Zhu 2019 Aging Cell
| Zhu B, Li Y, Xiang L, Zhang J, Wang L, Guo B, Liang M, Chen L, Xiang L, Dong J, Liu M, Mei W, Li H, Xiang G (2019) Alogliptin improves survival and health of mice on a high-fat diet. Aging Cell 18:e12883. |
Zhu B, Li Y*, Xiang L, Zhang J*, Wang L, Guo B, Liang M, Chen L, Xiang L, Dong J, Liu M, Mei W, Li H, Xiang G (2019) Aging Cell
Abstract: Alogliptin is a commonly prescribed drug treating patients with type 2 diabetes. Here, we show that long-term intervention with alogliptin (0.03% w/w in diet) improves survival and health of mice on a high-fat diet. Alogliptin intervention takes beneficial effects associated with longevity, including increased insulin sensitivity, attenuated functionality decline, decreased organ pathology, preserved mitochondrial function, and reduced oxidative stress. Autophagy activation is proposed as an underlying mechanism of these beneficial effects. We conclude that alogliptin intervention could be considered as a potential strategy for extending lifespan and healthspan in obesity and overweight.
© 2019 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. • Keywords: DPP-4 inhibitor, GLP-1, Healthspan, High-fat diet, Longevity • Bioblast editor: Plangger M
Labels: MiParea: Respiration, Exercise physiology;nutrition;life style, Pharmacology;toxicology
Pathology: Aging;senescence, Diabetes
Organism: Mouse Tissue;cell: Liver Preparation: Isolated mitochondria
Coupling state: LEAK, OXPHOS, ET
Pathway: N, S, NS, ROX
HRR: Oxygraph-2k
2019-01
