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COST Action CA15203 (2016-2021): MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping
Liepins Edgars
MitoPedia topics: EAGLE
COST: Member COST WG1: WG1 COST WG2: WG2
COST Mentor: Mentor
Name | Liepinsh Edgars, Dr. |
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Institution | Laboratory of Pharmaceutical Pharmacology,
Latvian Institute of Organic Synthesis, LV |
Address | Aizkraukles Street 21, LV-1006 |
City | Riga |
State/Province | |
Country | Latvia |
[email protected] | |
Weblink | |
O2k-Network Lab | LV Riga Liepins E |
Labels:
Publications
Published | Reference | |
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Cardoso 2025 Biochim Biophys Acta Mol Basis Dis | 2025 | Cardoso LHD, Cecatto C, Ozola M, Korzh S, Zvejniece L, Gukalova B, Doerrier C, Dambrova M, Makrecka-Kuka M, Gnaiger E, Liepinsh E (2025) Fatty acid β-oxidation in brain mitochondria: Insights from high-resolution respirometry in mouse, rat and Drosophila brain, ischemia and aging models. Biochim Biophys Acta Mol Basis Dis 1871:167544. https://doi.org/10.1016/j.bbadis.2024.167544 |
Liepinsh 2024 Br J Pharmacol | 2024 | Liepinsh E, Zvejniece L, Clemensson L, Ozola M, Vavers E, Cirule H, Korzh S, Skuja S, Groma V, Briviba M, Grinberga S, Liu W, Olszewski P, Gentreau M, Fredriksson R, Dambrova M, Schiöth HB (2024) Hydroxymethylglutaryl-CoA reductase activity is essential for mitochondrial β-oxidation of fatty acids to prevent lethal accumulation of long-chain acylcarnitines in the mouse liver. Br J Pharmacol [Epub ahead of print]. https://doi.org/10.1111/bph.16363 |
Zvejniece 2023 Biomed Pharmacother | 2023 | Zvejniece L, Svalbe B, Vavers E, Ozola M, Grinberga S, Gukalova B, Sevostjanovs E, Liepinsh E, Dambrova M (2023) Decreased long-chain acylcarnitine content increases mitochondrial coupling efficiency and prevents ischemia-induced brain damage in rats. |
Dambrova 2022 BEC | 2022 | Dambrova M, Cecatto C, Vilskersts R, Liepinsh E (2022) Mitochondrial metabolites acylcarnitines: therapeutic potential and drug targets. Bioenerg Commun 2022.15. https://doi.org/10.26124/bec:2022-0015 |
Dambrova 2022 Pharmacol Rev | 2022 | Dambrova M, Makrecka-Kuka M, Kuka J, Vilskersts R, Nordberg D, Attwood MM, Smesny S, Sen ZD, Guo AC, Oler E, Tian S, Zheng J, Wishart DS, Liepinsh E, Schioth HB. (2022) Acylcarnitines: Nomenclature, Biomarkers, Therapeutic Potential, Drug Targets, and Clinical Trials. https://doi.org/10.1124/pharmrev.121.000408 |
Liepinsh 2021 Free Radic Biol Med | 2021 | Liepinsh E, Kuka J, Vilks K, Svalbe B, Stelfa G, Vilskersts R, Sevostjanovs E, Goldins NR, Groma V, Grinberga S, Plaas M, Makrecka-Kuka M, Dambrova M (2021) Low cardiac content of long-chain acylcarnitines in TMLHE knockout mice prevents ischaemia-reperfusion-induced mitochondrial and cardiac damage. Free Radic Biol Med 177:370-80. |
BEC 2020.1 doi10.26124bec2020-0001.v1 | 2020 | Gnaiger E et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1. https://doi.org/10.26124/bec:2020-0001.v1 |
Makrecka-Kuka 2020 Cardiovasc Drugs Ther | 2020 | Makrecka-Kuka Marina, Korzh Stanislava, Videja Melita, Vilks Karlis, Cirule Helena, Kuka Janis, Dambrova Maija, Liepinsh Edgars (2020) Empagliflozin protects cardiac mitochondrial fatty acid metabolism in a mouse model of diet-induced lipid overload. Cardiovasc Drugs Ther 34:791-97. |
Liepinsh 2020 Physiol Rep | 2020 | Liepinsh E, Makarova E, Plakane L, Konrade I, Liepins K, Videja M, Sevostjanovs E, Grinberga S, Makrecka-Kuka M, Dambrova M (2020) Low-intensity exercise stimulates bioenergetics and increases fat oxidation in mitochondria of blood mononuclear cells from sedentary adults. Physiol Rep 8:e14489. |
Makrecka-Kuka 2019 Acta Physiol (Oxf) | 2019 | Makrecka-Kuka M, Liepinsh E, Murray AJ, Lemieux H, Dambrova M, Tepp K, Puurand M, Käämbre T, Han WH, de Goede P, O'Brien KA, Turan B, Tuncay E, Olgar Y, Rolo AP, Palmeira CM, Boardman NT, Wüst RCI, Larsen TS (2019) Altered mitochondrial metabolism in the insulin-resistant heart. Acta Physiol (Oxf) 228:e13430. |
Makrecka-Kuka 2017 Toxicol Lett | 2017 | Makrecka-Kuka M, Volska K, Antone U, Vilskersts R, Grinberga S, Bandere D, Liepinsh E, Dambrova M (2017) Trimethylamine N-oxide impairs pyruvate and fatty acid oxidation in cardiac mitochondria. Toxicol Lett 267:32-8. |
Makrecka-Kuka 2017 Sci Rep | 2017 | Makrecka-Kuka M, Sevostjanovs E, Vilks K, Volska K, Antone U, Kuka J, Makarova E, Pugovics O, Dambrova M, Liepinsh E (2017) Plasma acylcarnitine concentrations reflect the acylcarnitine profile in cardiac tissues. Sci Rep 7:17528. |
Liepinsh 2016 Biochem J | 2016 | Liepinsh E, Makrecka-Kuka M, Volska K, Kuka J, Makarova E, Antone U, Sevostjanovs E, Vilskersts R, Strods A, Tars K, Dambrova M (2016) Long-chain acylcarnitines determine ischaemia/reperfusion-induced damage in heart mitochondria. Biochem J 473:1191-202. |
Abstracts
Published | Reference | |
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Cecatto 2023 BPS2023 San Diego | 2023 | Cecatto C, Schmitt Sabine, Cardoso L, Videja M, Dambrova M, Makrecka-Kuka M, Liepinsh E, Gnaiger E (2023) Contribution of fatty acid oxidation to respiratory control in brain mitochondria. 67th Annual Meeting of the Biophysical Society. |
Dambrova 2022 Abstract Bioblast | 2022 | 8.2. «10+5» Dambrova Maija, Vilskersts R, Liepinsh E(2022) Mitochondrial metabolites acylcarnitines: therapeutic potential and drug targets. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001 »MitoFit Preprint« |
Wuest 2019 MiPschool Coimbra | 2019 | Altered mitochondrial metabolism in the diabetic heart. |
Lemieux 2019b MiP2019 | 2019 | Altered mitochondrial metabolism in the diabetic heart. |
Liepins 2018 MiP2018 | 2018 | Mitochondrial and extramitochondrial effects of long-chain acylcarnitines. |
Makrecka-Kuka 2018 MiP2018 | 2018 | Fatty acid oxidation in brain: from aging to ischemia and sepsis. |
Dambrova 2018 MiP2018 | 2018 | L-Carnitine: from discovery to cardiometabolic risk markers. |
Kuka 2018 MiP2018 | 2018 | The discovery of methyl-GBB - acylcarnitine lowering as an effective strategy to treat cardiometabolic diseases. |
Makarova 2018 MiP2018 | 2018 | Plasma concentrations of fatty acids and acylcarnitines as biomarkers for diagnosis of insulin resistance in adipose and muscle tissues. |
Volska 2018 MiP2018 | 2018 | The mechanisms of long-chain acylcarnitine accumulation during ischemia. |
Makrecka-Kuka 2018 MiPschool Tromso E1 | 2018 | Cardiac fatty acid oxidation: from in vitro to in vivo. |
Makrecka-Kuka 2017 Abstract MITOEAGLE Barcelona | 2017 | Fatty acid oxidation evaluation in mitochondria. |
Makrecka-Kuka 2017 MiP2017 | 2017 | Heart, brain and kidneys: who will survive? Tissue-specific changes in mitochondrial function in the experimental model of endotoxemia. |
Makrecka-Kuka 2016 Abstract MitoFit Science Camp 2016 | 2016 | Long-chain acylCoAs vs acylcarnitines in mitochondrial bioenergetics: from in vitro to in vivo. |
Makrecka 2013 Abstract MiP2013 | 2013 | Makrecka-Kuka M, Volska K, Kuka J, Liepins E, Dambrova M (2013) The accumulation of long chain acyl-carnitines is a major cause of mitochondrial damage during ischemia. Mitochondr Physiol Network 18.08. |
MitoEAGLE Feedback
- We are mostly interested in two WG: (1) Since we are working mostly with heart and muscles, we are interested in WG 2 - MitoEAGLE data repository in muscle and other tissues. (2) WG 1 - Standard operating procedures and user requirement document: Protocols, terminology, documentation. Since we have an expertise in fatty acid metabolism, we are specially interested in experimental protocols for the evaluation of mitochondrial capacities regarding fatty acid metabolism. Of course our parts of the WG are also in our interest. - Marina Makrecka-Kuka, Edgars Liepins (2016).