Molina 2023 JAMA Cardiol

Molina AJA, Gnaiger E, Kitzman DW (2023) Mitochondrial respiration and exercise performance in patients with heart failure with preserved ejection fraction-reply. JAMA Cardiol 8:1101-2. https://doi.org/10.1001/jamacardio.2023.3577

» PMID: 37819648

Molina Anthony JA, Gnaiger Erich, Kitzman Dalane W (2023) JAMA Cardiol

Abstract: First, with regard to the comparison of peak exercise oxygen consumption (peak V_O2) between individuals with and without obesity, it is established in clinical studies to use peak V_O2 indexed to body weight. While skeletal muscle mass contributes more than adipose to peak V_O2, equally important are factors such as muscle composition and quality. We have shown that muscle composition, fiber type, quality, mitochondrial content, and capillarization differ substantially between participants with heart failure with preserved ejection fraction (HFpEF) and healthy control participants. These abnormalities, including those reported in our study,² cause abnormal oxygen use, including when accounting for lean mass.

• Bioblast editor: Gnaiger E • O2k-Network Lab: US CA San Diego Molina AJA, AT Innsbruck Oroboros

(2) Scandalis L, Kitzman DW, Nicklas BJ, Lyles M, Brubaker P, Nelson MB, Gordon M, Stone J, Bergstrom J, Neufer PD, Gnaiger E, Molina AJA (2023) Skeletal muscle mitochondrial respiration and exercise intolerance in patients with heart failure with preserved ejection fraction. JAMA Cardiol 8:575–84. https://doi.org/10.1001/jamacardio.2023.0957

Labels: MiParea: Respiration, Exercise physiology;nutrition;life style  Pathology: Cardiovascular, Obesity 

Organism: Human  Tissue;cell: Skeletal muscle