Difference between revisions of "Convergent electron flow"

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Convergent electron flow

Description

Convergent electron flow is built into the metabolic design of the Electron transfer-pathway. The glycolytic pathways are characterized by important divergent branchpoints: phosphoenolpyruvate (PEPCK) branchpoint to pyruvate or oxaloactetate; pyruvate branchpoint to (aerobic) acetyl-CoA or (anaerobic) lactate or alanine. The mitochondrial Electron transfer-pathway, in contrast, is characterized by convergent junctions: (1) the N-junction and F-junction in the mitochondrial matrix at ET-pathway level 4, with dehydrogenases (including the TCA cycle) and ß-oxidation generating NADH and FADH₂ as substrates for Complex I and electron-transferring flavoprotein complex, respectively, and (2) the Q-junction with inner mt-membrane respiratory complexes at ET-pathway level 3, reducing the oxidized ubiquinone and partially reduced semiquinone to the fully reduced ubiquinol, feeding electrons into Complex III.

Abbreviation: n.a.

Reference: Gnaiger 2014 MitoPathways, Gnaiger_2009_Int J Biochem Cell Biol

MitoPedia methods: Respirometry

MitoPedia topics: Substrate and metabolite

More details

» Additive effect of convergent electron flow

» Respiratory complexes - more than five

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 |abbr=n.a.
 |description=[[Image:SUIT-catg_FNSGp.jpg|right|300px|Convergent electron flow]]
-'''Convergent electron flow''' is built into the metabolic design of the [[electron transfer system]]. The glycolytic pathways are characterized by important ''divergent branchpoints'': phosphoenolpyruvate (PEPCK) branchpoint to pyruvate or oxaloactetate; pyruvate branchpoint to (aerobic) acetyl-CoA or (anaerobic) lactate or alanine. The mitochondrial electron transfer system, in contrast, is characterized by ''convergent junctions'': (1) the [[N-junction]] and [[F-junction]] in the [[mitochondrial matrix]] at ET-pathway level 4, with dehydrogenases (including the TCA cycle) and ß-oxidation generating NADH and FADH<sub>2</sub> as substrates for [[Complex I]] and [[electron-transferring flavoprotein complex]], respectively, and (2) the [[Q-junction]] with inner mt-membrane respiratory complexes at ET-pathway level 3, reducing the oxidized ubiquinone and partially reduced semiquinone to the fully reduced ubiquinol, feeding electrons into [[Complex III]].
+'''Convergent electron flow''' is built into the metabolic design of the [[Electron transfer-pathway]]. The glycolytic pathways are characterized by important ''divergent branchpoints'': phosphoenolpyruvate (PEPCK) branchpoint to pyruvate or oxaloactetate; pyruvate branchpoint to (aerobic) acetyl-CoA or (anaerobic) lactate or alanine. The mitochondrial Electron transfer-pathway, in contrast, is characterized by ''convergent junctions'': (1) the [[N-junction]] and [[F-junction]] in the [[mitochondrial matrix]] at ET-pathway level 4, with dehydrogenases (including the TCA cycle) and ß-oxidation generating NADH and FADH<sub>2</sub> as substrates for [[Complex I]] and [[electron-transferring flavoprotein complex]], respectively, and (2) the [[Q-junction]] with inner mt-membrane respiratory complexes at ET-pathway level 3, reducing the oxidized ubiquinone and partially reduced semiquinone to the fully reduced ubiquinol, feeding electrons into [[Complex III]].
 |info=[[Gnaiger 2014 MitoPathways]], [[Gnaiger_2009_Int J Biochem Cell Biol]]
 }}