Difference between revisions of "Gvozdjakova 2021 PLoS One"
(Created page with "{{Publication |title=Gvozdjáková A, Sumbalová Z, Kucharská J, Szamosová M, Čápová L, Rausová Z, Vančová O, Mojto V, Langsjoen P, Palacka P (2021) Platelet mitochond...") |
|||
| (4 intermediate revisions by 2 users not shown) | |||
| Line 1: | Line 1: | ||
{{Publication | {{Publication | ||
|title=Gvozdjáková A, Sumbalová Z, Kucharská J, Szamosová M, Čápová L, Rausová Z, Vančová O, Mojto V, Langsjoen P, Palacka P (2021) Platelet mitochondrial respiration and coenzyme Q | |title=Gvozdjáková A, Sumbalová Z, Kucharská J, Szamosová M, Čápová L, Rausová Z, Vančová O, Mojto V, Langsjoen P, Palacka P (2021) Platelet mitochondrial respiration and coenzyme Q<sub>10</sub> could be used as new diagnostic strategy for mitochondrial dysfunction in rheumatoid diseases. PLoS ONE 16:e0256135. | ||
|info=[https://pubmed.ncbi.nlm.nih.gov/34582480 PMID: 34582480 Open Access] | |info=[https://pubmed.ncbi.nlm.nih.gov/34582480 PMID: 34582480 Open Access] | ||
|authors= | |authors=Gvozdjakova Anna, Sumbalova Zuzana, Kucharska Jarmila, Szamosova Monika, Capova Lubica, Rausova Zuzana, Vancova Olga, Mojto Viliam, Langsjoen Peter, Palacka Patrik | ||
|year=2021 | |year=2021 | ||
|journal=PLoS | |journal=PLoS ONE | ||
|abstract=Rheumatoid arthritis (RA) is a chronic inflammatory autoimunne disorder affecting both small and large synovial joints, leading to their destruction. Platelet biomarkers are involved in inflammation in RA patients. Increased circulating platelet counts in RA patients may contribute to platelet hyperactivity and thrombosis. In this pilot study we evaluated platelet mitochondrial bioenergy function, | |abstract=Rheumatoid arthritis (RA) is a chronic inflammatory autoimunne disorder affecting both small and large synovial joints, leading to their destruction. Platelet biomarkers are involved in inflammation in RA patients. Increased circulating platelet counts in RA patients may contribute to platelet hyperactivity and thrombosis. In this pilot study we evaluated platelet mitochondrial bioenergy function, CoQ<sub>10</sub> levels and oxidative stress in RA patients. | ||
Twenty-one RA patients and 19 healthy volunteers participated in the study. High resolution respirometry (HRR) was used for analysis of platelet mitochondrial bioenergetics. | Twenty-one RA patients and 19 healthy volunteers participated in the study. High resolution respirometry (HRR) was used for analysis of platelet mitochondrial bioenergetics. CoQ<sub>10</sub> was determined by HPLC method; TBARS were detected spectrophotometrically. | ||
Slight dysfunction in platelet mitochondrial respiration and reduced platelet | Slight dysfunction in platelet mitochondrial respiration and reduced platelet CoQ<sub>10</sub> levels were observed in RA patients compared with normal controls. | ||
The observed decrease in platelet | The observed decrease in platelet CoQ<sub>10</sub> levels may lead to platelet mitochondrial dysfunction in RA diseases. Determination of platelet mitochondrial function and platelet CoQ<sub>10</sub> levels could be used as new diagnostic strategies for mitochondrial bioenergetics in rheumatoid diseases. | ||
|editor=[[Plangger M]] | |editor=[[Plangger M]] | ||
|mipnetlab=SK Bratislava Sumbalova Z | |||
}} | }} | ||
== Cited by == | |||
{{Template:Cited by Komlodi 2021 MitoFit CoQ}} | |||
{{Labeling | {{Labeling | ||
|area=Respiration | |area=Respiration, Patients | ||
|diseases=Other | |||
|organism=Human | |||
|tissues=Platelet | |||
|preparations=Permeabilized cells, Intact cells | |||
|couplingstates=LEAK, ROUTINE, OXPHOS, ET | |||
|pathways=N, S, NS, ROX | |||
|instruments=Oxygraph-2k | |instruments=Oxygraph-2k | ||
|additional=2021-10 | |additional=2021-10, MitoFit 2021 CoQ | ||
}} | }} | ||
Latest revision as of 01:38, 4 November 2021
| Gvozdjáková A, Sumbalová Z, Kucharská J, Szamosová M, Čápová L, Rausová Z, Vančová O, Mojto V, Langsjoen P, Palacka P (2021) Platelet mitochondrial respiration and coenzyme Q10 could be used as new diagnostic strategy for mitochondrial dysfunction in rheumatoid diseases. PLoS ONE 16:e0256135. |
Gvozdjakova Anna, Sumbalova Zuzana, Kucharska Jarmila, Szamosova Monika, Capova Lubica, Rausova Zuzana, Vancova Olga, Mojto Viliam, Langsjoen Peter, Palacka Patrik (2021) PLoS ONE
Abstract: Rheumatoid arthritis (RA) is a chronic inflammatory autoimunne disorder affecting both small and large synovial joints, leading to their destruction. Platelet biomarkers are involved in inflammation in RA patients. Increased circulating platelet counts in RA patients may contribute to platelet hyperactivity and thrombosis. In this pilot study we evaluated platelet mitochondrial bioenergy function, CoQ10 levels and oxidative stress in RA patients.
Twenty-one RA patients and 19 healthy volunteers participated in the study. High resolution respirometry (HRR) was used for analysis of platelet mitochondrial bioenergetics. CoQ10 was determined by HPLC method; TBARS were detected spectrophotometrically.
Slight dysfunction in platelet mitochondrial respiration and reduced platelet CoQ10 levels were observed in RA patients compared with normal controls.
The observed decrease in platelet CoQ10 levels may lead to platelet mitochondrial dysfunction in RA diseases. Determination of platelet mitochondrial function and platelet CoQ10 levels could be used as new diagnostic strategies for mitochondrial bioenergetics in rheumatoid diseases.
• Bioblast editor: Plangger M • O2k-Network Lab: SK Bratislava Sumbalova Z
Cited by
- Komlódi T, Cardoso LHD, Doerrier C, Moore AL, Rich PR, Gnaiger E (2021) Coupling and pathway control of coenzyme Q redox state and respiration in isolated mitochondria. Bioenerg Commun 2021.3. https://doi.org/10.26124/bec:2021-0003
Labels: MiParea: Respiration, Patients Pathology: Other
Organism: Human Tissue;cell: Platelet Preparation: Permeabilized cells, Intact cells
Coupling state: LEAK, ROUTINE, OXPHOS, ET
Pathway: N, S, NS, ROX
HRR: Oxygraph-2k
2021-10, MitoFit 2021 CoQ
