Flux control efficiency: Difference between revisions
(Created page with "{{MitoPedia |abbr=''FCC'' |info=Gnaiger 2013 Abstract MiP2013 }} {{MitoPedia methods |mitopedia method=Respirometry }} {{MitoPedia topics |mitopedia topic=Respiratory control...") |
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|abbr=''FCC'' | |abbr=''FCC'' | ||
|description='''Flux control capacities''' express the control of respiration by a specific metabolic variable, ''X'', as a dimensionless (normalized) fractional change of flux, Δ''j''. ''Z'' is the [[reference sate]] with high (stimulated or un-inhibited) flux; ''Y'' is the [[background state]] at low flux, upon which ''X'' acts. This yields the flux control ratio ''j<sub>Y</sub>''=''Y/Z''); ''X'' is either added (stimulation, activation) or removed (reversal of inhibition) to yield a flux ''Z'' from background ''Y''. Note that ''X'', ''Y'' and ''Z'' denote both, the metabolic control variable (''X'') or respiratory state (''Y, Z'') and the corresponding respiratory flux, ''X''=''Z-Y''. Experimentally, inhibitors are added rather than removed; then ''Z'' is the reference state and ''Y'' the background state in the presence of the inhibitor. The flux control capacity of ''X'' upon background ''Y'' is expressed as the change of flux from ''Y'' to ''Z'' normalized for the reference state ''Z'': | |||
:: Δ''j<sub>Z-Y</sub> = (''Z-Y'')/''Z'' = 1-''j<sub>Y</sub>'' | |||
[[Substrate control capacitiy|Substrate control capacities]] express the relative change of oxygen flux in response to a transition of substrate availability in a defined coupling state. [[Coupling control capacity|Coupling and phosphorylation control capacities]] are determined in an [[ETS-competent substrate state]]. | |||
|info=[[Gnaiger 2013 Abstract MiP2013]] | |info=[[Gnaiger 2013 Abstract MiP2013]] | ||
}} | }} |
Revision as of 22:52, 3 August 2013
Description
Flux control capacities express the control of respiration by a specific metabolic variable, X, as a dimensionless (normalized) fractional change of flux, Δj. Z is the reference sate with high (stimulated or un-inhibited) flux; Y is the background state at low flux, upon which X acts. This yields the flux control ratio jY=Y/Z); X is either added (stimulation, activation) or removed (reversal of inhibition) to yield a flux Z from background Y. Note that X, Y and Z denote both, the metabolic control variable (X) or respiratory state (Y, Z) and the corresponding respiratory flux, X=Z-Y. Experimentally, inhibitors are added rather than removed; then Z is the reference state and Y the background state in the presence of the inhibitor. The flux control capacity of X upon background Y is expressed as the change of flux from Y to Z normalized for the reference state Z:
- ΔjZ-Y = (Z-Y)/Z = 1-jY
Substrate control capacities express the relative change of oxygen flux in response to a transition of substrate availability in a defined coupling state. Coupling and phosphorylation control capacities are determined in an ETS-competent substrate state.
Abbreviation: FCC
Reference: Gnaiger 2013 Abstract MiP2013
MitoPedia methods:
Respirometry
MitoPedia topics: "Respiratory control ratio" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property.
Respiratory control ratio"Respiratory control ratio" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property.