- high-resolution terminology - matching measurements at high-resolution
Flux control efficiency
Description
Flux control capacities express the control of respiration by a specific metabolic variable, X, as a dimensionless (normalized) fractional change of flux, Ξj. Z is the reference state with high (stimulated or un-inhibited) flux; Y is the background state at low flux, upon which X acts. This yields the flux control ratio jY=Y/Z); X is either added (stimulation, activation) or removed (reversal of inhibition) to yield a flux Z from background Y. Note that X, Y and Z denote both, the metabolic control variable (X) or respiratory state (Y, Z) and the corresponding respiratory flux, X=Z-Y. Experimentally, inhibitors are added rather than removed; then Z is the reference state and Y the background state in the presence of the inhibitor. The flux control capacity of X upon background Y is expressed as the change of flux from Y to Z normalized for the reference state Z:
- ΞjZ-Y = (Z-Y)/Z = 1-jY
Substrate control capacities express the relative change of oxygen flux in response to a transition of substrate availability in a defined coupling state. Coupling and phosphorylation control capacities are determined in an ETS-competent substrate state.
Abbreviation: FCC
Reference: Gnaiger 2013 Abstract MiP2013
MitoPedia methods:
Respirometry
MitoPedia topics: "Respiratory control ratio" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property.
Respiratory control ratio"Respiratory control ratio" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property.
