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Daura 2021 Neurobiol Dis - Revision history
2024-03-29T00:57:39Z
Revision history for this page on the wiki
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https://wiki.oroboros.at/index.php?title=Daura_2021_Neurobiol_Dis&diff=237186&oldid=prev
Gnaiger Erich at 10:32, 27 March 2023
2023-03-27T10:32:18Z
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Gnaiger Erich
https://wiki.oroboros.at/index.php?title=Daura_2021_Neurobiol_Dis&diff=219344&oldid=prev
Plangger Mario at 00:43, 27 July 2021
2021-07-27T00:43:10Z
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|area=Respiration, Genetic knockout;overexpression</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|area=Respiration<ins style="font-weight: bold; text-decoration: none;">, nDNA;cell genetics</ins>, Genetic knockout;overexpression</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|diseases=Neurodegenerative</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|diseases=Neurodegenerative</div></td></tr>
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Plangger Mario
https://wiki.oroboros.at/index.php?title=Daura_2021_Neurobiol_Dis&diff=219343&oldid=prev
Reiswig Regina at 15:00, 26 July 2021
2021-07-26T15:00:21Z
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Reiswig Regina
https://wiki.oroboros.at/index.php?title=Daura_2021_Neurobiol_Dis&diff=219342&oldid=prev
Reiswig Regina at 14:58, 26 July 2021
2021-07-26T14:58:19Z
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Reiswig Regina
https://wiki.oroboros.at/index.php?title=Daura_2021_Neurobiol_Dis&diff=219341&oldid=prev
Reiswig Regina at 14:57, 26 July 2021
2021-07-26T14:57:17Z
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Reiswig Regina
https://wiki.oroboros.at/index.php?title=Daura_2021_Neurobiol_Dis&diff=219340&oldid=prev
Reiswig Regina at 14:56, 26 July 2021
2021-07-26T14:56:31Z
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|organism=Mouse</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|organism=Mouse</div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">|tissues=Stem cells</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|preparations=Permeabilized cells</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|preparations=Permeabilized cells</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|couplingstates=LEAK, OXPHOS, ET</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|couplingstates=LEAK, OXPHOS, ET</div></td></tr>
</table>
Reiswig Regina
https://wiki.oroboros.at/index.php?title=Daura_2021_Neurobiol_Dis&diff=219339&oldid=prev
Reiswig Regina: Created page with "{{Publication |title=Daura E, Tegelberg S, Yoshihara M, Jackson C, Simonetti F, Aksentjeff K, Ezer S, Hakala P, Katayama S, Kere J, Lehesjoki AE, Joensuu T (2021) Cystatin B-d..."
2021-07-26T14:34:28Z
<p>Created page with "{{Publication |title=Daura E, Tegelberg S, Yoshihara M, Jackson C, Simonetti F, Aksentjeff K, Ezer S, Hakala P, Katayama S, Kere J, Lehesjoki AE, Joensuu T (2021) Cystatin B-d..."</p>
<p><b>New page</b></p><div>{{Publication<br />
|title=Daura E, Tegelberg S, Yoshihara M, Jackson C, Simonetti F, Aksentjeff K, Ezer S, Hakala P, Katayama S, Kere J, Lehesjoki AE, Joensuu T (2021) Cystatin B-deficiency triggers ectopic histone H3 tail cleavage during neurogenesis. Neurobiol Dis 156:105418.<br />
|info=[https://pubmed.ncbi.nlm.nih.gov/34102276/ PMID: 34102276 Open Access]<br />
|authors=Daura Eduard, Tegelberg Saara, Yoshihara Masahito, Jackson Christopher, Simonetti Francesca, Aksentjeff Katri, Ezer Sini, Hakala Paula, Katayama Shintaro, Kere Juha, Lehesjoki Anna-Elina, Joensuu Tarja<br />
|year=2021<br />
|journal=Neurobiol Dis<br />
|abstract=Cystatin B (CSTB) acts as an inhibitor of cysteine proteases of the cathepsin family and loss-of-function mutations result in human brain diseases with a genotype-phenotype correlation. In the most severe case, CSTB-deficiency disrupts brain development, and yet the molecular basis of this mechanism is missing. Here, we establish CSTB as a regulator of chromatin structure during neural stem cell renewal and differentiation. Murine neural precursor cells (NPCs) undergo transient proteolytic cleavage of the N-terminal histone H3 tail by cathepsins B and L upon induction of differentiation into neurons and glia. In contrast, CSTB-deficiency triggers premature H3 tail cleavage in undifferentiated self-renewing NPCs and sustained H3 tail proteolysis in differentiating neural cells. This leads to significant transcriptional changes in NPCs, particularly of nuclear-encoded mitochondrial genes. In turn, these transcriptional alterations impair the enhanced mitochondrial respiration that is induced upon neural stem cell differentiation. Collectively, our findings reveal the basis of epigenetic regulation in the molecular pathogenesis of CSTB deficiency.Cystatin B (CSTB) acts as an inhibitor of cysteine proteases of the cathepsin family and loss-of-function mutations result in human brain diseases with a genotype-phenotype correlation. In the most severe case, CSTB-deficiency disrupts brain development, and yet the molecular basis of this mechanism is missing. Here, we establish CSTB as a regulator of chromatin structure during neural stem cell renewal and differentiation. Murine neural precursor cells (NPCs) undergo transient proteolytic cleavage of the N-terminal histone H3 tail by cathepsins B and L upon induction of differentiation into neurons and glia. In contrast, CSTB-deficiency triggers premature H3 tail cleavage in undifferentiated self-renewing NPCs and sustained H3 tail proteolysis in differentiating neural cells. This leads to significant transcriptional changes in NPCs, particularly of nuclear-encoded mitochondrial genes. In turn, these transcriptional alterations impair the enhanced mitochondrial respiration that is induced upon neural stem cell differentiation. Collectively, our findings reveal the basis of epigenetic regulation in the molecular pathogenesis of CSTB deficiency.<br />
|keywords=Cathepsin, Cystatin B, Histone cleavage, Histone clipping, Neural differentiation, Progressive myoclonus epilepsy<br />
|editor=[[Reiswig R]]<br />
}}<br />
{{Labeling<br />
|area=Respiration, Genetic knockout;overexpression<br />
|organism=Mouse<br />
|preparations=Permeabilized cells<br />
|couplingstates=LEAK, OXPHOS, ET<br />
|pathways=N, CIV, NS<br />
|instruments=Oxygraph-2k<br />
|additional=2021-07<br />
}}</div>
Reiswig Regina