Mahapatra 2024 J Gerontol A Biol Sci Med Sci

[[Has title::Mahapatra G, Gao Z, Bateman JR 3rd, Lockhart SN, Bergstrom J, Piloso JE, Craft S, Molina AJA (2024) Peripheral blood cells from older adults exhibit sex-associated differences in mitochondrial function. J Gerontol A Biol Sci Med Sci [Epub ahead of print]. https://doi.org/10.1093/gerona/glae098]]

» [[Has info::PMID: 38602189 Open Access]]

Was written by::Mahapatra Gargi, Was written by::Gao Zhengrong, Was written by::Bateman James R 3rd, Was written by::Lockhart Samuel Neal, Was written by::Bergstrom Jaclyn, Was written by::Piloso Jemima Elizabeth, Was written by::Craft Suzanne, Was written by::Molina Anthony JA (Was published in year::2024) Was published in journal::J Gerontol A Biol Sci Med Sci

Abstract: [[has abstract::Blood based mitochondrial bioenergetic profiling is a feasible, economical, and minimally invasive approach that can be used to examine mitochondrial function and energy metabolism in human subjects. In this study, we use two complementary respirometric techniques to evaluate mitochondrial bioenergetics in both intact and permeabilized peripheral blood mononuclear cells (PBMCs) and platelets to examine sex dimorphism in mitochondrial function among older adults. Employing equal numbers of PBMCs and platelets to assess mitochondrial bioenergetics, we observe significantly higher respiration rates in female compared to male participants. Mitochondrial bioenergetic differences remain significant after controlling for independent parameters including demographic parameters (age, years of education), and cognitive parameters (mPACC5, COGDX). Our study illustrates that circulating blood cells, immune cells in particular, have distinctly different mitochondrial bioenergetic profiles between females and males. These differences should be taken into account as blood based bioenergetic profiling is now commonly used to understand the role of mitochondrial bioenergetics in human health and aging.]] • Keywords: has publicationkeywords::Sex differences, has publicationkeywords::Lymphocytes, has publicationkeywords::Mitochondrial bioenergetics, has publicationkeywords::Neutrophils, has publicationkeywords::Peripheral blood mononuclear cells, has publicationkeywords::Platelets • Bioblast editor: [[has editor::Plangger M]] • O2k-Network Lab: Was published by MiPNetLab::US CA San Diego Molina AJA

Labels: MiParea: MiP area::Respiration, MiP area::Gender 

Organism: Organism::Human  Tissue;cell: tissue and cell::Blood cells  Preparation: Preparation::Permeabilized cells, Preparation::Intact cells 

Coupling state: Coupling states::ROUTINE, Coupling states::OXPHOS, Coupling states::ET  Pathway: Pathways::F, Pathways::N, Pathways::Gp, Pathways::CIV, Pathways::NS, Pathways::Other combinations, Pathways::ROX  HRR: Instrument and method::Oxygraph-2k