Difference between revisions of "Glutamate-anaplerotic pathway control state"
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{{MitoPedia | {{MitoPedia | ||
|abbr=G | |abbr=G | ||
|description=[[File:G.jpg|left|200px|G]] '''G''': [[Glutamate]] is a [[ETS substrate types |NADH-linked type 4 substrate]]. When supplied as the sole fuel substrate, G is transported by the electroneutral glutamate-/OH- exchanger, and is oxidised via mt [[glutamate dehydrogenase]] in the mitochondrial matrix. | |description=[[File:G.jpg|left|200px|G]] '''G''': [[Glutamate]] is a [[ETS substrate types |NADH-linked type 4 substrate]]. When supplied as the sole fuel substrate in the '''glutamate pathway control state''', G is transported by the electroneutral glutamate-/OH- exchanger, and is oxidised via mt [[glutamate dehydrogenase]] in the mitochondrial matrix. | ||
|info=[[Gnaiger 2014 MitoPathways]] - Chapter 3.3 | |info=[[Gnaiger 2014 MitoPathways]] - Chapter 3.3 | ||
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|mitopedia concept=Respiratory state, SUIT state | |mitopedia concept=Respiratory state, SUIT state | ||
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== G(L) == | == G(L) == | ||
Revision as of 10:08, 8 November 2016
- high-resolution terminology - matching measurements at high-resolution
Glutamate-anaplerotic pathway control state
Description
G: Glutamate is a NADH-linked type 4 substrate. When supplied as the sole fuel substrate in the glutamate pathway control state, G is transported by the electroneutral glutamate-/OH- exchanger, and is oxidised via mt glutamate dehydrogenase in the mitochondrial matrix.
Abbreviation: G
Reference: Gnaiger 2014 MitoPathways - Chapter 3.3
MitoPedia concepts:
Respiratory state,
SUIT state
G(L)
G(P)
G(E)
Details
- In human skeletal muscle mitochondria, OXPHOS capacity with glutamate alone is 50% to 85% of respiration with Glutamate&Malate. Accumulation of fumarate inhibits succinate dehydrogenase and glutamate dehydrogenase.
- Glutamate derived from hydrolyzation of glutamine is an important aerobic substrate in cultured cells. Mitochondrial glutamate dehydrogenase is particularly active in astrocytes, preventing glutamate induced neurotoxicity. mtNAD-malic enzyme supports an anaplerotic pathway when carbohydrate is limiting.
