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Keppner 2020 Thesis

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Keppner GM (2020) Impact of gut microbiota composition, liver metabolism and respiratory capacity of peripheral blood mononuclear cells on resting metabolic rate. PhD Thesis 100.

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Keppner GM (2020) PhD Thesis

Abstract: Obesity is a worldwide health problem with an increasing incidence over the last decades. Treatments include a reduction of energy intake and an increase in energy expenditure, which require a precise knowledge about the daily energy expenditure and its components. Resting metabolic rate (RMR) is with 60 - 80% the biggest component of daily energy expenditure and therefore of special interest. RMR is characterized by a high inter-individual variation. Variables taken into consideration when predicting RMR are sex, age, race, fat mass and fat free mass (FFM). However, even after adjusting RMR for these influencing variables, a residual variation of approximately 30% remains unexplained. In the present work the impact of liver metabolism, gut microbiota composition and the respiratory capacity of peripheral blood mononuclear cells (PBMCs) on RMR variation is analyzed.

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2020-06