- high-resolution terminology - matching measurements at high-resolution
NS-S pathway control efficiency
Description
The CI+II-CII substrate control factor expresses the fractional change of flux in a defined coupling control state when inhibition by rotenone is removed from CII-linked respiration (succinate) in the presence of a CI-linked substrate combination. Experimentally rotenone (Rot) is added to CI+II-linked respiration. The reversed protocol, adding CI-linked substrates to a CII-linked background state does not provide a valid estimation of CII-linked respiration with succinate in the absence of Rot, since oxaloacetate accumulates as a potent inhibitor of succinate dehydrogenase (CII).
Abbreviation: ΞjCI+II-CII
Reference: Flux control factor
MitoPedia methods:
Respirometry
MitoPedia topics: "Respiratory control ratio" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property.
Respiratory control ratio"Respiratory control ratio" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property.
