- high-resolution terminology - matching measurements at high-resolution
NS-S pathway control efficiency
Description
The CI&II-CII substrate control factor expresses the fractional change of flux in a defined coupling control state when inhibition by rotenone is removed from CII-linked respiration (succinate) in the presence of a CI-linked substrate combination. Experimentally rotenone (Rot) is added to CI&II-linked respiration. The reversed protocol, adding CI-linked substrates to a CII-linked background state does not provide a valid estimation of CII-linked respiration with succinate in the absence of Rot, since oxaloacetate accumulates as a potent inhibitor of succinate dehydrogenase (CII).
Abbreviation: jCI&II-CII
Reference: Flux control factor
MitoPedia concepts:
Respiratory control ratio
MitoPedia methods:
Respirometry
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