Carnitine palmitoyltransferase II

high-resolution terminology - matching measurements at high-resolution

Carnitine palmitoyltransferase II

Description

Carnitine palmitoyltransferase 2 (CPT-2, also known as carnitine acyltransferase II) is part of the carnitine shuttle which is responsible for the mitochondrial transport of long-chain fatty acids. CPT-2 is located on the inner side of the mtIM and converts the acyl-carnitines (produced in the reaction catalyzed by carnitine palmitoyltransferase I) to carnitine and acyl-CoAs, which undergo ß-oxidation in the mitochondrial matrix. Free carnitines are transported out of the mitochondrial matrix in exchange for acyl-carnitines via an integral mtIM protein carnitine-acylcarnitine translocase (CACT). Short- and medium-chain fatty acids do not require the carnitine shuttle for mitochondrial transport.

Abbreviation: CPT-2

MitoPedia topics: Enzyme 

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MitoPedia:FAT4BRAIN