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== Preface == | == Preface == | ||
Margreiter R | Margreiter R (Innsbruck): p 13. | ||
Gnaiger E, Gellerich FN | Gnaiger E, Gellerich FN (Innsbruck) | ||
: Trends in bioenergetics. An introduction: p 14. | : Trends in bioenergetics. An introduction: p 14. | ||
Oberkofler G, Goller P | Oberkofler G, Goller P (Innsbruck) | ||
: "German Ideology" as seen by Erwin Schrödinger in letters to Hans Thirring. From their correspondence (1946-1949): p 19. | : "German Ideology" as seen by Erwin Schrödinger in letters to Hans Thirring. From their correspondence (1946-1949): p 19. | ||
== Part 1. What is negative entropy? From world views to bioenergetics == | == Part 1. What is negative entropy? From world views to bioenergetics == | ||
Götschl J | Götschl J (Graz) | ||
: Erwin Schrödinger's world view. The role of physics and biology in his philosophical system: p 23. | : Erwin Schrödinger's world view. The role of physics and biology in his philosophical system: p 23. | ||
Wagensberg J | Wagensberg J (Barcelona) | ||
: Science, art and revelation: p 32. | : Science, art and revelation: p 32. | ||
Azzone GF | Azzone GF (Padova) | ||
: Negentropy and historical arrow of time - thermodynamical and informational aspects of the Darwinian revolution: p 38. | : Negentropy and historical arrow of time - thermodynamical and informational aspects of the Darwinian revolution: p 38. | ||
Lantos CP | Lantos CP (Buenos Aires) | ||
: Negative entropy: another approach: p 45. | : Negative entropy: another approach: p 45. | ||
Welch GR | Welch GR (New Orleans) | ||
: Schrödinger's What is Life?: the biophysical legacy 50 years later: p 48. | : Schrödinger's What is Life?: the biophysical legacy 50 years later: p 48. | ||
Ho MW | Ho MW (London) | ||
: What is Schrödinger's negentropy? p 50 | : What is Schrödinger's negentropy? p 50 | ||
Gnaiger E | Gnaiger E (Innsbruck) | ||
: Negative entropy for living systems. Controversy between Nobel laureates Schrödinger, Pauling and Perutz: p 62. [[Gnaiger 1994 BTK-62 |»Bioblast Access]] | : Negative entropy for living systems. Controversy between Nobel laureates Schrödinger, Pauling and Perutz: p 62. [[Gnaiger 1994 BTK-62 |»Bioblast Access]] | ||
Kushmerick MJ | Kushmerick MJ (Seattle) | ||
: A paradigm for energy balance in muscle function: p 71. | : A paradigm for energy balance in muscle function: p 71. | ||
Lloyd D | Lloyd D (Cardiff) | ||
: A controlled chaotic attractor controls life: p 77. | : A controlled chaotic attractor controls life: p 77. | ||
Azzone GF | Azzone GF (Padova) | ||
: Disease as instability, error and entropy: p 81. | : Disease as instability, error and entropy: p 81. | ||
== Part 2. Control and regulation: theory, models, and experiment == | == Part 2. Control and regulation: theory, models, and experiment == | ||
Kholodenko BN, Westerhoff HV, Cascante M | Kholodenko BN, Westerhoff HV, Cascante M (Moscow, Amsterdam, Barcelona) | ||
: The macro- and microworld of control theory: p 88. | : The macro- and microworld of control theory: p 88. | ||
Hofmeyr JHS, Cornish-Bowden A | Hofmeyr JHS, Cornish-Bowden A (Stellenbosch, Marseille) | ||
: How should we quantify metabolic regulation? p 91 | : How should we quantify metabolic regulation? p 91 | ||
Westerhoff HV, Jensen PR, Rohwer JM, Kholodenko BN | Westerhoff HV, Jensen PR, Rohwer JM, Kholodenko BN (Amsterdam, Lyngby, Moscow) | ||
: Control and regulation: the best of both worlds: p 95. | : Control and regulation: the best of both worlds: p 95. | ||
Heinrich R, Klipp E, Stephani A, Wilhelm T | Heinrich R, Klipp E, Stephani A, Wilhelm T (Berlin) | ||
: Evolutionary optimization of enzymes on the basis of kinetic and thermodynamic principles: p 99. | : Evolutionary optimization of enzymes on the basis of kinetic and thermodynamic principles: p 99. | ||
Schuster S, Hilgetag C, Fell DA | Schuster S, Hilgetag C, Fell DA (Berlin, Oxford) | ||
: Detecting elementary modes of functioning in metabolic networks: p 103. | : Detecting elementary modes of functioning in metabolic networks: p 103. | ||
== Part 3. Coupling and mechanisms in the regulation of electron, ATP and ion fluxes == | == Part 3. Coupling and mechanisms in the regulation of electron, ATP and ion fluxes == | ||
Luvisetto S, Canton M, Schmehl I, Azzone GF | Luvisetto S, Canton M, Schmehl I, Azzone GF (Padova) | ||
: Leaks and slips during mitochondrial electron transfer: p 122. | : Leaks and slips during mitochondrial electron transfer: p 122. | ||
Brand MD, Chien LF, Diolez PH | Brand MD, Chien LF, Diolez PH (Cambridge, Bordeaux) | ||
: Experimental discrimination between proton leak and redox slip during mitochondrial electron transport: p 125. | : Experimental discrimination between proton leak and redox slip during mitochondrial electron transport: p 125. | ||
Canton M, Luvisetto S, Schmehl I, Azzone GF | Canton M, Luvisetto S, Schmehl I, Azzone GF (Padova) | ||
: Permeability of the inner mitochondrial membrane and respiration: p 129. | : Permeability of the inner mitochondrial membrane and respiration: p 129. | ||
Schmehl I, Canton M, Luvisetto S, Azzone GF | Schmehl I, Canton M, Luvisetto S, Azzone GF (Padova) | ||
: The uncoupling mechanism of the anesthetic bupivacaine: p 133. | : The uncoupling mechanism of the anesthetic bupivacaine: p 133. | ||
Leverve X, Fontaine E, Espié P, Keriel C, Guérin B, Rigoulet M | Leverve X, Fontaine E, Espié P, Keriel C, Guérin B, Rigoulet M (Grenoble, Bordeaux) | ||
: Influence of the mechanism of change in ATP synthase-ATPase. Stoichiometry on the control of oxidative phosphorylation ''in situ'': p 137. | : Influence of the mechanism of change in ATP synthase-ATPase. Stoichiometry on the control of oxidative phosphorylation ''in situ'': p 137. | ||
Ouhabi R, Boue-Grabot M, Mazat JP | Ouhabi R, Boue-Grabot M, Mazat JP (Bordeaux) | ||
: ATP synthesis in permeabilized cells: assessment of the ATP/O ratios ''in situ'': p 141. | : ATP synthesis in permeabilized cells: assessment of the ATP/O ratios ''in situ'': p 141. | ||
Fitton V, Ouhabi R, Guérin B, Rigoulet M | Fitton V, Ouhabi R, Guérin B, Rigoulet M (Bordeaux) | ||
: Permeabilized spheroplasts as a tool for studying the mechanistic stoichiometry of yeast oxidative phosphorylation: p 145. | : Permeabilized spheroplasts as a tool for studying the mechanistic stoichiometry of yeast oxidative phosphorylation: p 145. | ||
Manon S, Roucou X, Guérin M | Manon S, Roucou X, Guérin M (Bordeaux) | ||
: Investigations upon the effect of monovalent cations on oxidative phosphorylation in yeast mitochondria: p 150. | : Investigations upon the effect of monovalent cations on oxidative phosphorylation in yeast mitochondria: p 150. | ||
Sparagna G, Gunter KK, Sheu SS, Gunter TE | Sparagna G, Gunter KK, Sheu SS, Gunter TE (Rochester) | ||
: Can mitochondria sequester calcium from physiological calcium pulses? p 154 | : Can mitochondria sequester calcium from physiological calcium pulses? p 154 | ||
Ichas F, Jouaville LS , Sidash, | Ichas F, Jouaville LS, Sidash SS, Mazat JP, Holmuhamedov EL (Bordeaux, Pushchino, Kalamazoo) | ||
: Mitochondrial calcium spiking: the physiological face of permeability transition: p 159. | : Mitochondrial calcium spiking: the physiological face of permeability transition: p 159. | ||
Dauncey MJ, Clausen T, Harrison AP | Dauncey MJ, Clausen T, Harrison AP (Cambridge, Århus) | ||
: Developmental regulation of Na+,K+- and Ca2+-ATPases in muscle: p 163. | : Developmental regulation of Na+,K+- and Ca2+-ATPases in muscle: p 163. | ||
Siegenbeek van Heukelom J et al | Siegenbeek van Heukelom J et al (Amsterdam, Moscow) | ||
: What is controlling the cell membrane potential? p 169 | : What is controlling the cell membrane potential? p 169 | ||
== Part 4. The microenvironment of mitochondria and cells: diffusion gradients, shuttles and signals == | == Part 4. The microenvironment of mitochondria and cells: diffusion gradients, shuttles and signals == | ||
Saks VA, Vasilyeva EV, Khuchua ZA, Belikova YO, Aliev MK, Kesvatera T, Tiivel T, Anflous K, Ventura-Clapier R, Keriel C, Fontaine E, Leverve X | Saks VA, Vasilyeva EV, Khuchua ZA, Belikova YO, Aliev MK, Kesvatera T, Tiivel T, Anflous K, Ventura-Clapier R, Keriel C, Fontaine E, Leverve X (Tallinn, Moscow, Paris, Grenoble) | ||
: ADP diffusion gradients and metabolic oscillatory signals to mitochondria in heart and liver cells: p 178. | : ADP diffusion gradients and metabolic oscillatory signals to mitochondria in heart and liver cells: p 178. | ||
Gellerich FN, Laterveer FD, Gnaiger E, Nicolay K | Gellerich FN, Laterveer FD, Gnaiger E, Nicolay K (Utrecht, Innsbruck) | ||
: Effect of macromolecules on ADP-transport into mitochondria: p 181*. [[Gellerich 1994 BTK-181 |»Bioblast Access]] | : Effect of macromolecules on ADP-transport into mitochondria: p 181*. [[Gellerich 1994 BTK-181 |»Bioblast Access]] | ||
Laterveer FD, Gellerich FN, Gnaiger E, Nicolay K | Laterveer FD, Gellerich FN, Gnaiger E, Nicolay K (Utrecht, Innsbruck) | ||
: Macromolecules increase the channeling of ADP from mitochondrially associated hexokinase to the mitochondrial matrix: p 186*. [[Laterveer 1994 BTK-186 |»Bioblast Access]] | : Macromolecules increase the channeling of ADP from mitochondrially associated hexokinase to the mitochondrial matrix: p 186*. [[Laterveer 1994 BTK-186 |»Bioblast Access]] | ||
Méndez G, Gnaiger E | Méndez G, Gnaiger E (Innsbruck, Buenos Aires) | ||
: How does oxygen pressure control oxygen flux in isolated mitochondria? A methodological approach by high-resolution respirometry and digital data analysis: p 191*. [[Mendez 1994 BTK-191 |»Bioblast Access]] | : How does oxygen pressure control oxygen flux in isolated mitochondria? A methodological approach by high-resolution respirometry and digital data analysis: p 191*. [[Mendez 1994 BTK-191 |»Bioblast Access]] | ||
Soboll S, Conrad A, Gruwel M | Soboll S, Conrad A, Gruwel M (Düsseldorf) | ||
: Determination of creatine kinase fluxes with purified creatine kinase and isolated mitochondria using 31P nuclear magnetic resonance: p 195. | : Determination of creatine kinase fluxes with purified creatine kinase and isolated mitochondria using 31P nuclear magnetic resonance: p 195. | ||
Hoerter JA, Gillet B, Mateo P, Lechene P, Beloeil JC | Hoerter JA, Gillet B, Mateo P, Lechene P, Beloeil JC (Chatenay Malabry, Gifs/Yvette) | ||
: Oscillations of intracellular pH or high energy phosphate content cannot be detected by gated NMR during the cardiac cycle of an isovolumic perfused rat heart: p 199. | : Oscillations of intracellular pH or high energy phosphate content cannot be detected by gated NMR during the cardiac cycle of an isovolumic perfused rat heart: p 199. | ||
== Part 5. The impact of bioenergetics on cellular, physiological and biotechnological processes == | == Part 5. The impact of bioenergetics on cellular, physiological and biotechnological processes == | ||
Gnaiger E, Wyss M | Gnaiger E, Wyss M (Innsbruck) | ||
: Chemical forces in the cell: calculations for the ATP system: p 207. [[Gnaiger 1994 BTK-207 |»Bioblast Access]] | : Chemical forces in the cell: calculations for the ATP system: p 207. [[Gnaiger 1994 BTK-207 |»Bioblast Access]] | ||
Jeneson JAL, Jubrias SA, Kushmerick MJ | Jeneson JAL, Jubrias SA, Kushmerick MJ (Utrecht, Seattle) | ||
: The flow-force relation of oxidative phosphorylation in human forearm muscle is sigmoidal: p 213. | : The flow-force relation of oxidative phosphorylation in human forearm muscle is sigmoidal: p 213. | ||
Mejsnar J, Marsík F | Mejsnar J, Marsík F (Praha) | ||
: Muscular contraction, dissipation and Schrödinger's negative entropy: p 215. | : Muscular contraction, dissipation and Schrödinger's negative entropy: p 215. | ||
Jensen PR, Rohwer JM, Michelsen O, Westerhoff HV | Jensen PR, Rohwer JM, Michelsen O, Westerhoff HV (Lyngby, Amsterdam) | ||
: Modelling of oxidative phosphorylation in ''E. coli'': p 218. | : Modelling of oxidative phosphorylation in ''E. coli'': p 218. | ||
Fishov I | Fishov I (Beer-Sheva) | ||
: Do oscillations control the bacterial cell cycle? p 221 | : Do oscillations control the bacterial cell cycle? p 221 | ||
Kemp RB, Hoare S, Schmalfeldt M, Bridge CMC, Evans PM, Gnaiger E | Kemp RB, Hoare S, Schmalfeldt M, Bridge CMC, Evans PM, Gnaiger E (Aberystwyth, Innsbruck) | ||
: A thermochemical study of the production of lactate by glutaminolysis and glycolysis in mouse macrophage hybridoma cells: p 226. [[Kemp 1994 BTK-226 |»Bioblast Access]] | : A thermochemical study of the production of lactate by glutaminolysis and glycolysis in mouse macrophage hybridoma cells: p 226. [[Kemp 1994 BTK-226 |»Bioblast Access]] | ||
Larsson C, Nilsson A, Gustafsson L | Larsson C, Nilsson A, Gustafsson L (Göteborg) | ||
: Catabolic capacity of carbon- or nitrogen-starved cultures of ''Saccharomyces cerevisiae'': p 232. | : Catabolic capacity of carbon- or nitrogen-starved cultures of ''Saccharomyces cerevisiae'': p 232. | ||
Krumschnabel G, Wieser W | Krumschnabel G, Wieser W (Innsbruck) | ||
: Energy allocation and material flux in fish hepatocytes under stress: p 238. | : Energy allocation and material flux in fish hepatocytes under stress: p 238. | ||
Marx A, de Graaf AA, Wiechert W, Eggeling L, Sahm H | Marx A, de Graaf AA, Wiechert W, Eggeling L, Sahm H (Jülich) | ||
: Carbon flux in lysine producing strain ''Corynebacterium glutamicum'' MH20-22B: analysis by 13C-NMR of amino acids and metabolite balancing: p 240. | : Carbon flux in lysine producing strain ''Corynebacterium glutamicum'' MH20-22B: analysis by 13C-NMR of amino acids and metabolite balancing: p 240. | ||
Zentgraf B | Zentgraf B (Furtwangen) | ||
* Remarks on biocalorimetry and biothermodynamics aimed at characterization of the physiological state: p 244. | * Remarks on biocalorimetry and biothermodynamics aimed at characterization of the physiological state: p 244. | ||
== Part 6. The impact of bioenergetics on clinical and pathological problems == | == Part 6. The impact of bioenergetics on clinical and pathological problems == | ||
Petronilli V, Nicolli A, Costantini P, Colonna R, Bernardi P | Petronilli V, Nicolli A, Costantini P, Colonna R, Bernardi P (Padova) | ||
: The permeability transition pore. Pathophysiology of a cyclosporin A-sensitive mitochondrial channel: p 259. | : The permeability transition pore. Pathophysiology of a cyclosporin A-sensitive mitochondrial channel: p 259. | ||
Gellerich FN, Steinlechner R, Wyss M, Eberl T, Müller LC, Skladal D, Sperl W, Dapunt O, Margreiter R, Gnaiger E | Gellerich FN, Steinlechner R, Wyss M, Eberl T, Müller LC, Skladal D, Sperl W, Dapunt O, Margreiter R, Gnaiger E (Innsbruck) | ||
: Mitochondrial function in the atrial appendage of the human heart. Characterization by high-resolution respirometry: p 263*. [[Gellerich 1994 BTK-263 |»Bioblast Access]] | : Mitochondrial function in the atrial appendage of the human heart. Characterization by high-resolution respirometry: p 263*. [[Gellerich 1994 BTK-263 |»Bioblast Access]] | ||
Skladal D, Sperl W, Schranzhofer R, Krismer M, Gnaiger E, Margreiter R, Gellerich FN | Skladal D, Sperl W, Schranzhofer R, Krismer M, Gnaiger E, Margreiter R, Gellerich FN (Innsbruck) | ||
: Preservation of mitochondrial functions in human skeletal muscle during storage in high energy preservation solution (HEPS): p 268*. [[Skladal 1994 BTK-268 |»Bioblast Access]] | : Preservation of mitochondrial functions in human skeletal muscle during storage in high energy preservation solution (HEPS): p 268*. [[Skladal 1994 BTK-268 |»Bioblast Access]] | ||
Mazat JP, Letellier T, Malgat M, Jouaville S, Morkuniene R | Mazat JP, Letellier T, Malgat M, Jouaville S, Morkuniene R (Bordeaux, Kaunas) | ||
: Application of control analysis to the study of metabolic diseases in mitochondria. Metabolic expression of mitochondrial DNA mutations: p 272. | : Application of control analysis to the study of metabolic diseases in mitochondria. Metabolic expression of mitochondrial DNA mutations: p 272. | ||
Kuznetsov AV, Clark JF, Winkler K, Kunz WS | Kuznetsov AV, Clark JF, Winkler K, Kunz WS (Magdeburg, Oxford) | ||
: Change in flux control coefficient of cytochrome ''c'' oxidase in copper deficient mottled brindled mice: p 275*. [[Kuznetsov 1994 BTK-275 |»Bioblast Access]] | : Change in flux control coefficient of cytochrome ''c'' oxidase in copper deficient mottled brindled mice: p 275*. [[Kuznetsov 1994 BTK-275 |»Bioblast Access]] | ||
Oexle K, Oberle J, Hübner C | Oexle K, Oberle J, Hübner C | ||
: Insulin-dependent diabetes mellitus in MELAS-mitochondriopathy: discussion of possible causal relations: p 278. | : Insulin-dependent diabetes mellitus in MELAS-mitochondriopathy: discussion of possible causal relations: p 278. | ||
Jeneson JAL, Westerhoff HV | Jeneson JAL, Westerhoff HV (Utrecht, Amsterdam) | ||
: Simulation of the flow-force relation of oxidative phosphorylation in Complex I deficiency: p 280. | : Simulation of the flow-force relation of oxidative phosphorylation in Complex I deficiency: p 280. | ||
Steinlechner R, Eberl T, Margreiter R, Gnaiger E | Steinlechner R, Eberl T, Margreiter R, Gnaiger E (Innsbruck) | ||
: Oxygen dependence of cellular respiration in endothelial cells: a sensitive toxicological test: p 283*. [[SteinlechnerMaran 1994 BTK-283 |»Bioblast Access]] | : Oxygen dependence of cellular respiration in endothelial cells: a sensitive toxicological test: p 283*. [[SteinlechnerMaran 1994 BTK-283 |»Bioblast Access]] | ||
T. Eberl, R. Steinlechner, W. Salvenmoser, B. Abendstein, M. Rhomberg, Schröcksnadel H, Schmid T, Gnaiger E, Margreiter R | T. Eberl, R. Steinlechner, W. Salvenmoser, B. Abendstein, M. Rhomberg, Schröcksnadel H, Schmid T, Gnaiger E, Margreiter R (Innsbruck) | ||
: Endothelial cell cultures as a model for organ preservation studies: p 288*. [[Eberl 1994 BTK-288 |»Bioblast Access]] | : Endothelial cell cultures as a model for organ preservation studies: p 288*. [[Eberl 1994 BTK-288 |»Bioblast Access]] | ||
Knoblechner A, Steinlechner R, Schirmer M, Gellerich FN, Margreiter R, Konwalinka G, Gnaiger E | Knoblechner A, Steinlechner R, Schirmer M, Gellerich FN, Margreiter R, Konwalinka G, Gnaiger E (Innsbruck) | ||
: The effect of 2-chlorodeoxyadenosine on endogenous respiration of a human lymphoma cell line (U-937): p 294*. [[Knoblechner 1994 BTK-294 |»Bioblast Access]] | : The effect of 2-chlorodeoxyadenosine on endogenous respiration of a human lymphoma cell line (U-937): p 294*. [[Knoblechner 1994 BTK-294 |»Bioblast Access]] | ||
== Part 7. Computer software for bioenergetics and metabolic control analysis == | == Part 7. Computer software for bioenergetics and metabolic control analysis == | ||
Mendes P, Kell DB | Mendes P, Kell DB (Aberystwyth) | ||
: Simultaneous estimates of single-enzyme kinetic parameters for multi-enzymatic systems using artificial neural networks: p 302. | : Simultaneous estimates of single-enzyme kinetic parameters for multi-enzymatic systems using artificial neural networks: p 302. | ||
Wiechert W | Wiechert W (Jülich) | ||
: Design of a software framework for flux determination by 13C NMR isotope labelling experiments: p 305. | : Design of a software framework for flux determination by 13C NMR isotope labelling experiments: p 305. | ||
== Announcements == | == Announcements == | ||
* Oroboros | * Oroboros (Grinzens-Innsbruck, Austria): p 316 | ||
* Acknowledgements for Financial Support: p 318 | * Acknowledgements for Financial Support: p 318 | ||
Revision as of 04:42, 3 July 2014
Gnaiger E, Gellerich FN, Wyss M (1994) What is Controlling Life? 50 years after Erwin Schrödinger's What is Life? Modern Trends in BiothermoKinetics 3, Innsbruck Univ Press, 336 pp. |
Gnaiger E, Gellerich FN, Wyss M (1994) Innsbruck Univ Press
Abstract: Erwin Schrödinger's 'What is Life?' is one of the most influential books of the last century in the biological sciences. It continues to provoke discussions and stimulate interdisciplinary developments in biophysics. Starting with reflections on Schrödinger's famous account of negative entropy in living systems, an international group of scientists presents the latest advancements on the dynamics and control of metabolic processes. This volume of Modern Trends in BioThermoKinetics develops for the first time the explicit link between thermodynamics, metabolic control, bioenergetics and clinical applications.
• O2k-Network Lab: AT_Innsbruck_Gnaiger E
Labels: MiParea: Respiration, mt-Awareness
Coupling state: OXPHOS
HRR: Oxygraph-2k, Theory
CONTENTS: Full Papers
- OROBOROS Oxygraph applications
Preface
Margreiter R (Innsbruck): p 13.
Gnaiger E, Gellerich FN (Innsbruck)
- Trends in bioenergetics. An introduction: p 14.
Oberkofler G, Goller P (Innsbruck)
- "German Ideology" as seen by Erwin Schrödinger in letters to Hans Thirring. From their correspondence (1946-1949): p 19.
Part 1. What is negative entropy? From world views to bioenergetics
Götschl J (Graz)
- Erwin Schrödinger's world view. The role of physics and biology in his philosophical system: p 23.
Wagensberg J (Barcelona)
- Science, art and revelation: p 32.
Azzone GF (Padova)
- Negentropy and historical arrow of time - thermodynamical and informational aspects of the Darwinian revolution: p 38.
Lantos CP (Buenos Aires)
- Negative entropy: another approach: p 45.
Welch GR (New Orleans)
- Schrödinger's What is Life?: the biophysical legacy 50 years later: p 48.
Ho MW (London)
- What is Schrödinger's negentropy? p 50
Gnaiger E (Innsbruck)
- Negative entropy for living systems. Controversy between Nobel laureates Schrödinger, Pauling and Perutz: p 62. »Bioblast Access
Kushmerick MJ (Seattle)
- A paradigm for energy balance in muscle function: p 71.
Lloyd D (Cardiff)
- A controlled chaotic attractor controls life: p 77.
Azzone GF (Padova)
- Disease as instability, error and entropy: p 81.
Part 2. Control and regulation: theory, models, and experiment
Kholodenko BN, Westerhoff HV, Cascante M (Moscow, Amsterdam, Barcelona)
- The macro- and microworld of control theory: p 88.
Hofmeyr JHS, Cornish-Bowden A (Stellenbosch, Marseille)
- How should we quantify metabolic regulation? p 91
Westerhoff HV, Jensen PR, Rohwer JM, Kholodenko BN (Amsterdam, Lyngby, Moscow)
- Control and regulation: the best of both worlds: p 95.
Heinrich R, Klipp E, Stephani A, Wilhelm T (Berlin)
- Evolutionary optimization of enzymes on the basis of kinetic and thermodynamic principles: p 99.
Schuster S, Hilgetag C, Fell DA (Berlin, Oxford)
- Detecting elementary modes of functioning in metabolic networks: p 103.
Part 3. Coupling and mechanisms in the regulation of electron, ATP and ion fluxes
Luvisetto S, Canton M, Schmehl I, Azzone GF (Padova)
- Leaks and slips during mitochondrial electron transfer: p 122.
Brand MD, Chien LF, Diolez PH (Cambridge, Bordeaux)
- Experimental discrimination between proton leak and redox slip during mitochondrial electron transport: p 125.
Canton M, Luvisetto S, Schmehl I, Azzone GF (Padova)
- Permeability of the inner mitochondrial membrane and respiration: p 129.
Schmehl I, Canton M, Luvisetto S, Azzone GF (Padova)
- The uncoupling mechanism of the anesthetic bupivacaine: p 133.
Leverve X, Fontaine E, Espié P, Keriel C, Guérin B, Rigoulet M (Grenoble, Bordeaux)
- Influence of the mechanism of change in ATP synthase-ATPase. Stoichiometry on the control of oxidative phosphorylation in situ: p 137.
Ouhabi R, Boue-Grabot M, Mazat JP (Bordeaux)
- ATP synthesis in permeabilized cells: assessment of the ATP/O ratios in situ: p 141.
Fitton V, Ouhabi R, Guérin B, Rigoulet M (Bordeaux)
- Permeabilized spheroplasts as a tool for studying the mechanistic stoichiometry of yeast oxidative phosphorylation: p 145.
Manon S, Roucou X, Guérin M (Bordeaux)
- Investigations upon the effect of monovalent cations on oxidative phosphorylation in yeast mitochondria: p 150.
Sparagna G, Gunter KK, Sheu SS, Gunter TE (Rochester)
- Can mitochondria sequester calcium from physiological calcium pulses? p 154
Ichas F, Jouaville LS, Sidash SS, Mazat JP, Holmuhamedov EL (Bordeaux, Pushchino, Kalamazoo)
- Mitochondrial calcium spiking: the physiological face of permeability transition: p 159.
Dauncey MJ, Clausen T, Harrison AP (Cambridge, Århus)
- Developmental regulation of Na+,K+- and Ca2+-ATPases in muscle: p 163.
Siegenbeek van Heukelom J et al (Amsterdam, Moscow)
- What is controlling the cell membrane potential? p 169
Part 4. The microenvironment of mitochondria and cells: diffusion gradients, shuttles and signals
Saks VA, Vasilyeva EV, Khuchua ZA, Belikova YO, Aliev MK, Kesvatera T, Tiivel T, Anflous K, Ventura-Clapier R, Keriel C, Fontaine E, Leverve X (Tallinn, Moscow, Paris, Grenoble)
- ADP diffusion gradients and metabolic oscillatory signals to mitochondria in heart and liver cells: p 178.
Gellerich FN, Laterveer FD, Gnaiger E, Nicolay K (Utrecht, Innsbruck)
- Effect of macromolecules on ADP-transport into mitochondria: p 181*. »Bioblast Access
Laterveer FD, Gellerich FN, Gnaiger E, Nicolay K (Utrecht, Innsbruck)
- Macromolecules increase the channeling of ADP from mitochondrially associated hexokinase to the mitochondrial matrix: p 186*. »Bioblast Access
Méndez G, Gnaiger E (Innsbruck, Buenos Aires)
- How does oxygen pressure control oxygen flux in isolated mitochondria? A methodological approach by high-resolution respirometry and digital data analysis: p 191*. »Bioblast Access
Soboll S, Conrad A, Gruwel M (Düsseldorf)
- Determination of creatine kinase fluxes with purified creatine kinase and isolated mitochondria using 31P nuclear magnetic resonance: p 195.
Hoerter JA, Gillet B, Mateo P, Lechene P, Beloeil JC (Chatenay Malabry, Gifs/Yvette)
- Oscillations of intracellular pH or high energy phosphate content cannot be detected by gated NMR during the cardiac cycle of an isovolumic perfused rat heart: p 199.
Part 5. The impact of bioenergetics on cellular, physiological and biotechnological processes
Gnaiger E, Wyss M (Innsbruck)
- Chemical forces in the cell: calculations for the ATP system: p 207. »Bioblast Access
Jeneson JAL, Jubrias SA, Kushmerick MJ (Utrecht, Seattle)
- The flow-force relation of oxidative phosphorylation in human forearm muscle is sigmoidal: p 213.
Mejsnar J, Marsík F (Praha)
- Muscular contraction, dissipation and Schrödinger's negative entropy: p 215.
Jensen PR, Rohwer JM, Michelsen O, Westerhoff HV (Lyngby, Amsterdam)
- Modelling of oxidative phosphorylation in E. coli: p 218.
Fishov I (Beer-Sheva)
- Do oscillations control the bacterial cell cycle? p 221
Kemp RB, Hoare S, Schmalfeldt M, Bridge CMC, Evans PM, Gnaiger E (Aberystwyth, Innsbruck)
- A thermochemical study of the production of lactate by glutaminolysis and glycolysis in mouse macrophage hybridoma cells: p 226. »Bioblast Access
Larsson C, Nilsson A, Gustafsson L (Göteborg)
- Catabolic capacity of carbon- or nitrogen-starved cultures of Saccharomyces cerevisiae: p 232.
Krumschnabel G, Wieser W (Innsbruck)
- Energy allocation and material flux in fish hepatocytes under stress: p 238.
Marx A, de Graaf AA, Wiechert W, Eggeling L, Sahm H (Jülich)
- Carbon flux in lysine producing strain Corynebacterium glutamicum MH20-22B: analysis by 13C-NMR of amino acids and metabolite balancing: p 240.
Zentgraf B (Furtwangen)
- Remarks on biocalorimetry and biothermodynamics aimed at characterization of the physiological state: p 244.
Part 6. The impact of bioenergetics on clinical and pathological problems
Petronilli V, Nicolli A, Costantini P, Colonna R, Bernardi P (Padova)
- The permeability transition pore. Pathophysiology of a cyclosporin A-sensitive mitochondrial channel: p 259.
Gellerich FN, Steinlechner R, Wyss M, Eberl T, Müller LC, Skladal D, Sperl W, Dapunt O, Margreiter R, Gnaiger E (Innsbruck)
- Mitochondrial function in the atrial appendage of the human heart. Characterization by high-resolution respirometry: p 263*. »Bioblast Access
Skladal D, Sperl W, Schranzhofer R, Krismer M, Gnaiger E, Margreiter R, Gellerich FN (Innsbruck)
- Preservation of mitochondrial functions in human skeletal muscle during storage in high energy preservation solution (HEPS): p 268*. »Bioblast Access
Mazat JP, Letellier T, Malgat M, Jouaville S, Morkuniene R (Bordeaux, Kaunas)
- Application of control analysis to the study of metabolic diseases in mitochondria. Metabolic expression of mitochondrial DNA mutations: p 272.
Kuznetsov AV, Clark JF, Winkler K, Kunz WS (Magdeburg, Oxford)
- Change in flux control coefficient of cytochrome c oxidase in copper deficient mottled brindled mice: p 275*. »Bioblast Access
Oexle K, Oberle J, Hübner C
- Insulin-dependent diabetes mellitus in MELAS-mitochondriopathy: discussion of possible causal relations: p 278.
Jeneson JAL, Westerhoff HV (Utrecht, Amsterdam)
- Simulation of the flow-force relation of oxidative phosphorylation in Complex I deficiency: p 280.
Steinlechner R, Eberl T, Margreiter R, Gnaiger E (Innsbruck)
- Oxygen dependence of cellular respiration in endothelial cells: a sensitive toxicological test: p 283*. »Bioblast Access
T. Eberl, R. Steinlechner, W. Salvenmoser, B. Abendstein, M. Rhomberg, Schröcksnadel H, Schmid T, Gnaiger E, Margreiter R (Innsbruck)
- Endothelial cell cultures as a model for organ preservation studies: p 288*. »Bioblast Access
Knoblechner A, Steinlechner R, Schirmer M, Gellerich FN, Margreiter R, Konwalinka G, Gnaiger E (Innsbruck)
- The effect of 2-chlorodeoxyadenosine on endogenous respiration of a human lymphoma cell line (U-937): p 294*. »Bioblast Access
Part 7. Computer software for bioenergetics and metabolic control analysis
Mendes P, Kell DB (Aberystwyth)
- Simultaneous estimates of single-enzyme kinetic parameters for multi-enzymatic systems using artificial neural networks: p 302.
Wiechert W (Jülich)
- Design of a software framework for flux determination by 13C NMR isotope labelling experiments: p 305.
Announcements
- Oroboros (Grinzens-Innsbruck, Austria): p 316
- Acknowledgements for Financial Support: p 318
- Index
Subject Index: p 319
Author Index: p 325
Addresses of Participants: p 329