Difference between revisions of "NS-pathway control state"
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{{MitoPedia | {{MitoPedia | ||
|abbr=CI&II-linked | |abbr=CI<small>&</small>II-linked | ||
|description=The '''Complex I&II-linked substrate state''' is induced in mt-preparations by addition of [[NADH]]-generating substrates (CI-linked) in combination with succinate (CII-linked). This physiological substrate combination is required for partial reconstiturion of [[TCA cycle]] function and convergent electron-input into the [[Q-junction]] to compensate for metabolite depletion into the incubation medium. An [[Additive effect of convergent CI&II electron flow]] is observed in most types of mitochondria. | |description=The '''Complex I<small>&</small>II-linked substrate state''' is induced in mt-preparations by addition of [[NADH]]-generating substrates (CI-linked) in combination with succinate (CII-linked). This physiological substrate combination is required for partial reconstiturion of [[TCA cycle]] function and convergent electron-input into the [[Q-junction]] to compensate for metabolite depletion into the incubation medium. An [[Additive effect of convergent CI&II electron flow]] is observed in most types of mitochondria. | ||
|info=[[Gnaiger 2014 MitoPathways]] | |info=[[Gnaiger 2014 MitoPathways]] | ||
}} | }} | ||
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|mitopedia topic=Respiratory state, Substrate and metabolite | |mitopedia topic=Respiratory state, Substrate and metabolite | ||
}} | }} | ||
= List of publications: CI&II-linked substrate state = | = List of publications: CI<small>&</small>II-linked substrate state = | ||
{{#ask:[[Category:Publications]] [[Substrate states::CI+II]] | {{#ask:[[Category:Publications]] [[Substrate states::CI+II]] | ||
|?Was published in year=Year | |?Was published in year=Year | ||
Revision as of 20:51, 31 August 2014
- high-resolution terminology - matching measurements at high-resolution
NS-pathway control state
Description
The Complex I&II-linked substrate state is induced in mt-preparations by addition of NADH-generating substrates (CI-linked) in combination with succinate (CII-linked). This physiological substrate combination is required for partial reconstiturion of TCA cycle function and convergent electron-input into the Q-junction to compensate for metabolite depletion into the incubation medium. An Additive effect of convergent CI&II electron flow is observed in most types of mitochondria.
Abbreviation: CI&II-linked
Reference: Gnaiger 2014 MitoPathways
MitoPedia topics: "Respiratory state" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property. Respiratory state"Respiratory state" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property., Substrate and metabolite
