Difference between revisions of "NS-pathway control state"
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Revision as of 15:51, 26 August 2016
- high-resolution terminology - matching measurements at high-resolution
NS-pathway control state
Description
The NS-linked substrate state (flux in the NS-linked substrate state, NS; or Complex I&II, CI&II-linked substrate state) is induced in mt-preparations by addition of NADH-generating substrates (N-linked substrate state, or CI-linked pathway control) in combination with succinate (S- or CII-linked). Whereas NS expresses substrate control in terms of substrate types (N and S), CI&II defines the same concept in terms of the convergent pathway to the Q-junction (pathway control). NS is the abbreviation for the combination of N- or NADH-linked substrates (CI-linked) and S- or succinate-linked substrates (CII-linked). This physiological substrate combination is required for partial reconstitution of TCA cycle function and convergent electron-input into the Q-junction, to compensate for metabolite depletion into the incubation medium. NS in combination exerts an additive effect of convergent electron flow in most types of mitochondria.
Abbreviation: NS, CI&II
Reference: Gnaiger 2014 MitoPathways, Gnaiger_2009_Int J Biochem Cell Biol
MitoPedia concepts:
Respiratory state,
SUIT state
MitoPedia topics:
Substrate and metabolite
