Citrate: Difference between revisions
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|description=[[File:Citrate 300 (1).png|left|100px|Oxaloacetic acid]] | |description=[[File:Citrate 300 (1).png|left|100px|Oxaloacetic acid]] | ||
''' | '''citrate''', C<sub>6</sub>H<sub>5</sub>O<sub>7</sub><sup>-3</sup>, is a tricarboxylic acid trianion, intermediate of the TCA, obtained by deprotonation of the three carboxy groups of citric acid. Citrate is formed from [[oxaloacetate]] and acetyl-CoA through the catalytic activity of the [[citrate synthase]]. In the TCA, citrate forms isocitrate by the activity of the [[aconitase]]. Citrate can be transported out of the mitochondria by the tricarboxylate transport, situated in the inner mitochondrial membrane. The transport occurs as an antiport of malate from the cytosol and it is a key process for fatty acid and oxaloacetate synthesis in the cytosol. | ||
Communicated by [[Iglesias-Gonzalez Javier]] and [[Cecatto Cristiane]] last update 2020-10-05 | |||
|info=[[Gnaiger 2014 MitoPathways]] | |info=[[Gnaiger 2014 MitoPathways]] | ||
|type=Enzyme | |type=Enzyme |
Revision as of 13:32, 5 October 2020
Description
citrate, C6H5O7-3, is a tricarboxylic acid trianion, intermediate of the TCA, obtained by deprotonation of the three carboxy groups of citric acid. Citrate is formed from oxaloacetate and acetyl-CoA through the catalytic activity of the citrate synthase. In the TCA, citrate forms isocitrate by the activity of the aconitase. Citrate can be transported out of the mitochondria by the tricarboxylate transport, situated in the inner mitochondrial membrane. The transport occurs as an antiport of malate from the cytosol and it is a key process for fatty acid and oxaloacetate synthesis in the cytosol.
Communicated by Iglesias-Gonzalez Javier and Cecatto Cristiane last update 2020-10-05
Reference: Gnaiger 2014 MitoPathways
MitoPedia topics: Substrate and metabolite