Difference between revisions of "Mracek 2013 Biochim Biophys Acta"
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Revision as of 16:05, 10 February 2022
| Mracek T, Drahota Z, Houstek J (2012) The function and the role of the mitochondrial glycerol-3-phosphate dehydrogenase in mammalian tissues. Biochim Biophys Acta 1827:401-10. |
Mracek T, Drahota Z, Houstek J (2012) Biochim Biophys Acta
Abstract: Mitochondrial glycerol-3-phosphate dehydrogenase (mGPDH) is not included in the traditional textbook schemes of the respiratory chain, reflecting the fact that it is a non-standard, tissue-specific component of mammalian mitochondria. But despite its very simple structure, mGPDH is a very important enzyme of intermediary metabolism and as a component of glycerophosphate shuttle it functions at the crossroads of glycolysis, oxidative phosphorylation and fatty acid metabolism. In this review we summarize the present knowledge on the structure and regulation of mGPDH and discuss its metabolic functions, reactive oxygen species production and tissue and organ specific roles in mammalian mitochondria at physiological and pathological conditions. • Keywords: GPD2 gene, mitochondrial glycerol-3-phosphate dehydrogenase, glycerophosphate shuttle, ROS production, pathophysiology • Bioblast editor: Doerrier C • O2k-Network Lab: CZ Prague Houstek J
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