Difference between revisions of "NS-S pathway control efficiency"

Revision as of 14:12, 14 August 2014

high-resolution terminology - matching measurements at high-resolution

NS-S pathway control efficiency

Description

The CI&II-CII substrate control factor expresses the fractional change of flux in a defined coupling control state when inhibition by rotenone is removed from CII-linked respiration (succinate) in the presence of a CI-linked substrate combination. Experimentally rotenone (Rot) is added to CI&II-linked respiration. The reversed protocol, adding CI-linked substrates to a CII-linked background state does not provide a valid estimation of CII-linked respiration with succinate in the absence of Rot, since oxaloacetate accumulates as a potent inhibitor of succinate dehydrogenase (CII).

Abbreviation: j_CI&II-CII

Reference: Flux control factor

MitoPedia methods: Respirometry

MitoPedia topics: "Respiratory control ratio" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property. Respiratory control ratio"Respiratory control ratio" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property.

Compare

CII control ratio

List of publications: CI&II and CII

@@ Line 1: / Line 1: @@
 {{MitoPedia
-|abbr=''j''<sub>C<sub>I+II</sub>-C<sub>II</sub></sub>
+|abbr=''j''<sub>CI&II-CII</sub>
-|description=The '''C<sub>I+II</sub>-C<sub>II</sub> [[substrate control factor]]''' expresses the fractional change of flux in a defined [[coupling control state]] when inhibition by [[rotenone]] is removed from [[CII-linked respiration |C<sub>II</sub>-linked respiration]] ([[succinate]]) in the presence of a C<sub>I</sub>-linked substrate combination. Experimentally rotenone (Rot) is added to [[CI+II-linked respiration |C<sub>I+II</sub>-linked respiration]]. The reversed protocol, adding C<sub>I</sub>-linked substrates to a C<sub>II</sub>-linked background state does not provide a valid estimation of C<sub>II</sub>-linked respiration with succinate in the absence of Rot, since [[oxaloacetate]] accumulates as a potent inhibitor of [[succinate dehydrogenase]] (C<sub>II</sub>).
+|description=The '''CI&II-CII [[substrate control factor]]''' expresses the fractional change of flux in a defined [[coupling control state]] when inhibition by [[rotenone]] is removed from [[CII-linked respiration]] ([[succinate]]) in the presence of a CI-linked substrate combination. Experimentally rotenone (Rot) is added to [[CI&II-linked respiration]]. The reversed protocol, adding CI-linked substrates to a CII-linked background state does not provide a valid estimation of CII-linked respiration with succinate in the absence of Rot, since [[oxaloacetate]] accumulates as a potent inhibitor of [[succinate dehydrogenase]] (CII).
 |info=[[Flux control factor]]
 }}
@@ Line 11: / Line 11: @@
 }}
 == Compare ==
-* [[CII control ratio |C<sub>II</sub> control ratio]]
+* [[CII control ratio]]
-== List of publications: CI+II and CII ==
+== List of publications: CI&II and CII ==
 {{#ask:[[Category:Publications]] [[Substrate states::CII]] [[Substrate states::CI+II]]
 |?Was published in year=Year