Complex I-linked substrate state

high-resolution terminology - matching measurements at high-resolution

Complex I-linked substrate state

Description

The Complex I-linked substrate state is induced in mt-preparations by addition of NADH-generating substrates individually or in combination: pyruvate, glutamate, malate, oxoglutarate, citrate, hydroxybutarate. These C_I-linked substrates are (indirectly) linked to Complex I by the corresponding dehydrogenase-catalyzed reactions reducing NAD⁺ to NADH+H⁺. In mt-preparations, C_II may be largely substrate-limited in C_I-linked respiration, due to metabolite depletion into the incubation medium.

Abbreviation: C_I-linked

Reference: Gnaiger 2014 MitoPathways

MitoPedia topics: "Respiratory state" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property. Respiratory state"Respiratory state" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property., Substrate and metabolite