Glombik 2019 Neurotox Res: Difference between revisions
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{{Publication | {{Publication | ||
|title=GΕombik K, Detka J, GΓ³ralska J, Kurek A, Solnica B, Budziszewska B (2019) Brain metabolic alterations in rats showing depression-like and obesity phenotypes. Neurotox Res | |title=GΕombik K, Detka J, GΓ³ralska J, Kurek A, Solnica B, Budziszewska B (2019) Brain metabolic alterations in rats showing depression-like and obesity phenotypes. Neurotox Res 37:406-24. | ||
|info=[https://www.ncbi.nlm.nih.gov/pubmed/31782099 PMID: 31782099 Open Access] | |info=[https://www.ncbi.nlm.nih.gov/pubmed/31782099 PMID: 31782099 Open Access] | ||
|authors=Glombik K, Detka J, Goralska J, Kurek A, Solnica B, Budziszewska B | |authors=Glombik K, Detka J, Goralska J, Kurek A, Solnica B, Budziszewska B | ||
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{{Labeling | {{Labeling | ||
|area=Respiration | |area=Respiration, Developmental biology, Exercise physiology;nutrition;life style | ||
|diseases=Obesity, Other | |||
|organism=Rat | |||
|tissues=Nervous system | |||
|preparations=Isolated mitochondria | |||
|enzymes=TCA cycle and matrix dehydrogenases | |||
|couplingstates=LEAK, OXPHOS, ET | |||
|pathways=N, S, NS, ROX | |||
|instruments=Oxygraph-2k | |instruments=Oxygraph-2k | ||
|additional=Labels, 2019-12, | |additional=Labels, 2019-12, | ||
}} | }} |
Latest revision as of 11:43, 3 March 2020
GΕombik K, Detka J, GΓ³ralska J, Kurek A, Solnica B, Budziszewska B (2019) Brain metabolic alterations in rats showing depression-like and obesity phenotypes. Neurotox Res 37:406-24. |
Glombik K, Detka J, Goralska J, Kurek A, Solnica B, Budziszewska B (2019) Neurotox Res
Abstract: Current data suggest an important role of brain metabolic disturbances in the pathogenesis of depression and obesity, diseases that frequently co-occur. Our aim was to determine whether there are changes in markers characterizing glucose metabolism in prenatal stress (PS; animal model of depression), in rats fed a high-fat diet (HFD), and especially in the model of depression and obesity co-occurrence. The changes in glucose-6-phosphate, glycogen, glucose transporters (GLUT1, GLUT4), glucagon-like peptide-1 receptor (GLP-1R), and mitochondrial complexes levels in the frontal cortex and/or hippocampus were observed. In the case of the coexistence of depression and obesity, the most important changes were (1) the decrease in the membrane form of GLUT4, which may suggest weaker insulin action in the frontal cortex, and (2) the diminished GLP-1R, which could cause neurodegenerative changes in the hippocampus. However, presented results suggested that HFD weakened the PS effect of uncoupling oxidative phosphorylation in the frontal cortex. β’ Keywords: Brain, Depression, Glucose, High-fat diet, Mitochondria, Oxidative phosphorylation β’ Bioblast editor: Plangger M
Labels: MiParea: Respiration, Developmental biology, Exercise physiology;nutrition;life style
Pathology: Obesity, Other
Organism: Rat Tissue;cell: Nervous system Preparation: Isolated mitochondria Enzyme: TCA cycle and matrix dehydrogenases
Coupling state: LEAK, OXPHOS, ET Pathway: N, S, NS, ROX HRR: Oxygraph-2k
Labels, 2019-12