Garedew 2005 Eur Shock Soc
| Garedew A, Hütter E, Haffner B, Gradl P, Gradl L, Jansen-Dürr P, Gnaiger E (2005) High-resolution respirometry for the study of mitochondrial function in health and disease. The OROBOROS O2k. Proc 11th Congress Eur Shock Soc, Vienna, Austria (Redl H, ed) Medimond, Bologna:107-11. |
Garedew A, Huetter E, Haffner B, Gradl P, Gradl L, Jansen-Duerr P, Gnaiger E (2005) Medimond
Abstract: High-resolution respirometry with mitochondria, cells or biopsies is based on the unique features of the OROBOROS O2k, combining instrumental design, electronics and task-specific DatLab software. Various respiratory states are analyzed with <0.4 million cells or <4 mg biopsy (muscle, liver) per assay. Complex substrate/inhibitor titration protocols are used to quantify functional properties of selected components of the respiratory chain. The electronic titration-injection micropump TIP2k is applied for kinetics as a modular component of the O2k. DatLab provides on-line instrumental background corrections of oxygen flux and on-line data analysis, and tabulated results are available at the end of an experiment. This sets a new standard for biomedical and clinical studies, combining high-resolution with instant diagnostic information.
• O2k-Network Lab: AT Innsbruck Gnaiger E, AT Innsbruck Jansen-Duerr P, AT Innsbruck OROBOROS
Labels: MiParea: Respiration, Instruments;methods
Organism: Human
Tissue;cell: Fibroblast
Preparation: Intact cells
Regulation: Uncoupler Coupling state: OXPHOS
HRR: Oxygraph-2k, TIP2k
The present paper is fully quality controlled, but concerns emerged about the integrity of the first author
- From https://www.linkedin.com/in/assegid/ 2017-04-10
- Assa Oumie - Currently Senior Analytical Development Scientist at Cell Therapy Catapult, growing the UK cell and gene therapy industry, delivering health and wealth. Previous to this I worked as a Lead Staff Scientist at Affymetrix UK for an NHS Diagnostic Lab-Academic Research Lab-CRO- Biotech collaborative R&D project, co-funded by the Innovate UK-Stratified Medicine Programme, to develop the OncoScan Assay for tumour genomic profiling.
- As a Post Doctoral Researcher of Cell and Molecular Biology at University College London (UCL) I studied cell metabolism and identified therapeutic targets against inflammation and statin-induced myopathy, in collaboration with academic and industrial partners. During my career at UCL I secured funding from research council, charity and pharmaceutical industry for three major research projects, supervised the research projects of students and junior staff and delivered module courses to graduate students.
- As a Business Development Associate and Post-Doctoral Researcher at Innsbruck Medical University (Austria) in partnership with a spin-out company, I played key roles in cell biology research, oxygen sensor and software development and validation, and customer technical support. Before moving to Innsbruck, I worked at the Medical Faculty of the University of Würzburg (Germany) where I conducted comparative metabolic investigation, on cancer and foetal cells, to better understand the mechanism of adaptation to hypoxia.
- From https://www.linkedin.com/in/assegid/ 2017-04-10
- Declaration
- Assegid Garedew but not Assa Oumie (no person of that name is known to us) was a Postdoc employed by our 'spin-out company' working at the Medical University of Innsbruck (DSL Research Laboratory) after moving to Innsbruck from the University of Würzburg. ~ Gnaiger Erich (talk) 14:01, 10 April 2017 (CEST)
- Declaration
