View source for Diaz 2023 Front Mol Biosci

{{Publication
|title=Diaz EC, Adams SH, Weber JL, Cotter M, Børsheim E (2023) Elevated LDL-C, high blood pressure, and low peak V˙O2 associate with platelet mitochondria function in children-The Arkansas Active Kids Study. Front Mol Biosci 10:1136975. https://doi.org/10.3389/fmolb.2023.1136975
|info=[https://pubmed.ncbi.nlm.nih.gov/37033448/ PMID: 37033448 Open Access]
|authors=Diaz Eva C, Adams Sean H, Weber JL, Cotter Matthew, Borsheim Elisabet
|year=2023
|journal=Front Mol Biosci
|abstract=Purpose: To evaluate the association of platelet (PL) mitochondria respiration with markers of cardiovascular health in children ages 7-10 years. Methods: PL mitochondrial respiration (''n'' = 91) was assessed by high-resolution respirometry (HRR): Routine (''R'') respiration, complex (C) I linked respiration (CI), and maximal uncoupled electron transport capacity of CII (CII''E'') were measured. The respiratory control ratio (RCR) was calculated as the ratio of maximal oxidative phosphorylation capacity of CI and CI LEAK respiration (PCI/''L''CI). Peak ˙''V''O2 (incremental bike test) and body composition (dual-energy X-ray absorptiometry) were measured. Multiple generalized linear regression analysis was used to model the association of measures by HRR with variables of interest: adiposity, low-density lipoprotein (LDL-C) and triglyceride (TG) status (normal vs. elevated) HOMA2-IR, blood pressure status (normal vs. high), and demographics. Results: ''R'' and CI-linked respiration positively associated with adiposity, high blood pressure (HBP), and peak ˙''V'' O2. ''R'' and CI-linked respiration had inverse association with age and elevated LDL-C. CII''E'' was higher in children with elevated LDL-C (log-β = -0.54, ''p'' = 0.010). HBP and peak ˙''V''O2 interacted in relation to RCR (log-β = -0.01, ''p'' = 0.028). Specifically, RCR was lowest among children with HBP and low aerobic capacity (i.e., mean peak ˙''V''O2 -1SD). HOMA2-IR did not associate with measures of PL mitochondria respiration. Conclusion: In PL, ''R'' and CI-linked mitochondrial respiration directly associate with adiposity, peak ˙''V''O2 and HBP. Elevated LDL-C associates with lower CI-linked respiration which is compensated by increasing CII respiration. PL bioenergetics phenotypes in children associate with whole-body metabolic health status.
|editor=Gnaiger E
|mipnetlab=US AR Little Rock Borsheim E
}}
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{{Labeling
|area=Respiration, Exercise physiology;nutrition;life style
|diseases=Aging;senescence
|organism=Human
|tissues=Blood cells, Platelet
|preparations=Permeabilized cells
|enzymes=Complex II;succinate dehydrogenase
|couplingstates=LEAK, ROUTINE, ET
|pathways=N, S
|instruments=Oxygraph-2k
}}