Difference between revisions of "Coupling-control state"
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|mitopedia concept=Respiratory state, SUIT state | |mitopedia concept=MiP concept, Respiratory state, SUIT concept, SUIT state | ||
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{{MitoPedia methods | {{MitoPedia methods | ||
|mitopedia method=Respirometry | |mitopedia method=Respirometry | ||
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{{MitoPedia O2k and high-resolution respirometry}} | |||
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[[File:EPL-free and excess.jpg|right|300px|thumb|[[Gnaiger 2014 MitoPathways |The Blue Book 2014: Fig. 2.4.]]]] | [[File:EPL-free and excess.jpg|right|300px|thumb|[[Gnaiger 2014 MitoPathways |The Blue Book 2014: Fig. 2.4.]]]] | ||
'''Coupling control states:''' [[Image:P.jpg|link=OXPHOS capacity|OXPHOS]] [[Image:R.jpg|link=ROUTINE respiration|ROUTINE]] [[Image:E.jpg|link=ETS capacity|ETS]] [[Image:L.jpg|link=LEAK respiration|LEAK]] - [[Image:ROX.jpg|link=Residual oxygen consumption|ROX]] | '''Coupling control states:''' [[Image:P.jpg|link=OXPHOS capacity|OXPHOS]] [[Image:R.jpg|link=ROUTINE respiration|ROUTINE]] [[Image:E.jpg|link=ETS capacity|ETS]] [[Image:L.jpg|link=LEAK respiration|LEAK]] - [[Image:ROX.jpg|link=Residual oxygen consumption|ROX]] | ||
Β Communicated by [[Gnaiger E]] 2011-02-25, edited 2016-10-20. | Β Communicated by [[Gnaiger E]] 2011-02-25, edited 2016-10-20. |
Revision as of 12:14, 8 November 2016
Description
Coupling control states are defined in mitochondrial preparations (isolated mitochondria, permeabilized cells, permeabilized tissues, homogenates) as LEAK, OXPHOS, and ETS states of respiration (L, P, E) in any pathway control state which is competent for electron transfer. These coupling states are induced by application of specific inhibitors of the phosphorylation system, titration of ADP and uncouplers. In intact cells, the coupling control states are LEAK, ROUTINE, and ETS states of respiration (L, R, E). Coupling control protocols induce these coupling control states sequentially at a constant pathway control state.
Abbreviation: CCS
Reference: Gnaiger 2009 Int J Biochem Cell Biol
MitoPedia concepts:
MiP concept,
Respiratory state,
SUIT concept,
SUIT state
MitoPedia methods:
Respirometry
Communicated by Gnaiger E 2011-02-25, edited 2016-10-20.