Bon 2022 J Clin Case Rep Stud

Bon E, Maksimovich NY, Dremza IK (2022) Alendronate-induced nephropathy. J Clin Case Rep Stud 3. https://doi.org/10.31579/2690-8808/108

» Open Access

Bon E, Maksimovich NY, Dremza IK (2022) J Clin Case Rep Stud

Abstract: Energy exchange in the cell is associated with mitochondria, which play an important role in vital processes. The Oxidative Phosphorylation System (OxРhoS), localized in the inner mitochondrial membrane, consists of five membrane enzymes. Four of the five protein complexes make up the "respiratory chain" and are involved in the transfer of electrons, which at three points is coupled with the translocation of protons across the inner mitochondrial membrane. The resulting proton gradient is used by the ATP synthase complex (the fifth enzyme complex) to phosphorylate ADP. The methods for studying the activity of the electron transport chain of mitochondria described in the article, especially their use in a complex, makes it possible to significantly detail the understanding of the pathogenesis of disorders of cell energy exchange that occurs in various diseases, which will improve the prevention and correction of mitochondrial dysfunction.

• Bioblast editor: Gnaiger E

Correction: FADH₂ and Complex II

FADH₂ is shown as the substrate feeding electrons into Complex II (CII). This is wrong and requires correction - for details see Gnaiger (2024).

Gnaiger E (2024) Complex II ambiguities ― FADH₂ in the electron transfer system. J Biol Chem 300:105470. https://doi.org/10.1016/j.jbc.2023.105470 - »Bioblast link«