Difference between revisions of "Charles 2020 Nanomedicine (Lond)"
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|title=Charles C, Cohen-Erez I, Kazaoka B, Melnikov O, Stein DE, Sensenig R, Rapaport H, Orynbayeva Z (2020) Mitochondrial responses to organelle-specific drug delivering nanoparticles composed of polypeptide and peptide complexes. Nanomedicine (Lond) [Epub ahead of print]. | |title=Charles C, Cohen-Erez I, Kazaoka B, Melnikov O, Stein DE, Sensenig R, Rapaport H, Orynbayeva Z (2020) Mitochondrial responses to organelle-specific drug delivering nanoparticles composed of polypeptide and peptide complexes. Nanomedicine (Lond) [Epub ahead of print]. | ||
|info=[https://www.ncbi.nlm.nih.gov/pubmed/33241963 PMID: 33241963] | |info=[https://www.ncbi.nlm.nih.gov/pubmed/33241963 PMID: 33241963] | ||
|authors=Charles | |authors=Charles Carleigh, Cohen-Erez Ifat, Kazaoka Blake, Melnikov Olga, Stein David E, Sensenig Richard, Rapaport Hanna, Orynbayeva Zulfiya | ||
|year=2020 | |year=2020 | ||
|journal=Nanomedicine (Lond) | |journal=Nanomedicine (Lond) |
Revision as of 16:42, 1 December 2020
Charles C, Cohen-Erez I, Kazaoka B, Melnikov O, Stein DE, Sensenig R, Rapaport H, Orynbayeva Z (2020) Mitochondrial responses to organelle-specific drug delivering nanoparticles composed of polypeptide and peptide complexes. Nanomedicine (Lond) [Epub ahead of print]. |
Charles Carleigh, Cohen-Erez Ifat, Kazaoka Blake, Melnikov Olga, Stein David E, Sensenig Richard, Rapaport Hanna, Orynbayeva Zulfiya (2020) Nanomedicine (Lond)
Abstract: The mechanistic study of the drug carrier-target interactions of mitochondria-unique nanoparticles composed of polypeptide-peptide complexes (mPoP-NPs).
The isolated organelles were employed to address the direct effects of mPoP-NPs on dynamic structure and functional wellbeing of mitochondria. Mitochondria morphology, respiration, membrane potential, reactive oxygen species generation, were examined by confocal microscopy, flow cytometry and oxygraphy. Lonidamine-encapsulated formulation was assessed to evaluate the drug delivery capacity of the naive nanoparticles.
The mPoP-NPs do not alter mitochondria structure and performance upon docking to organelles, while successfully delivering drug that causes organelle dysfunction.
The study gives insight into interactions of mPoP-NPs with mitochondria and provides substantial support for consideration of designed nanoparticles as biocompatible and efficient mitochondria-targeted platforms. β’ Keywords: OxPhos, TPP+, Cancer, Ionidamine, Membrane potential, Mitochondria, Nanoparticles β’ Bioblast editor: Plangger M
Labels: MiParea: Respiration
HRR: Oxygraph-2k
2020-12