Permeabilized cells	Mouse	Fat
Komlodi 2022 BEC	2022	Komlódi T, Tretter L (2022) The protonmotive force – not merely membrane potential. Bioenerg Commun 2022.16. https://doi.org/10.26124/bec:2022-0016	LEAK OXPHOS		Isolated mitochondria
Erdem 2022 Nat Commun	2022	Erdem A, Marin S, Pereira-Martins DA, Geugien M, Cunningham A, Pruis MG, Weinhäuser I, Gerding A, Bakker BM, Wierenga ATJ, Rego EM, Huls G, Cascante M, Schuringa JJ (2022) Inhibition of the succinyl dehydrogenase complex in acute myeloid leukemia leads to a lactate-fuelled respiratory metabolic vulnerability. https://doi.org/10.1038/s41467-022-29639-0	LEAK OXPHOS ET	N	Permeabilized cells	Human	Other cell lines
Garcia-Roche 2022 J Dairy Sci	2022	García-Roche M, Talmón D, Cañibe G, Astessiano AL, Mendoza A, Quijano C, Cassina A, Carriquiry M (2022) Differential hepatic mitochondrial function and gluconeogenic gene expression in 2 Holstein strains in a pasture-based system. https://doi.org/10.3168/jds.2021-21358	LEAK OXPHOS ET	N S NS ROX	Intact cells	Bovines	Liver
Weiss 2022 J Cell Mol Med	2022	Weiss SL, Zhang D, Farooqi S, Wallace DC (2022) Sodium butyrate reverses lipopolysaccharide-induced mitochondrial dysfunction in lymphoblasts. https://doi.org/10.1111/jcmm.17342	ROUTINE OXPHOS ET	N	Intact cells		Other cell lines
Soares 2022 Geroscience	2022	Soares RN, Ramirez-Perez FI, Cabral-Amador FJ, Morales-Quinones M, Foote CA, Ghiarone T, Sharma N, Power G, Smith JA, Rector RS, Martinez-Lemus LA, Padilla J, Manrique-Acevedo C (2022) SGLT2 inhibition attenuates arterial dysfunction and decreases vascular F-actin content and expression of proteins associated with oxidative stress in aged mice. https://doi.org/10.1007/s11357-022-00563-x	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells	Mouse	Endothelial;epithelial;mesothelial cell
Petry 2022 Antioxidants (Basel)	2022	Petry SF, Römer A, Rawat D, Brunner L, Lerch N, Zhou M, Grewal R, Sharifpanah F, Sauer H, Eckert GP, Linn T (2022) Loss and recovery of glutaredoxin 5 is inducible by diet in a murine model of diabesity and mediated by free fatty acids in vitro. https://doi.org/10.3390/antiox11040788	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Mouse	Islet cell;pancreas;thymus
Hansen 2022 Magn Reson Med	2022	Hansen K, Hansen ESS, Jespersen NRV, Bøtker HE, Pedersen M, Wang T, Laustsen C (2022) Hyperpolarized ¹³C MRI reveals large changes in pyruvate metabolism during digestion in snakes. https://doi.org/10.1002/mrm.29239	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Reptiles	Liver
Quast 2022 Basic Res Cardiol	2022	Quast C, Kober F, Becker K, Zweck E, Hoffe J, Jacoby C, Flocke V, Gyamfi-Poku I, Keyser F, Piayda K, Erkens R, Niepmann S, Adam M, Baldus S, Zimmer S, Nickenig G, Grandoch M, Bönner F, Kelm M, Flögel U (2022) Multiparametric MRI identifies subtle adaptations for demarcation of disease transition in murine aortic valve stenosis. https://doi.org/10.1007/s00395-022-00936-5	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Mouse	Heart
Alexander 2022 Cardiovasc Drugs Ther	2022	Alexander ED, Aldridge JL, Burleson TS, Frasier CR (2022) Teriflunomide treatment exacerbates cardiac ischemia reperfusion injury in isolated rat hearts. https://doi.org/10.1007/s10557-022-07341-z	ET LEAK OXPHOS	N NS	Isolated mitochondria	Rat	Heart
Kataura 2022 Dev Cell	2022	Kataura T, Sedlackova L, Otten EG, Kumari R, Shapira D, Scialo F, Stefanatos R, Ishikawa KI, Kelly G, Seranova E, Sun C, Maetzel D, Kenneth N, Trushin S, Zhang T, Trushina E, Bascom CC, Tasseff R, Isfort RJ, Oblong JE, Miwa S, Lazarou M, Jaenisch R, Imoto M, Saiki S, Papamichos-Chronakis M, Manjithaya R, Maddocks ODK, Sanz A, Sarkar S, Korolchuk VI (2022) Autophagy promotes cell survival by maintaining NAD levels. https://doi.org/10.1016/j.devcel.2022.10.008	LEAK OXPHOS	N NS	Permeabilized cells	Mouse	Fibroblast
Bina 2022 Mol Cell Biochem	2022	Bînă AM, Aburel OM, Avram VF, Lelcu T, Lința AV, Chiriac DV, Mocanu AG, Bernad E, Borza C, Craina ML, Popa ZL, Muntean DM, Crețu OM (2022) Impairment of mitochondrial respiration in platelets and placentas: a pilot study in preeclamptic pregnancies. https://doi.org/10.1007/s11010-022-04415-2	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Isolated mitochondria Intact cells	Human	Genital Platelet
Broome 2022 Redox Biol	2022	Broome SC, Pham T, Braakhuis AJ, Narang R, Wang HW, Hickey AJR, Mitchell CJ, Merry TL (2022) MitoQ supplementation augments acute exercise-induced increases in muscle PGC1α mRNA and improves training-induced increases in peak power independent of mitochondrial content and function in untrained middle-aged men. https://doi.org/10.1016/j.redox.2022.102341	LEAK OXPHOS ET	N CIV NS ROX	Permeabilized tissue	Human	Skeletal muscle
Siewiera 2022 Int J Mol Sci	2022	Siewiera K, Labieniec-Watala M, Kassassir H, Wolska N, Polak D, Watala C (2022) Potential role of mitochondria as modulators of blood platelet activation and reactivity in diabetes and effect of metformin on blood platelet bioenergetics and platelet activation. https://doi.org/10.3390/ijms23073666	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Rat	Platelet
Desjardins 2022 Proc Natl Acad Sci U S A	2022	Desjardins EM, Smith BK, Day EA, Ducommun S, Sanders MJ, Nederveen JP, Ford RJ, Pinkosky SL, Townsend LK, Gutgesell RM, Lu R, Sakamoto K, Steinberg GR (2022) The phosphorylation of AMPKβ1 is critical for increasing autophagy and maintaining mitochondrial homeostasis in response to fatty acids. https://doi.org/10.1073/pnas.2119824119	LEAK OXPHOS ET	N NS	Isolated mitochondria	Mouse	Liver
Trewin 2022 BMC Biol	2022	Trewin AJ, Silver J, Dillon HT, Della Gatta PA, Parker L, Hiam DS, Lee YP, Richardson M, Wadley GD, Lamon S (2022) Long non-coding RNA Tug1 modulates mitochondrial and myogenic responses to exercise in skeletal muscle. https://doi.org/10.1186/s12915-022-01366-4	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells	Mouse	Skeletal muscle
Niemann 2022 Biology (Basel)	2022	Niemann B, Pan R, Issa H, Simm A, Schulz R, Rohrbach S (2022) AMPK activation is indispensable for the protective effects of caloric restriction on left ventricular function in postinfarct myocardium. https://doi.org/10.3390/biology11030448	LEAK OXPHOS	N S	Permeabilized tissue	Mouse Rat	Heart
Melin 2022 JHEP Rep	2022	Melin N, Yarahmadov T, Sanchez-Taltavull D, Birrer FE, Brodie TM, Petit B, Felser A, Nuoffer JM, Montani M, Vozenin MC, Herrmann E, Candinas D, Aebersold DM, Stroka D (2022) A new mouse model of radiation-induced liver disease reveals mitochondrial dysfunction as an underlying fibrotic stimulus. https://doi.org/10.1016/j.jhepr.2022.100508	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Mouse	Liver
Salazar-Petres 2022 Biol Reprod	2022	Salazar-Petres E, Pereira-Carvalho D, Lopez-Tello J, Sferruzzi-Perri AN (2022) Placental structure, function, and mitochondrial phenotype relate to fetal size in each fetal sex in mice†. https://doi.org/10.1093/biolre/ioac056	LEAK OXPHOS ET	F N S CIV NS ROX	Permeabilized tissue	Mouse	Genital
Starr 2022 Curr Res Physiol	2022	Starr VJ, Dzialowski EM (2022) Developing chicken cardiac muscle mitochondria are resistant to variations in incubation oxygen levels. https://doi.org/10.1016/j.crphys.2022.03.001	LEAK OXPHOS	N S CIV NS ROX	Permeabilized tissue	Chicken	Heart
Barath 2022 Int J Mol Sci	2022	Baráth B, Jász DK, Horváth T, Baráth B, Maróti G, Strifler G, Varga G, Sándor L, Perényi D, Tallósy S, Donka T, Jávor P, Boros M, Hartmann P (2022) Mitochondrial side effects of surgical prophylactic antibiotics Ceftriaxone and Rifaximin lead to bowel mucosal damage. Int J Mol Sci 23:5064. https://doi.org/10.3390/ijms23095064	LEAK OXPHOS	S	Homogenate Isolated mitochondria	Rat	Liver
Galambo 2022 Curr Res Physiol	2022	Galambo D, Bergdahl A (2022) Physiological levels of cardiolipin acutely affect mitochondrial respiration in vascular smooth muscle cells. https://doi.org/10.1016/j.crphys.2022.100097	LEAK OXPHOS	F N NS ROX	Permeabilized cells	Mouse	Other cell lines
Jedlicka 2022 Physiol Res	2022	Jedlička J, Grundmanová M, Švíglerová J, Tůma Z, Nalos L, Rajdl D, Štengl M, Kuncová J (2022) Mitochondrial dysfunction in kidney cortex and medulla of subtotally nephrectomized rats. Physiol Res 71:S219-26. https://doi.org/10.33549/physiolres.935000	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue	Rat	Kidney
Jedlicka 2022a Physiol Res	2022	Jedlička J, Tůma Z, Razak K, Kunc R, Kala A, Proskauer Pena S, Lerchner T, Ježek K, Kuncová J (2022) Impact of aging on mitochondrial respiration in various organs. https://doi.org/10.33549/physiolres.934995	LEAK ROUTINE OXPHOS ET	F N S CIV NS ROX	Permeabilized tissue Homogenate Intact cells	Rat	Heart Skeletal muscle Nervous system Liver Kidney Platelet
Cruz-Gregorio 2022 Antioxidants (Basel)	2022	Cruz-Gregorio A, Aranda-Rivera AK, Aparicio-Trejo OE, Medina-Campos ON, Sciutto E, Fragoso G, Pedraza-Chaverri J (2022) GK-1 Induces oxidative stress, mitochondrial dysfunction, decreased membrane potential, and impaired autophagy flux in a mouse model of breast cancer. https://doi.org/10.3390/antiox12010056	LEAK OXPHOS	N ROX	Isolated mitochondria	Mouse	Endothelial;epithelial;mesothelial cell
Lemminger 2022 Antioxidants (Basel)	2022	Lemminger AK, Fiorenza M, Eibye K, Bangsbo J, Hostrup M (2022) High-intensity exercise training alters the effect of N-acetylcysteine on exercise-related muscle ionic shifts in men. https://doi.org/10.3390/antiox12010053	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Juhaszova 2022 Function (Oxf)	2022	Juhaszova M, Kobrinsky E, Zorov DB, Nuss HB, Yaniv Y, Fishbein KW, de Cabo R, Montoliu L, Gabelli SB, Aon MA, Cortassa S, Sollott SJ (2022) ATP synthase K⁺- and H⁺-fluxes drive ATP synthesis and enable mitochondrial K⁺-"uniporter" function: II. Ion and ATP synthase flux regulation. Function (Oxf) 3(2):zqac001. doi: 10.1093/function/zqac001	LEAK OXPHOS
Spielmann 2022 Mamm Genome	2022	Spielmann N, Schenkl C, Komlódi T, da Silva-Buttkus P, Heyne E, Rohde J, Amarie OV, Rathkolb B, Gnaiger E, Doenst T, Fuchs H, Gailus-Durner V, de Angelis MH, Szibor M (2022) Knockout of the Complex III subunit Uqcrh causes bioenergetic impairment and cardiac contractile dysfunction. Mamm Genome 10.1007/s00335-022-09973-w	LEAK OXPHOS ET	N S NS ROX	Intact organism Isolated mitochondria	Mouse	Heart
Tomar 2022 Biochim Biophys Acta Bioenerg	2022	Tomar N, Zhang X, Kandel SM, Sadri S, Yang C, Liang M, Audi SH, Cowley AW Jr, Dash RK (2022) Substrate-dependent differential regulation of mitochondrial bioenergetics in the heart and kidney cortex and outer medulla. https://doi.org/10.1016/j.bbabio.2021.148518	LEAK OXPHOS ET	F N S	Isolated mitochondria	Rat	Heart Kidney
Lehto 2022 Neurochem Res	2022	Lehto A, Koch K, Barnstorf-Brandes J, Viel C, Fuchs M, Klein J (2022) ß-Hydroxybutyrate improves mitochondrial function after transient ischemia in the mouse. https://doi.org/10.1007/s11064-022-03637-6	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Mouse	Nervous system
Lewis 2022 Methods Mol Biol	2022	Lewis MT, Levitsky Y, Bazil JN, Wiseman RW (2022) Measuring mitochondrial function: from organelle to organism. Methods Mol Biol 2022;2497:141-172. doi: 10.1007/978-1-0716-2309-1_10	OXPHOS		Intact organism Isolated mitochondria	Human	Skeletal muscle
Siow 2022 J Cell Sci	2022	Siow WX, Kabiri Y, Tang R, Chao YK, Plesch E, Eberhagen C, Flenkenthaler F, Fröhlich T, Bracher F, Grimm C, Biel M, Zischka H, Vollmar AM, Bartel K (2022) Lysosomal TRPML1 regulates mitochondrial function in hepatocellular carcinoma cells. https://doi.org/10.1242/jcs.259455	LEAK OXPHOS	N S ROX	Permeabilized cells	Mouse	Liver
Vandenberg 2022 Am J Physiol Cell Physiol	2022	Vandenberg GG, Thotakura A, Scott AL (2022) Mitochondrial bioenergetics of astrocytes in Fragile X syndrome: new perspectives on culture conditions and sex effects. Am J Physiol Cell Physiol 322:C125-35. https://doi.org/10.1152/ajpcell.00130.2021	LEAK OXPHOS	N S CIV NS ROX	Permeabilized cells	Mouse	Nervous system
Tang 2022 Elife	2022	Tang Y, Zong H, Kwon H, Qiu Y, Pessin JB, Wu L, Buddo KA, Boykov I, Schmidt CA, Lin CT, Neufer PD, Schwartz GJ, Kurland IJ, Pessin JE (2022) TIGAR deficiency enhances skeletal muscle thermogenesis by increasing neuromuscular junction cholinergic signaling. https://doi.org/10.7554/elife.73360	OXPHOS		Permeabilized tissue	Mouse	Skeletal muscle
Jayasankar 2022 ACS Omega	2022	Jayasankar V, Vrdoljak N, Roma A, Ahmed N, Tcheng M, Minden MD, Spagnuolo PA (2022) Novel mango ginger bioactive (2,4,6-trihydroxy-3,5-diprenyldihydrochalcone) inhibits mitochondrial metabolism in combination with Avocatin B. ACS Omega 7:1682-93. https://doi.org/10.1021/acsomega.1c04053	OXPHOS	F N	Permeabilized cells
Patyal 2022 Int J Mol Sci	2022	Patyal P, Nguyen B, Zhang X, Azhar G, Ameer FS, Verma A, Crane J, Kc G, Che Y, Wei JY (2022) Rho/SRF inhibitor modulates mitochondrial functions. https://doi.org/10.3390/ijms231911536	LEAK ROUTINE OXPHOS ET	N S CIV ROX	Permeabilized cells Intact cells	Mouse	Skeletal muscle
Kleinwaechter 2022 RSC Chem Biol	2022	Kleinwaechter I, Mohr B, Joppe A, Hellmann N, Bereau T, Osiewacz HD, Schneider D (2022) CLiB - a novel cardiolipin-binder isolated via data-driven and in vitro screening. RSC Chem Biol 3:941-54. https://doi.org/10.1039/d2cb00125j	LEAK OXPHOS	N ROX	Isolated mitochondria	Fungi
Lebenzon 2022 Proc Natl Acad Sci U S A	2022	Lebenzon JE, Denezis PW, Mohammad L, Mathers KE, Turnbull KF, Staples JF, Sinclair BJ (2022) Reversible mitophagy drives metabolic suppression in diapausing beetles. Proc Natl Acad Sci U S A 119:e2201089119. https://doi.org/10.1073/pnas.2201089119	LEAK OXPHOS ET	N	Permeabilized tissue	Hexapods	Skeletal muscle
Spagnuolo 2022 Mol Neurobiol	2022	Spagnuolo MS, Mazzoli A, Nazzaro M, Troise AD, Gatto C, Tonini C, Colardo M, Segatto M, Scaloni A, Pallottini V, Iossa S, Cigliano L (2022) Long-lasting Impact of sugar intake on neurotrophins and neurotransmitters from adolescence to young adulthood in rat frontal cortex. https://doi.org/10.1007/s12035-022-03115-8	LEAK OXPHOS ET	N S NS ROX	Homogenate	Rat	Nervous system
Heher 2022 Redox Biol	2022	Heher P, Ganassi M, Weidinger A, Engquist EN, Pruller J, Nguyen TH, Tassin A, Declèves AE, Mamchaoui K, Banerji CRS, Grillari J, Kozlov AV, Zammit PS (2022) Interplay between mitochondrial reactive oxygen species, oxidative stress and hypoxic adaptation in facioscapulohumeral muscular dystrophy: Metabolic stress as potential therapeutic target. https://doi.org/10.1016/j.redox.2022.102251	LEAK OXPHOS	N S	Permeabilized tissue	Human	Skeletal muscle
Hegazy 2022 Biomedicines	2022	Hegazy L, Gill LE, Pyles KD, Kaiho C, Kchouk S, Finck BN, McCommis KS, Elgendy B (2022) Identification of novel mitochondrial pyruvate carrier inhibitors by homology modeling and pharmacophore-based virtual screening. https://doi.org/10.3390/biomedicines10020365	LEAK OXPHOS	N NS	Isolated mitochondria	Mouse	Heart
Zhao 2022 J Cell Sci	2022	Zhao Q, Yan S, Lu J, Parker DJ, Wu H, Sun Q, Crossman DK, Liu S, Wang Q, Sesaki H, Mitra K, Liu K, Jiao K (2022) Drp1 regulates transcription of ribosomal protein genes in embryonic hearts. https://doi.org/10.1242/jcs.258956	LEAK OXPHOS	N	Permeabilized tissue	Mouse	Heart
Lopes 2022 Int J Mol Sci	2022	Lopes JA, Collino F, Rodrigues-Ferreira C, Sampaio LDS, Costa-Sarmento G, Wendt CHC, Almeida FP, Miranda KR, Kasai-Brunswick TH, Lindoso RS, Vieyra A (2022) Early effects of extracellular vesicles secreted by adipose tissue mesenchymal cells in renal ischemia followed by reperfusion: mechanisms rely on a decrease in mitochondrial anion superoxide production. https://doi.org/10.3390/ijms23062906	LEAK OXPHOS ET	S ROX	Isolated mitochondria	Human	Kidney
Harris 2022 Autophagy	2022	Harris MP, Zhang QJ, Cochran CT, Ponce J, Alexander S, Kronemberger A, Fuqua JD, Zhang Y, Fattal R, Harper T, Murry ML, Grueter CE, Abel ED, Lira VA (2022) Perinatal versus adult loss of ULK1 and ULK2 distinctly influences cardiac autophagy and function. https://doi.org/10.1080/15548627.2021.2022289	LEAK OXPHOS	F N	Permeabilized tissue	Mouse	Heart
Damgaard 2022 iScience	2022	Damgaard MV, Nielsen TS, Basse AL, Chubanava S, Trost K, Moritz T, Dellinger RW, Larsen S, Treebak JT (2022) Intravenous nicotinamide riboside elevates mouse skeletal muscle NAD⁺ without impacting respiratory capacity or insulin sensitivity. iScience 25:103863. https://doi.org/10.1016/j.isci.2022.103863	LEAK OXPHOS	N NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Antona 2022 Cancers (Basel)	2022	Antona A, Varalda M, Roy K, Favero F, Mazzucco E, Zuccalà M, Leo G, Soggia G, Bettio V, Tosi M, Gaggianesi M, Riva B, Reano S, Genazzani A, Manfredi M, Stassi G, Corà D, D'Alfonso S, Capello D (2022) Dissecting the mechanism of action of spiperone-a candidate for drug repurposing for colorectal cancer. https://doi.org/10.3390/cancers14030776	LEAK OXPHOS ET	N ROX	Intact cells	Human	Endothelial;epithelial;mesothelial cell
Muccini 2022 Oxid Med Cell Longev	2022	Muccini AM, Tran NT, Hale N, McKenzie M, Snow RJ, Walker DW, Ellery SJ (2022) The effects of in utero fetal hypoxia and creatine treatment on mitochondrial function in the late gestation fetal sheep brain. https://doi.org/10.1155/2022/3255296	LEAK OXPHOS	S	Isolated mitochondria	Other mammals	Nervous system
Markovic 2022 Biomedicines	2022	Marković A, Tauchmannová K, Šimáková M, Mlejnek P, Kaplanová V, Pecina P, Pecinová A, Papoušek F, Liška F, Šilhavý J, Mikešová J, Neckář J, Houštěk J, Pravenec M, Mráček T (2022) Genetic complementation of ATP synthase deficiency due to dysfunction of TMEM70 assembly factor in rat. https://doi.org/10.3390/biomedicines10020276	LEAK OXPHOS ET	F N S NS	Homogenate	Rat	Heart Liver
Rome 2022 Mol Metab	2022	Rome FI, Hughey CC (2022) Disrupted liver oxidative metabolism in glycine N-methyltransferase-deficient mice is mitigated by dietary methionine restriction. https://doi.org/10.1016/j.molmet.2022.101452	LEAK OXPHOS ET	N CIV ROX	Isolated mitochondria	Mouse	Liver
Chojnacka 2022 Mol Biol Cell	2022	Chojnacka KJ, Elancheliyan P, Mussulini BHM, Mohanraj K, Callegari S, Gosk A, Banach T, Góral T, Szczepanowska K, Rehling P, Serwa RA, Chacinska A (2022) Ovarian carcinoma immunoreactive antigen-like protein 2 (OCIAD2) is a novel complex III-specific assembly factor in mitochondria. https://doi.org/10.1091/mbc.e21-03-0143	LEAK ROUTINE OXPHOS ET	F N S Gp CIV NS ROX	Permeabilized cells Intact cells	Human	HEK
Qvit 2022 Pharmaceuticals (Basel)	2022	Qvit N, Lin AJ, Elezaby A, Ostberg NP, Campos JC, Ferreira JCB, Mochly-Rosen D (2022) A selective inhibitor of cardiac troponin I phosphorylation by delta protein kinase C (δPKC) as a treatment for ischemia-reperfusion injury. https://doi.org/10.3390/ph15030271	LEAK OXPHOS	NS	Isolated mitochondria	Rat	Heart
De Jong 2022 Nutrients	2022	De Jong NP, Rudolph MC, Jackman MR, Sharp RR, Jones K, Houck J, Pan Z, Reusch JEB, MacLean PS, Bessesen DH, Bergouignan A (2022) Short-term adaptations in skeletal muscle mitochondrial oxidative capacity and metabolic pathways to breaking up sedentary behaviors in overweight or obese adults. https://doi.org/10.3390/nu14030454	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Zhang 2022 Mol Med Rep	2022	Zhang J, Sun B, Yang J, Chen Z, Li Z, Zhang N, Li H, Shen L (2022) Comparison of the effect of rotenone and 1‑methyl‑4‑phenyl‑1,2,3,6‑tetrahydropyridine on inducing chronic Parkinson's disease in mouse models. https://doi.org/10.3892/mmr.2022.12607	LEAK OXPHOS ET	N NS	Isolated mitochondria	Mouse	Nervous system
De Lazzari 2022 Neurobiol Dis	2022	De Lazzari F, Agostini F, Plotegher N, Sandre M, Greggio E, Megighian A, Bubacco L, Sandrelli F, Whitworth AJ, Bisaglia M (2022) DJ-1 promotes energy balance by regulating both mitochondrial and autophagic homeostasis. https://doi.org/10.1016/j.nbd.2022.105941	OXPHOS	N S	Homogenate	Drosophila
Sumbalova 2022 Front Mol Biosci	2022	Sumbalová Z, Kucharská J, Rausová Z, Palacka P, Kovalčíková E, Takácsová T, Mojto V, Navas P, Lopéz-Lluch G, Gvozdjáková A (2022) Reduced platelet mitochondrial respiration and oxidative phosphorylation in patients with post COVID-19 syndrome are regenerated after spa rehabilitation and targeted ubiquinol therapy. https://doi.org/10.3389/fmolb.2022.1016352	LEAK ROUTINE OXPHOS ET	N NS	Permeabilized cells Intact cells	Human	Platelet
Hansen 2022 Free Radic Biol Med	2022	Hansen C, Møller S, Ehlers T, Wickham KA, Bangsbo J, Gliemann L, Hellsten Y (2022) Redox balance in human skeletal muscle-derived endothelial cells - Effect of exercise training. https://doi.org/10.1016/j.freeradbiomed.2021.12.265	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Endothelial;epithelial;mesothelial cell
Englund 2022 Mol Metab	2022	Englund DA, Jolliffe A, Aversa Z, Zhang X, Sturmlechner I, Sakamoto AE, Zeidler JD, Warner GM, McNinch C, White TA, Chini EN, Baker DJ, van Deursen JM, LeBrasseur NK (2022) p21 induces a senescence program and skeletal muscle dysfunction. https://doi.org/10.1016/j.molmet.2022.101652	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Leggio 2022 Adv Healthc Mater	2022	Leggio L, L'Episcopo F, Magrì A, Ulloa-Navas MJ, Paternò G, Vivarelli S, Bastos CAP, Tirolo C, Testa N, Caniglia S, Risiglione P, Pappalardo F, Serra A, García-Tárraga P, Faria N, Powell JJ, Peruzzotti-Jametti L, Pluchino S, García-Verdugo JM, Messina A, Marchetti B, Iraci N (2022) Small extracellular vesicles secreted by nigrostriatal astrocytes rescue cell death and preserve mitochondrial function in Parkinson's disease. https://doi.org/10.1002/adhm.202201203	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Neuroblastoma
Adant 2022 Mol Metab	2022	Adant I, Bird M, Decru B, Windmolders P, Wallays M, de Witte P, Rymen D, Witters P, Vermeersch P, Cassiman D, Ghesquière B (2022) Pyruvate and uridine rescue the metabolic profile of OXPHOS dysfunction. https://doi.org/10.1016/j.molmet.2022.101537	LEAK OXPHOS ET	N S Gp CIV NS ROX	Permeabilized cells	Human	Fibroblast
Pileggi 2022 EBioMedicine	2022	Pileggi CA, Blondin DP, Hooks BG, Parmar G, Alecu I, Patten DA, Cuillerier A, O'Dwyer C, Thrush AB, Fullerton MD, Bennett SAL, Doucet É, Haman F, Cuperlovic-Culf M, McPherson R, Dent RRM, Harper ME (2022) Exercise training enhances muscle mitochondrial metabolism in diet-resistant obesity. https://doi.org/10.1016/j.ebiom.2022.104192	LEAK OXPHOS ET	N NS ROX	Permeabilized tissue	Human	Skeletal muscle
Wang 2022 Transl Cancer Res	2022	Wang B, Liu B, Luo Q, Sun D, Li H, Zhang J, Jin X, Cheng X, Niu J, Yuan Q, Chen Y (2022) PANK1 associates with cancer metabolism and immune infiltration in clear cell renal cell carcinoma: a retrospective prognostic study based on the TCGA database. https://doi.org/10.21037/tcr-22-1488	LEAK OXPHOS ET	N NS S		Human	Kidney Endothelial;epithelial;mesothelial cell
Brunetta 2022 Redox Biol	2022	Brunetta HS, Petrick HL, Momken I, Handy RM, Pignanelli C, Nunes EA, Piquereau J, Mericskay M, Holloway GP (2022) Nitrate consumption preserves HFD-induced skeletal muscle mitochondrial ADP sensitivity and lysine acetylation: A potential role for SIRT1. https://doi.org/10.1016/j.redox.2022.102307	LEAK OXPHOS	F N NS	Permeabilized tissue	Mouse	Skeletal muscle
Jelenik 2022 Pharmacol Res	2022	Jelenik T, Kodde A, Pesta D, Phielix E, Oosting A, Rohbeck E, Dewidar B, Mastrototaro L, Trenkamp S, Keijer J, van der Beek EM, Roden M (2022) Dietary lipid droplet structure in postnatal life improves hepatic energy and lipid metabolism in a mouse model for postnatal programming. https://doi.org/10.1016/j.phrs.2022.106193	LEAK OXPHOS ET	N NS ROX	Permeabilized tissue	Mouse	Skeletal muscle Liver
Hadjihambi 2022 J Hepatol	2022	Hadjihambi A, Konstantinou C, Klohs J, Monsorno K, Le Guennec A, Donnelly C, Cox J, Kusumbe A, Hosford PS, Soffientini U, Lecca S, Mameli M, Jalan R, Paolicelli RC, Pellerin L (2022) Partial MCT1 invalidation protects against diet-induced non-alcoholic fatty liver disease and the associated brain dysfunction. https://doi.org/10.1016/j.jhep.2022.08.008	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue Homogenate	Mouse	Nervous system
Aya 2022 Eur J Pharmacol	2022	Shiraki A, Oyama J, Shimizu T, Nakajima T, Yokota T, Node K (2022) Empagliflozin improves cardiac mitochondrial function and survival through energy regulation in a murine model of heart failure. Eur J Pharmacol 931: 175194.	OXPHOS		Permeabilized tissue	Mouse	Heart
Daradics 2022 PLoS One	2022	Daradics N, Horvath G, Tretter L, Paal A, Fulop A, Budai A, Szijarto A (2022) The effect of Cyclophilin D depletion on liver regeneration following associating liver partition and portal vein ligation for staged hepatectomy. https://doi.org/10.1371/journal.pone.0271606	LEAK OXPHOS	N S	Isolated mitochondria	Mouse	Liver
Hong 2022 Cell Stem Cell	2022	Hong X, Isern J, Campanario S, Perdiguero E, Ramírez-Pardo I, Segalés J, Hernansanz-Agustín P, Curtabbi A, Deryagin O, Pollán A, González-Reyes JA, Villalba JM, Sandri M, Serrano AL, Enríquez JA, Muñoz-Cánoves P (2022) Mitochondrial dynamics maintain muscle stem cell regenerative competence throughout adult life by regulating metabolism and mitophagy. https://doi.org/10.1016/j.stem.2022.07.009	LEAK OXPHOS	N S CIV NS ROX	Permeabilized cells	Mouse	Skeletal muscle
Thapa 2022 Physiol Rep	2022	Thapa D, Bugga P, Mushala BAS, Manning JR, Stoner MW, McMahon B, Zeng X, Cantrell PS, Yates N, Xie B, Edmunds LR, Jurczak MJ, Scott I (2022) GCN5L1 impairs diastolic function in mice exposed to a high fat diet by restricting cardiac pyruvate oxidation. https://doi.org/10.14814/phy2.15415	LEAK OXPHOS ET	N ROX		Mouse	Heart
Smith 2022 J Pineal Res	2022	Smith KLM, Swiderska A, Lock MC, Graham L, Iswari W, Choudhary T, Thomas D, Kowash HM, Desforges M, Cottrell EC, Trafford AW, Giussani DA, Galli GLJ (2022) Chronic developmental hypoxia alters mitochondrial oxidative capacity and reactive oxygen species production in the fetal rat heart in a sex-dependent manner. https://doi.org/10.1111/jpi.12821	LEAK OXPHOS ET	N S CIV NS ROX	Homogenate	Rat	Heart
VanLieshout 2022 Mol Metab	2022	vanLieshout TL, Stouth DW, Hartel NG, Vasam G, Ng SY, Webb EK, Rebalka IA, Mikhail AI, Graham NA, Menzies KJ, Hawke TJ, Ljubicic V (2022) The CARM1 transcriptome and arginine methylproteome mediate skeletal muscle integrative biology. https://doi.org/10.1016/j.molmet.2022.101555	LEAK OXPHOS	N NS	Permeabilized tissue	Mouse	Skeletal muscle
Wu 2022 Antioxidants (Basel)	2022	Wu YL, Chang JC, Chao YC, Chan H, Hsieh M, Liu CS (2022) In vitro efficacy and molecular mechanism of curcumin analog in pathological regulation of spinocerebellar ataxia type 3. https://doi.org/10.3390/antiox11071389	LEAK OXPHOS ET	N S NS ROX	Intact cells	Human	Neuroblastoma
Meza-Buendia 2022 PLoS One	2022	Meza-Buendia AK, Aparicio-Trejo OE, Díaz F, Caamal-Monsreal C, Pedraza-Chaverri J, Álvarez-Delgado C, Paschke K, Rosas C (2022) High resolution respirometry of isolated mitochondria from adult Octopus maya (Class: Cephalopoda) systemic heart. https://doi.org/10.1371/journal.pone.0273554	LEAK OXPHOS	ROX	Isolated mitochondria	Molluscs	Heart
Fialova 2022 Biomed Pharmacother	2022	Fialova JL, Hönigova K, Raudenska M, Miksatkova L, Zobalova R, Navratil J, Šmigová J, Moturu TR, Vicar T, Balvan J, Vesela K, Abramenko N, Kejik Z, Kaplanek R, Gumulec J, Rosel D, Martasek P, Brábek J, Jakubek M, Neuzil J, Masarik M (2022) Pentamethinium salts suppress key metastatic processes by regulating mitochondrial function and inhibiting dihydroorotate dehydrogenase respiration. https://doi.org/10.1016/j.biopha.2022.113582	OXPHOS		Permeabilized cells	Human	Endothelial;epithelial;mesothelial cell
O'Hanlon 2022 Neurobiol Dis	2022	O'Hanlon ME, Tweedy C, Scialo F, Bass R, Sanz A, Smulders-Srinivasan TK (2022) Mitochondrial electron transport chain defects modify Parkinson's disease phenotypes in a Drosophila model. https://doi.org/10.1016/j.nbd.2022.105803	LEAK OXPHOS	N Gp CIV ROX	Homogenate	Drosophila
Gonzalez-Franquesa 2022 Redox Biol	2022	Gonzalez-Franquesa A, Gama-Perez P, Kulis M, Szczepanowska K, Dahdah N, Moreno-Gomez S, Latorre-Pellicer A, Fernández-Ruiz R, Aguilar-Mogas A, Hoffman A, Monelli E, Samino S, Miró-Blanch J, Oemer G, Duran X, Sanchez-Rebordelo E, Schneeberger M, Obach M, Montane J, Castellano G, Chapaprieta V, Sun W, Navarro L, Prieto I, Castaño C, Novials A, Gomis R, Monsalve M, Claret M, Graupera M, Soria G, Wolfrum C, Vendrell J, Fernández-Veledo S, Enríquez JA, Carracedo A, Perales JC, Nogueiras R, Herrero L, Trifunovic A, Keller MA, Yanes O, Sales-Pardo M, Guimerà R, Blüher M, Martín-Subero JI, Garcia-Roves PM (2022) Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue. https://doi.org/10.1016/j.redox.2022.102353	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue Homogenate	Mouse	Skeletal muscle Nervous system Liver Fat
McKenna 2022 J Appl Physiol (1985)	2022	McKenna CF, Salvador AF, Keeble AR, Khan NA, De Lisio M, Konopka AR, Paluska SA, Burd NA (2022) Muscle strength after resistance training correlates to mediators of muscle mass and mitochondrial respiration in middle-aged adults. https://doi.org/10.1152/japplphysiol.00186.2022	LEAK OXPHOS ET	NS	Permeabilized tissue	Human	Skeletal muscle
Pallag 2022 Int J Mol Sci	2022	Pallag G, Nazarian S, Ravasz D, Bui D, Komlódi T, Doerrier C, Gnaiger E, Seyfried TN, Chinopoulos C (2022) Proline oxidation supports mitochondrial ATP production when Complex I is inhibited. https://doi.org/10.3390/ijms23095111	LEAK OXPHOS ET	N S Gp CIV NS Other combinations ROX	Isolated mitochondria	Mouse	Liver Kidney
De Goede 2022 FASEB J	2022	de Goede P, Wüst RCI, Schomakers BV, Denis S, Vaz FM, Pras-Raves ML, van Weeghel M, Yi CX, Kalsbeek A, Houtkooper RH (2022) Time-restricted feeding during the inactive phase abolishes the daily rhythm in mitochondrial respiration in rat skeletal muscle. FASEB J 36:e22133.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Rat	Skeletal muscle
Molinie 2022 Biochim Biophys Acta Bioenerg	2022	Molinié T, Cougouilles E, David C, Cahoreau E, Portais JC, Mourier A (2022) MDH2 produced OAA is a metabolic switch rewiring the fuelling of respiratory chain and TCA cycle. Biochim Biophys Acta Bioenerg 1863:148532.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Mouse	Heart Liver
Nath 2022 Cell Rep	2022	Nath AS, Parsons BD, Makdissi S, Chilvers RL, Mu Y, Weaver CM, Euodia I, Fitze KA, Long J, Scur M, Mackenzie DP, Makrigiannis AP, Pichaud N, Boudreau LH, Simmonds AJ, Webber CA, Derfalvi B, Hammon Y, Rachubinski RA, Di Cara F (2022) Modulation of the cell membrane lipid milieu by peroxisomal β-oxidation induces Rho1 signaling to trigger inflammatory responses . Cell Rep 38:110433.	LEAK ROUTINE OXPHOS ET	N Gp CIV ROX	Permeabilized cells Intact cells
Fischer 2022 Metabolites	2022	Fischer C, Valente de Souza L, Komlódi T, Garcia-Souza LF, Volani C, Tymoszuk P, Demetz E, Seifert M, Auer K, Hilbe R, Brigo N, Petzer V, Asshoff M, Gnaiger E, Weiss G (2022) Mitochondrial respiration in response to iron deficiency anemia. Comparison of peripheral blood mononuclear cells and liver. https://doi.org/10.3390/metabo12030270	LEAK ROUTINE OXPHOS ET	N S NS Other combinations ROX	Permeabilized cells Homogenate	Rat	Liver Blood cells
Tepp 2022 Biochem Biophys Rep	2022	Tepp K, Aid-Vanakova J, Puurand M, Timohhina N, Reinsalu L, Tein K, Plaas M, Shevchuk I, Terasmaa A, Kaambre T (2022) Wolframin deficiency is accompanied with metabolic inflexibility in rat striated muscles. Biochem Biophys Rep 30:101250.	LEAK OXPHOS	N S CIV ROX	Permeabilized tissue	Rat	Skeletal muscle
Lai 2022 PLoS One	2022	Lai RE, Holman ME, Chen Q, Rivers J, Lesnefsky EJ, Gorgey AS (2022) Assessment of mitochondrial respiratory capacity using minimally invasive and noninvasive techniques in persons with spinal cord injury. PLoS One 17:e0265141.	LEAK OXPHOS	N S	Permeabilized tissue		Skeletal muscle
Ahn 2022 Aging Cell	2022	Ahn B, Ranjit R, Kneis P, Xu H, Piekarz KM, Freeman WM, Kinter M, Richardson A, Ran Q, Brooks SV, Van Remmen H (2022) Scavenging mitochondrial hydrogen peroxide by peroxiredoxin 3 overexpression attenuates contractile dysfunction and muscle atrophy in a murine model of accelerated sarcopenia. Aging Cell 21:e13569.	LEAK OXPHOS	N S NS ROX	Isolated mitochondria	Mouse	Skeletal muscle
Davies 2022 Biomolecules	2022	Davies KL, Smith DJ, El-Bacha T, Wooding PFP, Forhead AJ, Murray AJ, Fowden AL, Camm EJ (2022) Cortisol regulates cerebral mitochondrial oxidative phosphorylation and morphology of the brain in a region-specific manner in the ovine fetus. https://doi.org/10.3390/biom12060768	LEAK OXPHOS	N S NS	Homogenate	Other mammals	Nervous system
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Schober 2022 Hum Mol Genet	2022	Schober FA, Tang JX, Sergeant K, Moedas MF, Zierz CM, Moore D, Smith C, Lewis D, Guha N, Hopton S, Falkous G, Lam A, Pyle A, Poulton J, Gorman GS, Taylor RW, Freyer C, Wredenberg A (2022) Pathogenic SLC25A26 variants impair SAH transport activity causing mitochondrial disease. https://doi.org/10.1093/hmg/ddac002	LEAK OXPHOS	N S CIV NS ROX	Permeabilized cells Intact cells	Mouse Drosophila	Fibroblast
Chinas 2022 Metabolites	2022	Chiñas Merlin A, Gonzalez K, Mockler S, Perez Y, Jia UA, Chicco AJ, Ullevig SL, Chung E (2022) Switching to a standard chow diet at weaning improves the effects of maternal and postnatal high-fat and high-sucrose diet on cardiometabolic health in adult male mouse offspring. https://doi.org/10.3390/metabo12060563	LEAK OXPHOS	F N NS	Isolated mitochondria	Mouse	Heart
Serna 2022 BEC	2022	Serna JDC, Ramos VM, Cabral-Costa JV, Vilas-Boas EA, Amaral AG, Ohya G, da Silva CCC, Kowaltowski AJ (2022) Measuring mitochondrial Ca²⁺ efflux in isolated mitochondria and permeabilized cells. Bioenerg Commun 2022.7. https://doi.org/10.26124/bec:2022-0007	LEAK OXPHOS	S ROX	Permeabilized cells Isolated mitochondria	Human Mouse	Liver Other cell lines
Guo 2022 Sci Adv	2022	Guo Q, Xu Z, Zhou D, Fu T, Wang W, Sun W, Xiao L, Liu L, Ding C, Yin Y, Zhou Z, Sun Z, Zhu Y, Zhou W, Jia Y, Xue J, Chen Y, Chen XW, Piao HL, Lu B, Gan Z (2022) Mitochondrial proteostasis stress in muscle drives a long-range protective response to alleviate dietary obesity independently of ATF4. https://doi.org/10.1126/sciadv.abo0340	LEAK OXPHOS	N S ROX	Permeabilized tissue Isolated mitochondria	Mouse	Skeletal muscle Fat
Rios-Morales 2022 Biochim Biophys Acta Mol Basis Dis	2022	Rios-Morales M, Vieira-Lara MA, Homan E, Langelaar-Makkinje M, Gerding A, Li Z, Huijkman N, Rensen PCN, Wolters JC, Reijngoud DJ, Bakker BM (2022) Butyrate oxidation attenuates the butyrate-induced improvement of insulin sensitivity in myotubes. https://doi.org/10.1016/j.bbadis.2022.166476	LEAK OXPHOS	F N	Permeabilized cells	Mouse	Skeletal muscle
Saraiva 2022 Pathogens	2022	Saraiva FMS, Cosentino-Gomes D, Inacio JDF, Almeida-Amaral EE, Louzada-Neto O, Rossini A, Nogueira NP, Meyer-Fernandes JR, Paes MC (2022) Hypoxia effects on Trypanosoma cruzi epimastigotes proliferation, differentiation, and energy metabolism. https://doi.org/10.3390/pathogens11080897	LEAK OXPHOS	S ROX	Permeabilized cells	Protists
Cho 2022 BMC Med	2022	Cho J, Johnson BD, Watt KD, Niven AS, Yeo D, Kim CH (2022) Exercise training attenuates pulmonary inflammation and mitochondrial dysfunction in a mouse model of high-fat high-carbohydrate-induced NAFLD. https://doi.org/10.1186/s12916-022-02629-1	LEAK OXPHOS	N NS	Homogenate	Mouse	Lung;gill
Delfinis 2022 JCI Insight	2022	Delfinis LJ, Bellissimo CA, Gandhi S, DiBenedetto SN, Garibotti MC, Thuhan AK, Tsitkanou S, Rosa-Caldwell ME, Rahman FA, Cheng AJ, Wiggs MP, Schlattner U, Quadrilatero J, Greene NP, Perry CG (2022) Muscle weakness precedes atrophy during cancer cachexia and is linked to muscle-specific mitochondrial stress. https://doi.org/10.1172/jci.insight.155147	LEAK OXPHOS	N	Permeabilized tissue	Mouse	Skeletal muscle
Ceja-Galicia 2022 Antioxidants (Basel)	2022	Ceja-Galicia ZA, García-Arroyo FE, Aparicio-Trejo OE, El-Hafidi M, Gonzaga-Sánchez G, León-Contreras JC, Hernández-Pando R, Guevara-Cruz M, Tovar AR, Rojas-Morales P, Aranda-Rivera AK, Sánchez-Lozada LG, Tapia E, Pedraza-Chaverri J (2022) Therapeutic effect of curcumin on 5/6Nx hypertriglyceridemia: association with the improvement of renal mitochondrial β-oxidation and lipid metabolism in kidney and liver. https://doi.org/10.3390/antiox11112195	LEAK OXPHOS	F N ROX	Isolated mitochondria	Rat	Kidney
Zhang 2022 Nat Metab	2022	Zhang CS, Li M, Wang Y, Li X, Zong Y, Long S, Zhang M, Feng JW, Wei X, Liu YH, Zhang B, Wu J, Zhang C, Lian W, Ma T, Tian X, Qu Q, Yu Y, Xiong J, Liu DT, Wu Z, Zhu M, Xie C, Wu Y, Xu Z, Yang C, Chen J, Huang G, He Q, Huang X, Zhang L, Sun X, Liu Q, Ghafoor A, Gui F, Zheng K, Wang W, Wang ZC, Yu Y, Zhao Q, Lin SY, Wang ZX, Piao HL, Deng X, Lin SC (2022) The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK. https://doi.org/10.1038/s42255-022-00640-7	LEAK OXPHOS	N S CIV ROX	Permeabilized tissue	Mouse	Skeletal muscle
Neupane 2022 Commun Biol	2022	Neupane N, Rajendran J, Kvist J, Harjuhaahto S, Hu B, Kinnunen V, Yang Y, Nieminen AI, Tyynismaa H (2022) Inter-organellar and systemic responses to impaired mitochondrial matrix protein import in skeletal muscle. https://doi.org/10.1038/s42003-022-04034-z	OXPHOS ET	N NS ROX	Isolated mitochondria	Mouse	Skeletal muscle
Quemeneur 2022 Sci Rep	2022	Quéméneur JB, Danion M, Cabon J, Collet S, Zambonino-Infante JL, Salin K (2022) The relationships between growth rate and mitochondrial metabolism varies over time. https://doi.org/10.1038/s41598-022-20428-9	LEAK OXPHOS	N CIV NS ROX	Homogenate	Fishes	Skeletal muscle
Wang 2022 Redox Biol	2022	Wang P, Cui Y, Liu Y, Li Z, Bai H, Zhao Y, Chang YZ (2022) Mitochondrial ferritin alleviates apoptosis by enhancing mitochondrial bioenergetics and stimulating glucose metabolism in cerebral ischemia reperfusion. https://doi.org/10.1016/j.redox.2022.102475	LEAK OXPHOS ET	N ROX	Homogenate	Mouse	Nervous system
Sleda 2022 mBio	2022	Sleda MA, Li ZH, Behera R, Baierna B, Li C, Jumpathong J, Malwal SR, Kawamukai M, Oldfield E, Moreno SNJ (2022) The heptaprenyl diphosphate synthase (Coq1) is the target of a lipophilic bisphosphonate that protects mice against toxoplasma gondii infection. https://doi.org/10.1128/mbio.01966-22	LEAK OXPHOS	S	Permeabilized cells Intact cells	Protists
Fuertes-Agudo 2022 Antioxidants (Basel)	2022	Fuertes-Agudo M, Luque-Tévar M, Cucarella C, Brea R, Boscá L, Quintana-Cabrera R, Martín-Sanz P, Casado M (2022) COX-2 expression in hepatocytes improves mitochondrial function after hepatic ischemia-reperfusion injury.	OXPHOS ET	F N Gp CIV NS Other combinations ROX	Isolated mitochondria	Mouse	Liver
Liu 2022 Adv Sci (Weinh)	2022	Liu H, Liu Y, Wang H, Zhao Q, Zhang T, Xie SA, Liu Y, Tang Y, Peng Q, Pang W, Yao W, Zhou J (2022) Geometric constraints regulate energy metabolism and cellular contractility in vascular smooth muscle cells by coordinating mitochondrial DNA methylation. https://doi.org/10.1002/advs.202203995	LEAK OXPHOS	N S CIV ROX	Permeabilized cells	Human	Other cell lines
De Paula Nascimento-Castro 2022 Biomedicines	2022	de Paula Nascimento-Castro C, Winkelmann-Duarte EC, Mancini G, Welter PG, Plácido E, Farina M, Gil-Mohapel J, Rodrigues ALS, de Bem AF, Brocardo PS (2022) Temporal characterization of behavioral and hippocampal dysfunction in the YAC128 mouse model of Huntington's disease. https://doi.org/10.3390/biomedicines10061433	LEAK OXPHOS ET	N S NS ROX	Homogenate	Mouse	Nervous system
Vanweert 2022 Nat Commun	2022	Vanweert F, Neinast M, Tapia EE, van de Weijer T, Hoeks J, Schrauwen-Hinderling VB, Blair MC, Bornstein MR, Hesselink MKC, Schrauwen P, Arany Z, Phielix E (2022) A randomized placebo-controlled clinical trial for pharmacological activation of BCAA catabolism in patients with type 2 diabetes. https://doi.org/10.1038/s41467-022-31249-9	LEAK OXPHOS ET	F N NS	Permeabilized tissue	Human	Skeletal muscle
Risiglione 2022 Life (Basel)	2022	Risiglione P, Cubisino SAM, Lipari CLR, De Pinto V, Messina A, Magrì A (2022) α-Synuclein A53T promotes mitochondrial proton gradient dissipation and depletion of the organelle respiratory reserve in a neuroblastoma cell line. https://doi.org/10.3390/life12060894	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Neuroblastoma
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Bresciani 2022 J Hepatol	2022	Bresciani N, Demagny H, Lemos V, Pontanari F, Li X, Sun Y, Li H, Perino A, Auwerx J, Schoonjans K (2022) The Slc25a47 locus is a novel determinant of hepatic mitochondrial function implicated in liver fibrosis. https://doi.org/10.1016/j.jhep.2022.05.040	LEAK OXPHOS ET	F N S NS ROX	Isolated mitochondria	Mouse	Liver
Pochakom 2022 Brain Sci	2022	Pochakom A, Mu C, Rho JM, Tompkins TA, Mayengbam S, Shearer J (2022) Selective probiotic treatment positively modulates the microbiota-gut-brain axis in the BTBR mouse model of autism. https://doi.org/10.3390/brainsci12060781	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells	Mouse	Nervous system
Dias 2022 Free Radic Biol Med	2022	Dias C, Lourenço CF, Laranjinha J, Ledo A (2022) Modulation of oxidative neurometabolism in ischemia/reperfusion by nitrite. https://doi.org/10.1016/j.freeradbiomed.2022.11.021	ROUTINE OXPHOS ET	N S ROX	Permeabilized tissue Intact cells	Rat	Nervous system
Fedorov 2022 Naunyn Schmiedebergs Arch Pharmacol	2022	Fedorov A, Lehto A, Klein J (2022) Inhibition of mitochondrial respiration by general anesthetic drugs. https://doi.org/10.1007/s00210-022-02338-9	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Mouse	Nervous system
Donnarumma 2022 Nat Commun	2022	Donnarumma E, Kohlhaas M, Vimont E, Kornobis E, Chaze T, Gianetto QG, Matondo M, Moya-Nilges M, Maack C, Wai T (2022) Mitochondrial Fission Process 1 controls inner membrane integrity and protects against heart failure. https://doi.org/10.1038/s41467-022-34316-3	LEAK OXPHOS ET	F N S CIV	Isolated mitochondria	Mouse	Heart
Gvozdjakova 2022 Environ Sci Pollut Res Int	2022	Gvozdjáková A, Sumbalová Z, Kucharská J, Rausová Z, Kovalčíková E, Takácsová T, Navas P, López-Lluch G, Mojto V, Palacka P (2022) Mountain spa rehabilitation improved health of patients with post-COVID-19 syndrome: pilot study. https://doi.org/10.1007/s11356-022-22949-2	LEAK ROUTINE OXPHOS ET	N NS	Permeabilized cells Intact cells	Human	Platelet
Cano-Sanchez 2022 PLoS Negl Trop Dis	2022	Cano-Sanchez M, Ben-Hassen K, Louis OP, Dantin F, Gueye P, Roques F, Mehdaoui H, Resiere D, Neviere R (2022) Bothrops lanceolatus snake venom impairs mitochondrial respiration and induces DNA release in human heart preparation. https://doi.org/10.1371/journal.pntd.0010523	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue	Human	Heart
Li 2022 Mol Med	2022	Li X, Zhou X, Liu X, Li X, Jiang X, Shi B, Wang S (2022) Spermidine protects against acute kidney injury by modulating macrophage NLRP3 inflammasome activation and mitochondrial respiration in an eIF5A hypusination-related pathway. https://doi.org/10.1186/s10020-022-00533-1	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells	Human	Blood cells
Sarabhai 2022 Diabetologia	2022	Sarabhai T, Mastrototaro L, Kahl S, Bönhof GJ, Jonuscheit M, Bobrov P, Katsuyama H, Guthoff R, Wolkersdorfer M, Herder C, Meuth SG, Dreyer S, Roden M (2022) Hyperbaric oxygen rapidly improves tissue-specific insulin sensitivity and mitochondrial capacity in humans with type 2 diabetes: a randomised placebo-controlled crossover trial. https://doi.org/10.1007/s00125-022-05797-0	LEAK OXPHOS ET	N NS ROX	Permeabilized tissue	Human	Skeletal muscle Fat
Takada 2022 Proc Natl Acad Sci U S A	2022	Takada S, Maekawa S, Furihata T, Kakutani N, Setoyama D, Ueda K, Nambu H, Hagiwara H, Handa H, Fumoto Y, Hata S, Masunaga T, Fukushima A, Yokota T, Kang D, Kinugawa S, Sabe H (2022) Succinyl-CoA-based energy metabolism dysfunction in chronic heart failure. Proc Natl Acad Sci U S A 119: e2203628119.	LEAK OXPHOS		Isolated mitochondria	Mouse	Heart
Paulus 2022 Basic Res Cardiol	2022	Paulus MG, Renner K, Nickel AG, Brochhausen C, Limm K, Zügner E, Baier MJ, Pabel S, Wallner S, Birner C, Luchner A, Magnes C, Oefner PJ, Stark KJ, Wagner S, Maack C, Maier LS, Streckfuss-Bömeke K, Sossalla S, Dietl A (2022) Tachycardiomyopathy entails a dysfunctional pattern of interrelated mitochondrial functions. https://doi.org/10.1007/s00395-022-00949-0	OXPHOS ET	NS F ROX	Permeabilized tissue Isolated mitochondria	Rabbit	Heart
Cherix 2022 Mol Psychiatry	2022	Cherix A, Poitry-Yamate C, Lanz B, Zanoletti O, Grosse J, Sandi C, Gruetter R, Cardinaux JR (2022) Deletion of Crtc1 leads to hippocampal neuroenergetic impairments associated with depressive-like behavior. https://doi.org/10.1038/s41380-022-01791-5	LEAK OXPHOS ET	N S NS ROX	Homogenate	Mouse	Nervous system
Mandic 2022 J Comp Physiol B	2022	Mandic M, Frazier AJ, Naslund AW, Todgham AE (2022) A comparative and ontogenetic examination of mitochondrial function in antarctic notothenioid species. https://doi.org/10.1007/s00360-022-01461-6	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue	Fishes	Heart
Xu 2022 Sci Adv	2022	Xu H, Ahn B, Van Remmen H (2022) Impact of aging and oxidative stress on specific components of excitation contraction coupling in regulating force generation. https://doi.org/10.1126/sciadv.add7377	LEAK OXPHOS	N S CIV NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Zhang 2022 Int J Mol Sci	2022	Zhang A, Gupte AA, Chatterjee S, Li S, Ayala AG, Miles BJ, Hamilton DJ (2022) Enhanced succinate oxidation with mitochondrial complex II reactive oxygen species generation in human prostate cancer. https://doi.org/10.3390/ijms232012168	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Human	Genital
Meszaros 2022 EBioMedicine	2022	Meszaros AT, Hofmann J, Buch ML, Cardini B, Dunzendorfer-Matt T, Nardin F, Blumer MJ, Fodor M, Hermann M, Zelger B, Otarashvili G, Schartner M, Weissenbacher A, Oberhuber R, Resch T, Troppmair J, Öfner D, Zoller H, Tilg H, Gnaiger E, Hautz T, Schneeberger S (2022) Mitochondrial respiration during normothermic liver machine perfusion predicts clinical outcome. https://doi.org/10.1016/j.ebiom.2022.104311	OXPHOS ET LEAK	F N S NS ROX	Homogenate	Human	Liver
Brown 2022 Redox Biol	2022	Brown JL, Peelor FF 3rd, Georgescu C, Wren JD, Kinter M, Tyrrell VJ, O'Donnell VB, Miller BF, Van Remmen H (2022) Lipid hydroperoxides and oxylipins are mediators of denervation induced muscle atrophy. https://doi.org/10.1016/j.redox.2022.102518	LEAK OXPHOS	N S CIV NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Felix 2022 Chemosphere	2022	Félix L, Carreira P, Peixoto F (2022) Effects of chronic exposure of naturally weathered microplastics on oxidative stress level, behaviour, and mitochondrial function of adult zebrafish (Danio rerio). https://doi.org/10.1016/j.chemosphere.2022.136895	LEAK OXPHOS	N S CIV ROX	Homogenate	Zebrafish	Nervous system Liver
Babylon 2022 Int J Mol Sci	2022	Babylon L, Schmitt F, Franke Y, Hubert T, Eckert GP (2022) Effects of combining biofactors on bioenergetic parameters, Aβ levels and survival in Alzheimer model organisms. https://doi.org/10.3390/ijms23158670	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Human	Neuroblastoma
Vizuete 2022 J Neuroinflammation	2022	Vizuete AFK, Fróes F, Seady M, Zanotto C, Bobermin LD, Roginski AC, Wajner M, Quincozes-Santos A, Gonçalves CA (2022) Early effects of LPS-induced neuroinflammation on the rat hippocampal glycolytic pathway. https://doi.org/10.1186/s12974-022-02612-w	LEAK OXPHOS ET	N S NS ROX	Homogenate	Rat	Nervous system
Dieter 2022 Int J Mol Sci	2022	Dieter F, Esselun C, Eckert GP (2022) Redox active α-lipoic acid differentially improves mitochondrial dysfunction in a cellular model of Alzheimer and its control cells. https://doi.org/10.3390/ijms23169186	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Human	Neuroblastoma
Theall 2021 Physiol Rep	2021	Theall B, Stampley J, Cho E, Granger J, Johannsen NM, Irving BA, Spielmann G (2021) Impact of acute exercise on peripheral blood mononuclear cells nutrient sensing and mitochondrial oxidative capacity in healthy young adults. Physiol Rep 9:e15147.	LEAK ROUTINE OXPHOS ET	N NS ROX	Permeabilized cells Intact cells	Human	Blood cells
Poles 2021 Front Immunol	2021	Poles MZ, Nászai A, Gulácsi L, Czakó BL, Gál KG, Glenz RJ, Dookhun D, Rutai A, Tallósy SP, Szabó A, Lőrinczi B, Szatmári I, Fülöp F, Vécsei L, Boros M, Juhász L, Kaszaki J (2021) Kynurenic acid and its synthetic derivatives protect against sepsis-associated neutrophil activation and brain mitochondrial dysfunction in rats. Front Immunol 12:717157. https://doi.org/10.3389/fimmu.2021.717157	OXPHOS	NS	Homogenate	Rat	Nervous system
Zanou 2021 Nat Commun	2021	Zanou N, Dridi H, Reiken S, Imamura de Lima T, Donnelly C, De Marchi U, Ferrini M, Vidal J, Sittenfeld L, Feige JN, Garcia-Roves PM, Lopez-Mejia IC, Marks AR, Auwerx J, Kayser B, Place N (2021) Acute RyR1 Ca²⁺ leak enhances NADH-linked mitochondrial respiratory capacity. Nat Commun 12:7219.	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells	Mouse	Skeletal muscle
Pesta 2021 Front Endocrinol (Lausanne)	2021	Pesta D, Jelenik T, Zaharia OP, Bobrov P, Görgens S, Bódis K, Karusheva Y, Krako Jakovljevic N, Lalic NM, Markgraf DF, Burkart V, Müssig K, Knebel B, Kotzka J, Eckel J, Strassburger K, Szendroedi J, Roden M (2021) NDUFB6 polymorphism is associated with physical activity-mediated metabolic changes in type 2 diabetes. https://doi.org/10.3389/fendo.2021.693683	LEAK OXPHOS ET	F N	Permeabilized cells	Mouse	Skeletal muscle
Gratl 2021 J Transl Med	2021	Gratl A, Pesta D, Gruber L, Speichinger F, Raude B, Omran S, Greiner A, Frese JP (2021) The effect of revascularization on recovery of mitochondrial respiration in peripheral artery disease: a case control study. https://doi.org/10.1186/s12967-021-02908-0J	LEAK OXPHOS ET	F N NS	Permeabilized tissue	Human	Skeletal muscle
Bischof 2021 Sci Transl Med	2021	Bischof C, Mirtschink P, Yuan T, Wu M, Zhu C, Kaur J, Pham MD, Gonzalez-Gonoggia S, Hammer M, Rogg EM, Sharma R, Bottermann K, Gercken B, Hagag E, Berthonneche C, Sossalla S, Stehr SN, Maxeiner J, Duda MA, Latreille M, Zamboni N, Martelli F, Pedrazzini T, Dimmeler S, Krishnan J (2021) Mitochondrial-cell cycle cross-talk drives endoreplication in heart disease. Sci Transl Med 13:eabi7964.	LEAK OXPHOS ET	S
Palzur 2021 Int J Mol Sci	2021	Palzur E, Edelman D, Sakas R, Soustiel JF (2021) Etifoxine restores mitochondrial oxidative phosphorylation and improves cognitive recovery following traumatic brain injury. Int J Mol Sci 22:12881. doi: 10.3390/ijms222312881	LEAK OXPHOS	N S ROX	Isolated mitochondria	Rat	Nervous system
Galli 2021 Front Physiol	2021	Galli GLJ, Ruhr IM, Crossley J, Crossley DA 2nd (2021) The long-term effects of developmental hypoxia on cardiac mitochondrial function in snapping turtles. Front Physiol 12:689684. doi: 10.3389/fphys.2021.689684	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Reptiles	Heart
Kumar 2021 JCI Insight	2021	Kumar A, Welch N, Mishra S, Bellar A, Silva RN, Li L, Singh SS, Sharkoff M, Kerr A, Chelluboyina AK, Sekar J, Attaway AH, Hoppel C, Willard B, Davuluri G, Dasarathy S (2021) Metabolic reprogramming during hyperammonemia targets mitochondrial function and postmitotic senescence. JCI Insight 6:e154089.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue Isolated mitochondria Intact cells	Mouse Rat	Skeletal muscle
Hodges 2021 J Biol Chem	2021	Hodges WT, Jarasvaraparn C, Ferguson D, Griffett K, Gill LE, Chen Y, Ilagan MXG, Hegazy L, Elgendy B, Cho K, Patti GJ, McCommis KS, Finck BN (2021) Mitochondrial pyruvate carrier inhibitors improve metabolic parameters in diet-induced obese mice. J Biol Chem 298:101554.	OXPHOS	N NS	Isolated mitochondria	Mouse	Heart
Pamenter 2021 Biol Lett	2021	Pamenter ME, Gomez CR, Richards JG, Milsom WK (2021) Mitochondrial responses to prolonged anoxia in brain of red-eared slider turtles. Biol Lett 12:20150797.	LEAK OXPHOS ET	N S CIV ROX	Permeabilized cells	Reptiles	Nervous system
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Davis 2021 Comparative Exercise Physiology	2021	Davis Michael, Barrett Montana, Popken Andrea (2021) Effect of hyperthermia and acidosis on equine skeletal muscle mitochondrial oxygen consumption. Comparative Exercise Physiology 17:171-179.	LEAK OXPHOS ET	N S NS	Permeabilized cells	Horse	Skeletal muscle
Yoshino 2021 Science	2021	Yoshino M, Yoshino J, Kayser BD, Patti GJ, Franczyk MP, Mills KF, Sindelar M, Pietka T, Patterson BW, Imai SI, Klein S (2021) Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science 372:1224-29. https://doi.org/10.1126/science.abe9985	LEAK OXPHOS ET	N S NS	Permeabilized tissue	Human	Skeletal muscle
Liu 2021 Front Physiol	2021	Liu H, Tenzing N, van Patot MT, Qile M, Ge RL, Wuren T (2021) Enhanced placental mitochondrial respiration in Tibetan women at high altitude. Front Physiol 12:697022. doi: 10.3389/fphys.2021.697022	LEAK OXPHOS ET	N S NS	Permeabilized tissue	Human	Genital
Bittel 2021 Diabetes	2021	Bittel DC, Bittel AJ, Varadhachary AS, Pietka T, Sinacore DR (2021) Deficits in the skeletal muscle transcriptome and mitochondrial coupling in progressive diabetes-induced CKD relate to functional decline. Diabetes 70:1130-44. https://doi.org/10.2337/db20-0688	LEAK OXPHOS ET	N NS	Permeabilized tissue	Human	Skeletal muscle
Glancy 2021 Physiol Rev	2021	Glancy B, Balaban RS (2021) Energy metabolism design of the striated muscle cell. Physiol Rev 101:1561-607. doi: 10.1152/physrev.00040.2020	OXPHOS				Skeletal muscle
Jacome-Sosa 2021 Commun Biol	2021	Jacome-Sosa M, Miao ZF, Peche VS, Morris EF, Narendran R, Pietka KM, Samovski D, Lo HG, Pietka T, Varro A, Love-Gregory L, Goldenring JR, Kuda O, Gamazon ER, Mills JC, Abumrad NA (2021) CD36 maintains the gastric mucosa and associates with gastric disease. Commun Biol 4:1247. https://doi.org/10.1038/s42003-021-02765-z	LEAK OXPHOS ET	N NS	Permeabilized tissue	Mouse	Endothelial;epithelial;mesothelial cell
Wuest 2021 Int J Mol Sci	2021	Wüst RCI, Coolen BF, Held NM, Daal MRR, Alizadeh Tazehkandi V, Baks-Te Bulte L, Wiersma M, Kuster DWD, Brundel BJJM, van Weeghel M, Strijkers GJ, Houtkooper RH (2021) The antibiotic doxycycline impairs cardiac mitochondrial and contractile function. Int J Mol Sci 22:4100.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Heart
Jasz 2021 J Cell Mol Med	2021	Jász DK, Szilágyi ÁL, Tuboly E, Baráth B, Márton AR, Varga P, Varga G, Érces D, Mohácsi Á, Szabó A, Bozó R, Gömöri K, Görbe A, Boros M, Hartmann P (2021) Reduction in hypoxia-reoxygenation-induced myocardial mitochondrial damage with exogenous methane. https://doi.org/10.1111/jcmm.16498	LEAK ROUTINE OXPHOS ET	S ROX	Permeabilized cells Isolated mitochondria	Rat	Heart
Zhang 2021 Pharmaceutics	2021	Zhang H, Zhang A, Gupte AA, Hamilton DJ (2021) Plumbagin elicits cell-specific cytotoxic effects and metabolic responses in melanoma cells. Pharmaceutics 13:706.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Endothelial;epithelial;mesothelial cell Other cell lines
Avram 2021 Life (Basel)	2021	Avram VF, Bina AM, Sima A, Aburel OM, Sturza A, Burlacu O, Timar RZ, Muntean DM, Elmer E, Cretu OM (2021) Improvement of platelet respiration by cell-permeable succinate in diabetic patients treated with statins. Life (Basel) 11:288.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Platelet
Dunn 2021 Arterioscler Thromb Vasc Biol	2021	Dunn LL, Kong SMY, Tumanov S, Chen W, Cantley J, Ayer A, Maghzal GJ, Midwinter RG, Chan KH, Ng MKC, Stocker R (2021) Hmox1 (heme oxygenase-1) protects against ischemia-mediated injury via stabilization of HIF-1α (hypoxia-inducible factor-1α). Arterioscler Thromb Vasc Biol 41:317-30.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Bouche 2021 PLoS One	2021	Bouche L, Kamel R, Tamareille S, Garcia G, Villedieu C, Pillot B, Gueguen N, Chehaitly A, Chao de la Barca JM, Beaumont J, Baetz D, Ovize M, Sesaki H, Henrion D, Reynier P, Lenaers G, Prunier F, Mirebeau-Prunier D (2021) DRP1 haploinsufficiency attenuates cardiac ischemia/reperfusion injuries. PLoS One 16:0248554.	LEAK OXPHOS ET	N S CIV NS ROX F	Permeabilized tissue	Mouse	Heart
Sladowska 2021 PLoS Biol	2021	Sladowska M, Turek M, Kim MJ, Drabikowski K, Mussulini BHM, Mohanraj K, Serwa RA, Topf U, Chacinska A (2021) Proteasome activity contributes to pro-survival response upon mild mitochondrial stress in Caenorhabditis elegans. PLoS Biol 19:3001302.	OXPHOS	N S CIV ROX	Isolated mitochondria	Caenorhabditis elegans
Kruse 2021 Life (Basel)	2021	Kruse CJ, Stern D, Mouithys-Mickalad A, Niesten A, Art T, Lemieux H, Votion DM (2021) In vitro assays for the assessment of impaired mitochondrial bioenergetics in equine atypical myopathy. Life (Basel) 11:719.	LEAK OXPHOS ET	F N S NS ROX	Intact cells Permeabilized cells	Horse	Skeletal muscle
Dubinin 2021 Membranes (Basel)	2021	Dubinin MV, Semenova AA, Nedopekina DA, Davletshin EV, Spivak AY, Belosludtsev KN (2021) Effect of F16-betulin conjugate on mitochondrial membranes and its role in cell death initiation. Membranes (Basel) 11:352.	LEAK OXPHOS ET	N S	Isolated mitochondria	Rat	Liver
Colin 2021 J Cell Mol Med	2021	Colin M, Dechene L, Ceusters J, Niesten A, Demazy C, Lagneaux L, Zouaoui Boudjeltia K, Franck T, Van Antwerpen P, Renard P, Mathieu V, Serteyn D (2021) Priming of mesenchymal stem cells with a hydrosoluble form of curcumin allows keeping their mesenchymal properties for cell-based therapy development. J Cell Mol Med 25:4877-81.	LEAK OXPHOS ET	N S NS	Intact cells	Horse	Stem cells
Palacka 2021 Int J Mol Sci	2021	Palacka P, Gvozdjáková A, Rausová Z, Kucharská J, Slopovský J, Obertová J, Furka D, Furka S, Singh KK, Sumbalová Z (2021) Platelet mitochondrial bioenergetics reprogramming in patients with urothelial carcinoma. https://doi.org/10.3390/ijms23010388	LEAK ROUTINE OXPHOS ET	F N S Gp NS ROX	Permeabilized cells Intact cells	Human	Platelet
Villanueva 2021 Transplant Direct	2021	Villanueva JE, Chew HC, Gao L, Doyle A, Scheuer SE, Hicks M, Jabbour A, Dhital KK, Macdonald PS (2021) The effect of increasing donor age on myocardial ischemic tolerance in a rodent model of donation after circulatory death. Transplant Direct 7:699.	LEAK OXPHOS ET	F N NS ROX S	Permeabilized tissue	Rat	Heart
Hamm 2021 Mol Ther Methods Clin Dev	2021	Hamm SE, Fathalikhani DD, Bukovec KE, Addington AK, Zhang H, Perry JB, McMillan RP, Lawlor MW, Prom MJ, Vanden Avond MA, Kumar SN, Coleman KE, Dupont JB, Mack DL, Brown DA, Morris CA, Gonzalez JP, Grange RW (2023) Voluntary wheel running complements microdystrophin gene therapy to improve muscle function in mdx mice. https://doi.org/10.1016/j.omtm.2021.02.024	LEAK OXPHOS	N NS	Permeabilized tissue	Mouse	Skeletal muscle
Elliehausen 2021 Exp Gerontol	2021	Elliehausen CJ, Minton DM, Nichol AD, Konopka AR (2021) Skeletal muscle mitochondrial respiration in a model of age-related osteoarthritis is impaired after dietary rapamycin. https://doi.org/10.1016/j.exger.2021.111579	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Guinea pig	Skeletal muscle
Newsom 2021 Med Sci Sports Exerc	2021	Newsom SA, Stierwalt HD, Ehrlicher SE, Robinson MM (2021) Substrate-specific respiration of isolated skeletal muscle mitochondria after 1 h of moderate cycling in sedentary adults. https://doi.org/10.1249/mss.0000000000002615	LEAK OXPHOS ET	F N S NS ROX	Isolated mitochondria	Human	Skeletal muscle
Krako Jakovljevic 2021 Int J Mol Sci	2021	Krako Jakovljevic N, Pavlovic K, Jotic A, Lalic K, Stoiljkovic M, Lukic L, Milicic T, Macesic M, Stanarcic Gajovic J, Lalic NM (2021) Targeting mitochondria in diabetes. Int J Mol Sci 22:6642.	LEAK OXPHOS ET	F N S	Permeabilized tissue	Human	Skeletal muscle Liver Blood cells
Basse 2021 Mol Metab	2021	Basse AL, Agerholm M, Farup J, Dalbram E, Nielsen J, Oertenblad N, Altıntas A, Ehrlich AM, Krag T, Bruzzone S, Dall M, de Guia RM, Jensen JB, Moeller AB, Karlsen A, Kjaer M, Barres R, Vissing J, Larsen S, Jessen N, Treebak JT (2021) Nampt controls skeletal muscle development by maintaining Ca²⁺ homeostasis and mitochondrial integrity. Mol Metab 53:101271.	LEAK OXPHOS	N CIV NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Pharaoh 2021 JCSM Rapid Commun	2021	Pharaoh G, Brown J, Ranjit R, Ungvari Z, Van Remmen H (2021) Reduced adenosine diphosphate sensitivity in skeletal muscle mitochondria increases reactive oxygen species production in mouse models of aging and oxidative stress but not denervation. https://doi.org/10.1002/rco2.29	LEAK OXPHOS	N S CIV NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Lelcu 2021 Children (Basel)	2021	Lelcu T, Bînă AM, Dănilă MD, Popoiu CM, Aburel OM, Arghirescu ST, Borza C, Muntean DM (2021) Assessment of platelet mitochondrial respiration in a pediatric population: A pilot study in healthy children and children with acute lymphoblastic leukemia. https://doi.org/10.3390/children8121196	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells	Human	Platelet
Acin-Perez 2021 Life (Basel)	2021	Acin-Perez R, Benincá C, Shabane B, Shirihai OS, Stiles L (2021) Utilization of human samples for assessment of mitochondrial bioenergetics: gold standards, limitations, and future perspectives. Life (Basel) 11:949. doi: 10.3390/life11090949	LEAK ROUTINE OXPHOS ET		Intact organ Permeabilized cells Permeabilized tissue Intact cells	Human	Skeletal muscle Blood cells Fibroblast Platelet
Juhaszova 2021 Function (Oxf)	2021	Juhaszova M, Kobrinsky E, Zorov DB, Nuss HB, Yaniv Y, Fishbein KW, de Cabo R, Montoliu L, Gabelli SB, Aon MA, Cortassa S, Sollott SJ (2021) ATP synthase K⁺- and H⁺-fluxes drive ATP synthesis and enable mitochondrial K⁺-"uniporter" function: I. Characterization of ion fluxes. Function (Oxf) 3(2):zqab065. doi: 10.1093/function/zqab065	LEAK OXPHOS		Isolated mitochondria
Knapp-Wilson 2021 J Cell Sci	2021	Knapp-Wilson A, Pereira GC, Buzzard E, Ford HC, Richardson A, Corey RA, Neal C, Verkade P, Halestrap AP, Gold VAM, Kuwabara PE, Collinson I (2021) Maintenance of complex I and its supercomplexes by NDUF-11 is essential for mitochondrial structure, function and health. J Cell Sci 134:jcs258399. doi: 10.1242/jcs.258399	LEAK OXPHOS ET	N S NS	Isolated mitochondria	Caenorhabditis elegans
Viel 2021 Pharmaceuticals (Basel)	2021	Viel C, Brandtner AT, Weißhaar A, Lehto A, Fuchs M, Klein J (2021) Effects of magnesium orotate, benfotiamine and a combination of vitamins on mitochondrial and cholinergic function in the TgF344-AD rat model of Alzheimer's disease. https://doi.org/10.3390/ph14121218	LEAK OXPHOS ET	N S CIV ROX	Isolated mitochondria	Rat	Nervous system
Liu 2021 Basic Res Cardiol	2021	Liu N, Kataoka M, Wang Y, Pu L, Dong X, Fu X, Zhang F, Gao F, Liang T, Pei J, Xiao C, Qiu Q, Hong T, Chen Q, Zhao J, Zhu L, He J, Hu X, Nie Y, Zhu W, Yu H, Cowan DB, Hu X, Wang J, Wang DZ, Chen J (2021) LncRNA LncHrt preserves cardiac metabolic homeostasis and heart function by modulating the LKB1-AMPK signaling pathway. Basic Res Cardiol 116:48.	OXPHOS	F N S CIV ROX	Permeabilized tissue	Mouse	Heart
Apostolopoulou 2021 Sci Adv	2021	Apostolopoulou M, Mastrototaro L, Hartwig S, Pesta D, Straßburger K, de Filippo E, Jelenik T, Karusheva Y, Gancheva S, Markgraf D, Herder C, Nair KS, Reichert AS, Lehr S, Müssig K, Al-Hasani H, Szendroedi J, Roden M (2021) Metabolic responsiveness to training depends on insulin sensitivity and protein content of exosomes in insulin-resistant males. https://doi.org/10.1126/sciadv.abi9551	LEAK OXPHOS ET	N NS ROX	Permeabilized tissue	Human	Skeletal muscle
McKenna 2021 Redox Biol	2021	McKenna HT, O'Brien KA, Fernandez BO, Minnion M, Tod A, McNally BD, West JA, Griffin JL, Grocott MP, Mythen MG, Feelisch M, Murray AJ, Martin DS (2021) Divergent trajectories of cellular bioenergetics, intermediary metabolism and systemic redox status in survivors and non-survivors of critical illness. Redox Biol 41:101907.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Larsen 2021 Cell Mol Gastroenterol Hepatol	2021	Larsen LE, van den Boogert MAW, Rios-Ocampo WA, Jansen JC, Conlon D, Chong PLE, Levels JHM, Eilers RE, Sachdev VV, Zelcer N, Raabe T, He M, Hand NJ, Drenth JPH, Rader DJ, Stroes ESG, Lefeber DJ, Jonker JW, Holleboom AG (2021) Defective lipid droplet - lysosome interaction causes fatty liver disease as evidenced by human mutations in TMEM199 and CCDC115. Cell Mol Gastroenterol Hepatol 13:583-97.	OXPHOS ET	F N	Intact cells	Human	Liver
Gvozdjakova 2021 PLoS One	2021	Gvozdjáková A, Sumbalová Z, Kucharská J, Szamosová M, Čápová L, Rausová Z, Vančová O, Mojto V, Langsjoen P, Palacka P (2021) Platelet mitochondrial respiration and coenzyme Q₁₀ could be used as new diagnostic strategy for mitochondrial dysfunction in rheumatoid diseases. PLoS ONE 16:e0256135.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Platelet
Cardinale 2021 J Appl Physiol (1985)	2021	Cardinale DA, Gejl KD, Petersen KG, Nielsen J, Ørtenblad N, Larsen FJ (2021) Short-term intensified training temporarily impairs mitochondrial respiratory capacity in elite endurance athletes. J Appl Physiol (1985) 131:388-400.	LEAK OXPHOS	F N CIV NS	Permeabilized tissue	Human	Skeletal muscle
Elksnis 2021 Clin Sci (Lond)	2021	Elksnis A, Schiffer TA, Palm F, Wang Y, Cen J, Turpaev K, Ngamjariyawat A, Younis S, Huang S, Shen Y, Leng Y, Bergsten P, Karlsborn T, Welsh N, Wang X (2021) Imatinib protects against human beta-cell death via inhibition of mitochondrial respiration and activation of AMPK. Clin Sci (Lond) 135:2243-63.	OXPHOS ET	N S	Isolated mitochondria	Rat	Kidney
Rossetti 2021 Sci Adv	2021	Rossetti G, Ermer JA, Stentenbach M, Siira SJ, Richman TR, Milenkovic D, Perks KL, Hughes LA, Jamieson E, Xiafukaiti G, Ward NC, Takahashi S, Gray N, Viola HM, Hool LC, Rackham O, Filipovska A (2021) A common genetic variant of a mitochondrial RNA processing enzyme predisposes to insulin resistance. Sci Adv 7:eabi7514.	LEAK OXPHOS ET	F N S ROX	Isolated mitochondria	Mouse	Liver
Bastos Sant'Anna Silva 2021 Cancers (Basel)	2021	Bastos Sant'Anna Silva AC, Perez Valencia JA, Sciacovelli M, Lalou C, Sarlak S, Tronci L, Nikitopoulou E, Meszaros AT, Frezza C, Rossignol R, Gnaiger E, Klocker H (2021) Succinate anaplerosis has an onco-driving potential in prostate cancer cells. https://doi.org/10.3390/cancers13071727	LEAK ROUTINE OXPHOS	S ROX	Permeabilized cells Intact cells	Human	Genital
Valera-Alberni 2021 Cell Rep	2021	Valera-Alberni M, Joffraud M, Miro-Blanch J, Capellades J, Junza A, Dayon L, Núñez Galindo A, Sanchez-Garcia JL, Valsesia A, Cercillieux A, Söllner F, Ladurner AG, Yanes O, Cantó C (2021) Crosstalk between Drp1 phosphorylation sites during mitochondrial remodeling and their impact on metabolic adaptation. Cell Rep 36:109565.	LEAK OXPHOS ET	N S NS ROX	Homogenate Isolated mitochondria	Mouse	Liver Fat
Marrocco 2021 J Immunol	2021	Marrocco A, Frawley K, Pearce LL, Peterson J, O'Brien JP, Mullett SJ, Wendell SG, St Croix CM, Mischler SE, Ortiz LA (2021) Metabolic adaptation of macrophages as mechanism of defense against crystalline silica. J Immunol 207:1627-40.	LEAK OXPHOS ET	N ROX		Mouse	Macrophage-derived
Zunica 2021 Cancer Metab	2021	Zunica ERM, Axelrod CL, Cho E, Spielmann G, Davuluri G, Alexopoulos SJ, Beretta M, Hoehn KL, Dantas WS, Stadler K, King WT, Pergola K, Irving BA, Langohr IM, Yang S, Hoppel CL, Gilmore LA, Kirwan JP (2021) Breast cancer growth and proliferation is suppressed by the mitochondrial targeted furazano[3,4-b]pyrazine BAM15. Cancer Metab 9:36.	LEAK OXPHOS ET	N S CIV NS ROX F DQ	Permeabilized cells Homogenate	Human Mouse	Endothelial;epithelial;mesothelial cell
Liang 2021 Biomed Pharmacother	2021	Liang L, Zhang G, Cheng C, Li H, Jin T, Su C, Xiao Y, Bradley J, Peberdy MA, Ornato JP, Mangino MJ, Tang W (2021) High-resolution respirometry for evaluation of mitochondrial function on brain and heart homogenates in a rat model of cardiac arrest and cardiopulmonary resuscitation. Biomed Pharmacother 142:111935.	LEAK OXPHOS ROUTINE	N S CIV ROX	Homogenate	Rat	Heart Nervous system
Drake 2021 Proc Natl Acad Sci U S A	2021	Drake JC, Wilson RJ, Laker RC, Guan Y, Spaulding HR, Nichenko AS, Shen W, Shang H, Dorn MV, Huang K, Zhang M, Bandara AB, Brisendine MH, Kashatus JA, Sharma PR, Young A, Gautam J, Cao R, Wallrabe H, Chang PA, Wong M, Desjardins EM, Hawley SA, Christ GJ, Kashatus DF, Miller CL, Wolf MJ, Periasamy A, Steinberg GR, Hardie DG, Yan Z (2021) Mitochondria-localized AMPK responds to local energetics and contributes to exercise and energetic stress-induced mitophagy. Proc Natl Acad Sci U S A 118:e2025932118.	LEAK OXPHOS ET	N S NS	Permeabilized tissue	Mouse	Skeletal muscle
Cannon 2021 Respir Physiol Neurobiol	2021	Cannon DT, Nogueira L, Gutierrez-Gonzalez AK, Gilmore NK, Bigby TD, Breen EC (2021) Role of IL-33 receptor (ST2) deletion in diaphragm contractile and mitochondrial function in the Sugen5416/hypoxia model of pulmonary hypertension. Respir Physiol Neurobiol 295:103783.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
King 2021 J Biol Chem	2021	King WT, Axelrod CL, Zunica ERM, Noland RC, Davuluri G, Fujioka H, Tandler B, Pergola K, Hermann GE, Rogers RC, López-Domènech S, Dantas WS, Stadler K, Hoppel CL, Kirwan JP (2021) Dynamin-related protein 1 regulates substrate oxidation in skeletal muscle by stabilizing cellular and mitochondrial calcium dynamics. J Biol Chem 297:101196.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized cells	Mouse	Skeletal muscle
Hoppel 2021 Cells	2021	Hoppel F, Garcia-Souza LF, Kantner-Rumplmair W, Burtscher M, Gnaiger E, Pesta D, Calabria E (2021) Human platelet mitochondrial function reflects systemic mitochondrial alterations: a protocol for application in field studies. https://doi.org/10.3390/cells10082088	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Platelet
Zuccarelli 2021 J Physiol	2021	Zuccarelli L, Baldassarre G, Magnesa B, Degano C, Comelli M, Gasparini M, Manferdelli G, Marzorati M, Mavelli I, Pilotto A, Porcelli S, Rasica L, Šimunič B, Pišot R, Narici M, Grassi B (2021) Peripheral impairments of oxidative metabolism after a 10-day bed rest are upstream of mitochondrial respiration. J Physiol 599:4813-29.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Trinity 2021 J Appl Physiol	2021	Trinity JD, Craig JC, Fermoyle CC, McKenzie AI, Lewis MT, Park SH, Rondina MT, Richardson RS (2021) Impact of presymptomatic COVID-19 on vascular and skeletal muscle function: a case study. J Appl Physiol (1985) 130:1961-70.	LEAK OXPHOS	N S NS	Permeabilized tissue	Human	Skeletal muscle
Oemer 2021 J Lipid Res	2021	Oemer G, Edenhofer ML, Wohlfarter Y, Lackner K, Leman G, Koch J, Cardoso LHD, Lindner HH, Gnaiger E, Dubrac S, Zschocke J, Keller MA (2021) Fatty acyl availability modulates cardiolipin composition and alters mitochondrial function in HeLa cells. https://doi.org/10.1016/j.jlr.2021.100111	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells	Human	HeLa
Gnaiger 2021 MitoFit BCA	2021	Gnaiger E (2021) Bioenergetic cluster analysis – mitochondrial respiratory control in human fibroblasts. MitoFit Preprints 2021.08. https://doi.org/10.26124/mitofit:2021-0008	LEAK OXPHOS ET	ROX	Intact cells	Human	Fibroblast
Mazzoli 2021 Nutrients	2021	Mazzoli A, Gatto C, Crescenzo R, Cigliano L, Iossa S (2021) Prolonged changes in hepatic mitochondrial activity and insulin sensitivity by high fructose intake in adolescent rats. Nutrients 13:1370.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Rat	Liver
Sahl 2021 Adipocyte	2021	Sahl RE, Høy Helms EF, Schmücker M, Flensted-Jensen M, Ingersen A, Morville T, Dela F, Helge JW, Larsen S (2021) Reliability and variation in mitochondrial respiration in human adipose tissue. Adipocyte 10:605-11.	LEAK OXPHOS ET	N NS	Permeabilized cells	Human	Fat
Tallosy 2021 Sci Rep	2021	Tallósy SP, Poles MZ, Rutai A, Fejes R, Juhász L, Burián K, Sóki J, Szabó A, Boros M, Kaszaki J (2021) The microbial composition of the initial insult can predict the prognosis of experimental sepsis. Sci Rep 11:22772.	LEAK OXPHOS	S ROX	Homogenate	Rat	Liver
Sharma 2021 Cancer Cell Int	2021	Sharma P, Sharma V, Ahluwalia TS, Dogra N, Kumar S, Singh S (2021) Let-7a induces metabolic reprogramming in breast cancer cells via targeting mitochondrial encoded ND4. Cancer Cell Int 21:629.	LEAK OXPHOS	N S	Permeabilized cells	Human	Endothelial;epithelial;mesothelial cell
Fischer 2021 Antioxidants	2021	Fischer C, Volani C, Komlódi T, Seifert M, Demetz E, Valente de Souza L, Auer K, Petzer V, von Raffay L, Moser P, Gnaiger E, Weiss G (2021) Dietary iron overload and Hfe^-/- related hemochromatosis alter hepatic mitochondrial function. https://doi.org/10.3390/antiox10111818	LEAK OXPHOS ET	ROX N S Gp		Mouse	Liver
Dall 2021 J Biol Chem	2021	Dall M, Hassing AS, Niu L, Nielsen TS, Ingerslev LR, Sulek K, Trammell SAJ, Gillum MP, Barrès R, Larsen S, Poulsen SS, Mann M, Ørskov C, Treebak JT (2021) Hepatocyte-specific perturbation of NAD⁺ biosynthetic pathways in mice induces reversible nonalcoholic steatohepatitis-like phenotypes. J Biol Chem 297:101388.	LEAK OXPHOS ET	N NS	Intact cells	Mouse	Liver
Antico 2021 Sci Adv	2021	Antico O, Ordureau A, Stevens M, Singh F, Nirujogi RS, Gierlinski M, Barini E, Rickwood ML, Prescott A, Toth R, Ganley IG, Harper JW, Muqit MMK (2021) Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1. Sci Adv 7:eabj0722.	LEAK OXPHOS ET	F N S Gp NS ROX	Intact cells	Mouse	Nervous system
Akinbiyi 2021 Sci Rep	2021	Akinbiyi EO, Abramowitz LK, Bauer BL, Stoll MSK, Hoppel CL, Hsiao CP, Hanover JA, Mears JA (2021) Blocked O-GlcNAc cycling alters mitochondrial morphology, function, and mass. Sci Rep 11:22106.	LEAK OXPHOS ET	F N S DQ CIV NS ROX	Permeabilized cells
Szczerbinski 2021 Cells	2021	Szczerbinski L, Taylor MA, Puchta U, Konopka P, Paszko A, Citko A, Szczerbinski K, Goscik J, Gorska M, Larsen S, Kretowski A (2021) The response of mitochondrial respiration and quantity in skeletal muscle and adipose tissue to exercise in humans with prediabetes. Cells 10:3013.	LEAK OXPHOS ET	N S	Permeabilized tissue	Human	Skeletal muscle Fat
Gupta 2021 Sci Rep	2021	Gupta MK, Sahu A, Sun Y, Mohan ML, Kumar A, Zalavadia A, Wang X, Martelli EE, Stenson K, Witherow CP, Drazba J, Dasarathy S, Naga Prasad SV (2021) Cardiac expression of microRNA-7 is associated with adverse cardiac remodeling. Sci Rep 11:22018.	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Mouse	Heart
De Moura Alvorcem 2021 J Neurochem	2021	de Moura Alvorcem, L, Britto R, Cecatto C, Roginski AC, Rohden F, Scholl JN, Guma FCR, Figueiro F, Amaral AU, Zanatta G, Seminotti B, Wajner M, Leipnitz G. (2021) Ethylmalonic acid impairs bioenergetics by disturbing succinate and glutamate oxidation and induces mitochondrial permeability transition pore opening in rat cerebellum. J Neurochem 158(2): 262–81.	LEAK OXPHOS	N S	Homogenate Isolated mitochondria	Rat	Nervous system
Komlodi 2021 BEC Q	2021	Komlódi T, Cardoso LHD, Doerrier C, Moore AL, Rich PR, Gnaiger E (2021) Coupling and pathway control of coenzyme Q redox state and respiration in isolated mitochondria. Bioenerg Commun 2021.3. https://doi.org/10.26124/bec:2021-0003	LEAK OXPHOS ET	N S NS	Isolated mitochondria	Mouse	Heart Nervous system
Riguet 2021 Nat Commun	2021	Riguet N, Mahul-Mellier AL, Maharjan N, Burtscher J, Croisier M, Knott G, Hastings J, Patin A, Reiterer V, Farhan H, Nasarov S, Lashuel HA (2021) Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties. Nat Commun 12:6579.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	HEK
Liepinsh 2021 Free Radic Biol Med	2021	Liepinsh E, Kuka J, Vilks K, Svalbe B, Stelfa G, Vilskersts R, Sevostjanovs E, Goldins NR, Groma V, Grinberga S, Plaas M, Makrecka-Kuka M, Dambrova M (2021) Low cardiac content of long-chain acylcarnitines in TMLHE knockout mice prevents ischaemia-reperfusion-induced mitochondrial and cardiac damage. Free Radic Biol Med 177:370-80.	LEAK OXPHOS	F N S NS ROX	Permeabilized tissue	Mouse	Heart
Liu 2021 FASEB J	2021	Liu Z, Chaillou T, Santos Alves E, Mader T, Jude B, Ferreira DMS, Hynynen H, Cheng AJ, Jonsson WO, Pironti G, Andersson DC, Kenne E, Ruas JL, Tavi P, Lanner JT (2021) Mitochondrial NDUFA4L2 is a novel regulator of skeletal muscle mass and force. FASEB J 35:e22010.	LEAK OXPHOS	N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Rodrigues 2021 Sci Rep	2021	Rodrigues AQ, Picolo VL, Goulart JT, Silva IMG, Ribeiro RB, Aguiar BA, Ferreira YB, Oliveira DM, Lucci CM, de Bem AF, Paulini F (2021) Metabolic activity in cryopreserved and grafted ovarian tissue using high-resolution respirometry. Sci Rep 11:21517.	LEAK OXPHOS ET	S	Homogenate	Mouse	Genital
Sarabhai 2021 Diabetologia	2021	Sarabhai T, Koliaki C, Mastrototaro L, Kahl S, Pesta D, Apostolopoulou M, Wolkersdorfer M, Bönner AC, Bobrov P, Markgraf DF, Herder C, Roden M (2021) Dietary palmitate and oleate differently modulate insulin sensitivity in human skeletal muscle. Diabetologia 65:301-14.	LEAK OXPHOS ET	N NS	Permeabilized tissue	Human	Skeletal muscle
Hoene 2021 Mol Metab	2021	Hoene M, Kappler L, Kollipara L, Hu C, Irmler M, Bleher D, Hoffmann C, Beckers J, Hrabě de Angelis M, Häring HU, Birkenfeld AL, Peter A, Sickmann A, Xu G, Lehmann R, Weigert C (2021) Exercise prevents fatty liver by modifying the compensatory response of mitochondrial metabolism to excess substrate availability. Mol Metab 54:101359.	LEAK OXPHOS ET	F N S NS ROX	Isolated mitochondria	Mouse	Liver
Leduc-Gaudet 2021 bioRxiv	2021	Leduc-Gaudet JP, Miguez K, Marina Cefis M, Moamer A, Chaffer TJ, Faitg J, Reynaud O, Broering FE, Shams A, Mayaki D, Huck L, Sandri M, Gouspillou G, Hussain SNA (2021) Role of autophagy in sepsis-induced skeletal muscle dysfunction, whole-body metabolism, and survival. bioRxiv doi: https://doi.org/10.1101/2021.08.05.455081.	LEAK OXPHOS	N	Permeabilized tissue	Mouse	Skeletal muscle
Santana-Roman 2021 Insects	2021	Santana-Román ME, Maycotte P, Uribe-Carvajal S, Uribe-Alvarez C, Alvarado-Medina N, Khan M, Siddiqui A, Pando-Robles V (2021) Monitoring mitochondrial function in Aedes albopictus C6/36 cell line during dengue virus infection. Insects 12:934.	LEAK OXPHOS ET	S	Permeabilized cells
Gomez-Valades 2021 Cell Metab	2021	Gómez-Valadés AG, Pozo M, Varela L, Boudjadja MB, Ramírez S, Chivite I, Eyre E, Haddad-Tóvolli R, Obri A, Milà-Guasch M, Altirriba J, Schneeberger M, Imbernón M, Garcia-Rendueles AR, Gama-Perez P, Rojo-Ruiz J, Rácz B, Alonso MT, Gomis R, Zorzano A, D'Agostino G, Alvarez CV, Nogueiras R, Garcia-Roves PM, Horvath TL, Claret M (2021) Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca²⁺ homeostasis with adipose tissue lipolysis . Cell Metab 33:1820-35.e9.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue Homogenate	Mouse	Nervous system
Branco Haas 2021 Thesis	2021	Branco Haas C (2021) Insulin signaling and microglia in the young and aged brain. PhD Thesis 135.	LEAK OXPHOS ET	N ROX	Intact cells
Cardoso 2021 BEC MgG	2021	Cardoso LHD, Doerrier C, Gnaiger E (2021) Magnesium Green for fluorometric measurement of ATP production does not interfere with mitochondrial respiration. Bioenerg Commun 2021.1. https://doi.org/10.26124/bec:2021-0001	LEAK OXPHOS ET	N S ROX	Isolated mitochondria	Mouse	Heart
Giordano 2021 Gene Ther	2021	Giordano L, Aneja MK, Sommer N, Alebrahimdehkordi N, Seraji A, Weissmann N, Rudolph C, Plank C, Jacobs HT, Szibor M (2021) Alternative oxidase encoded by sequence-optimized and chemically-modified RNA transfected into mammalian cells is catalytically active. https://doi.org/10.1038/s41434-021-00235-z	LEAK ROUTINE OXPHOS	N S CIV ROX	Permeabilized cells Intact cells	Mouse	Fibroblast
Holody 2021 Mitochondrion	2021	Holody C, Anfray A, Mast H, Lessard M, Han WH, Carpenter R, Bourque S, Sauvé Y, Lemieux H (2021) Differences in relative capacities of oxidative phosphorylation pathways may explain sex- and tissue-specific susceptibility to vision defects due to mitochondrial dysfunction. Mitochondrion 56:102-10.	LEAK OXPHOS	N S CIV NS ROX	Homogenate	Rat	Nervous system
Baldini 2021 Life Sci	2021	Baldini F, Fabbri R, Eberhagen C, Voci A, Portincasa P, Zischka H, Vergani L (2021) Adipocyte hypertrophy parallels alterations of mitochondrial status in a cell model for adipose tissue dysfunction in obesity. Life Sci 265:118812.	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells	Mouse	Fibroblast
Pereyra 2021 J Lipid Res	2021	Pereyra AS, Harris KL, Soepriatna AH, Waterbury QA, Bharathi SS, Zhang Y, Fisher-Wellman KH, Goergen CJ, Goetzman ES, Ellis JM (2021) Octanoate is differentially metabolized in liver and muscle and fails to rescue cardiomyopathy in CPT2 deficiency. J Lipid Res 62:100069.	LEAK OXPHOS	F N	Homogenate Isolated mitochondria	Mouse	Heart Skeletal muscle Liver
Vidimce 2021 Front Pharmacol	2021	Vidimce J, Pillay J, Shrestha N, Dong LF, Neuzil J, Wagner KH, Holland OJ, Bulmer AC (2021) Mitochondrial function, fatty acid metabolism, and body composition in the hyperbilirubinemic gunn rat. Front Pharmacol 12:586715.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue Homogenate	Rat	Skeletal muscle Liver
Xiao 2021 PLoS Genet	2021	Xiao L, Liu J, Sun Z, Yin Y, Mao Y, Xu D, Liu L, Xu Z, Guo Q, Ding C, Sun W, Yang L, Zhou Z, Zhou D, Fu T, Zhou W, Zhu Y, Chen XW, Li JZ, Chen S, Xie X, Gan Z (2021) AMPK-dependent and -independent coordination of mitochondrial function and muscle fiber type by FNIP1. PLoS Genet 17:e1009488.	LEAK OXPHOS	N S	Permeabilized tissue	Mouse	Skeletal muscle
Fang 2021 Cell Rep	2021	Fang H, Ye X, Xie J, Li Y, Li H, Bao X, Yang Y, Lin Z, Jia M, Han Q, Zhu J, Li X, Zhao Q, Yang Y, Lyu J (2021) A membrane arm of mitochondrial complex I sufficient to promote respirasome formation. Cell Rep 35:108963.	LEAK ROUTINE OXPHOS ET	N S	Permeabilized cells Intact cells
Goldberg 2021 Biochem J	2021	Goldberg EJ, Buddo KA, McLaughlin KL, Fernandez RF, Pereyra AS, Psaltis CE, Lin CT, Hagen JT, Boykov IN, Nguyen TK, Gowdy KM, Ellis JM, Neufer PD, McClung JM, Fisher-Wellman KH (2021) Tissue-specific characterization of mitochondrial branched-chain keto acid oxidation using a multiplexed assay platform. Biochem J 476:1521-37.	LEAK OXPHOS ET	N S NS ROX F	Isolated mitochondria	Mouse	Heart Skeletal muscle Liver
Furihata 2021 BMC Pharmacol Toxicol	2021	Furihata T, Maekawa S, Takada S, Kakutani N, Nambu H, Shirakawa R, Yokota T, Kinugawa S (2021) Premedication with pioglitazone prevents doxorubicin-induced left ventricular dysfunction in mice. BMC Pharmacol Toxicol 22:27.	OXPHOS		Isolated mitochondria	Mouse	Heart
Davis 2021 J Appl Physiol	2021	Davis MS, Barrett MR (2021) Effect of conditioning and physiology hyperthermia on canine skeletal muscle mitochondrial oxygen consumption. J Appl Physiol. 130:1317-1325	LEAK OXPHOS	N S NS	Permeabilized cells	Dog	Skeletal muscle
Tonnesen 2021 Mol Cell Biochem	2021	Tonnesen PT, Hjortbak MV, Lassen TR, Seefeldt JM, Bøtker HE, Jespersen NR (2021) Myocardial salvage by succinate dehydrogenase inhibition in ischemia-reperfusion injury depends on diabetes stage in rats. Mol Cell Biochem 476:2675-84.	LEAK OXPHOS	F N	Permeabilized tissue	Rat	Heart
Willis 2021 Sci Rep	2021	Willis JR, Hickey AJR, Devaux JBL (2021) Thermally tolerant intertidal triplefin fish (Tripterygiidae) sustain ATP dynamics better than subtidal species under acute heat stress. Sci Rep 11:11074.	LEAK OXPHOS ET ROUTINE	N ROX NS	Homogenate	Fishes	Nervous system
Terwilliger 2021 Vasc Med	2021	Terwilliger ZS, Ryan TE, Goldberg EJ, Schmidt CA, Yamaguchi DJ, Karnekar R, Brophy P, Green TD, Zeczycki TN, Mac Gabhann F, Annex BH, McClung JM (2021) Racial differences in the limb skeletal muscle transcriptional programs of patients with critical limb ischemia. Vasc Med 26:247-58.	OXPHOS LEAK	N S CIV ROX NS	Permeabilized tissue	Human	Skeletal muscle
Mukherjee 2021 JCI Insight	2021	Mukherjee S, Mo J, Paolella LM, Perry CE, Toth J, Hugo MM, Chu Q, Tong Q, Chellappa K, Baur JA (2021) SIRT3 is required for liver regeneration but not for the beneficial effect of nicotinamide riboside. JCI Insight 6:e14719.	OXPHOS	N S CIV ROX F	Isolated mitochondria	Mouse	Liver
Deline 2021 Biochim Biophys Acta Bioenerg	2021	Deline ML, Grashei M, van Heijster FHA, Schilling F, Straub J, Fromme T (2021) Adenylate kinase derived ATP shapes respiration and calcium storage of isolated mitochondria. Biochim Biophys Acta Bioenerg 1862:148409.	OXPHOS LEAK	S	Isolated mitochondria	Mouse	Liver
Lefranc 2021 Int J Mol Sci	2021	Lefranc C, Friederich-Persson M, Foufelle F, Nguyen Dinh Cat A, Jaisser F (2021) Adipocyte-mineralocorticoid receptor alters mitochondrial quality control leading to mitochondrial dysfunction and senescence of visceral adipose tissue. Int J Mol Sci 22:2881.	LEAK OXPHOS ET	N	Isolated mitochondria	Mouse	Fat
Schumann 2021 Commun Biol	2021	Schumann T, Koenig J, von Loeffelholz C, Vatner DF, Zhang D, Perry RJ, Bernier M, Chami J, Henke C, Kurzbach A, El-Agroudy NN, Willmes DM, Pesta D, de Cabo R, O Sullivan JF, Simon E, Shulman GI, Hamilton BS, Birkenfeld AL (2021) Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance. Commun Biol 4:826.	LEAK ROUTINE OXPHOS ET	F N NS ROX	Intact cells	Mouse	Liver
Connell 2021 J Nutr	2021	Connell NJ, Grevendonk L, Fealy CE, Moonen-Kornips E, Bruls YMH, Schrauwen-Hinderling VB, de Vogel J, Hageman R, Geurts J, Zapata-Perez R, Houtkooper RH, Havekes B, Hoeks J, Schrauwen P (2021) NAD⁺-precursor supplementation with L-tryptophan, nicotinic acid, and nicotinamide does not affect mitochondrial function or skeletal muscle function in physically compromised older adults. J Nutr 151:2917-31	LEAK OXPHOS ET	F N NS	Permeabilized tissue	Human	Skeletal muscle
Mazzoli 2021 Antioxidants (Basel)	2021	Mazzoli A, Spagnuolo MS, Nazzaro M, Gatto C, Iossa S, Cigliano L (2021) Fructose removal from the diet reverses inflammation, mitochondrial dysfunction, and oxidative stress in hippocampus. Antioxidants (Basel) 10:487.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Rat	Nervous system
Mendham 2021 Diabetologia	2021	Mendham AE, Goedecke JH, Zeng Y, Larsen S, George C, Hauksson J, Fortuin-de Smidt MC, Chibalin AV, Olsson T, Chorell E (2021) Exercise training improves mitochondrial respiration and is associated with an altered intramuscular phospholipid signature in women with obesity. Diabetologia 64:1642-59.	LEAK OXPHOS ET	F N S NS ROX	Intact cells	Human	Skeletal muscle
Thoral 2021 Biol Lett	2021	Thoral E, Roussel D, Chinopoulos C, Teulier L, Salin K (2021) Low oxygen levels can help to prevent the detrimental effect of acute warming on mitochondrial efficiency in fish. Biol Lett 17:20200759.	LEAK OXPHOS	N CIV NS ROX	Homogenate	Fishes	Skeletal muscle
Chambers 2021 JCI Insight	2021	Chambers KT, Cooper MA, Swearingen AR, Brookheart RT, Schweitzer GG, Weinheimer CJ, Kovacs A, Koves TR, Muoio DM, McCommis KS, Finck BN (2021) Myocardial Lipin 1 knockout in mice approximates cardiac effects of human LPIN1 mutations. JCI Insight 6:134340.	LEAK OXPHOS ET	F N S	Permeabilized tissue	Mouse	Heart
Knapp-Wilson 2021 bioRxiv	2021	Knapp-Wilson A, Pereira GC, Buzzard E, Richardson A, Corey RA, Neal C, Verkade P, Halestrap AP, Gold VAM, Kuwabara P, Collinson I (2021) Maintenance of complex I and respiratory super-complexes by NDUF-11 is essential for respiratory function, mitochondrial structure and health in C. elegans. bioRxiv doi: https://doi.org/10.1101/2021.01.06.425530.	LEAK OXPHOS	N S	Isolated mitochondria	Caenorhabditis elegans
Klepinina 2021 PLoS One	2021	Klepinina L, Klepinin A, Truu L, Chekulayev V, Vija H, Kuus K, Teino I, Pook M, Maimets T, Kaambre T (2021) Colon cancer cell differentiation by sodium butyrate modulates metabolic plasticity of Caco-2 cells via alteration of phosphotransfer network. PLoS One 16:e0245348.	LEAK ROUTINE OXPHOS ET	N NS ROX	Permeabilized cells Intact cells	Human	Endothelial;epithelial;mesothelial cell
Van Polanen 2021 Physiol Rep	2021	van Polanen N, Zacharewicz E, de Ligt M, Timmers S, Moonen-Kornips E, Schaart G, Hoeks J, Schrauwen P, Hesselink MKC (2021) Resveratrol-induced remodelling of myocellular lipid stores: A study in metabolically compromised humans. Physiol Rep 9:e14692.	OXPHOS ET	F N	Permeabilized tissue	Human	Skeletal muscle
Meng 2021 FEBS Open Bio	2021	Meng L, Chen D, Meng G, Lu L, Han C (2021) Dysregulation of the Sirt5/IDH2 axis contributes to sunitinib resistance in human renal cancer cells. FEBS Open Bio 11:921-31.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Human	Kidney
Schmidt 2021 Cancer Metab	2021	Schmidt CA, McLaughlin KL, Boykov IN, Mojalagbe R, Ranganathan A, Buddo KA, Lin CT, Fisher-Wellman KH, Neufer PD (2021) Aglycemic growth enhances carbohydrate metabolism and induces sensitivity to menadione in cultured tumor-derived cells. Cancer Metab 9:3.	LEAK OXPHOS ET	N S Gp CIV ROX	Isolated mitochondria	Human	Liver
Christiansen 2021 Sci Rep	2021	Christiansen LB, Dohlmann TL, Ludvigsen TP, Parfieniuk E, Ciborowski M, Szczerbinski L, Kretowski A, Desler C, Tiano L, Orlando P, Martinussen T, Olsen LH, Larsen S (2021) Atorvastatin impairs liver mitochondrial function in obese Göttingen Minipigs but heart and skeletal muscle are not affected. Sci Rep 11:2167.	LEAK OXPHOS ET	F N S CIV NS	Permeabilized tissue	Pig	Heart Skeletal muscle Liver
Correia 2021 Hum Mutat	2021	Correia SP, Moedas MF, Naess K, Bruhn H, Maffezzini C, Calvo-Garrido J, Lesko N, Wibom R, Schober FA, Jemt A, Stranneheim H, Freyer C, Wedell A, Wredenberg A (2021) Severe congenital lactic acidosis and hypertrophic cardiomyopathy caused by an intronic variant in NDUFB7. Hum Mutat 42:378-84.	LEAK OXPHOS	N S NS	Permeabilized cells	Human	Fibroblast
Fink 2021 Pharmacol Res Perspect	2021	Fink BD, Yu L, Coppey L, Obrosov A, Shevalye H, Kerns RJ, Yorek MA, Sivitz WI (2021) Effect of mitoquinone on liver metabolism and steatosis in obese and diabetic rats. Pharmacol Res Perspect 9:e00701.	LEAK OXPHOS	NS	Isolated mitochondria	Rat	Liver
Yardeni 2021 Proc Natl Acad Sci U S A	2021	Yardeni T, Cristancho AG, McCoy AJ, Schaefer PM, McManus MJ, Marsh ED, Wallace DC (2021) An mtDNA mutant mouse demonstrates that mitochondrial deficiency can result in autism endophenotypes. Proc Natl Acad Sci U S A 118:e2021429118.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Mouse	Nervous system
Watt 2021 Nat Commun	2021	Watt KI, Henstridge DC, Ziemann M, Sim CB, Montgomery MK, Samocha-Bonet D, Parker BL, Dodd GT, Bond ST, Salmi TM, Lee RS, Thomson RE, Hagg A, Davey JR, Qian H, Koopman R, El-Osta A, Greenfield JR, Watt MJ, Febbraio MA, Drew BG, Cox AG, Porrello ER, Harvey KF, Gregorevic P (2021) Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease. Nat Commun 12:2887.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Furihata 2021 Commun Biol	2021	Furihata T, Takada S, Kakutani N, Maekawa S, Tsuda M, Matsumoto J, Mizushima W, Fukushima A, Yokota T, Enzan N, Matsushima S, Handa H, Fumoto Y, Nio-Kobayashi J, Iwanaga T, Tanaka S, Tsutsui H, Sabe H, Kinugawa S (2021) Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure. Commun Biol 4:138.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Mouse	Heart
Salin 2021 Mar Environ Res	2021	Salin K, Mathieu-Resuge M, Graziano N, Dubillot E, Le Grand F, Soudant P, Vagner M (2021) The relationship between membrane fatty acid content and mitochondrial efficiency differs within- and between- omega-3 dietary treatments. Mar Environ Res 163:105205.	LEAK OXPHOS	N NS	Isolated mitochondria	Fishes	Skeletal muscle
Braga 2021 Sci Rep	2021	Braga RR, Crisol BM, Brícola RS, Sant'ana MR, Nakandakari SCBR, Costa SO, Prada PO, da Silva ASR, Moura LP, Pauli JR, Cintra DE, Ropelle ER (2021) Exercise alters the mitochondrial proteostasis and induces the mitonuclear imbalance and UPR^mt in the hypothalamus of mice. Sci Rep 11:3813.	LEAK OXPHOS ET	N NS	Isolated mitochondria	Mouse	Nervous system
Wigner 2021 Sci Rep	2021	Wigner P, Zielinski K, Labieniec-Watala M, Marczak A, Szwed M (2021) Doxorubicin-transferrin conjugate alters mitochondrial homeostasis and energy metabolism in human breast cancer cells. Sci Rep 11:4544.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Other cell lines
Moon 2021 J Lipid Res	2021	Moon SH, Dilthey BG, Liu X, Guan S, Sims HF, Gross RW (2021) High-Fat diet activates liver iPLA₂γ generating eicosanoids that mediate metabolic stress. J Lipid Res 62:100052.	LEAK OXPHOS ET	N S NS	Isolated mitochondria	Mouse	Liver
Scalzo 2021 J Physiol	2021	Scalzo RL, Schauer IE, Rafferty D, Knaub LA, Kvaratskhelia N, Johnson TK, Pott GB, Abushamat LA, Whipple MO, Huebschmann AG, Cree-Green M, Reusch JEB, Regensteiner JG (2021) Single-leg exercise training augments in vivo skeletal muscle oxidative flux and vascular content and function in adults with type 2 diabetes. J Physiol 600:963-78.	LEAK OXPHOS ET	F N NS	Permeabilized tissue	Human	Skeletal muscle
Matsumoto 2021 Circ Heart Fail	2021	Matsumoto J, Takada S, Furihata T, Nambu H, Kakutani N, Maekawa S, Mizushima W, Nakano I, Fukushima A, Yokota T, Tanaka S, Handa H, Sabe H, Kinugawa S (2021) Brain-derived neurotrophic factor improves impaired fatty acid oxidation via the activation of adenosine monophosphate-activated protein kinase-ɑ - proliferator-activated receptor-r coactivator-1ɑ signaling in skeletal muscle of mice with heart failure. Circ Heart Fail 14: e005890.	LEAK OXPHOS		Permeabilized tissue	Mouse	Skeletal muscle
Nambu 2021 Cardiovasc Res	2021	Nambu H, Takada S, Maekawa S, Matsumoto J, Kakutani N, Furihata T, Shirakawa R, Katayama T, Nakajima T, Yamanashi K, Obata Y, Nakano I, Tsuda M, Saito A, Fukushima A, Yokota T, Nio-Kobayashi J, Yasui H, Higashikawa K, Kuge Y, Anzai T, Sabe H, Kinugawa S (2021) Inhibition of xanthine oxidase in the acute phase of myocardial infarction prevents skeletal muscle abnormalities and exercise intolerance. Cardiovasc Res 117:805-19.	LEAK OXPHOS		Permeabilized tissue	Mouse	Skeletal muscle
Hoppel 2021 Front Physiol	2021	Hoppel F, Calabria E, Pesta DH, Kantner-Rumplmair W, Gnaiger E, Burtscher M (2021) Effects of ultramarathon running on mitochondrial function of platelets and oxidative stress parameters: a pilot study. https://doi.org/10.3389/fphys.2021.632664	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Platelet
Su 2021 Chin J Physiol	2021	Su Y, Wang Y, Xu P, Sun Y, Ping Z, Huang H, Cao X (2021) Study on the time-effectiveness of exercise preconditioning on heart protection in exhausted rats. Chin J Physiol 64:97-105.	LEAK OXPHOS	N S CIV NS ROX	Permeabilized tissue	Rat	Heart
Vandenberg 2021 Neurochem Int	2021	Vandenberg GG, Dawson NJ, Head A, Scott GR, Scott AL (2021) Astrocyte-mediated disruption of ROS homeostasis in Fragile X mouse model. Neurochem Int 146:105036.	LEAK OXPHOS	N CIV NS	Permeabilized cells	Mouse	Nervous system
Hansen 2021 Physiol Rep	2021	Hansen C, Olsen K, Pilegaard H, Bangsbo J, Gliemann L, Hellsten Y (2021) High metabolic substrate load induces mitochondrial dysfunction in rat skeletal muscle microvascular endothelial cells. Physiol Rep 9:e14855.	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Rat	Skeletal muscle Endothelial;epithelial;mesothelial cell
Burska 2021 Biochim Biophys Acta Mol Basis Dis	2021	Burska D, Stiburek L, Krizova J, Vanisova M, Martinek V, Sladkova J, Zamecnik J, Honzik T, Zeman J, Hansikova H, Tesarova M (2021) Homozygous missense mutation in UQCRC2 associated with severe encephalomyopathy, mitochondrial complex III assembly defect and activation of mitochondrial protein quality control. Biochim Biophys Acta Mol Basis Dis 1867:166147.	LEAK OXPHOS ET	CIV NS ROX N S	Permeabilized cells	Human	Fibroblast
Daura 2021 Neurobiol Dis	2021	Daura E, Tegelberg S, Yoshihara M, Jackson C, Simonetti F, Aksentjeff K, Ezer S, Hakala P, Katayama S, Kere J, Lehesjoki AE, Joensuu T (2021) Cystatin B-deficiency triggers ectopic histone H3 tail cleavage during neurogenesis. Neurobiol Dis 156:105418.	LEAK OXPHOS ET	N CIV NS	Permeabilized cells	Mouse	Stem cells Nervous system
Bandara 2021 Mitochondrion	2021	Bandara AB, Drake JC, James CC, Smyth JW, Brown DA (2021) Complex I protein NDUFS2 is vital for growth, ROS generation, membrane integrity, apoptosis, and mitochondrial energetics. Mitochondrion 58:160-68.	LEAK OXPHOS ET	N S	Permeabilized cells	Human	HEK
Schroeder 2021 Cell Rep	2021	Schroeder S, Hofer SJ, Zimmermann A, Pechlaner R, Dammbrueck C, Pendl T, Marcello GM, Pogatschnigg V, Bergmann M, Mueller M, Gschiel V, Ristic S, Tadic J, Iwata K, Richter G, Farzi A, Uecal M, Schaefer U, Poglitsch M, Royer P, Mekis R, Agreiter M, Toelle RC, Sotonyi P, Willeit J, Mairhofer B, Niederkofler H, Pallhuber I, Rungger G, Tilg H, Defrancesco M, Marksteiner J, Sinner F, Magnes C, Pieber TR, Holzer P, Kroemer G, Carmona-Gutierrez D, Scorrano L, Dengjel J, Madl T, Sedej S, Sigrist SJ, Racz B, Kiechl S, Eisenberg T, Madeo F (2021) Dietary spermidine improves cognitive function. Cell Rep 35:108985.	LEAK OXPHOS ET	N NS ROX S	Homogenate	Mouse Drosophila	Nervous system
Sighel 2021 Cell Rep	2021	Sighel D, Notarangelo M, Aibara S, Re A, Ricci G, Guida M, Soldano A, Adami V, Ambrosini C, Broso F, Rosatti EF, Longhi S, Buccarelli M, D'Alessandris QG, Giannetti S, Pacioni S, Ricci-Vitiani L, Rorbach J, Pallini R, Roulland S, Amunts A, Mancini I, Modelska A, Quattrone A (2021) Inhibition of mitochondrial translation suppresses glioblastoma stem cell growth. Cell Rep 35:109024.	ROUTINE OXPHOS	N S NS ROX	Permeabilized cells Intact cells	Human	Nervous system Stem cells
Nedel 2021 Intensive Care Med Exp	2021	Nedel WL, Kopczynski A, Rodolphi MS, Strogulski NR, De Bastiani M, Montes THM, Abruzzi J Jr, Galina A, Horvath TL, Portela LV (2021) Mortality of septic shock patients is associated with impaired mitochondrial oxidative coupling efficiency in lymphocytes: a prospective cohort study. Intensive Care Med Exp 9:39.	LEAK OXPHOS	N NS ROX	Permeabilized cells	Human	Lymphocyte
Avin 2021 Sci Rep	2021	Avin KG, Hughes MC, Chen NX, Srinivasan S, O'Neill KD, Evan AP, Bacallao RL, Schulte ML, Moorthi RN, Gisch DL, Perry CGR, Moe SM, O'Connell TM (2021) Skeletal muscle metabolic responses to physical activity are muscle type specific in a rat model of chronic kidney disease. Sci Rep 11:9788.	LEAK OXPHOS	N NS	Permeabilized tissue	Rat	Skeletal muscle
Goncalves 2021 Redox Biol	2021	Goncalves LS, Sales LP, Saito TR, Campos JC, Fernandes AL, Natali J, Jensen L, Arnold A, Ramalho L, Bechara LRG, Esteca MV, Correa I, Sant'Anna D, Ceroni A, Michelini LC, Gualano B, Teodoro W, Carvalho VH, Vargas BS, Medeiros MHG, Baptista IL, Irigoyen MC, Sale C, Ferreira JCB, Artioli GG (2021) Histidine dipeptides are key regulators of excitation-contraction coupling in cardiac muscle: evidence from a novel CARNS1 knockout rat model. Redox Biol 44:102016.	LEAK OXPHOS ET	NS	Isolated mitochondria	Rat	Heart
Tungtur 2021 Sci Rep	2021	Tungtur SK, Wilkins HM, Rogers RS, Badawi Y, Sage JM, Agbas A, Jawdat O, Barohn RJ, Swerdlow RH, Nishimune H (2021) Oxaloacetate treatment preserves motor function in SOD1G93A mice and normalizes select neuroinflammation-related parameters in the spinal cord. Sci Rep 11:11051.	LEAK OXPHOS ET	N ROX	Isolated mitochondria	Mouse	Nervous system
Jimenez-Uribe 2021 Free Radic Biol Med	2021	Jimenez-Uribe AP, Bellido B, Aparicio-Trejo OE, Tapia E, Sanchez-Lozada LG, Hernandez-Santos JA, Fernandez-Valverde F, Hernandez-Cruz EY, Orozco-Ibarra M, Pedraza-Chaverri J (2021) Temporal characterization of mitochondrial impairment in the unilateral ureteral obstruction model in rats. Free Radic Biol Med 172:358-71.	LEAK OXPHOS	N S ROX	Isolated mitochondria	Rat	Kidney
Peruzzotti-Jametti 2021 PLoS Biol	2021	Peruzzotti-Jametti L, Bernstock JD, Willis CM, Manferrari G, Rogall R, Fernandez-Vizarra E, Williamson JC, Braga A, van den Bosch A, Leonardi T, Krzak G, Kittel A, Beninca C, Vicario N, Tan S, Bastos C, Bicci I, Iraci N, Smith JA, Peacock B, Muller KH, Lehner PJ, Buzas EI, Faria N, Zeviani M, Frezza C, Brisson A, Matheson NJ, Viscomi C, Pluchino S (2021) Neural stem cells traffic functional mitochondria via extracellular vesicles. PLoS Biol 19:3001166.	LEAK OXPHOS	N S Gp CIV ROX	Permeabilized cells	Mouse	Nervous system Stem cells
Kakimoto 2021 Redox Biol	2021	Kakimoto PA, Serna JDC, de Miranda Ramos V, Zorzano A, Kowaltowski AJ (2021) Increased glycolysis is an early consequence of palmitate lipotoxicity mediated by redox signaling. Redox Biol 45:102026.	LEAK OXPHOS	N S NS	Permeabilized cells	Human	Liver
Flensted-Jensen 2021 Free Radic Biol Med	2021	Flensted-Jensen M, Gram M, Dela F, Helge JW, Larsen S (2021) Six weeks of high intensity cycle training reduces H₂O₂ emission and increases antioxidant protein levels in obese adults with risk factors for type 2 diabetes. Free Radic Biol Med 173:1-6.	LEAK OXPHOS	N NS	Permeabilized tissue	Human	Skeletal muscle
Babylon 2021 Antioxidants (Basel)	2021	Babylon L, Grewal R, Stahr PL, Eckert RW, Keck CM, Eckert GP (2021) Hesperetin nanocrystals improve mitochondrial function in a cell model of early Alzheimer disease. Antioxidants (Basel) 10:1003.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Human	Neuroblastoma
Ljubojevic-Holzer 2021 Cardiovasc Res	2021	Ljubojevic-Holzer S, Kraler S, Djalinac N, Abdellatif M, Voglhuber J, Schipke J, Schmidt M, Kling KM, Franke GT, Herbst V, Zirlik A, von Lewinski D, Scherr D, Rainer PP, Kohlhaas M, Nickel A, Muehlfeld C, Maack C, Sedej S (2021) Loss of autophagy protein ATG5 impairs cardiac capacity in mice and humans through diminishing mitochondrial abundance and disrupting Ca²⁺ cycling. https://doi.org/10.1093/cvr/cvab112	LEAK OXPHOS ET	F N	Isolated mitochondria	Mouse	Heart
Dorigatti 2021 Geroscience	2021	Dorigatti JD, Thyne KM, Ginsburg BC, Salmon AB (2021) Beta-guanidinopropionic acid has age-specific effects on markers of health and function in mice. Geroscience 43:1497-511.	LEAK OXPHOS ET	N S NS ROX F	Permeabilized tissue	Mouse	Skeletal muscle
Kaspar 2021 Sci Adv	2021	Kaspar S, Oertlin C, Szczepanowska K, Kukat A, Senft K, Lucas C, Brodesser S, Hatzoglou M, Larsson O, Topisirovic I, Trifunovic A (2021) Adaptation to mitochondrial stress requires CHOP-directed tuning of ISR. Sci Adv 7:0971.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Mouse	Heart
Davies 2021 FASEB J	2021	Davies KL, Smith DJ, El-Bacha T, Stewart ME, Easwaran A, Wooding PFP, Forhead AJ, Murray AJ, Fowden AL, Camm EJ (2021) Development of cerebral mitochondrial respiratory function is impaired by thyroid hormone deficiency before birth in a region-specific manner. FASEB J 35:21591.	LEAK OXPHOS	N S NS	Homogenate	Other mammals	Nervous system
Prieto-Carrasco 2021 Biology (Basel)	2021	Prieto-Carrasco R, Silva-Palacios A, Rojas-Morales P, Aparicio-Trejo OE, Medina-Reyes EI, Hernandez-Cruz EY, Sanchez-Garibay C, Salinas-Lara C, Pavon N, Roldan FJ, Zazueta C, Tapia E, Pedraza-Chaverri J (2021) Unilateral ureteral obstruction for 28 days in rats is not associated with changes in cardiac function or alterations in mitochondrial function. Biology (Basel) 10:671.	LEAK OXPHOS ET	N S ROX	Isolated mitochondria	Rat	Heart
Flockhart 2021 Cell Metab	2021	Flockhart M, Nilsson LC, Tais S, Ekblom B, Apro W, Larsen FJ (2021) Excessive exercise training causes mitochondrial functional impairment and decreases glucose tolerance in healthy volunteers. Cell Metab 33:957-70.	LEAK OXPHOS ET	F N S NS	Isolated mitochondria	Human	Skeletal muscle
Taylor 2021 Int J Mol Sci	2021	Taylor OJ, Thatcher MO, Carr ST, Gibbs JL, Trumbull AM, Harrison ME, Winden DR, Pearson MJ, Tippetts TS, Holland WL, Reynolds PR, Bikman BT (2021) High-mobility group box 1 disrupts metabolic function with cigarette smoke exposure in a ceramide-dependent manner. Int J Mol Sci 18:1099.	LEAK OXPHOS ET	N NS ROX	Permeabilized cells Permeabilized tissue	Mouse	Skeletal muscle
James 2021 Nat Commun	2021	James OJ, Vandereyken M, Marchingo JM, Singh F, Bray SE, Wilson J, Love AG, Swamy M (2021) IL-15 and PIM kinases direct the metabolic programming of intestinal intraepithelial lymphocytes. Nat Commun 12:4290.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Mouse	Lymphocyte
Dos Santos Escaliante 2021 Int J Biol Macromol	2021	Dos Santos Escaliante LA, Busato B, de Oliveira Petkowicz CL, Suter Correia Cadena SM, Rodrigues Noleto G (2021) Cytotoxic effect of xyloglucan and oxovanadium (IV/V) xyloglucan complex in HepG2 cells. Int J Biol Macromol 185:40-48.	LEAK OXPHOS	N S CIV ROX	Permeabilized cells	Human	Liver
Seefeldt 2021 Sci Rep	2021	Seefeldt JM, Lassen TR, Vognstoft Hjortbak M, Jespersen NR, Kvist F, Hansen J, Boetker HE (2021) Cardioprotective effects of empagliflozin after ischemia and reperfusion in rats. Sci Rep 11:9544.	LEAK OXPHOS	N S NS ROX	Permeabilized tissue	Rat	Heart
Giovarelli 2021 Pharmacol Res	2021	Giovarelli M, Zecchini S, Catarinella G, Moscheni C, Sartori P, Barbieri C, Roux-Biejat P, Napoli A, Vantaggiato C, Cervia D, Perrotta C, Clementi E, Latella L, De Palma C (2021) Givinostat as metabolic enhancer reverting mitochondrial biogenesis deficit in Duchenne Muscular Dystrophy. Pharmacol Res 170:105751.	LEAK OXPHOS	N S CIV NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Bernal-Ramirez 2021 Oxid Med Cell Longev	2021	Bernal-Ramirez J, Silva-Platas C, Jerjes-Sanchez C, Ramos-Gonzalez MR, Vazquez-Garza E, Chapoy-Villanueva H, Ramirez-Rivera A, Zarain-Herzberg A, Garcia N, Garcia-Rivas G (2021) Resveratrol prevents right ventricle dysfunction, calcium mishandling, and energetic failure via SIRT3 stimulation in pulmonary arterial hypertension. Oxid Med Cell Longev 2021:9912434.	OXPHOS ET	S	Isolated mitochondria	Rat	Heart
Wall 2021 Dis Model Mech	2021	Wall JM, Basu A, Zunica ERM, Dubuisson OS, Pergola K, Broussard JP, Kirwan JP, Axelrod CL, Johnson AE (2021) CRISPR/Cas9-engineered Drosophila knock-in models to study VCP diseases. Dis Model Mech 14:dmm048603.	LEAK OXPHOS ET	N S Gp CIV NS ROX	Permeabilized tissue	Drosophila	Skeletal muscle
Axelrod 2021 EMBO Mol Med	2021	Axelrod CL, King WT, Davuluri G, Noland RC, Hall J, Hull M, Dantas WS, Zunica ER, Alexopoulos SJ, Hoehn KL, Langohr I, Stadler K, Doyle H, Schmidt E, Nieuwoudt S, Fitzgerald K, Pergola K, Fujioka H, Mey JT, Fealy C, Mulya A, Beyl R, Hoppel CL, Kirwan JP (2021) BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic control. EMBO Mol Med 12:12088.	ROUTINE OXPHOS ET LEAK	F N S NS ROX DQ	Intact cells Permeabilized tissue	Mouse	Skeletal muscle
Whitehead 2021 Nat Commun	2021	Whitehead A, Krause FN, Moran A, MacCannell ADV, Scragg JL, McNally BD, Boateng E, Murfitt SA, Virtue S, Wright J, Garnham J, Davies GR, Dodgson J, Schneider JE, Murray AJ, Church C, Vidal-Puig A, Witte KK, Griffin JL, Roberts LD (2021) Brown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis. Nat Commun 12:1905.	LEAK OXPHOS ET	F N S NS	Permeabilized cells	Human	Skeletal muscle
Dubinin 2021 Free Radic Biol Med	2021	Dubinin MV, Semenova AA, Ilzorkina AI, Penkov NV, Nedopekina DA, Sharapov VA, Khoroshavina EI, Davletshin EV, Belosludtseva NV, Spivak AY, Belosludtsev KN (2021) Mitochondria-targeted prooxidant effects of betulinic acid conjugated with delocalized lipophilic cation F16. Free Radic Biol Med 168:55-69.	LEAK OXPHOS ET	N S NS	Isolated mitochondria	Rat	Liver
Friederich 2021 Mol Genet Metab	2021	Friederich MW, Geddes GC, Wortmann SB, Punnoose A, Wartchow E, Knight KM, Prokisch H, Creadon-Swindell G, Mayr JA, Van Hove JLK (2021) Pathogenic variants in MRPL44 cause infantile cardiomyopathy due to a mitochondrial translation defect. Mol Genet Metab 133:362-71.	LEAK OXPHOS ET	N		Human	Fibroblast
Honecker 2021 Int J Obes (Lond)	2021	Honecker J, Weidlich D, Heisz S, Lindgren CM, Karampinos DC, Claussnitzer M, Hauner H (2021) A distribution-centered approach for analyzing human adipocyte size estimates and their association with obesity-related traits and mitochondrial function. Int J Obes (Lond) [Ephub ahead of print].	LEAK ROUTINE OXPHOS ET		Intact cells	Human	Fat
Figueira 2021 Arch Biochem Biophys	2021	Figueira TR, Francisco A, Ronchi JA, Dos Santos GRRM, Santos WD, Treberg JR, Castilho RF (2021) NADPH supply and the contribution of NAD(P)⁺ transhydrogenase (NNT) to H₂O₂ balance in skeletal muscle mitochondria. Arch Biochem Biophys 707:108934.	LEAK OXPHOS ET	N F	Isolated mitochondria	Mouse	Skeletal muscle
Cai 2021 Free Radic Biol Med	2021	Cai H, Bian X, Chen L, Zhang N, Li L, Tang W, Liu X, Li Z (2021) Selective intra-arterial brain cooling induces cerebral protection against ischemia/reperfusion injury through SENP1-Sirt3 signaling. Free Radic Biol Med 171:272-83.	LEAK OXPHOS	N	Isolated mitochondria	Mouse	Nervous system
Morgan 2021 Resuscitation	2021	Morgan RW, Sutton RM, Himebauch AS, Roberts AL, Landis WP, Lin Y, Starr J, Ranganathan A, Delso N, Mavroudis CD, Volk L, Slovis J, Marquez AM, Nadkarni VM, Hefti M, Berg RA, Kilbaugh TJ (2021) A randomized and blinded trial of inhaled nitric oxide in a piglet model of pediatric cardiopulmonary resuscitation. Resuscitation 162:274-83 .	LEAK OXPHOS	N NS	Homogenate	Pig	Nervous system
Lei 2021 Ecotoxicol Environ Saf	2021	Lei C, Liao J, Li Q, Shi J, Zhang H, Guo J, Han Q, Hu L, Li Y, Pan J, Tang Z (2021) Copper induces mitochondria-mediated apoptosis via AMPK-mTOR pathway in hypothalamus of pigs. Ecotoxicol Environ Saf 220:112395.	LEAK OXPHOS ET	N S ROX		Pig	Nervous system
Cheng 2021 Comp Biochem Physiol B Biochem Mol Biol	2021	Cheng H, Munro D, Huynh K, Pamenter ME (2021) Naked mole-rat skeletal muscle mitochondria exhibit minimal functional plasticity in acute or chronic hypoxia. Comp Biochem Physiol B Biochem Mol Biol 255:110596.	OXPHOS ET LEAK	F N S CIV NS ROX	Isolated mitochondria	Other mammals	Skeletal muscle
MacCannell 2021 Int J Obes (Lond)	2021	MacCannell ADV, Futers TS, Whitehead A, Moran A, Witte KK, Roberts LD (2021) Sexual dimorphism in adipose tissue mitochondrial function and metabolic flexibility in obesity. Int J Obes (Lond) 45:1773-81.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Fat
MiPNet21.17 BloodCellsIsolation	2020-10-22	O2k-Protocols: Isolation of blood cells for HRR.	LEAK ROUTINE OXPHOS ET	F N S Gp CIV NS ROX	Intact cells Permeabilized cells	Human	Blood cells Platelet
Aparicio-Trejo 2020 Free Radic Biol Med	2020	Aparicio-Trejo OE, Avila-Rojas SH, Tapia E, Rojas-Morales P, León-Contreras JC, Martínez-Klimova E, Hernández-Pando R, Sánchez-Lozada LG, Pedraza-Chaverri J (2020) Chronic impairment of mitochondrial bioenergetics and β-oxidation promotes experimental AKI-to-CKD transition induced by folic acid. Free Radic Biol Med 154:18-32.	LEAK OXPHOS	F N S ROX	Isolated mitochondria	Rat	Kidney
Jian 2020 Cell Metab	2020	Jian C, Fu J, Cheng X, Shen LJ, Ji YX, Wang X, Pan S, Tian H, Tian S, Liao R, Song K, Wang HP, Zhang X, Wang Y, Huang Z, She ZG, Zhang XJ, Zhu L, Li H (2020) Low-dose sorafenib acts as a mitochondrial uncoupler and ameliorates nonalcoholic steatohepatitis. Cell Metab 31:892-908. https://doi.org/10.1016/j.cmet.2020.04.011	LEAK OXPHOS ET	N S CIV ROX	Permeabilized cells	Mouse	Liver
Politis-Barber 2020 Am J Physiol Endocrinol Metab	2020	Politis-Barber V, Brunetta HS, Paglialunga S, Petrick HL, Holloway GP (2020) Long-term high-fat feeding exacerbates short-term increases in adipose mitochondrial reactive oxygen species, without impairing mitochondrial respiration. Am J Physiol Endocrinol Metab 319:E376-87.	LEAK OXPHOS	F N Gp NS	Permeabilized cells	Mouse	Fat
Buch 2020 FASEB J	2020	Buch BT, Halling JF, Ringholm S, Gudiksen A, Kjøbsted R, Olsen MA, Wojtaszewski JFP, Pilegaard H (2020) Colchicine treatment impairs skeletal muscle mitochondrial function and insulin sensitivity in an age-specific manner. FASEB J 34:8653-70.	LEAK OXPHOS	N NS	Permeabilized tissue	Mouse	Skeletal muscle
Lozano 2020 Part Fibre Toxicol	2020	Lozano O, Silva-Platas C, Chapoy-Villanueva H, Pérez BE, Lees JG, Ramachandra CJA, Contreras-Torres FF, Lázaro-Alfaro A, Luna-Figueroa E, Bernal-Ramírez J, Gordillo-Galeano A, Benitez A, Oropeza-Almazán Y, Castillo EC, Koh PL, Hausenloy DJ, Lim SY, García-Rivas G (2020) Amorphous SiO₂ nanoparticles promote cardiac dysfunction via the opening of the mitochondrial permeability transition pore in rat heart and human cardiomyocytes. Part Fibre Toxicol 17:15.	LEAK OXPHOS ET	S	Isolated mitochondria	Rat Human	Heart
Chen 2020 Biochim Biophys Acta Mol Basis Dis	2020	Chen T, Hill JT, Moore TM, Cheung ECK, Olsen ZE, Piorczynski TB, Marriott TD, Tessem JS, Walton CM, Bikman BT, Hansen JM, Thomson DM (2020) Lack of skeletal muscle liver kinase B1 alters gene expression, mitochondrial content, inflammation and oxidative stress without affecting high-fat diet-induced obesity or insulin resistance. Biochim Biophys Acta Mol Basis Dis 1866:165805.	LEAK OXPHOS ET	N NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Feng 2020 Int J Biol Macromol	2020	Feng Q, Shao M, Han J, Tang T, Zhang Y, Liu F (2020) TFAM, a potential oxidative stress biomarker used for monitoring environment pollutants in Musca domestica. Int J Biol Macromol 155:524-34.	LEAK OXPHOS	N S ROX	Isolated mitochondria	Hexapods
Hassan 2020 MitoFit Preprint Arch	2020	Hassan Hazirah, Gnaiger Erich, Zakaria Fazaine, Makpol Suzana, Abdul Karim Norwahidah (2020) Alterations in mitochondrial respiratory capacity and membrane potential: a link between mitochondrial dysregulation and autism. https://doi.org/10.26124/mitofit:200003	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Human
Liu 2020 J Clin Invest	2020	Liu L, Ding C, Fu T, Feng Z, Lee JE, Xiao L, Xu Z, Yin Y, Guo Q, Sun Z, Sun W, Mao Y, Yang L, Zhou Z, Zhou D, Xu L, Zhu Z, Qiu Y, Ge K, Gan Z (2020) Histone methyltransferase MLL4 controls myofiber identity and muscle performance through MEF2 interaction. J Clin Invest 130:4710-25.	LEAK OXPHOS	N	Permeabilized tissue	Mouse	Skeletal muscle
Zhou 2020 Biomed Pharmacother	2020	Zhou J, Zhang Y, Li S, Zhou Q, Lu Y, Shi J, Liu J, Wu Q, Zhou S (2020) Dendrobium nobile Lindl. alkaloids-mediated protection against CCl4-induced liver mitochondrial oxidative damage is dependent on the activation of Nrf2 signaling pathway. Biomed Pharmacother 129:110351.	LEAK OXPHOS	N	Isolated mitochondria	Mouse	Liver
Sowton 2020 Mol Genet Metab Rep	2020	Sowton AP, Padmanabhan N, Tunster SJ, McNally BD, Murgia A, Yusuf A, Griffin JL, Murray AJ, Watson ED (2020) Mtrr hypomorphic mutation alters liver morphology, metabolism and fuel storage in mice. Mol Genet Metab Rep 23:100580.	LEAK OXPHOS	N NS	Homogenate	Mouse	Liver
Kapser-Fischer 2020 Thesis	2020	Kapser-Fischer IP (2020) Dietary interventions in C57BL/6 mice and their interplay with selected metabolic and genetic parameters. PhD Thesis 120.	LEAK OXPHOS		Homogenate	Mouse	Fat
Reutzel 2020 Oxid Med Cell Longev	2020	Reutzel M, Grewal R, Dilberger B, Silaidos C, Joppe A, Eckert GP (2020) Cerebral mitochondrial function and cognitive performance during aging: A longitudinal study in NMRI mice. Oxid Med Cell Longev 2020:4060769.	LEAK ET OXPHOS	N S CIV ROX	Isolated mitochondria	Mouse	Nervous system
Almoiliqy 2020 Acta Pharmacol Sin	2020	Almoiliqy M, Wen J, Xu B, Sun YC, Lian MQ, Li YL, Qaed E, Al-Azab M, Chen DP, Shopit A, Wang L, Sun PY, Lin Y (2020) Cinnamaldehyde protects against rat intestinal ischemia/reperfusion injuries by synergistic inhibition of NF-κB and p53. Acta Pharmacol Sin 41:1208-22.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Rat	Endothelial;epithelial;mesothelial cell
Gvozdjakova 2020 Diagnostics (Basel)	2020	Gvozdjáková A, Sumbalová Z, Kucharská J, Komlósi M, Rausová Z, Vančová O, Számošová M, Mojto V (2020) Platelet mitochondrial respiration, endogenous coenzyme Q₁₀ and oxidative stress in patients with chronic kidney disease. Diagnostics (Basel) 10:176.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Platelet
... further results

Abstracts: OXPHOS

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	Year	Reference	Coupling	Pathway	Preparation	Organism	Tissue;cell
Sobotka 2024 EBEC	2024	Sobotka O, Cardoso L, Garcia-Souza L, Sobotka L, Gnaiger E (2024) The effect of glucose on mitochondrial respiration in hepatocellular carcinoma cells. EBEC 2024.	ROUTINE LEAK OXPHOS ET	S NS	Permeabilized cells Intact cells	Human
Nizami 2024 Abstract IOC163	2024	Nizami HL, Szybowska P, Singhal P, Lee CF (2024) Investigating the effect of Nampt overexpression on cardiac mitochondrial respiration in Ndufs4-cKO mice. Mitochondr Physiol Network 28.11.	OXPHOS	N S	Isolated mitochondria	Mouse	Heart
Dantas 2024 Abstract IOC163	2024	Dantas WS, Heintz EC, Zunica ERM, Dousay M, Davuluri G, Yu CS, Murphy MP, Axelrod CL, Kirwan JP (2024) Mito-Q supplementation reverses sarcopenic obesity in aged mice by restoring mitochondrial function and enhancing antioxidant response. Mitochondr Physiol Network 28.11.	OXPHOS	N S		Mouse
Cardoso 2023 MiP2023	2023	Electron transfer from beta-oxidation and TCA cycle and impact of OXPHOS coupling on NADH and coenzyme Q redox states.	OXPHOS
Gnaiger 2023 MiP2023	2023	From globesity to mitObesity.	OXPHOS			Human	Skeletal muscle
Timon-Gomez 2023 EUROMIT2023 Bologna	2023	Timon-Gomez A, Cardoso L, Baglivo E, Doerrier C, Gnaiger E (2023) Mitochondrial injury in warm ischemia studied by high-resolution respirometry. EUROMIT2023 International Conference on Mitochondrial Pathology.	OXPHOS ET	F N S Gp	Homogenate Isolated mitochondria Intact cells	Human Mouse	Heart Nervous system HEK
Cecatto 2023 BPS2023 San Diego	2023	Cecatto C, Schmitt Sabine, Cardoso L, Videja M, Dambrova M, Makrecka-Kuka M, Liepinsh E, Gnaiger E (2023) Contribution of fatty acid oxidation to respiratory control in brain mitochondria. 67th Annual Meeting of the Biophysical Society.	OXPHOS	F N Gp NS	Permeabilized tissue Homogenate	Mouse	Heart Nervous system Kidney
Irving 2022 Abstract Bioblast	2022	7.4. «5 min» Irving Brian A, Stampley J, Quiriarte H, Wigger Z, Stephens J, Soto P, Allerton TA (2022) Impact of nitric oxide promotors on mitochondrial bioenergetics in a murine model of Alzheimer's disease. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001	LEAK OXPHOS ET	N Gp NS ROX	Permeabilized tissue Homogenate	Mouse	Nervous system
Magri 2022 Abstract Bioblast	2022	8.5. «5 min» Magrì Andrea, Cubisino SAM, De Pinto V, Messina A (2022) Modulation of mitochondrial respiration in ALS cells by hexokinase-based peptides: a novel therapeutic approach to fight neurodegeneration. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Nervous system
Isola 2022 Abstract Bioblast	2022	P12. Isola Raffaella, Noli R, Isola M, Crisafulli A, Vargiu R, Loy F, Lai Y (2022) In rat brain and heart acute hypoxia induced mild changes in OXPHOS in both sexes. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001	OXPHOS ET	F N S DQ CIV	Isolated mitochondria	Rat	Heart Nervous system
Goulding 2022 Abstract Bioblast	2022	7.2. «5 min» Goulding Richie P, Strating S, van der Laan M, Noort W, Kolodyazhna A, Bloemers FW, Wüst RCI (2022) Mitochondrial function is not impaired in type 1 diabetes but does not respond to 4-weeks endurance training. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001	OXPHOS		Permeabilized tissue	Human	Skeletal muscle
Batra 2022 Abstract Bioblast	2022	7.8. «5 min» Subramaniam S, Jeet V, Gunter JH, Clements JA, Popat A, Batra Jyotsna (2022) Nano-encapsulated dichloroacetophenone (DAP), a regulator of essential mitochondrial enzyme, is a potential inhibitor of prostate cancer cell growth. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001	OXPHOS
Axelrod 2022 Abstract Bioblast	2022	3.6. «5 min» Axelrod Christopher L, Heintz EC, Albaugh VL, Kirwan JP (2022) Segmental regulation of intestinal mitochondrial function. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001	LEAK OXPHOS ET	N S CIV	Isolated mitochondria	Mouse	Endothelial;epithelial;mesothelial cell
Cardoso 2022 Abstract Bioblast	2022	4.3. «10+5» Cardoso Luiza HD, Doerrier C, Donnelly C, Komlódi T, Gnaiger E (2022) Redox monitoring and respiration - a new horizon with the NextGen-O2k. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells Isolated mitochondria	Mouse	Liver HEK
Bettinazzi 2022 Abstract Bioblast	2022	P01. Bettinazzi Stefano, Camus F, Dowling DK, Lane N (2022) Linking the mitonuclear genotype with mitochondrial function and organismal fitness. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001	OXPHOS
Komlodi 2022 Abstract Bioblast	2022	3.1. «10+5» Komlódi Timea, Tretter L (2022) The protonmotive force – not merely membrane potential. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001 »MitoFit Preprint«	LEAK OXPHOS		Isolated mitochondria
Schmitt 2022 Abstract Bioblast	2022	2.2. «10+5» Schmitt Sabine, Gnaiger E (2022) Using oxygen and hydrogen gas in studies of mitochondrial respiration and hydrogen peroxide production under hyperoxic, normoxic, and hypoxic conditions. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001	LEAK OXPHOS	N	Permeabilized cells		HEK
Molina 2022 Abstract Bioblast	2022	3.2. «10+5» Heimler SR, Phang HJ, Bergstrom J, Mahapatra G, Dozier S, Gnaiger E, Molina Anthony JA (2022) Platelet bioenergetics are associated with resting metabolic rate and exercise capacity in older women. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001 »Bioenergetics Communications«	OXPHOS ET	F N S Gp ROX	Permeabilized cells	Human	Blood cells
Cardoso 2022 ESCI Bari	2022	Cardoso LHD, Donnelly C, Komlódi T, Gnaiger E (2022) Bioenergetic fingerprinting with coupling and pathway control of coenzyme Q redox state and respiration in permeabilized HEK 293T cells. 56^th Annual Scientific Meeting of the European Society for Clinical Investigation.	LEAK OXPHOS ET	N S NS	Permeabilized cells	Human	HEK
Cecatto 2022 EBEC	2022	Cecatto C, Cardoso LHD, Gnaiger E (2022) Mitochondrial calcium uptake capacity is lower than calcium retention capacity in the presence and absence of cyclosporin A. EBEC 2022.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Mouse	Liver
Schmitt 2022 EBEC	2022	Schmitt S, Gnaiger E (2022) Short-term effect of molecular hydrogen on mitochondrial respiration and hydrogen peroxide production in permeabilized HEK 293T cells. EBEC 2022.	LEAK OXPHOS	N	Permeabilized cells	Human	HEK
Cardoso 2022a EBEC	2022	Cardoso LHD, Donnelly C, Komlódi T, Gnaiger E (2022) Characterizing electron transfer through the mitochondrial Q-junction from fatty acid oxidation and TCA cycle on HEK 293T cells: correlation with respiration. EBEC 2022.	LEAK OXPHOS ET	F N S NS	Permeabilized cells	Human	HEK
Doerrier 2020 PaduaMuscleDays	2020	Doerrier C, Di Marcello M, Gnaiger E (2020) Commitment to reproducibility in targeting mitochondrial respiratory control: basic and advanced applications of the O2k-FluoRespirometer. PaduaMuscleDays.	OXPHOS		Permeabilized cells Permeabilized tissue Homogenate Isolated mitochondria Intact cells		Skeletal muscle Blood cells
Doerrier 2020 PaduaMuscleDays Poster	2020	Doerrier C, Gama-Perez P, Chabi B, Ost M, Distefano G, Pesta D, Dahdah N, Lemieux H, Holody C, Carpenter RG, Tepp K, Puurand M, Kaambre T, Dubouchaud H, Cortade F, Calabria E, Casado M, Fernandez-Ortiz M, Acuna-Castroviejo D, Villena JA, Grefte S, Keijer J, O'Brien K, Sowton A, Murray AJ, Campbell MD, Marcinek DJ, Nollet E, Wuest R, Dayanidhi S, Soendergaard SD, Chroeis KM, Gonzalez-Franquesa A, Goodpaster BH, Coen PM, Larsen S, Gnaiger E, Garcia-Roves PM (2020) Commitment to reproducibility in mitochondrial respiration studies with permeabilized muscle fibers. PaduaMuscleDays.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Human Mouse	Skeletal muscle
Rutai 2019 Crit Care	2019	Rutai A, Fejes R, Tallósy SZ, Poles M, Juhász L, Mészáros A, Boros M, Kaszaki J (2019) Potential role of endothelin receptors in the therapy of experimental sepsis. Crit Care.	OXPHOS	N S		Rat
Kandel 2019 Biophys J	2019	Kandel SM, Tomar N, Zheleznova N, Audi SH, Cowley Jr AW, Dash RK (2019) Calcium stimulation of mitochondrial respiration is substrate dependent and tissue specific. Biophys J.	LEAK OXPHOS	F N S	Isolated mitochondria	Rat	Heart Kidney
Gnaiger 2019 MiP2019	2019	OXPHOS capacity in human muscle tissue and body mass excess – the MitoEAGLE mission towards an integrative database (Version 6; 2020-01-12).	OXPHOS	NS	Intact organism Permeabilized tissue Isolated mitochondria	Human	Skeletal muscle
Silva 2019 ESCI2019	2019	Silva FSG, Komlodi T, Garcia-Souza LF, Bento G, Doerrier C, Oliveira PJ, Gnaiger E (2019) Can fatty acid oxidation be specifically blocked by the CPT1 inhibitor etomoxir?	OXPHOS ET	F N S	Permeabilized cells Isolated mitochondria	Human Mouse	Liver
Goikoetxea-Usandizaga 2019 MiPschool Coimbra	2019	Methylation Controlled J protein (MCJ): A therapeutic target in hepatic ischemia and reperfusion injury.	OXPHOS		Homogenate Isolated mitochondria Intact cells	Mouse	Liver
Van der Ende 2019 MiPschool Coimbra	2019	Mitochondrial respiration in muscle tissue of colon cancer patients.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Minuzzi 2019 MiPschool Coimbra	2019	A pilot study on mitochondrial function of mouse skin using high-resolution respirometry.	LEAK OXPHOS ET	F N S	Permeabilized tissue	Mouse	Endothelial;epithelial;mesothelial cell
Santos 2019 MiPschool Coimbra	2019	Uncoupling Protein 1 inhibition and mitochondrial respiration in epicardial adipose tissue from hear failure patients.	OXPHOS	F N		Human	Heart Fat
Garcia 2019 MiPschool Coimbra	2019	Functional interactions between the Drosophila melanogaster mitochondrial glycerol-3-phosphate dehydrogenase and a xenotopically expressed alternative oxidase.	LEAK OXPHOS	N Gp		Drosophila
Beleza 2019 MiPschool Coimbra	2019	Gestational exercise counteracts the deleterious consequences imposed by diabetes mellitus developed during pregnancy on 16 weeks old male offspring liver mitochondrial function.	LEAK OXPHOS	N S		Rat	Liver
Goncalves Debora 2019 MiPschool Coimbra	2019	Aging effects on mitochondrial control factors in Pink1 knockout Drosophila melanogaster.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Drosophila
Garcia-Roves 2019 MiPschool Coimbra	2019	Generating reference values on mitochondrial respiration in permeabilized muscle fibers.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Silva 2019 MiPschool Coimbra	2019	Off-target effects of etomoxir on mitochondrial Complex I.	OXPHOS ET	F N Other combinations	Permeabilized cells Isolated mitochondria	Human Mouse	Liver
Chabi 2019 MiP2019	2019	Generating reference values on mitochondrial respiration in permeabilized muscle fibers.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Abdel-Rahman 2019 MiP2019	2019	Mitochondrial respiration in platelets of children with autism spectrum disorder.	ROUTINE OXPHOS	N NS	Intact cells	Human	Platelet
Sumbalova 2019b MiP2019	2019	The decline of mitochondrial respiration in isolated platelets after short-term storage.	LEAK OXPHOS	F N S Gp CIV NS ROX	Intact cells	Human	Platelet
Sumbalova 2019a MiP2019	2019	Platelet mitochondrial function, coenzyme Q₁₀, and oxidative stress in patients with chronic kidney diseases.	LEAK OXPHOS	F N S Gp CIV NS ROX	Intact cells	Human	Platelet
Lemieux 2019a MiP2019	2019	Partial prevention of oxidative stress damage to mitochondria with photobiomodulation.	LEAK OXPHOS ET	N S CIV NS		Other invertebrates
Kramer 2019 Abstract IOC141	2019	Kramer P, Distefano G, Monte J, Mills A, Edmunds L, Jurczak M, Cummings SR, Kritchevsky S, Newman AB, Hepple RT, Goodpaster B, Coen PM, Molina A (2019) The Study of Muscle, Mobility, and Aging (SOMMA): A multi-institutional respirometry study. Mitochondr Physiol Network 24.02.	LEAK OXPHOS ET	N CIV NS ROX		Human	Skeletal muscle
Dominguez-Amorocho 2019 MiP2019	2019	Role of Sirtuin 1/3 in CD4⁺ T cells activation and differentiation in obese and transplanted animals.	LEAK ET OXPHOS	ROX		Mouse	Lymphocyte
Axelrod 2019 Abstract IOC141	2019	Axelrod CL, Davuluri G, Zunica ERM, Noland RC, Hoppel CL, Kirwan JP (2019) Administration of BAM15 to obese C57BL/6J mice increases skeletal muscle fatty acid oxidation independent of OXPHOS or ETC capacity. Mitochondr Physiol Network 24.02.	OXPHOS ET	F		Mouse	Skeletal muscle
Lelcu 2019 MiP2019	2019	Assessment of platelet respiration in blood malignancies: a pilot study in children and adults.	LEAK OXPHOS ET	N NS ROX	Permeabilized cells	Human	Platelet
Aid-Vanakova 2019 MiP2019	2019	Adaptation of muscle OXPHOS in developing glucose intolerance - Wfs1 mice model.	LEAK OXPHOS	N S		Mouse	Skeletal muscle Heart
Pavlovic 2019 MiP2019	2019	Effects of therapeutic metformin concentration on mitochondria in muscle cells.	ROUTINE OXPHOS	N S	Intact cells	Mouse	Skeletal muscle
Timohhina 2019 MiP2019	2019	Metabolic effects of mitochondria-targeted antioxidant peptides in colorectal cancer cells.	LEAK OXPHOS ET	ROX		Human	Endothelial;epithelial;mesothelial cell
Acuna-Castroviejo 2018 MiP2018	2018	Mitochondria, melatonin, and neuroinflammation in Parkinson's disease. Acuna-Castroviejo_Presentation	LEAK OXPHOS	N		Mouse	Nervous system
Lemieux 2018 MiP2018	2018	Plasticity of a critical regulator of energy production under hypothermia, the phosphorylation system.	OXPHOS	N S	Intact organism	Other invertebrates
Votion 2018 MiP2018	2018	Functional diagnosis of mitochondrial defects in equine atypical myopathy and targeted mitochondrial therapy: a preliminary study.	OXPHOS	F N S NS	Intact cells	Horse	Skeletal muscle
Wilson 2018 Virginia Tech	2018	Wilson ZT, Perry JB, Brow DA (2018) High-resolution respirometry of heart mitochondria in healthy and stressed states. Virginia Tech.	OXPHOS	N	Isolated mitochondria		Heart
Liu 2018 Atherosclerosis Suppl	2018	Liu D (2018) Enhanced Trpc3-mediated mitochondrial respiratory dysfunction by inhibition of mitochondria-hexokinase in monocytes from hypertension rats. Atherosclerosis Suppl.	ROUTINE OXPHOS ET	N NS	Intact cells	Rat	Blood cells
White 2018 J Anim Sci	2018	Differing mitochondrial capacity in two separate skeletal muscles from calm and temperamental Brahman heifers.	OXPHOS	N		Bovines	Skeletal muscle
Makrecka-Kuka 2018 MiP2018	2018	Fatty acid oxidation in brain: from aging to ischemia and sepsis.	OXPHOS	F	Homogenate	Mouse Rat	Nervous system
Kuka 2018 MiP2018	2018	The discovery of methyl-GBB - acylcarnitine lowering as an effective strategy to treat cardiometabolic diseases.	LEAK OXPHOS			Rat	Heart
Bastos Sant'Anna Silva 2018 TRANSMIT Bertinoro di Romagna IT	2018	Cellular succinate transport and mitochondrial respiratory function in prostate cancer.	ROUTINE LEAK OXPHOS ET	S ROX	Permeabilized cells Intact cells	Human	HEK Genital
Sobotka 2018 MiP2018	2018	Measurement of ROS production under hypoxia and unexpected methodological pitfalls of Amplex UltraRed assay.	LEAK OXPHOS		Isolated mitochondria	Mouse Saccharomyces cerevisiae	Heart Nervous system
Gnaiger 2018 MiP2018	2018	Mitochondrial respiratory control by fuel substrates and specific inhibitors of respiratory enzymes: Building blocks of mitochondrial physiology Part 2.	OXPHOS	N F S Gp DQ CIV NS Other combinations
Doerrier 2018 MiP2018a	2018	Inter-laboratory harmonization of protocols for mitochondrial function evaluation in permeabilized muscle fibers.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Pereira da Silva Grilo da Silva 2018 MiP2018	2018	The unspecific effect of etomoxir on mitochondrial respiration.	OXPHOS ET	F N S NS Other combinations	Permeabilized cells Isolated mitochondria	Human Mouse	Nervous system Liver Other cell lines
Danhelovska 2018 MiP2018	2018	The relevance of ACBD3 protein in energy metabolism in various cell lines. Danhelovska_Presentation	OXPHOS			Human	HEK HeLa
Meszaros 2018 EBEC2018	2018	Tissue- and substrate-specific patterns in the oxygen kinetics of mitochondrial respiration.	LEAK OXPHOS ET	N	Isolated mitochondria	Mouse	Heart Nervous system Liver
Stankova 2018 MiP2018	2018	Impact of western diet on energy metabolism in mouse liver.	OXPHOS ET	S F N	Homogenate	Mouse	Liver
Doerrier 2018 EBEC2018	2018	Respiratory mapping of mitochondrial pathways for establishing a database of mitochondrial physiology.	LEAK ROUTINE OXPHOS ET	F N S Gp CIV NS Other combinations ROX	Permeabilized cells Homogenate Isolated mitochondria	Human Mouse	Heart Nervous system Blood cells HEK Platelet
Komlodi 2018 EBEC2018	2018	Electron supply to the Q-junction: assessment of mitochondrial respiration, H₂O₂ flux and the redox state of the Q-pool.	LEAK OXPHOS	S Gp	Isolated mitochondria	Mouse	Nervous system
Doerrier 2018 ESCI2018	2018	High-resolution respirometry, two techniques combined in one to explore mitochondrial function in health and disease	LEAK ROUTINE OXPHOS ET	F N S Gp ROX CIV	Permeabilized cells Permeabilized tissue Homogenate Isolated mitochondria	Human Mouse	Heart Skeletal muscle Nervous system Blood cells HEK
Chang 2018 Life Sciences Meeting 2018 Innsbruck AT	2018	pH dependence of mitochondrial respiration and H₂O₂ production in oral cancer cells – a pilot study.	LEAK ROUTINE OXPHOS ET	F N S Gp CIV NS Other combinations ROX	Permeabilized cells	Human	HEK Kidney
Schoepf 2018 33rd Annual EAU Congress Copenhagen	2018	Shift of mitochondrial oxidative phosphorylation is associated with mtDNA mutational load in primary prostate cancer tissue.	LEAK OXPHOS ET	F N NS Other combinations ROX	Permeabilized cells Permeabilized tissue	Human	Genital
Chang 2018 Biophys J	2018	Mitochondrial dysfunction in malignant hyperthermia susceptible skeletal muscle.	OXPHOS	N S	Permeabilized tissue	Human Mouse	Skeletal muscle
McMaster 2018 Am J Obstet Gynecol	2018	Preeclampsia is associated with placental mitochondrial dysfunction.	LEAK ROUTINE OXPHOS ET	N	Isolated mitochondria	Human
De Goede 2018 MiP2018	2018	Timing of feeding behavior affects daily rhythms in body temperature and muscle mitochondrial metabolism.	OXPHOS ET		Permeabilized tissue	Rat	Skeletal muscle
Doerrier 2018 MiP2018c	2018	Inter-laboratory study on human permeabilized myofibers: effects of fiber preparation, respiration buffer, and blebbistatin on mitochondrial respiratory capacity and oxygen limitation.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Meszaros 2018 Mt Med Hinxton	2018	High-resolution mitochondrial oxygen kinetics as diagnostic tool in Complex IV impairments.	LEAK OXPHOS ET	N CIV NS	Isolated mitochondria	Mouse	Heart Nervous system Liver
Li 2018 IBEC	2018	Li C, Li N, Zhang Y (2018) UPRmt and mitophagy are selectively activated depending on muscle fiber types in insulin resistant rats. IBEC.	LEAK OXPHOS			Rat	Skeletal muscle
Kovalev 2018 EMBS	2018	Kovalev A, Sokolova I, Sukhotin A (2018) Allometry of mitochondrial respiration in mussels. EMBS.	LEAK OXPHOS ET	CIV	Isolated mitochondria	Molluscs	Liver Islet cell;pancreas;thymus
Konopka 2018 FASEB J	2018	Konopka AR, Castor WM, Reid J, Schoenberg H, Laurin J, Wolff C, Hamilton K, Miller B (2018) Metformin blunts exercise-induced improvements in skeletal muscle mitochondrial respiration independent of changes in mitochondrial biogenesis. FASEB J.	OXPHOS ET	F N NS	Permeabilized tissue	Human	Skeletal muscle
Krajcova 2018 MiPschool Tromso E2	2018	High-resolution respirometry to assess function of mitochondria in native homogenates of human heart muscle.	LEAK OXPHOS ET	N NS ROX	Homogenate	Human	Heart
Garipi 2018 MiPschool Tromso E2	2018	Phenotyping mitochondrial metabolism in Barrett’s metaplasia-dysplasia-adenocarcinoma sequence: respiratory capacity, extracelular proton flux and ROS production	LEAK ROUTINE OXPHOS ET	CIV NS ROX	Permeabilized cells Permeabilized tissue	Human	Endothelial;epithelial;mesothelial cell Other cell lines
Cardoso 2018 MiPschool Tromso E2	2018	Concomitant respiration and ATP production measurements to analyse P»/O₂ ratios at physiological normoxia.	OXPHOS
Bastos Sant'Anna Silva 2018 MiPschool Tromso C4	2018	Role of succinate in prostate cancer cells: uptake and mitochondrial respiratory function.	LEAK ROUTINE OXPHOS ET	S ROX	Intact cells	Human	Genital
Wuest 2018 MiPschool Tromso D3	2018	Metabolic flexibility and mitochondrial function in the diabetic heart.	OXPHOS	N S		Pig Mouse Rat	Heart
Hoppel 2018 MiPschool Tromso D1	2018	Two populations of muscle mitochondria: heart and skeletal muscle.	OXPHOS		Isolated mitochondria	Rat Dog Other mammals	Heart Skeletal muscle
Gnaiger 2018 MiPschool Tromso A1	2018	Mitochondrial states and rates: 1. Electron transfer pathways and respiratory control. 2. Coupling control.	LEAK ET OXPHOS	F N S Gp DQ CIV NS Other combinations
Gnaiger 2018 AussieMit	2018	Komlodi Timea, Sobotka Ondrej, Doerrier Carolina, Gnaiger Erich (2018) Mitochondrial H₂O₂ production is low under tissue normoxia but high at in-vitro air-level oxygen pressure - comparison of LEAK and OXPHOS states. AussieMit 2018 Melbourne AU.	LEAK ROUTINE OXPHOS	NS	Isolated mitochondria Intact cells	Mouse Saccharomyces cerevisiae	Heart Nervous system
Doerrier 2018 MiP2018b	2018	Evaluation of anaplerotic pathways to avoid artefacts in respirometric measurement of fatty acid oxidation.	OXPHOS	F N	Permeabilized cells Homogenate Isolated mitochondria	Human Mouse	Heart Nervous system Blood cells HEK Platelet
Chicco 2018 MiP2018b	2018	Defective cardiolipin remodeling and cardiac mitochondrial dysfunction: supercomplexes or just complex?	OXPHOS	F N NS	Permeabilized tissue	Mouse	Heart
Chicco 2018 MiP2018a	2018	Maternal aging increases granulosa cell mitochondrial ROS release and reduces oocyte OXPHOS-linked respiration: implications for embryo development.	OXPHOS ET			Horse	Genital
Garcia-Roves 2018 MiP2018b	2018	Generating mitochondrial respirometry reference values from permeabilized mouse soleus muscle fibers. Working Group 2 report. Garcia-Roves_Presentation	OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Porter 2018 MiP2018b	2018	Skeletal muscle mitochondrial thermogenesis in hypermetabolic humans.	LEAK OXPHOS
Wuest 2018 MiP2018b	2018	The antibiotic doxycycline impairs cardiac mitochondrial and contractile function.	OXPHOS ET	N S		Rat	Heart Other cell lines
Stelfa 2018 MiP2018	2018	Neuroprotective compound R-phenibut protects brain mitochondria against anoxia-reoxygenation damage in vitro.	OXPHOS	S	Homogenate	Rat	Nervous system
Krajcova 2018 ICO134	2018	Skeletal muscle bioenergetics in critically ill patients: effect of early rehabilitation on mitochondrial functions and insulin resistance during and 6 months after critical illness.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Human	Skeletal muscle
Komlodi 2018 AussieMit	2018	Komlodi T, Hunger M, Moore AL, Gnaiger E (2018) Electron transfer at the Q-junction: new perspectives from combined measurement of mitochondrial O₂ flux, H₂O₂ flux, and coenzyme Q redox state. AussieMit 2018 Melbourne AU.	LEAK OXPHOS	S Gp	Isolated mitochondria	Mouse	Nervous system
Ravasz 2018 Abstract The evolving concept of mitochondria	2018	Vast pools of endogenous quinones sustain NADH oxidation by Complex I during anoxia, supporting substrate-level phosphorylation in mouse liver mitochondria.	LEAK OXPHOS	N	Isolated mitochondria	Mouse	Liver
Waldauf 2017 MITOEAGLE Obergurgl	2017	Effect of propofol on energy metabolism in an in vitro model of human skeletal muscle homogenates.	LEAK OXPHOS ET	F N S CIV NS	Homogenate	Human	Skeletal muscle
Gnaiger 2017 MiPschool A1	2017	Elemental steps towards understanding mitochondrial core energy metabolism: coupling control.	LEAK ROUTINE OXPHOS ET	ROX	Intact cells Permeabilized cells Permeabilized tissue Isolated mitochondria
Krajcova 2017 MITOEAGLE Obergurgl	2017	Developing a method of assessing mitochondrial functions in homogenates of human heart muscle.	LEAK OXPHOS ET	N NS	Homogenate	Human
Ukropec 2017 MITOEAGLE Obergurgl	2017	Could functional state of muscle mitochondria reflect exercise-induced changes in insulin sensitivity, glucose tolerance and cognitive performance in individuals with mild cognitive impairment?	LEAK OXPHOS ET	F N S Gp NS	Permeabilized cells		Skeletal muscle
Komlodi 2017 MiPschool Obergurgl	2017	Electron pressure exerted by convergent succinate- and glycerophosphate-pathways to the Q-junction regulate reversed electron transfer to Complex I and H₂O₂ production.	LEAK OXPHOS	N S Gp Other combinations ROX	Isolated mitochondria	Mouse	Nervous system
Keppner 2017 MiPschool Obergurgl	2017	Different respiratory states to determine LEAK and uncoupled respiration in the SUIT protocol: effect and consequences.	LEAK OXPHOS ET	N NS	Permeabilized cells		Blood cells
O'Brien 2017 Abstract IOC122	2017	PPARα independent effects of nitrate supplementation on skeletal muscle mitochondrial function in hypoxia.	LEAK OXPHOS	F		Mouse	Skeletal muscle
Distefano 2017 MiPschool Obergurgl	2017	Effects of calorie restriction-induced weight loss and exercise on skeletal muscle mitochondrial energetics of older obese subjects.	LEAK OXPHOS ET	F NS	Permeabilized tissue	Human	Skeletal muscle
Isola 2017 MiPschool Obergurgl	2017	Do mitochondria counteract diabetes impairment by means of morphological and physiological strategies?	OXPHOS	F N	Isolated mitochondria	Rat
Juhasz 2017 MiPschool Obergurgl	2017	Blockade of N-methyl-D-aspartate receptors improves polymicrobial sepsis-evoked mitochondrial dysfunction in rats.	LEAK OXPHOS	N S	Homogenate	Rat	Liver
Meszaros 2017 MiPschool Obergurgl	2017	(Very) High-resolution respirometry – a deep dive into oxygen dependence of mitochondrial respiration.	LEAK OXPHOS	N S	Isolated mitochondria	Mouse	Liver Nervous system Kidney
Markova 2017 MiPschool Obergurgl	2017	Mitochondrial respiration in the rat left heart ventricle after inhibition of pyruvate dehydrogenase kinase.	LEAK OXPHOS	N S CIV NS ROX	Homogenate	Rat	Heart
Collins 2017 MiPschool Obergurgl	2017	The effects of a Mediterranean versus Western diet on nonhuman primate skeletal muscle bioenergetics.	OXPHOS	F N S Gp CIV NS ROX	Intact cells
Amick 2017 MiPschool Obergurgl	2017	Bioenergetic profiling of mitochondria isolated from three distinct brain regions relevant to AD pathology in non-human primates.	LEAK OXPHOS	F N	Isolated mitochondria	Other mammals	Nervous system
Truu 2017 Abstract IOC122	2017	Bioenergetics of colorectal cancer.	OXPHOS	N S			Endothelial;epithelial;mesothelial cell
Han 2017 Abstract IOC122	2017	Retinal mitochondria respiration defects precede hyperglycemia onset in type 2 diabetes.	OXPHOS	NS	Homogenate	Rat	Nervous system
Gnaiger 2017 Abstract EUROMIT2017 Cologne	2017	Again not a Warburg effect - mitochondrial function in primary prostate cancer.	OXPHOS ET	N NS S		Human	Endothelial;epithelial;mesothelial cell Genital Fibroblast
Nemec 2017 Abstract MITOEAGLE Barcelona	2017	Functional state of mitochondria in patients with preclinical cognitive deficit.	OXPHOS ET	F	Permeabilized tissue	Human	Skeletal muscle
Dubouchaud 2017 Abstract MITOEAGLE Barcelona	2017	Impact of high-fat diet or PUFAs consumption on the mitochondrial function.	OXPHOS	F N	Permeabilized tissue Isolated mitochondria	Rat	Skeletal muscle Liver
Doerrier 2017 Abstract MitoEAGLE Barcelona	2017	SUIT reference protocol for comparative mitochondrial physiology.	LEAK ROUTINE OXPHOS ET	F N S Gp CIV	Permeabilized cells Homogenate Isolated mitochondria	Human Mouse	Heart Nervous system HEK
Aasum 2017 Abstract MITOEAGLE Barcelona	2017	Mitochondrial function in the diabetic heart – effect of an acute fat-load.	OXPHOS		Isolated mitochondria	Mouse	Heart
Komlodi 2017 Abstract MITOEAGLE Barcelona	2017	Succinate dehydrogenase regulation via oxaloacetate in brain mitochondria.	OXPHOS LEAK ET	N S	Isolated mitochondria Homogenate	Guinea pig Mouse	Nervous system Kidney Heart Liver
Michalak 2017 Abstract MITOEAGLE Barcelona	2017	Mitochonrial respiration in intact peripheral blood mononuclear cells in patients with extrapyramidal syndromes.	LEAK ROUTINE OXPHOS ET	ROX	Intact cells	Human	Blood cells
Sobotka 2017 Abstract MITOEAGLE Barcelona	2017	The effect of 24 weeks of high-fat and high-cholesterol diet on rat liver mitochondria. Sobotka_Presentation	OXPHOS ET	F N S Gp ROX	Isolated mitochondria	Rat	Liver
Vaka 2017 Hypertension	2017	Abstract P265: Placental ischemia causes renal mitochondrial impairment in reduced uterine perfusion pressure rats.	OXPHOS	N S	Isolated mitochondria	Rat	Kidney Genital
Gnaiger 2017 Abstract MitoEAGLE Barcelona	2017	Quality first: a paradigm shift in mt-respiratory control towards global connection.	LEAK OXPHOS ET	N S NS	Permeabilized tissue	Human Mouse	Heart Genital
Doerrier 2017 MiPschool C2	2017	Substrate-uncoupler-inhibitor titration (SUIT) protocols – fundamental principles.	LEAK ROUTINE OXPHOS ET	F N S Gp CIV	Permeabilized cells Homogenate Isolated mitochondria	Human Mouse	Heart Nervous system HEK
White 2017 J Anim Sci	2017	Influence of temperament on skeletal muscle mitochondrial capacity of Brahman cows.	OXPHOS ET	N S NS		Bovines	Skeletal muscle
Schilling 2017 J Mol Cell Cardiol	2017	Loss of caveolin-1 alters cardiac mitochondrial function and increases susceptibility to stress.	OXPHOS	N CIV NS	Isolated mitochondria	Mouse	Heart
Larsen 2017 MiP2017 WG2	2017	The effect on respiratory capacity using different respiration buffers.	OXPHOS	N NS	Permeabilized tissue	Human	Skeletal muscle
Sobotka 2017 MiP2017	2017	Metabolic changes in rat liver mitochondria during the development of liver steatosis.	OXPHOS ET	N NS	Isolated mitochondria	Rat	Liver
Meszaros 2017 MiP2017	2017	Mitochondrial oxygen kinetics as a sensitive diagnostic tool to determine apparent cytochrome c oxidase excess capacity.	LEAK OXPHOS ET	N NS	Isolated mitochondria	Mouse	Nervous system Liver Kidney
Komlodi 2017 MiP2017	2017	H₂O₂ production under hypoxia in brain and heart mitochondria: does O₂ concentration matter?	LEAK OXPHOS	N NS	Isolated mitochondria	Mouse	Heart Nervous system
Irving 2017 MiP2017	2017	Impact of acute exercise on PBMC respiratory function and methodological considerations.	LEAK ROUTINE OXPHOS ET	N NS ROX			Blood cells
Hoppel 2017 MiP2017	2017	Pathways of mitochondrial fatty acid oxidation. Hoppel_Presentation	OXPHOS	F N S		Rat	Liver
Doerrier 2017 MiP2017 WG2	2017	Upper limit of OXPHOS capacity in permeabilized myofibers: effect of oxygen, ADP and blebbistatin in MiR05Cr and Buffer Z.	LEAK OXPHOS ET	N NS	Permeabilized tissue	Mouse	Skeletal muscle
Markova 2017 MiP2017	2017	Porcine sepsis and associated myocardial depression.	LEAK OXPHOS	N S CIV NS ROX		Pig	Heart
Han 2017 MiP2017	2017	Metabolic syndrome differentially impacts the retina and underlying retinal pigment epithelium cells.	LEAK OXPHOS	S CIV NS		Rat	Nervous system
Makrecka-Kuka 2017 MiP2017	2017	Heart, brain and kidneys: who will survive? Tissue-specific changes in mitochondrial function in the experimental model of endotoxemia.	OXPHOS		Permeabilized tissue Homogenate	Mouse	Heart Nervous system Kidney
Scheiber 2017 Europ Heart J	2017	High-resolution respirometry in human endomyocardial biopsies to assess myocardial mitochondrial function.	OXPHOS	F N NS	Permeabilized tissue	Human	Heart
Nakajima 2017 Europ Heart J	2017	Mitochondrial dysfunction in epicardial adipose tissue; possible role in progression of coronary artery disease.	OXPHOS	F N NS	Permeabilized tissue	Human	Fat
Labieniec-Watala 2017 MiP2017	2017	Lack of the effect of low metformin concentrations on the response of breast cancer cell mitochondria to radiotherapy under conditions of the in vitro experimental hyperglycemia. Labieniec-Watala_Presentation	OXPHOS ET	N S NS ROX	Permeabilized cells	Human	Genital
Garcia-Roves 2017 MiP2017	2017	Mitochondrial respirometry reference values from permeabilized mouse soleus muscle fibers. MitoEAGLE WG2 pilot study. Garcia-Roves_Presentation	OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Kolonics 2017 MiP2017	2017	Different molecular composition of Lysimachia species result in distinct metabolism.	OXPHOS	N NS		Mouse Plants	Heart Liver
Kovalcikova 2017 MiP2017	2017	Mitochondrial protein TMEM70: key role in the biogenesis of ATP synthase verified in a mouse knockout model.	LEAK OXPHOS			Mouse	Heart Liver
Lemieux 2017 MiP2017	2017	Compounding effects of age and sexual dimorphism on cardiac mitochondrial function in type 2 diabetes.	OXPHOS	F CIV	Permeabilized tissue	Rat	Heart
Bezuidenhout 2016b Abstract MitoFit Science Camp 2016	2016	Analysis and comparison of mitochondrial function using cooling plate or ice during mechanical separation of mouse skeletal muscle fibers.	LEAK OXPHOS ET	N S ROX	Permeabilized tissue	Mouse	Skeletal muscle
Makrecka-Kuka 2016 Abstract MitoFit Science Camp 2016	2016	Long-chain acylCoAs vs acylcarnitines in mitochondrial bioenergetics: from in vitro to in vivo.	OXPHOS	F	Isolated mitochondria	Rat	Heart
Neufer 2016 Abstract MitoFit Science Camp 2016	2016	Direct real-time quantification of mitochondrial oxidative phosphorylation efficiency in permeabilized skeletal muscle myofibers.	OXPHOS		Permeabilized tissue Isolated mitochondria		Skeletal muscle Blood cells
Marcinek 2016 Abstract MitoFit Science Camp 2016	2016	Targeting mitochondrial redox stress reveals two phases for reversal of mitochondrial dysfunction in aged mouse skeletal muscle.	OXPHOS		Permeabilized tissue	Mouse	Skeletal muscle
Krumschnabel 2016b Abstract MitoFit Science Camp 2016	2016	O2k-MultiSensor: Mitochondrial respiration media for HRR and simultaneous O2k-Fluorometry.	LEAK OXPHOS ET	N S NS ROX		Human	Kidney HEK
Volani 2016 Abstract MitoFit Science Camp 2016	2016	Effects of iron imbalances on mitochondrial activity in mouse liver homogenate and permabilized rat PBMCs.	LEAK OXPHOS ET	N S	Homogenate	Mouse Rat	Liver Blood cells Lymphocyte
Hoppel 2016c Abstract MitoFit Science Camp 2016	2016	Mitochondrial respiration in permeabilized skin fibroblasts.	OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Human	Endothelial;epithelial;mesothelial cell Fibroblast
Burtscher J 2016 Abstract MitoFit Science Camp 2016	2016	Oxidative phosphorylation in the healthy and epileptic mouse brain.	OXPHOS ET	N S	Homogenate	Mouse	Nervous system
Calzia 2016 Abstract MitoFit Science Camp 2016	2016	Mitochondrial respiration shows tissue- and strain-specific aging in short- and long-lived N. furzeri strains.	LEAK OXPHOS ET	NS		Fishes	Heart Skeletal muscle Nervous system Liver
Chicco 2016c Abstract MitoFit Science Camp 2016	2016	Investigating the mechanism of cardiac mitochondrial respiratory impairment in Barth Syndrome.	OXPHOS	F N S CIV Other combinations		Mouse	Heart
Maarman 2016 Abstract MitoFit Science Camp 2016	2016	Melatonin rescues uric acid-induced impairment of respiration in myotubes.	OXPHOS	N		Mouse	Skeletal muscle Other cell lines
Madlala 2016 Abstract MitoFit Science Camp 2016	2016	Fructose-induced defects in selected mitochondrial enzymes is detected by respirometry using glutamate&malate but not pyruvate&malate substrates.	LEAK OXPHOS ET	N	Permeabilized cells	Human	Liver
Herminghaus 2016 Abstract MitoFit Science Camp 2016	2016	Sterile laparotomy time-dependently modulates hepatic but not colonic mitochondrial function similar to moderate abdominal sepsis.	LEAK OXPHOS	N NS		Rat	Liver Endothelial;epithelial;mesothelial cell
Chicco 2016b Abstract MitoFit Science Camp 2016	2016	OXPHOS coupling efficiency of permeabilized muscle fibers predicts metabolic efficiency of subjects exercising at 5260 m.	LEAK OXPHOS ET	F N	Permeabilized tissue	Human	Skeletal muscle
Chicco 2016a Abstract MitoFit Science Camp 2016	2016	Oxygen dependence of H₂O₂ release from skeletal muscle and cardiac mitochondria: influence of sample preparation.	OXPHOS	NS	Permeabilized tissue Homogenate Isolated mitochondria	Mouse	Heart Skeletal muscle
Gnaiger 2016 Abstract UMDF2016	2016	Schöpf B, Schäfer G, Weber A, Talasz H, Eder IE, Klocker H, Gnaiger E (2016) Oxidative phosphorylation and mitochondrial function differ between human prostate tissue and cultured cells.	LEAK OXPHOS ET	F N NS	Permeabilized cells Permeabilized tissue	Human	Endothelial;epithelial;mesothelial cell Genital Other cell lines Fibroblast
Soendergaard 2016 Abstract IOC109	2016	Soendergaard SD (2016) Acute exposure of human muscle fibers to EPO or Actovegin has a marked effect on the mitochondrial respiratory capacity. Mitochondr Physiol Network 21.01.	OXPHOS ET	N NS	Permeabilized tissue	Human	Skeletal muscle
Sparagna 2016 Abstract IOC109	2016	Sparagna GC (2016) Measuring cardiac mitochondrial function in pediatric patients before and after implantation of a left ventricular assist device. Mitochondr Physiol Network 21.01.	LEAK OXPHOS	N S NS		Human	Heart
Sumbalova 2016 Abstract Mito Xmas Meeting Innsbruck	2016	Methods for evaluation of mitochondrial membrane potential with multi-sensor high-resolution respirometry: potentiometry vs fluorometry.	LEAK OXPHOS ET	F N S NS ROX		Mouse	Nervous system
Osiki 2016 Abstract MitoFit Science Camp 2016	2016	Suitability of octanoylcarnitine & malate for assessment of beta oxidation capacity by respirometry in aconitase-inhibited samples.	OXPHOS ET	F N Other combinations		Rat	Skeletal muscle
Davies 2016 Abstract Proceedings of The Physiological Society	2016	Development of mitochondrial function in the cortex and cerebellum of the ovine fetus.	LEAK OXPHOS	N S NS	Homogenate	Bovines	Nervous system
Hellgren 2016 Abstract Proceedings of The Physiological Society	2016	Sexual dimorphism in cardiac mitochondria following intrauterine hypoxia.	OXPHOS				Nervous system Heart
Volani 2016 Abstract Mito Xmas Meeting Innsbruck	2016	Effects of systemic iron perturbations on mitochondrial activity and on cellular metabolism in vivo.	LEAK ROUTINE OXPHOS ET	N S	Homogenate	Mouse	Liver
Schoepf 2016 Abstract Mito Xmas Meeting Innsbruck	2016	Mitochondrial function in primary prostate cancer.	LEAK OXPHOS ET	N S Other combinations	Permeabilized tissue	Human
Doerrier 2016b Abstract Mito Xmas Meeting Innsbruck	2016	Searching for specific targets of ischemic damage of cardiac mitochondria using O2k-Fluorometry.	LEAK OXPHOS ET	F N S Gp CIV ROX	Isolated mitochondria	Mouse	Heart
Garcia-Souza 2016 Abstract Mito Xmas Meeting Innsbruck	2016	Assessment of fatty acid oxidation in mouse brain and liver mitochondria.	OXPHOS	F N	Homogenate Isolated mitochondria		Nervous system Liver
Gnaiger 2016 Abstract Mito Xmas Meeting Innsbruck	2016	The world as a laboratory: exploring mitochondrial fitness.	OXPHOS			Human	Skeletal muscle
Laner 2016 Abstract Mito Xmas Meeting Innsbruck	2016	OXPHOS and ET capacity in permeabilized fibers of canine superathletes.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Dog	Skeletal muscle
Lamberti 2016 Abstract MitoFit Science Camp 2016	2016	Development of a reference sample for HRR.	LEAK ROUTINE OXPHOS ET	F N S Gp CIV NS Other combinations ROX		Human	Kidney HEK
Cecatto 2016 Abstract IOC116	2016	Cecatto C, Silva JC, Wajner A, Godoy KS, Ribeiro, RT, Amaral AU, Wajner M (2016) cis-4-Decenoic and decanoic acids impair mitochondrial energy, redox and Ca²⁺ homeostasis and induce mitochondrial permeability transition pore opening in rat brain and liver. Mitochondr Physiol Network 21.11	LEAK OXPHOS ET	F N CIV Other combinations	Permeabilized tissue Isolated mitochondria	Rat	Nervous system Liver
Sobotka 2016 Abstract IOC116	2016	Sobotka O, Kucera Otto, Stankova P, Endlicher R, Nozickova K, Banni A, Cervinkova Z (2016) Mitochondrial respiration in fatty liver. Mitochondr Physiol Network 21.11	LEAK OXPHOS ET	F N S Gp CIV NS Other combinations ROX	Isolated mitochondria	Rat	Liver
Sumbalova 2016b Abstract MitoFit Science Camp 2016	2016	Human blood cells: isolation and HRR.	LEAK ROUTINE OXPHOS ET	F N S Gp CIV NS Other combinations ROX	Permeabilized cells Intact cells	Human	Blood cells Lymphocyte Platelet
Laner 2016 Abstract MitoFit Science Camp 2016	2016	OXPHOS and ET-capacity in permeabilized fibers of canine superathletes. Analysis of HRR data presenting unexpected challenges.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Dog	Skeletal muscle
Sumbalova 2016a Abstract MitoFit Science Camp 2016	2016	Optimizing strategies on the malate concentration in SUIT protocols.	OXPHOS ET	N S NS		Rat	Nervous system
Kane 2016 Abstract MitoFit Science Camp 2016	2016	Effects of inhibiting myosin-ATPase on mitochondrial respiratory capacity in permeabilized skeletal muscle.	OXPHOS	F N	Permeabilized tissue	Rat	Skeletal muscle
Doerrier 2016 Abstract MitoFit Science Camp 2016	2016	Development of a SUIT reference protocol for OXPHOS analysis by high-resolution respirometry.	LEAK ROUTINE OXPHOS ET	F N S Gp CIV NS ROX	Permeabilized cells Permeabilized tissue Homogenate Isolated mitochondria	Human Mouse	Heart Blood cells HEK Platelet
Krumschnabel 2016a Abstract MitoFit Science Camp 2016	2016	O2k-Protocols: Mitochondrial preparations for HRR.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue Homogenate Isolated mitochondria	Mouse	Heart
Valenti 2015 Abstract MiPschool London 2015	2015	Different modulation of mitochondrial function by epigallocatechin-3 gallate in human disease: a matter of life and death.	OXPHOS				Endothelial;epithelial;mesothelial cell
Gnaiger 2015 Abstract MiP2015	2015	Mitochondrial function of cyropreserved HEK 293T cells: development of a reference sample for high-resolution respirometry.	LEAK ROUTINE OXPHOS ET	N S NS	Permeabilized cells Intact cells	Human	HEK
Hoppel 2015 Abstract MiP2015	2015	Effects of ultramarathon performance on mitochondrial respiration in human platelets.	ROUTINE OXPHOS ET	N S NS	Permeabilized cells	Human	Blood cells Platelet
Calzia 2015 Abstract MiP2015	2015	Mitochondrial respiration in homogenized small tissue biopsies from the M. Vastus lateralis of patients with Huntington's Disease before and after cycling exercise.	LEAK OXPHOS ET	N S ROX		Human	Skeletal muscle
Morris 2015 Abstract MiPschool Greenville 2015	2015	Intrinsic high aerobic capacity is associated with protection of mitochondrial respiratory capacity and decreased inflammation following chronic high-fat/high-cholesterol diet challenge.	OXPHOS ET	N		Rat	Liver
George 2015 Abstract MiPschool Greenville 2015	2015	Mitochondria do not directly oxidize lactate within the cerebral cortex or hippocampus.	OXPHOS	N	Permeabilized tissue	Human Mouse Rat	Skeletal muscle Nervous system
Matarne 2015 Abstract MiPschool Greenville 2015	2015	Chronic activation of AMP-activated protein kinase increases oxidative capacity and monocarboxylate transporter expression in skeletal muscle of pigs.	OXPHOS			Pig	Skeletal muscle
Funk 2015 Abstract MiPschool Greenville 2015	2015	Isolated mitochondria from liver and brain of long-lived growth hormone receptor gene disrupted mice demonstrate reduced respiration rates.	LEAK OXPHOS		Isolated mitochondria	Mouse	Nervous system Liver
Doerrier 2015 Abstract MiPschool Greenville 2015	2015	"Succinate paradox" study by high resolution respirometry combined with fluorometry and spectrofluorometry: NextGen-O2k.	LEAK OXPHOS	S	Isolated mitochondria	Mouse	Heart
Gnaiger 2015 Abstract DrugDiscovery conference 2015	2015	A lifestyle drug for mitochondrial fitness – from respiratory mitochondrial diagnosis to therapy.	OXPHOS			Human
Laner 2015 Abstract MiPschool Greenville 2015	2015	Comparative mitochondrial physiology: OXPHOS and ET capacity in permeabilized fibers of canine superathletes.	OXPHOS ET	F N S NS	Permeabilized tissue	Dog	Skeletal muscle
Sheldon 2015 Abstract MiPschool Greenville 2015	2015	eNOS is required to preserve hepatic mitochondrial function in western diet-induced nonalcoholic fatty liver disease.	LEAK OXPHOS ET	N NS		Mouse	Liver
Bhattarai 2015 Abstract MiPschool Greenville 2015	2015	Exercise improves whole-body and skeletal muscle oxidative capacity in burned children.	OXPHOS		Permeabilized tissue	Human	Skeletal muscle
Hill 2015 Abstract MiPschool London 2015	2015	A novel inhibitor of the mitochondrial permeability transition pore is beneficial in an experimental model of multiple sclerosis.	OXPHOS ET		Isolated mitochondria	Mouse	Liver
Ljubkovic 2015 Fatty Acid Oxidation O2k-Network Discussion Forum	2015	Ljubkovic 2015 Fatty Acid Oxidation O2k-Network Discussion Forum	OXPHOS ET	F N NS	Permeabilized tissue	Human	Heart
De Bari 2015 Abstract MiPschool London 2015	2015	The mitochondrial metabolism of lactate isomers in human prostate cancer cells.	OXPHOS		Homogenate Isolated mitochondria	Human	Genital
Nuskova 2015 Abstract MiPschool London 2015	2015	Insufficient energy provision or increased oxidative stress – what matters more in ATP synthase deficiencies?	ROUTINE OXPHOS			Human	HEK
Ali 2015 Abstract MiPschool Cape Town 2015	2015	Early gender-related dimorphism in heart and brain mitochondria function and ROS dynamics.	LEAK OXPHOS ET			Mouse	Heart Nervous system
Ojuka 2015 Abstract MiPschool Cape Town 2015	2015	Use of malate or carnitine as co-substrates for assessment of fatty acid oxidation.	LEAK OXPHOS ET		Permeabilized cells Permeabilized tissue Isolated mitochondria
Maarman 2015 Abstract MiPschool Cape Town 2015	2015	Characterisation of mitochondrial function in a model of pulmonary hypertension-induced right ventricular failure.	LEAK OXPHOS	N S NS	Isolated mitochondria	Rat	Heart
Gnaiger 2015 Abstract MiPschool Cape Town 2015 II	2015	On coupling control of mitochondrial respiration. What is wrong with the RCR?	LEAK ROUTINE OXPHOS ET	N S ROX
Ost 2015 Abstract IOC100	2015	Ost M (2015) “Mitokines” and the organismal role of mitochondrial function in energy homeostasis & metabolism. Mitochondr Physiol Network 20.01.	LEAK OXPHOS		Permeabilized tissue	Mouse	Skeletal muscle Fibroblast
Laner 2015 Abstract MiPschool Cape Town 2015	2015	The Oroboros Oxygraph-2k for high-resolution respirometry and O2k-Fluorometry: a new quality in OXPHOS analysis.	LEAK ROUTINE OXPHOS ET	N S NS	Isolated mitochondria Intact cells	Mouse Saccharomyces cerevisiae	Heart
Gnaiger 2015 Abstract MiPschool Cape Town 2015	2015	The functional design of the electron transfer system (ETS) and mitochondrial respiratory control.	LEAK ROUTINE OXPHOS ET	N S NS	Permeabilized cells Permeabilized tissue Homogenate Isolated mitochondria
Oliveira 2015 Abstract IOC100	2015	Oliveira MT, Saari S, Andjelkovic A, Jacobs HT (2015) Investigating the metabolic alterations caused by the transgenic expression of the mitochondrial alternative oxidase of Ciona intestinalis in Drosophila melanogaster. Mitochondr Physiol Network 20.01.	OXPHOS			Hexapods Other invertebrates
Brown 2015 Abstract MiPschool Cape Town 2015	2015	Protection of post-ischemic mitochondrial bioenergetics by targeting cardiolipin-dependent membrane fluidity.	OXPHOS	N S NS	Intact organism Permeabilized tissue Isolated mitochondria	Rat	Heart
Pretorius 2015 Abstract MiPschool Cape Town 2015	2015	Metallothioneins are involved in mitochondrial function and disease.	OXPHOS			Mouse
Madlala 2015 Fatty Acid Oxidation O2k-Network Discussion Forum	2015	Madlala 2015 Fatty Acid Oxidation O2k-Network Discussion Forum	OXPHOS	F	Permeabilized tissue	Rat	Skeletal muscle
Lindquist 2015 Abstract IOC106	2015	Alteraas EK, Lindquist C, Berge RK, Bjorndal B (2015) OXPHOS capacity in mouse liver altered by modified fatty acids that inhibit or stimulate beta-oxidation. Mitochondr Physiol Network 20.10.	OXPHOS ET		Homogenate	Mouse	Liver
Coen 2015 Fatty Acid Oxidation O2k-Network Discussion Forum	2015	Coen 2015 Fatty Acid Oxidation O2k-Network Discussion Forum	OXPHOS	F N NS	Permeabilized tissue
McCurdy 2015 Fatty Acid Oxidation O2k-Network Discussion Forum	2015	Cannon 2015 Fatty Acid Oxidation O2k-Network Discussion Forum	OXPHOS	F N	Permeabilized tissue	Other mammals	Skeletal muscle
Chou 2015 Fatty Acid Oxidation O2k-Network Discussion Forum	2015	Chou 2015 Fatty Acid Oxidation O2k-Network Discussion Forum	OXPHOS ET	F N S NS ROX	Permeabilized cells Permeabilized tissue		Blood cells Lymphocyte Platelet
Ciapaite 2015 Fatty Acid Oxidation O2k-Network Discussion Forum	2015	Ciapaite 2015 Fatty Acid Oxidation O2k-Network Discussion Forum	LEAK OXPHOS ET	F	Permeabilized tissue	Human Rat	Skeletal muscle
Chavanelle 2015 Fatty Acid Oxidation O2k-Network Discussion Forum	2015	Chavanelle 2015 Fatty Acid Oxidation O2k-Network Discussion Forum	LEAK OXPHOS	F N	Permeabilized tissue	Mouse	Skeletal muscle
Schauer 2015 Fatty Acid Oxidation O2k-Network Discussion Forum	2015	Schauer 2015 Fatty Acid Oxidation O2k-Network Discussion Forum	OXPHOS ET	F	Permeabilized tissue
Smith 2015 Fatty Acid Oxidation O2k-Network Discussion Forum	2015	Smith 2015 Fatty Acid Oxidation O2k-Network Discussion Forum	OXPHOS ET	F	Permeabilized tissue
Ojuka 2015 Fatty Acid Oxidation O2k-Network Discussion Forum	2015	Ojuka 2015 Fatty Acid Oxidation O2k-Network Discussion Forum	OXPHOS ET	F	Permeabilized tissue
Wuest 2015 Fatty Acid Oxidation O2k-Network Discussion Forum	2015	Wuest 2015 Fatty Acid Oxidation O2k-Network Discussion Forum	OXPHOS ET	F N S NS ROX	Permeabilized tissue	Rat	Heart
Karabatsiakis 2015 Abstract MiP2015	2015	Mitochondrial respiration of peripheral blood mononuclear cells in patients with borderline personality disorder.	LEAK ROUTINE OXPHOS ET	ROX		Human	Blood cells
Cannon 2015 Fatty Acid Oxidation O2k-Network Discussion Forum	2015	Cannon 2015 Fatty Acid Oxidation O2k-Network Discussion Forum	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Human Mouse	Skeletal muscle
Volani 2015 Abstract IOC106	2015	Volani C, Haschka D, Demetz E, Doerrier C, Gnaiger E, Weiss G (2015) Determination of mitochondrial respiration in peripheral blood mononuclear cells. Mitochondr Physiol Network 20.10.	ROUTINE OXPHOS ET	N S	Homogenate Intact cells	Human Mouse	Heart Liver Blood cells Lymphocyte
Laner 2015 Abstract MiP2015	2015	Comparative mitochondrial physiology: OXPHOS and ET capacity in permeabilized fibers of canine superathletes.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Dog	Skeletal muscle
Sumbalova 2015 Abstract MiP2015	2015	High-resolution measurement of mitochondrial membrane potential and respiration – comparison of potentiometric and fluorometric methods.	LEAK OXPHOS ET	N S NS	Isolated mitochondria	Mouse	Nervous system
Renshaw 2015 Abstract MiP2015	2015	Mitochondrial responses to thermal stress: is the ability to withstand anoxia-induced stress associated with cross-tolerance to thermal stress?	LEAK OXPHOS ET	N S	Homogenate	Fishes	Nervous system
Doerrier 2015 Abstract MiP2015	2015	Simultaneous measurement of mitochondrial respiration, hydrogen peroxide production, and NADH autofluorescence to assess mitochondrial function.	LEAK OXPHOS	S	Isolated mitochondria	Mouse	Heart
Devaux 2015 Abstract MiP2015	2015	Mitochondrial complexes I and II behave differently in two anoxia-tolerant species: adaptive mitochondrial plasticity may be related to the ability to undergo metabolic depression.	LEAK OXPHOS ET	N S	Homogenate	Fishes	Nervous system
Boyle 2015 Abstract MiP2015	2015	Kv1.3 channels in mitochondria: Are they important in cellular proliferation?	OXPHOS			Human	Endothelial;epithelial;mesothelial cell HEK
Weidgang 2015 Abstract MiP2015	2015	Mitochondrial respiration in homogenized biopsies from kidney, liver, heart and diaphragm from mice after blunt thoracic trauma and hemorrhagic shock. Effects of a novel hydrogen sulfide donor AP39.	LEAK OXPHOS ET	N S	Homogenate	Mouse	Heart Skeletal muscle Liver Kidney
Sleiman 2015 Abstract MiP2015	2015	Mitochondrial respiration in sequential biospies from skeletal muscles during hemorrhagic shock and over the course of 48h of reperfusion in pigs.	LEAK OXPHOS ET	N S	Homogenate	Pig	Skeletal muscle
Shevchuk 2015 Abstract MiP2015	2015	Analysis of energy fluxes in colorectal cancer saponin skinned tissues and Caco-2 cells.	OXPHOS	N S	Permeabilized cells	Human	Endothelial;epithelial;mesothelial cell
Rohlena 2015 Abstract MiP2015	2015	Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation.	ROUTINE OXPHOS ET	S ROX	Permeabilized cells Isolated mitochondria	Human	Other cell lines
Ali 2015 Abstract MiP2015	2015	Mitochondrial function and ROS homeostasis in young mouse heart and brain: the sex factor!	LEAK OXPHOS ET		Homogenate	Mouse	Heart Nervous system
Sparks 2014 Abstract MiP2014	2014	NAMPT remodels substrate metabolism in skeletal muscle.	LEAK OXPHOS	N S	Permeabilized tissue	Mouse	Skeletal muscle
Zorzano 2014 Abstract MiP2014	2014	Metabolic implications of mitofusin 2 dysfunction.	LEAK OXPHOS			Mouse	Skeletal muscle
Sumbalova 2014 Abstract MiP2014	2014	Optimization of malate concentration for high-resolution respirometry: mitochondria from rat liver and brain.	OXPHOS ET	F N S NS	Isolated mitochondria	Rat	Nervous system Liver
Volodina 2014 Abstract MiP2014	2014	Multipotent stromal cells injection improves rat liver regeneration through activation of mitochondrial functions after subtotal hepatectomy.	LEAK OXPHOS ET	N NS	Isolated mitochondria	Rat	Liver
Zapisek 2014 Abstract MiP2014	2014	YER077C encodes a novel PPR protein essential for mitochondrial genome expression in Saccharomyces cerevisiae.	OXPHOS			Saccharomyces cerevisiae
Wohlwend 2014 Abstract MiP2014	2014	Exercise modality specific mitochondrial adaptations in skeletal muscle of elderly people.	OXPHOS	N NS	Permeabilized cells	Human	Skeletal muscle
Maddalena 2014 Abstract MiP2014	2014	Experimental considerations for evaluating bioenergetic effects of a mitochondria-targeted compound, TPP-IOA.	OXPHOS		Isolated mitochondria
Paes 2014 Abstract IOC 2014-04 Schroecken	2014	Paes MC, Saraiva FMS, Nogueira NP, Laranja GAT, Coelho MGP, Oliveira MF (2014) Heme increases mitochondrial membrane potential and ROS production in Trypanosoma cruzi epimastigotes. Mitochondr Physiol Network 19.02.	LEAK OXPHOS ET	S Other combinations	Permeabilized cells Oxidase;biochemical oxidation	Protists
Mendonca 2014 Abstract IOC 2014-04 Schroecken	2014	Mendonca AP, Rodrigues MF, Amoedo ND, Oliveira MF (2014) Effects of iron on mitochondrial physiology of central nervous system cell lines. Mitochondr Physiol Network 19.02.	LEAK OXPHOS ET				Nervous system Other cell lines Neuroblastoma
Maedo 2014 Abstract IOC 2014-04 Schroecken	2014	Maedo K, Kaldma A, Planken A, Klepinin A, Chekulayev V, Varikmaa M, Tepp K, Chevchuk I, Kaambre T (2014) Regulation of mitochondrial respiration in human colorectal cancer cells in situ: the possible role of beta-tubulins. Mitochondr Physiol Network 19.02.	OXPHOS		Permeabilized tissue	Human	Endothelial;epithelial;mesothelial cell
Amoedo 2014 Abstract MiP2014	2014	The metabolic panorama during tumor progression towards malignancy.	OXPHOS	F S	Permeabilized cells		Other cell lines
Bristot 2014 Abstract MiP2014	2014	High-resolution respirometry and bioenergetics evaluation in fibroblasts derived from patients with TP53 germline mutations.	LEAK OXPHOS		Intact cells	Human	Fibroblast
Brown DA 2014 Abstract MiP2014	2014	The cardiolipin-targeting peptide Bendavia preserves post-ischemic mitochondrial energetics by sustaining respiratory supercomplexes.	OXPHOS	N S	Permeabilized tissue	Rat	Heart
Burtscher 2014 Abstract MiP2014	2014	Region-specific differences in Complex I- and Complex II-linked respiration in the mouse brain.	OXPHOS ET	N S CIV NS	Permeabilized tissue	Mouse	Nervous system
Busch 2014 Abstract MiP2014	2014	Mitochondrial fusion and fission dynamics are indispensable for homogenization of inner mitochondrial membrane proteins: insights from superresolution studies.	OXPHOS			Human
Schoepf 2014 Abstract MiP2014	2014	OXPHOS analysis in small prostate biopsies.	LEAK OXPHOS ET	N S CIV NS	Permeabilized tissue	Human	Genital
Dohlmann 2014 Abstract MiP2014	2014	Mitochondrial adaptations to high-intensity training in young and elderly men and women.	OXPHOS ET		Permeabilized cells	Human	Skeletal muscle HeLa Fibroblast
Mracek 2014 Abstract MiP2014	2014	Function of mitochondrial energy provision apparatus is compromised in patients with chronic heart failure. Mitochondr Physiol Network 19.13.	OXPHOS	S	Permeabilized tissue	Human	Heart
Neufer 2014 Abstract MiP2014	2014	Assessing ATP production and oxygen consumption simultaneously in permeabilized fibers: ATP/O.	OXPHOS		Permeabilized tissue	Mouse	Skeletal muscle
Paju 2014 Abstract MiP2014	2014	Characterization of the effects of pro-inflammatory cytokines on energy metabolism in human myoblasts.	OXPHOS	N S	Permeabilized cells	Human	Skeletal muscle
Pecina 2014 Abstract MiP2014	2014	Manifestation of mitochondrial disorders of nuclear origin in lymphocytes.	OXPHOS	N S Gp CIV	Permeabilized cells	Human	Blood cells Lymphocyte
Perry 2014 Abstract MiP2014	2014	Evaluation of critical experimental parameters for assessing mitochondrial bioenergetics in permeabilized myofibers.	OXPHOS		Permeabilized tissue	Human	Skeletal muscle
Power 2014 Abstract MiP2014	2014	The hot heart: cardiac mitochondrial energetics during hyperthermia.	LEAK OXPHOS		Isolated mitochondria	Rat	Heart
Porter 2014 Abstract IOC95	2014	Porter C (2014) The impact of resistance exercise training on skeletal muscle mitochondrial respiration in healthy young adults. Mitochondr Physiol Network 19.10	LEAK OXPHOS ET		Permeabilized tissue	Human	Skeletal muscle
Grefte 2014 Abstract MiP2014	2014	Myotube formation does not require mitochondrial ATP production but is inhibited by rotenone via the Rho-associated, coiled-coil containing protein kinase II.	OXPHOS			Mouse	Skeletal muscle
Hahn 2014 Abstract MiP2014	2014	Validation of oxygen consumption measurements in muscle and fibroblasts from patients with mitochondrial diseases.	OXPHOS		Permeabilized cells	Human	Skeletal muscle Fibroblast
Harrison 2014 Abstract MiP2014	2014	The relationship between cytochrome redox state and oxygen consumption in isolated mouse and beef heart mitochondria during hypoxia.	OXPHOS		Isolated mitochondria	Rat Bovines	Heart
Hepple 2014 Abstract MiP2014	2014	Denervation modulates mitochondrial function when aging muscle atrophy becomes severe: implications for therapeutic intervention.	OXPHOS		Permeabilized tissue	Human	Skeletal muscle
Herbst 2014 Abstract MiP2014	2014	Analysis of mitochondrial function in multiple brain regions through in situ permeabilization.	OXPHOS		Permeabilized tissue Isolated mitochondria	Mouse	Nervous system
Herminghaus 2014 Abstract MiP2014	2014	Severity of polymicrobial sepsis modulates mitochondrial function in rat liver.	LEAK OXPHOS	N S	Isolated mitochondria	Rat	Liver
Hickey 2014 Abstract MiP2014	2014	Mitochondrial inefficiencies and anoxic ATP hydrolysis capacities in diabetic rat heart.	OXPHOS	N S	Permeabilized tissue	Rat	Heart
Horscroft 2014 Abstract MiP2014	2014	Substrate utilisation in the hypoxic heart: a glycolysis/glucose oxidation mismatch?	OXPHOS	F N		Rat	Heart
Jana Prado 2014 Abstract MiP2014	2014	Defining the role of mitochondrial electron transfer Complex I on the modulation of Ca²⁺ homeostasis: effects of metformin on cancer cell metabolism. Mitochondr Physiol Network 19.13.	OXPHOS
Jezek 2014 Abstract MiP2014	2014	Mitochondrial cristae morphology changes: from Hackenbrock to hypoxia.	LEAK OXPHOS		Isolated mitochondria		Other cell lines
Kandashvili 2014 Abstract MiP2014	2014	Regulation of energy metabolism in human colorectal cancer cells in situ.	OXPHOS		Permeabilized tissue	Human	Endothelial;epithelial;mesothelial cell
Kluckova 2014 Abstract MiP2014	2014	Proximal ubiquinone binding site in mitochondrial respiratory Complex II is a target for vitamin E analog MitoVES, an experimental anti-cancer agent. Mitochondr Physiol Network 19.13.	OXPHOS ET	S			Other cell lines
Krumschnabel 2014 Abstract MiP2014	2014	Simultaneous high-resolution measurement of mitochondrial respiration and hydrogen peroxide production.	LEAK OXPHOS ET	N S NS	Homogenate Isolated mitochondria	Mouse	Nervous system
Gnaiger 2014 Abstract MiP2014	2014	Cell ergometry: OXPHOS and ET-pathway coupling efficiency.	OXPHOS
Laner 2014 Abstract MiP2014	2014	Cytochrome c flux control factor as a quality criterion in respiratory OXPHOS analysis in canine permeabilized fibers.	LEAK ROUTINE OXPHOS ET	N NS	Permeabilized tissue	Dog	Skeletal muscle
Dennerlein 2014 Abstract IOC96	2014	Dennerlein S (2014) Insights into COX-assembly: An important but not the only OXPHOS complex. Mitochondr Physiol Network 19.11.	OXPHOS			Human
Sobotka 2014 Abstract IOC95	2014	Sobotka O (2014) Effect of α-Tocopheryl succinate on Complex II. Mitochondr Physiol Network 19.10	OXPHOS	S	Homogenate Isolated mitochondria	Rat	Heart Liver
Doerrier 2014 Abstract SECF	2014	Evaluation of melatonin treatment in mitochondria of permeabilized myocardial fibers from septic mice.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue Isolated mitochondria	Mouse	Heart
Larsen 2014 Abstract MiP2014	2014	The effect of high intensity training on mitochondrial fat oxidation in skeletal muscle and subcutaneous adipose tissue.	OXPHOS	F N S NS	Permeabilized tissue	Human	Skeletal muscle Fat
Lai 2014 Abstract1 MiP2014	2014	Improved isolation of high quality subsarcolemmal and interfibrillar mitochondria from skeletal muscle.	LEAK OXPHOS	N	Isolated mitochondria	Rat Dog	Heart Skeletal muscle Fibroblast
Komlodi 2014 Abstract MiP2014	2014	Methylenblue, an enhancer of mitochondrial substrate-level phosphorylation.	OXPHOS ET	N S	Isolated mitochondria	Guinea pig	Nervous system
Dungel 2013 Abstract MiP2013	2013	Dungel P, Perlinger M, Faulhammer B, Weidinger A, Redl H, Kozlov AV (2013) Iron-mediated injury of mitochondria is attenuated by nitrite. Mitochondr Physiol Network 18.08.	OXPHOS	N S	Isolated mitochondria	Rat	Liver
Darveau 2013 Abstract MiP2013	2013	Darveau CA, Teulier L, Crevier J, Weber JM (2013) Diversity and evolution of mitochondrial metabolism: Proline as a metabolic reward for pollinators. Mitochondr Physiol Network 18.08.	OXPHOS	N S Gp NS Other combinations	Permeabilized tissue	Hexapods	Skeletal muscle
Dzialowski 2013 Abstract MiP2013	2013	Dzialowski EM, Ream S, Duquaine A, Sirsat TS, Goy Sirsat SK (2013) Mitochondrial function and the development of endothermy in the precocial Pekin duck (Anas pekin). Mitochondr Physiol Network 18.08.	LEAK OXPHOS ET	F N S NS	Intact organism Permeabilized tissue	Birds	Skeletal muscle
Hickey 2013 Abstract MiP2013	2013	Hickey AJ, Iftikar FI, MacDonald J, Baker D (2013) Mitochondria in a changing climate? The role of mitochondrial in hyperthermic heart failure in different fish species. Mitochondr Physiol Network 18.08.	LEAK ROUTINE OXPHOS ET	N S CIV NS	Permeabilized tissue	Other mammals Fishes	Heart
Irving 2013 Abstract MiP2013	2013	Irving BA, Stahl R, Kane CJ, Chernousov M, Argyropoulos G, Carey D (2013) Sex differences in murine mitochondrial oxidative capacity following a 24 week high-fat diet. Mitochondr Physiol Network 18.08.	LEAK OXPHOS ET	N NS	Permeabilized tissue Homogenate	Mouse	Skeletal muscle Liver Fat
Garcia-Roves 2013 Abstract MiP2013	2013	Garcia-Roves PM, Gonzalez-Franquesa A, Martinez-Navarro L, Fernandez-Ruiz R (2013) Metabolic flexibility before and after lifestyle intervention in a diet-induced type 2 diabetes animal model. Mitochondr Physiol Network 18.08.	LEAK OXPHOS ET	N S CIV NS	Permeabilized cells Permeabilized tissue Homogenate	Mouse	Skeletal muscle Nervous system Liver Islet cell;pancreas;thymus Fat
Jezek 2013 Abstract MiP2013	2013	Ježek P, Ježek J, Zelenka J, Dlasková A, Jabůrek M (2013) Antioxidant synergy of mitochondrial uncoupling protein UCP2 and phospholipase iPLA2γ. Mitochondr Physiol Network 18.08.	LEAK ROUTINE OXPHOS ET	N S ROX	Isolated mitochondria Intact cells	Mouse	Lung;gill Islet cell;pancreas;thymus
Hand 2013 Abstract MiP2013	2013	Hand SC, Patil Y (2013) Defense against ATP depletion during the energy-limited state of diapause. Mitochondr Physiol Network 18.08.	LEAK OXPHOS ET	N S	Intact organism Homogenate Isolated mitochondria Enzyme	Artemia Crustaceans
Schulte 2013 Abstract MiP2013	2013	Chung DJ, Schulte PM, Richards JG (2013) The effect of low-temperature acclimation on mitochondrial function in the common killifish (Fundulus heteroclitus), a top-down elasticity analysis. Mitochondr Physiol Network 18.08.	LEAK OXPHOS		Isolated mitochondria	Fishes	Liver
Bir 2013 Abstract MiP2013	2013	Bir A, Sen O, Anand S, Banerjee P, Sahoo A, Khemka V, Cappai R, Chakrabarti S (2013) α-Synuclein mediated alterations in mitochondrial oxidative phosphorylation system: Implications in the pathogenesis of Parkinson’s disease. Mitochondr Physiol Network 18.08.	OXPHOS		Isolated mitochondria Intact cells	Rat	Nervous system Other cell lines
Chicco 2013 Abstract MiP2013 Poster	2013	Chicco AJ, Claiborne MS, Le CH, Mulligan CM (2013) Remodeling of skeletal muscle mitochondria in response to exercise training in taz shRNA mouse model of human Barth Syndrome. Mitochondr Physiol Network 18.08.	OXPHOS	N	Isolated mitochondria	Mouse	Skeletal muscle
Christen 2013 Abstract MiP2013	2013	Christen F, Desrosiers V, Blier PU (2013) Thermal sensitivity of mitochondria from arctic charr heart: Mitochondrial respiration and ROS production. Mitochondr Physiol Network 18.08.	OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Other mammals Fishes	Heart
Jacobs 2013 Abstract MiP2013	2013	Jacobs R, Flück D, Bonne TC, Bürgi S, Christensen PM, Toigo M, Lundby C (2013) Improvements in exercise performance with high-intensity interval training are facilitated by an increase in skeletal muscle mitochondria content. Mitochondr Physiol Network 18.08.	OXPHOS		Intact organism Permeabilized tissue	Human	Skeletal muscle
Larsen FJ 2013 Abstract MiP2013	2013	Larsen FJ, Schiffer TA, Lundberg JO, Weitzberg E (2013) Human mitochondria has a unique response to ischemia-reperfusion injury compared to mitochondria from rat, mouse and pig . Mitochondr Physiol Network 18.08.	OXPHOS	ROX	Isolated mitochondria	Human Pig Mouse Rat
Kotwica 2013 Abstract MiP2013	2013	Kotwica AO, Horscroft JA, Murray AJ(2013) Mitochondrial respiration in heart and soleus of ob/ob mice. Mitochondr Physiol Network 18.08.	LEAK OXPHOS	F N S	Permeabilized tissue	Mouse	Heart Skeletal muscle
Korzeniewski 2013 Abstract MiP2013	2013	Korzeniewski B (2013) Regulation of oxidative phosphorylation during work transitions in different tissues results from its kinetic properties. Mitochondr Physiol Network 18.08.	LEAK OXPHOS				Heart Skeletal muscle
Chicco 2013 Abstract MiP2013	2013	Chicco AJ, Le CH, Schlater A, Kanatous S (2013) Comparative muscle mitochondrial physiology of the northern elephant seal. Mitochondr Physiol Network 18.08.	LEAK OXPHOS ET	F N Other combinations	Permeabilized tissue	Human Other mammals	Skeletal muscle
Calzia 2013 Abstract MiP2013	2013	Calzia E, Wagner K, Wagner F, Groeger M, Matallo J, McCook O, Wachter U, Vogt J, Radermacher P (2013) Studying mitochondrial effects of sulfide. Does the species matter? Mitochondr Physiol Network 18.08.	LEAK OXPHOS ET			Pig Mouse	Liver
Brandt 2013 Abstract MiP2013	2013	Brandt T, Mourier A, Stewart JB, Larsson NG, Kühlbrandt W (2013) Structure and function of aged mouse mitochondria. Mitochondr Physiol Network 18.08.	OXPHOS		Isolated mitochondria	Mouse	Heart Liver Kidney
Boushel 2013 Abstract MiP2013	2013	Boushel RC (2013) Convective O₂ delivery, diffusion and mitochondrial OXPHOS components of V_O2 during exercise in health and disease. Mitochondr Physiol Network 18.08.	OXPHOS	N S NS	Intact organism Permeabilized cells Permeabilized tissue	Human	Skeletal muscle
Borutaite 2013 Abstract MiP2013	2013	Borutaite V, Jablonskiene G, Arandarcikaite O (2013) Mitochondrial response to heart and brain ischemia. Mitochondr Physiol Network 18.08.	LEAK OXPHOS	N S	Isolated mitochondria	Pig Rat	Heart Nervous system
Blier 2013 Abstract MiP2013	2013	Blier PU, Lemieux H, Pichaud N (2013) Holding our breath in our modern world: are mitochondria keeping the pace with global changes? Mitochondr Physiol Network 18.08.	OXPHOS			Other invertebrates
Amoedo 2013 Abstract MiP2013	2013	Amoêdo ND, Rodrigues MF, Pereira S, Melo F, Jasiulionis M, Galina A, Rumjanek FD(2013) Comparative biochemistry of tumorigenesis: role of mitochondria in the metastatic process. Mitochondr Physiol Network 18.08.	LEAK ROUTINE OXPHOS ET	N S ROX	Permeabilized cells Enzyme Intact cells	Mouse	Endothelial;epithelial;mesothelial cell Other cell lines
Shabalina 2013 Abstract IOC79	2013	Shabalina IG (2013) Enhanced Complex I but low Complex II substrate-derived ROS production rates in mice, prematurely aging due to enhanced mitochondrial DNA mutation rate. Mitochondr Physiol Network 18.07	LEAK OXPHOS ET	N S NS	Isolated mitochondria	Mouse	Heart Skeletal muscle Liver
Gnaiger 2013 Abstract Neurocon Kolkata	2013	Gnaiger E (2013) Body mass index and the risk of neurodegeneration: from mitochondrial fitness to brain function. Abstract Neurocon 2013, Kolkata, India. Symposium: Neurocon 2013. January 17-20.	OXPHOS		Permeabilized tissue	Human	Skeletal muscle
Oliveira Pinto 2013 Abstract IOC75	2013	Oliveira Pinto M (2013) Studies on the energy and redox metabolism of the blood fluke Schistosoma mansoni. Mitochondr Physiol Network 18.03.	OXPHOS	Other combinations	Intact organism	Other invertebrates
Laner 2013 ASMRM	2013	Laner V, Gradl P, Eigentler A, Fontana-Ayoub M, Fasching M, Gnaiger E (2013) The Oroboros O2k for high-resolution respirometry and O2k-Fluorometry: a new quality in OXPHOS analysis. ASMRM2013.	LEAK OXPHOS ET	N S NS	Homogenate	Mouse	Heart
Hendricks 2013 Abstract MiP2013	2013	Hendricks E, Nathan BP, Menze MA (2013) Bioenergetics of permeabilized and intact nerve cell terminals from ApoE deficient and wild type mice. Mitochondr Physiol Network 18.08.	LEAK ROUTINE OXPHOS ET	N S NS	Intact cells Permeabilized cells Isolated mitochondria	Mouse	Nervous system
Gnaiger 2013 Abstract MiP2013	2013	Gnaiger E, Søndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Díez-Sánchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet J, Christiansen M, Helge JW, Saltin B, Boushel R (2013) Biochemical coupling efficiency in permeabilized fibers from arm and leg muscle in Inuit versus Caucasians: A functional test of the uncoupling hypothesis in Greenland. Mitochondr Physiol Network 18.08.	LEAK OXPHOS ET	F N S NS	Permeabilized tissue	Human	Skeletal muscle
Menze 2013 Abstract MiP2013	2013	Menze MA, Marunde MA, Samarajeewa DA, Anderson J, Li S, Hand SC (2013) Group1 LEA protein ameliorates inhibition of mitochondrial respiration in Drosophila melanogaster Kc167 cells and isolated mitochondria. Mitochondr Physiol Network 18.08.	LEAK ROUTINE OXPHOS	N	Intact organism Intact cells Permeabilized cells Isolated mitochondria Enzyme	Drosophila Artemia Crustaceans Hexapods	Other cell lines CHO HEK Macrophage-derived
Prouteau-Angebault 2013 Abstract IOC75	2013	Prouteau-Angebault C (2013) Are cardiolipins involved in the mitochondrial respiratory chain defect in OPA1 mouse model? Mitochondr Physiol Network 18.03.	OXPHOS	N S CIV	Permeabilized cells Homogenate Isolated mitochondria	Mouse	Skeletal muscle Nervous system
Camacho-Pereira 2013 Abstract IOC75	2013	Camacho-Pereira J (2013) CD38 as a regulator of mitochondrial function. Mitochondr Physiol Network 18.03.	LEAK ROUTINE OXPHOS ET	N S NS	Intact cells Permeabilized cells Isolated mitochondria	Mouse	Liver HEK Macrophage-derived
Lemieux 2013 Abstract MiP2013	2013	Lemieux H, Warren BE, Lucchinetti E, Lou PH, Zhang L, Gandhi M, Clanachan AS, Zaugg M(2013) Early mitochondrial dysfunction associated with type 2 diabetes mellitus in the heart and skeletal muscle. Mitochondr Physiol Network 18.08.	OXPHOS	F N S CIV NS Other combinations	Permeabilized tissue	Rat	Heart Skeletal muscle
Larsen S 2013 Abstract MiP2013	2013	Larsen S, Dohlmann TL, Hindsø M, Dela F, Helge JW (2013) High intensity training decreases mitochondrial ADP sensitivity in human adipose and skeletal muscle tissue. Mitochondr Physiol Network 18.08.	OXPHOS		Intact organism Permeabilized tissue	Human	Skeletal muscle Fat
DeLany 2013 TOS	2013	Skeletal muscle mitochondrial respiration is lower in African American compared to Caucasian women and is associated with resting metabolic rate and cardiorespiratory fitness.	LEAK OXPHOS		Permeabilized tissue	Human	Skeletal muscle
Gnaiger 2013 Abstract Mito2013	2013	Gnaiger E, Søndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Díez-Sánchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet J, Christiansen M, Helge JW, Saltin B, Boushel R (2013) Conserved mitochondrial coupling efficiency and adaptive substrate control in Inuit and Caucasians: adaptation and acclimatization to the Arctic winter.	LEAK OXPHOS ET	F N S NS	Permeabilized tissue	Human	Skeletal muscle
Gnaiger 2013 Abstract ASMRM	2013	Gnaiger E(2013) Loss of mitochondrial competence and degenerative disease: cause and effect. Abstract ASMRM-Seoul.	LEAK OXPHOS			Human
Pecina 2013 Abstract MiP2013	2013	Pecina P, Houšťková H, Mráček T, Pecinová A, Nůsková H, Tesařová M, Hansíková H, Janota J, Zeman J, Houštěk J (2013) The use of lymphocytes for diagnostics of mitochondrial oxidative phosphorylation disorders. Mitochondr Physiol Network 18.08.	LEAK OXPHOS ET	N S Gp NS Other combinations ROX	Permeabilized cells Homogenate	Human	Blood cells Lymphocyte
Krumschnabel 2013 Abstract MiP2013	2013	Krumschnabel G, Eigentler A, Fontana-Ayoub M, Draxl A, Fasching M, Gnaiger E (2013) Tissue homogenates for respiratory OXPHOS analysis in comparative mitochondrial physiology: mouse and trout – heart and liver. Mitochondr Physiol Network 18.08.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Mouse Fishes	Heart Nervous system Liver
Dela 2013 Abstract MiP2013	2013	Dela F (2013) Glucose tolerance and skeletal muscle coenzyme Q(10). Mitochondr Physiol Network 18.08.	OXPHOS	N S NS	Permeabilized tissue	Human	Skeletal muscle
Scott 2013 Abstract MiP2013	2013	Scott GR, Mahalingam S, McClelland GB(2013) Mitochondrial adaptations to hypoxia in high-altitude birds and mammals. Mitochondr Physiol Network 18.08.	LEAK OXPHOS		Isolated mitochondria Enzyme	Other mammals Birds	Skeletal muscle
Chicco 2013 Abstract IOC79	2013	Chicco AJ (2013) Substrate-specific impairment of oxidative phosphorylation in Tafazzin-deficient cardiac mitochondria: potential role of CoA deficiency. Mitochondr Physiol Network 18.07	OXPHOS	F N S	Permeabilized cells Isolated mitochondria	Mouse	Heart
Holloway 2013 Abstract MiP2013	2013	Holloway GP (2013) Tissue specific changes in respiratory substrate kinetics in the ZDF rat and in response to resveratrol supplementation. Mitochondr Physiol Network 18.08.	OXPHOS		Permeabilized tissue	Rat	Heart Skeletal muscle
Galina 2013 Abstract MiP2013	2013	Galina A, Messeder DJM, Camacho-Pereira J, Pereira da Silva AP, Rodrigues-Ferreira C (2013) Effects of antitumor alkylating agent 3-bromopyruvate on energy transducing pathways in hepatoma HepG2, liver mitochondria and SERCA: Is there any role for mitochondrial hexokinase activity? Mitochondr Physiol Network 18.08.	LEAK ROUTINE OXPHOS ET	N S	Permeabilized cells Isolated mitochondria Enzyme Intact cells	Rat	Skeletal muscle Nervous system Liver Other cell lines
Cavalcanti de Albuquerque 2013 Abstract MiP2013	2013	Cavalcanti de Albuquerque JP, Salvador IC, Martins EG, Jardim-Messeder D; Werneck de Castro JPS; Carvalho DP; Galina A (2013) Skeletal muscle mitochondrial function in ovariectomized rats: A time course study and the role of estrogen replacement. Mitochondr Physiol Network 18.08.	LEAK OXPHOS ET	F N S Gp NS ROX	Intact organism Permeabilized tissue	Rat	Skeletal muscle
Gellerich 2013 Abstract MiP2013	2013	Gellerich FN, Korzeniewski B, Gizatullina Z, Debska-Vielhaber G, Gainutdinov T, König R, Reymann K, Vielhaber S(2013) The mitochondrial gas pedal, a unique property of neurons exists also in heart and skeletal muscle but not in astrocytes. New evidences by in silico investigations and (patho-)physiological consequences. Mitochondr Physiol Network 18.08.	OXPHOS	N	Isolated mitochondria		Nervous system
Votion 2013 Abstract MiP2013	2013	Votion DM, Mouithys-Mickalad A, Ceusters Justine D, Lemieux H, Tosi I, Franck T, Art T, Niesten A, Serteyn D (2013) The challenge of understanding myopathies in horses using permeabilized muscle cells. Mitochondr Physiol Network 18.08.	OXPHOS ET	F N S NS ROX	Permeabilized tissue	Horse	Skeletal muscle
Vercesi 2013 Abstract MiP2013	2013	Vercesi AE (2013) Mitochondrial respiration, Ca²⁺ transport and oxidative stress: Fungi, trypanosomes, plants and mammals. Mitochondr Physiol Network 18.08.	OXPHOS	N	Permeabilized cells Isolated mitochondria	Rat Other invertebrates Fungi Plants Protists	Heart
Lindenberg 2013 Abstract MiP2013	2013	Lindenberg K, Matallo J, Fleischer C, Lenk T, Lehnert S, Jahn O, Otto M, Calzia E, Landwehrmeyer GB (2013) Similar alterations in mitochondrial proteome of brain and skeletal muscle in two transgenic mouse models for Huntington´s disease. Mitochondr Physiol Network 18.08.	OXPHOS		Isolated mitochondria	Mouse	Skeletal muscle Nervous system
Lundby 2013 Abstract MiP2013	2013	Lundby C, Bonne T, Flück D, Jacobs R, Meinild AK, Lundby S, Robach P (2013) The effects of hypoxic training on aerobic performance in normoxia and moderate hypoxia: a randomized, double blind, placebo controlled study. Mitochondr Physiol Network 18.08.	OXPHOS		Permeabilized tissue	Human	Skeletal muscle
Oliveira MF 2013 Abstract MiP2013	2013	Oliveira MF (2013) Comparative mitochondrial physiology in blood feeding insect vectors and parasites. Mitochondr Physiol Network 18.08.	LEAK ROUTINE OXPHOS ET	F N S Gp CIV ROX	Intact organism Intact organ Permeabilized cells Permeabilized tissue Homogenate Intact cells	Human Drosophila Hexapods Other invertebrates	Skeletal muscle Neuroblastoma
Palm 2013 Abstract MiP2013	2013	Palm F, Hansell P, Friederich-Persson M (2013) Role of mitochondrial function for the onset and progression of kidney disease. Mitochondr Physiol Network 18.08.	LEAK OXPHOS		Intact organ Intact cells Isolated mitochondria	Mouse Rat	Kidney
Pichaud 2013 Abstract MiP2013	2013	Pichaud N, Blier PU(2013) Importance of mitochondrial haplotypes in the expression of metabolic phenotypes under different conditions. Mitochondr Physiol Network 18.08.	LEAK OXPHOS ET	N S Gp CIV NS ROX	Permeabilized tissue	Drosophila Hexapods	Skeletal muscle
Quistorff 2013 Abstract MiP2013	2013	Quistorff B (2013) With type 2 diabetes mitochondrial dysfunction develops earlier in liver than in skeletal muscle. Mitochondr Physiol Network 18.08.	LEAK OXPHOS	F S Other combinations		Rat	Skeletal muscle Liver
Shabalina 2013 Abstract MiP2013	2013	Shabalina IG, Petrovic N, Kalinovich AV, Cannon B, Nedergaard J (2013) Comparative study of brown and white adipose tissue mitochondria in mice upon cold acclimation. Mitochondr Physiol Network 18.08.	OXPHOS ET	Gp	Isolated mitochondria		Fat
Slinde 2013 Abstract MiP2013	2013	Slinde E, Egelandsdal B, Olsen RE (2013) Respiration of tissue and mitochondria from Atlantic salmon (Salmo salar, L) liver, muscle, heart, brain and blood. Mitochondr Physiol Network 18.08.	LEAK OXPHOS ET	N ROX	Permeabilized tissue Isolated mitochondria	Other mammals Fishes	Heart Liver Blood cells
Salin 2013 Abstract MiP2013	2013	Salin K, Luquet E, Rey B, Roussel D, Voituron Y (2013) Mitochondrial functioning, a proximate mechanism underlying the pace-of- life? Mitochondr Physiol Network 18.08.	LEAK OXPHOS ET	S CIV	Isolated mitochondria Enzyme Oxidase;biochemical oxidation	Other mammals Amphibians	Liver
Staples 2013 Abstract MiP2013	2013	Staples JF(2013) Mechanisms of mitochondrial metabolic suppression in hibernation. Mitochondr Physiol Network 18.08.	OXPHOS	S	Isolated mitochondria	Other mammals	Liver
Szibor 2013 Abstract MiP2013	2013	Szibor M, Heidler J, Gizatullina Z, Salwig I, Dhandapani PK, Wittig I, Rustin P (2013) Expression of Ciona intestinalis alternative oxidase in mouse. Mitochondr Physiol Network 18.08.	LEAK OXPHOS	ROX	Isolated mitochondria Oxidase;biochemical oxidation	Mouse	Heart Skeletal muscle Nervous system Liver Lung;gill
Tepp 2013 Abstract MiP2013	2013	Tepp K, Anmann T, Varikmaa M, Timohhina N, Shevchuk I, Chekulayev V, Saks V, Kaambre T (2013) Bioenergetic aspects of postnatal development of cardiac cells: Formation of structure-function relationship. Mitochondr Physiol Network 18.08.	OXPHOS	N S CIV	Intact cells Permeabilized cells Permeabilized tissue	Rat	Heart
Volska 2013 Abstract MiP2013	2013	Volska K, Makrecka-Kuka M, Svalbe B, Dambrova M (2013) The inhibitor of L-carnitine biosynthesis protects brain mitochondria against anoxia-reoxygenation injury. Mitochondr Physiol Network 18.08.	LEAK OXPHOS	N	Isolated mitochondria	Rat	Nervous system
Votion 2012 Abstract Bioblast	2012	Votion DM (2012) The cause of atypical myopathy in grazing European horses revealed. Mitochondr Physiol Network 17.12.	OXPHOS	N S NS	Permeabilized cells	Horse	Skeletal muscle
Le 2012 Abstract Bioblast	2012	Le CH, Hocker AD, Dreyer HC, Roach RC, Gnaiger E, Chicco AJ (2012) Two-week acclimatization to 5200m markedly alters substrate utilization and increases OXPHOS efficiency, with no effect on respiratory capacity in skeletal muscle mitochondria. Mitochondr Physiol Network 17.12.	OXPHOS ET	N S	Permeabilized tissue	Human	Skeletal muscle
Labieniec-Watala 2012 Abstract Bioblast	2012	Labieniec-Watala M, Siewiera K, Watala C (2012) Seasonal fluctuations affect the physiology of laboratory animals – facts and artifacts from the perspective of heart mitochondrial respiratory response to tested compounds. Mitochondr Physiol Network 17.12.	LEAK OXPHOS ET	N S NS	Homogenate Isolated mitochondria	Mouse Rat	Heart Liver Fibroblast
Amoedo 2012 Abstract Bioblast	2012	Amoedo ND, Rodrigues MF, Pereira SAS, Melo FH, Jasiulionis MG, Galina A, Rumjanek FD (2012) Mitochondrial function and bioenergetics during malignant transformation and metastasis. Mitochondr Physiol Network 17.12.	LEAK ROUTINE OXPHOS ET	S	Intact cells	Mouse	Other cell lines
Hoppel 2012 Abstract Bioblast	2012	Hoppel CL (2012) Mitochondrial functional testing – muscle biopsy, isolated mitochondria and others. Mitochondr Physiol Network 17.12.	OXPHOS		Permeabilized tissue Isolated mitochondria	Human	Skeletal muscle Liver
Hand 2012 Abstract Bioblast	2012	Patil Y, Gnaiger E, Hand SC (2012) Respiration in embryo lysates reveals diminished Complex I activity and inhibition of the phosphorylation system during diapause in Artemia franciscana. Mitochondr Physiol Network 17.12.	OXPHOS ET	N S NS	Homogenate	Artemia Crustaceans
Galina 2012 Abstract Bioblast	2012	Simonin V, Galina A (2012) Nitric oxide inhibits succinate dehydrogenase-driven oxygen consumption in potato tuber mitochondria in an oxygen tension-independent manner. Mitochondr Physiol Network 17.12.	OXPHOS	N S NS
Doerrier 2012 Abstract Bioblast	2012	Doerrier C, Garcia JA, Escames G, Acuna-Castroviejo D (2012) Treatment with melatonin prevents myocardial mitochondrial dysfunction in experimental sepsis in mice. Mitochondr Physiol Network 17.12.	LEAK OXPHOS ET	N S NS	Permeabilized tissue	Mouse	Heart
Cervinkova 2012 Abstract Bioblast	2012	Cervinkova Z, Stankova P, Cervinka M, Kucera O, Drahota Z (2012) Evaluation of mitochondrial functions – an important tool for experimental hepatology. Mitochondr Physiol Network 17.12.	OXPHOS	N S	Permeabilized cells Homogenate Isolated mitochondria Intact cells	Rat	Liver
Acuna-Castroviejo 2012 Abstract Bioblast	2012	Acuna-Castroviejo D (2012) Melatonin and the quality of life: the melatonin-mitochondrion connection. Mitochondr Physiol Network 17.12.	ROUTINE OXPHOS	N S NS	Intact organism Isolated mitochondria Intact cells	Mouse Rat	Heart Skeletal muscle Nervous system Liver
Hedges IBEC2012	2012	Hedges CP, Hickey AJ, McMahon CD, Smith HK (2012) A fiber-type-specific role for myostatin in regulating mitochondrial function. IBEC2012.	OXPHOS		Permeabilized tissue	Mouse	Skeletal muscle
Plenge 2012 Endocrine Abstracts	2012	Plenge U, Guadeloupe-Grau A, Andersen P, Lundby C, Dela F, Pott F, Helge J, Belhage B, Boushel RC (2012) Recombinant erythropoietin treatment enhances mitochondrial function in human skeletal muscle. Endocrine Abstracts 29 P302 .	OXPHOS		Permeabilized tissue	Human	Skeletal muscle
Towheed 2012 Abstract IOC72	2012	Towheed A (2012) Elucidating pathogenesis of ATP synthase dysfunction in a Drosophila model of mitochondrial encephalomyopathy. Mitochondr Physiol Network 17.13.	LEAK ROUTINE OXPHOS ET	N S NS	Intact organism Permeabilized tissue	Drosophila Hexapods
Horscroft 2012 Abstract IOC72	2012	Horscroft JA, Kotwica AO, Ashmore T, Colleoni F, Morash AJ, Gilbert E, Gnaiger E, Martin DS, Murray AJ (2012) Mitochondrial function at altitude in lowland Europeans and highland Sherpas. Mitochondr Physiol Network 17.13.	LEAK OXPHOS ET	N NS		Human	Skeletal muscle
Kamath 2012 Abstract IOC72	2012	Kamath VG, Lizenby ZJ, Adusumilli VRKR, Hsiung CH, McKee EE (2012) Measuring mitochondrial OXPHOS as a nucleoside reverse transcriptase inhibitor induced cardiac toxicity endpoint. Mitochondr Physiol Network 17.13.	LEAK OXPHOS ET		Isolated mitochondria	Rat
Tronstad 2012 Abstract Bioblast	2012	Nikolaisen J, Nilsson LIH, Hagland HR, Koopman WJ, Tronstad KJ (2012) Mitochondrial morphology and biogenesis in cellular stress. Mitochondr Physiol Network 17.12.	OXPHOS			Human Rat	Liver Endothelial;epithelial;mesothelial cell Blood cells
Jacobs 2012 Abstract Bioblast	2012	Jacobs R, Lundby C (2012) Mitochondria express enhanced quality as well as quantity in parallel with aerobic fitness across recreationally active individuals up to elite athletes. Mitochondr Physiol Network 17.12.	LEAK OXPHOS ET	F N S NS	Permeabilized cells	Human	Skeletal muscle
Mark 2012 Abstract Bioblast	2012	Mark FC, Strobel A, Poertner HO (2012) Ocean warming and acidification – when fish mitochondria turn sour. Mitochondr Physiol Network 17.12.	LEAK ROUTINE OXPHOS	N S CIV NS	Permeabilized tissue Isolated mitochondria	Fishes	Heart Liver
Hepple 2012 Abstract Bioblast	2012	Hepple RT, Picard M, Taivassalo T (2012) Is latent mitochondrial dysfunction in aging muscle exposed through mitochondrial isolation? Mitochondr Physiol Network 17.12.	LEAK OXPHOS		Permeabilized tissue Isolated mitochondria		Skeletal muscle
Horvath 2012 Abstract Bioblast	2012	Horvath G, Eigentler A, Gnaiger E, Tretter L (2012) Respiratory substrate effects on mitochondrial membrane potential - experiments with mouse cardiac muscle homogenate. Mitochondr Physiol Network 17.12.	LEAK OXPHOS ET	N S NS	Homogenate	Mouse	Heart
Dzialowski 2012 Abstract IOC72	2012	Dzialowski EM, Sirsat T, Goy S (2012) T3: Does it really make the alligator go “Tick, Tock”? Mitochondr Physiol Network 17.13.	LEAK OXPHOS	N S NS	Isolated mitochondria	Reptiles	Heart Skeletal muscle
Irving 2012 Abstract IOC72	2012	Irving BA (2012) AgRP deficient female mice have elevated body weight and hypothalamic mitochondrial oxidative capacity. Mitochondr Physiol Network 17.13.	OXPHOS	N S NS	Permeabilized tissue	Mouse Rat	Skeletal muscle Nervous system Liver Fat
Gnaiger 2011 Abstract-MonteVerita	2011	Gnaiger E (2011) Mitochondrial respiratory capacity at maximum aerobic exercise levels: Are intracellular oxygen levels limiting? Abstract Monte Verita.	OXPHOS	N S NS		Human
Nuskova 2011 Abstract IOC61	2011	Nuskova H, Pecina P, Kovarova N, Dell’Agnello C, Zeviani M, Houstek J (2011) Cytochrome c oxidase with decreased H+/e− ratio in SURF1 knockout mice. MiPNet16.01.	OXPHOS		Isolated mitochondria Intact cells	Mouse	Endothelial;epithelial;mesothelial cell Fibroblast
Magnifico 2011 Abstract IOC61	2011	Magnifico MC, Arese M, Mastronicola D, Forte E, Giuffre A, Testa F, Sarti P (2011) NO-signalling and cell bioenergetics. MiPNet16.01.	OXPHOS		Intact cells	Human	Endothelial;epithelial;mesothelial cell
Pinho 2011 Abstract IOC65	2011	Pinho JPC, Goncalves RL, Oliveira MF (2011) Studies on the dynamic changes of mitochondrial function following a blood meal in the kissing bug Rhodnius prolixus. MiPNet16.03.	OXPHOS		Isolated mitochondria Enzyme	Hexapods
Lemieux 2011 Abstract Bordeaux	2011	Lemieux H, Semsroth S, Antretter H, Hoefer D, Gnaiger E (2011) Increased OXPHOS capacity after cold preservation of the human heart – a paradox resolved by a dyscoupling mechanism. MiP2011	OXPHOS			Human	Heart
Pesta 2011Abstract Mitochondrial Medicine-Diagnosis	2011	Pesta D, Wiethuechter A, Karall D, Schocke M, Gnaiger E (2011) Functional mitochondrial diagnosis in a patient suffering from sudden exercise intolerance. Abstract Mitochondrial Medicine Chicago.	OXPHOS		Permeabilized tissue Homogenate	Human
Gnaiger 2011 Abstract SMRM-Hyderabad	2011	Gnaiger E, Wright-Paradis C, Sondergaard H, Calbet J, Damsgaard R, Munck-Andersen T, Saltin B, Boushel RC (2011) Conserved mitochondrial coupling and adaptive substrate control in Inuit and Caucasians: Acclimatization to active life styles in the Arctic winter. Abstract SMRM-Hyderabad.	LEAK OXPHOS			Human
Sumbalova 2011 Abstract Mitochondrial Medicine	2011	Sumbalova Z, Fasching M, Gnaiger E (2011) Substrate control in mitochondrial respiration and regulation of mitochondrial membrane potential. Abstract Mitochondrial Medicine Chicago.	LEAK OXPHOS ET	N S NS	Homogenate Isolated mitochondria	Mouse	Nervous system
Pesta 2011Abstract ACSM	2011	Pesta D, Jacobs R, Macek C, Hoppel F, Faulhaber M, Lundby C, Burtscher M, Gnaiger E, Schocke M (2011) Investigation of muscle metabolism of the quadriceps via high-resolution respirometry and 31P MRS in connection with a 10 week endurance training. Medicine & Science in Sports & Exercise 43: 71	OXPHOS		Permeabilized cells	Human	Skeletal muscle
Pesta 2011Abstract Mitochondrial Medicine-Training	2011	Pesta D, Hoppel F, Macek C, Messner H, Faulhaber M, Kobel C, Parson W, Burtscher M, Schocke M, Gnaiger E (2011) Mitochondrial improvements after strength, endurance, and intermittend hypoxic training in sedentary humans. A respiratory study on permeabilized muscle fibers. Abstract Mitochondrial Medicine Chicago.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Matallo MiP2010	2010	Matallo J, Reich V, Calzia E, Radermacher P, Groeger M (2010) Interactions between sulfide and mitochondrial respiration in cultured murine alveolar macrophage. Abstract. MiP2010.	OXPHOS ET	N S	Permeabilized cells		Lung;gill Macrophage-derived
Vaupel MiP2010	2010	Vaupel P, Mayer A (2010) Evidence against a mitochondrial dysfunction in cancer cells as a hallmark of malignant growth. Abstract MiP2010.	OXPHOS		Intact cells
Gnaiger Abstract MiP2010 2-01	2010	Gnaiger E (2010) Measuring the upper limit of mitochondrial performance - how and why?	OXPHOS		Isolated mitochondria Intact cells	Human	Fibroblast
Kim MiP2010	2010	Kim HK, Park WS, Choi SW, Ha SH, Kim N, Han J (2010) BH4 deficiency involved in cardiac mitochondria metabolic pathway remodelling. MiP2010.	OXPHOS			Mouse	Heart
El-Bacha MiP2010	2010	Amoedo ND, Rodrigues MF, Pezutto P, Lourenco MVC, Madeiro da Costa RF, Oliveira MF, Galina A, Rumjanek FD, El-Bacha T (2010) Metabolic reprogramming of lung cancer cell induced by sodium butyrate: studies on mitochondrial physiology and bioenergetics.	OXPHOS		Intact cells		Other cell lines
Pesta 2010 MiP Abstract	2010	Pesta D, Faulhaber M, Burtscher M, Gnaiger E, Schocke M (2010) Investigation of muscle metabolism of the M. quadriceps via ³¹P MRS and high-resolution respirometry in connection with 10 weeks of strength and endurance training in normoxia and hypoxia. MiP2010.	LEAK OXPHOS ET	F N S NS		Human
Dela MiP2010	2010	Kraunsoee R, Boushel RC, Hansen CN, Schjerling P, Qvortrup K, Stoecke M, Mikines KJ, Dela F (2010) Mitochondrial respiration in subcutaneous and visceral adipose tissue from patients with morbid obesity. Mitochondr Physiol Network 15.6:50-1.	OXPHOS		Permeabilized tissue	Human
Lane MiP2010	2010	Lane N (2010) Mitochondria and the origin of complex life. Abstract MiP2010.	OXPHOS			Eubacteria Archea
Pesta 2010 Abstract IOC60	2010	Pesta D, Macek C, Hoppel F, Faulhaber M, Burtscher M, Gnaiger E, Schocke M (2010) The impact of endurance training on muscle oxidative capacity. MiPNet15.10.	OXPHOS		Enzyme	Human
ElBacha 2010 Abstract IOC60	2010	El-Bacha T, Abud M, Galina A, Da Poian AT (2010) Bioenergetics of liver mitochondria from mice infected with Dengue virus. MiPNet15.10.	OXPHOS		Isolated mitochondria	Mouse	Liver
Amoedo 2010 Abstract MiP2010	2010	Amoêdo ND, Rodrigues MF, Pezutto P, Lourenço MVC, Madeiro da Costa RF, Oliveira MF, Galina A, Rumjanek FD, El-Bacha T (2010) Metabolic reprogramming of lung cancer cell induced by sodium butyrate: Studies on mitochondrial physiology and bioenergetics. Mitochondr Physiol Network 15.06.	OXPHOS ET		Intact cells	Human	Endothelial;epithelial;mesothelial cell Fibroblast
Garedew 2006 Biochim Biophys Acta	2006	Garedew A, Lemieux H, Schachner T, Blier PU, Tardif J-C, Gnaiger E (2006) High excess capacity of cytochrome c oxidase in permeabilized fibers of the mouse heart. Biochim Biophys Acta, EBEC Short Reports Suppl 14 (2006):167-8.	OXPHOS	N S NS	Permeabilized tissue Enzyme Oxidase;biochemical oxidation	Mouse	Heart
Lemieux 2006 Biochim Biophys Acta	2006	Lemieux H, Garedew A, Blier PU, Tardif J-C, Gnaiger E (2006) Temperature effects on the control and capacity of mitochondrial respiration in permeabilized fibers of the mouse heart. Biochim Biophys Acta, EBEC Short Reports Suppl 14 (2006):201-2.	OXPHOS		Permeabilized tissue Enzyme Oxidase;biochemical oxidation	Mouse	Heart
Gnaiger 2005 Abstract MiP2005	2005	Gnaiger Erich, Wright-Paradis C, Sondergaard H, Lundby C, Calbet Jose AL, Saltin Bengt, Helge J, Boushel R (2005) High-resolution respirometry in small biopsies of human muscle: correlations with body mass index and age. MiP2005.	OXPHOS ET	F N CIV NS	Permeabilized tissue	Human	Skeletal muscle

Labels:

Coupling state: OXPHOS

HRR: Theory

MitoPedia concepts: Respiratory state, SUIT concept, SUIT state, Recommended

MitoPedia methods: Respirometry

MitoPedia topics: EAGLE