Difference between revisions of "Complex I-linked substrate state"
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Revision as of 14:58, 8 February 2016
- high-resolution terminology - matching measurements at high-resolution
Complex I-linked substrate state
Description
The Complex I-linked substrate state is induced in mt-preparations by addition of NADH-generating substrates individually or in combination: pyruvate, glutamate, malate, oxoglutarate, citrate, hydroxybutyrate. These CI-linked substrates are (indirectly) linked to Complex I by the corresponding dehydrogenase-catalyzed reactions reducing NAD+ to NADH+H+. In mt-preparations, CII may be largely substrate-limited in CI-linked respiration, due to metabolite depletion into the incubation medium.
Alternatively, the abbreviation CI refers to the enzyme Complex I.
Abbreviation: CI, CI-linked
Reference: Gnaiger 2014 MitoPathways
MitoPedia concepts:
Respiratory state
MitoPedia O2k and high-resolution respirometry: "SUIT state" is not in the list (O2k hardware, DatLab, Oroboros QM, O2k-Open Support, O2k-Respirometry, O2k-FluoRespirometry) of allowed values for the "MitoPedia O2k and high-resolution respirometry" property. SUIT state"SUIT state" is not in the list (O2k hardware, DatLab, Oroboros QM, O2k-Open Support, O2k-Respirometry, O2k-FluoRespirometry) of allowed values for the "MitoPedia O2k and high-resolution respirometry" property.
MitoPedia topics:
Substrate and metabolite
