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Bioblast alert - 2023
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Bioblast alert 2023(07) - Breast cancer: 2023-10-19
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"GK-1 [immunomodulatory peptide] inhibits cellular respiration and induces mitochondrial uncoupling in breast tumors."
- Cruz-Gregorio A, Aranda-Rivera AK, Aparicio-Trejo OE, Medina-Campos ON, Sciutto E, Fragoso G, Pedraza-Chaverri J (2022) GK-1 Induces oxidative stress, mitochondrial dysfunction, decreased membrane potential, and impaired autophagy flux in a mouse model of breast cancer. »Bioblast link«
- from the O2k-Network »MX Mexico City Pedraza Chaverri J«
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"BAD [Bcl-2-associated death promoter] increases sensitivity of breast cancer cells to docetaxel."
- Mann J, Yang N, Montpetit R, Kirschenman R, Lemieux H, Goping IS (2020) BAD sensitizes breast cancer cells to docetaxel with increased mitotic arrest and necroptosis. »Bioblast link«
- from the O2k-Network »CA Edmonton Lemieux H«
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"Isoselenazolium salts exhibit in vitro cytotoxic effects against breast cancer cells."
- Makrecka-Kuka M, Dimitrijevs P, Domracheva I, Jaudzems K, Dambrova M, Arsenyan P (2020) Fused isoselenazolium salts suppress breast cancer cell growth by dramatic increase in pyruvate-dependent mitochondrial ROS production. »Bioblast link«
- from the O2k-Network »LV Riga Liepins E«
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Bioblast alert 2023(06) - World Mitochondrial Disease Week: 2023-09-18
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World Mitochondrial Disease Week – Sep 18-24
World Mitochondrial Disease Week raises awareness of mitochondrial disease through educational, fundraising and advocacy activities.
»See what is happening near you«
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In 1962, the first report of a patient with a mitochondrial disease was published.
- Luft R, Ikkos D, Palmieri G, Ernster L, Afzelius B (1962). A case of severe hypermetabolism of nonthyroid origin with a defect in the maintenance of mitochondrial respiratory control: a correlated clinical, biochemical, and morphological study. »Bioblast link«
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The first mitochondrial DNA mutations associated with disease were described in 1988.
These discoveries were a game changer in the field of mitochondrial diseases.
- Holt IJ, Harding A E, Morgan-Hughes JA (1988) Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies. »Bioblast link«
- Wallace DC, Singh G, Lott MT, Hodge JA, Schurr TG, Lezza AM, Elsas LJ 2nd, Nikoskelainen EK (1988) Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy. »Bioblast link«
- Zeviani M, Moraes CT, DiMauro S, Nakase H, Bonilla E, Schon EA, Rowland LP (1988) Deletions of mitochondrial DNA in Kearns-Sayre syndrome. »Bioblast link«
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Research in the field of mitochondrial medicine offers hope that treatments and cures for mitochondrial diseases will be found.
- - as part of the joint project between Oroboros and VASCage
- - October 16, 2023
- - Join in person: inform us until Oct 1 by email to [email protected], limited spaces available
- - Location: MiPArt, Schoepfstrasse 18, 6020 Innsbruck, AT
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Bioblast alert 2023(05) - Comparative physiology: 2023-09-08
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"[...] adaptive changes in the physiology of specific mitochondrial fractions can help overcome the metabolic challenges of life in the harsh environment at high altitude."
- Dawson NJ, Scott GR (2022) Adaptive increases in respiratory capacity and O2 affinity of subsarcolemmal mitochondria from skeletal muscle of high-altitude deer mice. »Bioblast link«
- from the O2k-Network »CA Hamilton Scott GR«
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Triplefin fish species have different ROS production and electron leakage according to their tolerance to hypoxia.
- Devaux JBL, Hedges CP, Birch N, Herbert N, Renshaw GMC, Hickey AJR (2023) Electron transfer and ROS production in brain mitochondria of intertidal and subtidal triplefin fish (Tripterygiidae). »Bioblast link«
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"Our study showed that salinity modulates the mitochondrial responses to long-term and acute hypoxia exposure in an euryhaline intertidal bivalve C. gigas."
- Steffen JBM, Sokolov EP, Sokolova IM (2023) Combined effects of salinity and intermittent hypoxia on mitochondrial capacity and reactive oxygen species efflux in the Pacific oyster, Crassostrea gigas »Bioblast link«
- from the O2k-Network »DE Rostock Sokolova I«
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"The higher ROS release rates observed in both the muscle and liver of older individuals may suggest that increased ROS release is evidence of mitochondrial dysfunction during ageing in finches."
- Salmón P, Millet C, Selman C, Monaghan P, Dawson NJ (2023) Tissue-specific reductions in mitochondrial efficiency and increased ROS release rates during ageing in zebra finches, Taeniopygia guttata. »Bioblast link«
- from the O2k-Network »DE Wilhelmshaven Salmon P«, »UK Glasgow Metcalfe NB«
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Bioblast alert 2023(04) - Bioenerg Commun: 2023-08-08
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An overview of the “do’s and don’ts” when it comes to assessing mitochondrial function in Drosophila
- Rodríguez E, Bettinazzi S, Inwongwan S, Camus MF, Lane N (2023) Harmonizing protocols to measure Drosophila respiratory function in mitochondrial preparations. Bioenerg Commun 2023.3. https://doi.org/10.26124/bec:2023-0003
- from the O2k-Network »UK London Lane N«
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Book of abstracts highlighting work on mitObesity and healthy aging
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Natural cycling of ADP with ATP attenuates mitochondrial permeability transition (mtPT) in permeabilized muscle fibers: can more assessments with and without adenylates provide new insights to the mtPT?
- Bellissimo CA, Soendergaard S, Hughes MC, Ramos SV, Larsen S, Perry CGR (2023) The influence of adenylate cycling on mitochondrial calcium-induced permeability transition in permeabilized skeletal muscle fibers. Bioenerg Commun 2023.1. https://doi.org/10.26124/bec:2023-0001
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Bioblast alert 2023(03) - mitObestiy and healthy aging: 2023-06-01
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"Obesity has an opposing association with mitochondrial respiration in adipose- and liver tissue with no overall association with NAFLD (nonalcoholic fatty liver disease) severity."
- Pedersen JS, Rygg MO, Chrøis K, Sustarsic EG, Gerhart-Hines Z, Wever Albrechtsen NJ, Serizawa RR, Kristiansen VB, Basse AL, Boilesen AEB, Olsen BH, Hansen T, Gluud LL, Madsbad S, Larsen S, Bendtsen F, Dela F (2022) Influence of NAFLD and bariatric surgery on hepatic and adipose tissue mitochondrial biogenesis and respiration. »Bioblast link«
- from the O2k-Network »DK Copenhagen Gerhart-Hines Z« and »DK Copenhagen Larsen S«
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"BAM15 is a tolerable and efficacious protonophore that protects against diet‐induced obesity."
- Axelrod CL, King WT, Davuluri G, Noland RC, Hall J, Hull M, Dantas WS, Zunica ER, Alexopoulos SJ, Hoehn KL, Langohr I, Stadler K, Doyle H, Schmidt E, Nieuwoudt S, Fitzgerald K, Pergola K, Fujioka H, Mey JT, Fealy C, Mulya A, Beyl R, Hoppel CL, Kirwan JP (2021) BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic control. »Bioblast link«
- from the O2k-Network »US LA Baton Rouge Noland RC« and »US OH Cleveland Hoppel CL«
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Decline of mitochondrial fitness in overweight states is a biomarker of the systemic mitObesity syndrome, providing a mechanistic link between common obesity and associated chronic comorbidities.
Body mass excess provides an evidence-based index of underweight, overweight and obesity across all heights and ages, applicable to all populations for which the healthy reference baseline is established.
- »Body mass excess and mitObesity«
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Join the 15th MiPconference: Bioenergetics Communications on ‘mitObesity and Healthy Aging’
Date: 2023 July 27-30
Location: Obergurgl, AT
More information: MiP2023 Obergurgl AT
Registration: online form
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Bioblast alert 2023(02) - DORA and BEC: 2023-05-10
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The San Francisco Declaration on Research Assessment (DORA) turns 10 years on May 16, 2023.
»Sign the declaration«
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Implementing DORA principles by publishing in Bioenergetics Communications - beyond counting papers: a presentation by Erich Gnaiger, BEC Editor-in-chief.
- Date: 2023 May 16, Tuesday
- Time: 16:00 (GMT+1)
- Join via Livestream
- Join in person: Registration free, inform us until May 15 by email to [email protected]
- Location: MiPArt, Schoepfstrasse 18, 6020 Innsbruck, AT
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"The burden of responsibilities for an urgent change of the academic publishing ecosystem and scientific communication culture must be shared between the shoulders of individual scientists, the backbone of scientific institutions, and the neurology of governmental regulations and funding agencies."
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Interested in publishing on ‘mitObesity and Healthy Aging’ in BEC?
Join the 15th MiPconference, 2023 July 27-30, Obergurgl, AT: MiP2023_Obergurgl_AT
We invite original articles to be published in a special issue of Bioenergetics Communications.
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Bioblast alert 2023(01) - Trypanosomatids: 2023-01-18
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Bionenerg Commun 2022.17: a review and hypothesis to explain the unusual metabolic network and its biological significance for bloodstream Trypanosoma brucei forms.
- Alencar MB, Ramos EV, Silber AM, Zíková A, Oliveira MF (2022) The extraordinary energy metabolism of the bloodstream Trypanosoma brucei forms: a critical review and hypothesis. Bioenerg Commun 2022.17. https://doi.org/10.26124/bec:2022-0017
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Bionenerg Commun 2022.20: a discussion of 17 years of data on trypanosomatids' mitochondrial susceptibility and adaptative processes.
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"We not only identified a new source of ROS production in Leishmania, but also described, for the first time, an enzyme with both ferric iron reductase and Nox activities."
- Rocco-Machado N, Cosentino-Gomes D, Nascimento MT, Paes-Vieira L, Khan YA, Mittra B, Andrews NW, Meyer-Fernandes JR (2019) Leishmania amazonensis ferric iron reductase (LFR1) is a bifunctional enzyme: Unveiling a NADPH oxidase activity. »Bioblast link«
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Summary
Bioblast alert - previous issues
Stay alert
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