Chance 1961 J Biol Chem-III: Difference between revisions
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{{Publication | {{Publication | ||
|title=Chance B, Hollunger G (1961) The interaction of energy and electron transfer reactions in mitochondria III. Substrate requirements for pyridine nucleotide reduction in mitochondria. J Biol Chem 236: 1555-1561. Ā | |title=Chance B, Hollunger G (1961) The interaction of energy and electron transfer reactions in mitochondria III. Substrate requirements for pyridine nucleotide reduction in mitochondria. J Biol Chem 236: 1555-1561. | ||
|info=[http://www.jbc.org/content/236/5/1555.full.pdf+html PMID: 13692278 Open Access] | |info=[http://www.jbc.org/content/236/5/1555.full.pdf+html PMID: 13692278 Open Access] | ||
|authors=Chance B, Hollunger G | |authors=Chance B, Hollunger G | ||
|year=1961 | |year=1961 | ||
|journal=J Biol Chem | |journal=J Biol Chem | ||
|abstract= | |abstract=# AĀ specificĀ succinateĀ requirementĀ forĀ energy-linkedĀ reduction ofĀ mitochondrialĀ pyridineĀ nucleotideĀ isĀ demonstratedĀ inĀ pigeon heartĀ andĀ guineaĀ pig kidneyĀ mitochondria. | ||
# AĀ specificĀ succinateĀ requirementĀ forĀ energy-linkedĀ reduction ofĀ mitochondrialĀ pyridineĀ nucleotideĀ isĀ demonstratedĀ inĀ pigeon heartĀ andĀ guineaĀ pig kidneyĀ mitochondria. | |||
# TheĀ succinateĀ usedĀ inĀ thisĀ reductionĀ canĀ beĀ generatedĀ in theĀ oxidationĀ ofĀ malateĀ plusĀ glutamateĀ orĀ ofĀ Ī±-ketoglutarate. Ā | # TheĀ succinateĀ usedĀ inĀ thisĀ reductionĀ canĀ beĀ generatedĀ in theĀ oxidationĀ ofĀ malateĀ plusĀ glutamateĀ orĀ ofĀ Ī±-ketoglutarate. Ā | ||
# TheĀ roleĀ ofĀ succinateĀ isĀ identifiedĀ byĀ theĀ specificĀ inhibitory responsesĀ ofĀ theĀ reactionĀ toĀ malonate,Ā phosphate,Ā andĀ fumarate. Ā | # TheĀ roleĀ ofĀ succinateĀ isĀ identifiedĀ byĀ theĀ specificĀ inhibitory responsesĀ ofĀ theĀ reactionĀ toĀ malonate,Ā phosphate,Ā andĀ fumarate. Ā | ||
# AtĀ leastĀ twoĀ kindsĀ ofĀ mitochondrialĀ pyridineĀ nucleotideĀ are shownĀ toĀ be reducibleĀ inĀ stateĀ 4 : (a)Ā aboutĀ one-thirdĀ inĀ theĀ absenceĀ ofĀ addedĀ succinateĀ inĀ a malonate-insensitiveĀ reactionĀ inĀ theĀ presenceĀ o fĀ aĀ substrateĀ suchĀ asĀ malateĀ plusĀ glutamateĀ andĀ (b)Ā about two-thirdsĀ inĀ theĀ presenceĀ ofĀ addedĀ succinateĀ inĀ a malonate-sensitive,Ā energy-linkedĀ reaction.Ā TheseĀ twoĀ kindsĀ ofĀ pyridineĀ nucleotideĀ mayĀ beĀ consideredĀ toĀ beĀ compartmented. | # AtĀ leastĀ twoĀ kindsĀ ofĀ mitochondrialĀ pyridineĀ nucleotideĀ are shownĀ toĀ be reducibleĀ inĀ stateĀ 4 : (a)Ā aboutĀ one-thirdĀ inĀ theĀ absenceĀ ofĀ addedĀ succinateĀ inĀ a malonate-insensitiveĀ reactionĀ inĀ theĀ presenceĀ o fĀ aĀ substrateĀ suchĀ asĀ malateĀ plusĀ glutamateĀ andĀ (b)Ā about two-thirdsĀ inĀ theĀ presenceĀ ofĀ addedĀ succinateĀ inĀ a malonate-sensitive,Ā energy-linkedĀ reaction.Ā TheseĀ twoĀ kindsĀ ofĀ pyridineĀ nucleotideĀ mayĀ beĀ consideredĀ toĀ beĀ compartmented. | ||
|keywords=pyridine nucleotide, succinate | |keywords=pyridine nucleotide, succinate | ||
}} | }} | ||
| Line 17: | Line 15: | ||
|tissues=Cardiac muscle, Kidney | |tissues=Cardiac muscle, Kidney | ||
|preparations=Isolated Mitochondria | |preparations=Isolated Mitochondria | ||
|couplingstates=OXPHOS | |||
|enzymes=Complex II; Succinate Dehydrogenase | |enzymes=Complex II; Succinate Dehydrogenase | ||
|topics= | |topics=Substrate; Glucose; TCA Cycle | ||
|additional=Made history | |additional=Made history | ||
}} | }} | ||
Revision as of 13:53, 15 November 2012
| Chance B, Hollunger G (1961) The interaction of energy and electron transfer reactions in mitochondria III. Substrate requirements for pyridine nucleotide reduction in mitochondria. J Biol Chem 236: 1555-1561. |
Chance B, Hollunger G (1961) J Biol Chem
Abstract:
- A specific succinate requirement for energy-linked reduction of mitochondrial pyridine nucleotide is demonstrated in pigeon heart and guinea pig kidney mitochondria.
- The succinate used in this reduction can be generated in the oxidation of malate plus glutamate or of Ī±-ketoglutarate.
- The role of succinate is identified by the specific inhibitory responses of the reaction to malonate, phosphate, and fumarate.
- At least two kinds of mitochondrial pyridine nucleotide are shown to be reducible in state 4 : (a) about one-third in the absence of added succinate in a malonate-insensitive reaction in the presence o f a substrate such as malate plus glutamate and (b) about two-thirds in the presence of added succinate in a malonate-sensitive, energy-linked reaction. These two kinds of pyridine nucleotide may be considered to be compartmented.
ā¢ Keywords: pyridine nucleotide, succinate
Labels:
Organism: Other Mammal"Other Mammal" is not in the list (Human, Pig, Mouse, Rat, Guinea pig, Bovines, Horse, Dog, Rabbit, Cat, ...) of allowed values for the "Mammal and model" property., Other Non-Mammal"Other Non-Mammal" is not in the list (Human, Pig, Mouse, Rat, Guinea pig, Bovines, Horse, Dog, Rabbit, Cat, ...) of allowed values for the "Mammal and model" property.
Tissue;cell: Cardiac muscle"Cardiac muscle" is not in the list (Heart, Skeletal muscle, Nervous system, Liver, Kidney, Lung;gill, Islet cell;pancreas;thymus, Endothelial;epithelial;mesothelial cell, Blood cells, Fat, ...) of allowed values for the "Tissue and cell" property., Kidney
Preparation: Isolated Mitochondria"Isolated Mitochondria" is not in the list (Intact organism, Intact organ, Permeabilized cells, Permeabilized tissue, Homogenate, Isolated mitochondria, SMP, Chloroplasts, Enzyme, Oxidase;biochemical oxidation, ...) of allowed values for the "Preparation" property.
Enzyme: Complex II; Succinate Dehydrogenase"Complex II; Succinate Dehydrogenase" is not in the list (Adenine nucleotide translocase, Complex I, Complex II;succinate dehydrogenase, Complex III, Complex IV;cytochrome c oxidase, Complex V;ATP synthase, Inner mt-membrane transporter, Marker enzyme, Supercomplex, TCA cycle and matrix dehydrogenases, ...) of allowed values for the "Enzyme" property.
Regulation: Substrate; Glucose; TCA Cycle"Substrate; Glucose; TCA Cycle" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property.
Coupling state: OXPHOS
Made history
