Difference between revisions of "NS-pathway control state"
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|abbr=NS | |abbr=NS | ||
|description=[[File:SUIT-Catg NS.jpg|right|300px|NS-substrate state]] | |description=[[File:SUIT-Catg NS.jpg|right|300px|NS-substrate state]] | ||
The '''NS-linked substrate state''' (or flux in the NS-linked substrate state, NS; Complex I<small>&</small>II) is induced in mt-preparations by addition of [[NADH]]-generating substrates ([[N-linked substrate state]]) in combination with [[succinate]] (S- or CII-linked). '''NS''' is the abbreviation for the combination of N- or [[NADH]]-linked substrates (CI-linked) and S- or [[succinate]]-linked substrates (CII-linked). This physiological substrate combination is required for partial reconstiturion of [[TCA cycle]] function and convergent electron-input into the [[Q-junction]] to compensate for metabolite depletion into the incubation medium. NS in combination exerts an [[additive effect of convergent | The '''NS-linked substrate state''' (or flux in the NS-linked substrate state, NS; Complex I<small>&</small>II) is induced in mt-preparations by addition of [[NADH]]-generating substrates ([[N-linked substrate state]]) in combination with [[succinate]] (S- or CII-linked). '''NS''' is the abbreviation for the combination of N- or [[NADH]]-linked substrates (CI-linked) and S- or [[succinate]]-linked substrates (CII-linked). This physiological substrate combination is required for partial reconstiturion of [[TCA cycle]] function and convergent electron-input into the [[Q-junction]] to compensate for metabolite depletion into the incubation medium. NS in combination exerts an [[additive effect of convergent electron flow]] in most types of mitochondria. | ||
|info=[[Gnaiger 2014 MitoPathways]], [[Gnaiger_2009_Int J Biochem Cell Biol]] | |info=[[Gnaiger 2014 MitoPathways]], [[Gnaiger_2009_Int J Biochem Cell Biol]] | ||
}} | }} | ||
Revision as of 10:39, 28 March 2016
- high-resolution terminology - matching measurements at high-resolution
NS-pathway control state
Description
The NS-linked substrate state (or flux in the NS-linked substrate state, NS; Complex I&II) is induced in mt-preparations by addition of NADH-generating substrates (N-linked substrate state) in combination with succinate (S- or CII-linked). NS is the abbreviation for the combination of N- or NADH-linked substrates (CI-linked) and S- or succinate-linked substrates (CII-linked). This physiological substrate combination is required for partial reconstiturion of TCA cycle function and convergent electron-input into the Q-junction to compensate for metabolite depletion into the incubation medium. NS in combination exerts an additive effect of convergent electron flow in most types of mitochondria.
Abbreviation: NS
Reference: Gnaiger 2014 MitoPathways, Gnaiger_2009_Int J Biochem Cell Biol
MitoPedia concepts:
Respiratory state
MitoPedia O2k and high-resolution respirometry: "SUIT state" is not in the list (O2k hardware, DatLab, Oroboros QM, O2k-Open Support, O2k-Respirometry, O2k-FluoRespirometry) of allowed values for the "MitoPedia O2k and high-resolution respirometry" property.
SUIT state"SUIT state" is not in the list (O2k hardware, DatLab, Oroboros QM, O2k-Open Support, O2k-Respirometry, O2k-FluoRespirometry) of allowed values for the "MitoPedia O2k and high-resolution respirometry" property.
MitoPedia topics:
Substrate and metabolite
