Miettinen 2017 Trends Cell Biol
| Miettinen TP, Björklund M (2017) Mitochondrial function and cell size: an allometric relationship. Trends Cell Biol 27:393-402. |
Miettinen TP, Björklund M (2017) Trends Cell Biol
Abstract: Allometric scaling of metabolic rate results in lower total mitochondrial oxygen consumption with increasing organismal size. This is considered a universal law in biology. Here, we discuss how allometric laws impose size-dependent limits to mitochondrial activity at the cellular level. This cell-size-dependent mitochondrial metabolic activity results in nonlinear scaling of metabolism in proliferating cells, which can explain size homeostasis. The allometry in mitochondrial activity can be controlled through mitochondrial fusion and fission machinery, suggesting that mitochondrial connectivity can bypass transport limitations, the presumed biophysical basis for allometry. As physical size affects cellular functionality, cell-size-dependent metabolism becomes directly relevant for development, metabolic diseases, and aging.
• Bioblast editor: Gnaiger E
Cited by
- Gnaiger E (2021) Bioenergetic cluster analysis – mitochondrial respiratory control in human fibroblasts. MitoFit Preprints 2021.8. https://doi.org/10.26124/mitofit:2021-0008
Labels: MiParea: Respiration, mt-Structure;fission;fusion
Preparation: Intact organism, Intact cells
Coupling state: ROUTINE
Body mass, MitoFit 2021 BCA
