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Spagnuolo 2022 Mol Neurobiol

From Bioblast
Publications in the MiPMap
Spagnuolo MS, Mazzoli A, Nazzaro M, Troise AD, Gatto C, Tonini C, Colardo M, Segatto M, Scaloni A, Pallottini V, Iossa S, Cigliano L (2022) Long-lasting Impact of sugar intake on neurotrophins and neurotransmitters from adolescence to young adulthood in rat frontal cortex.

ยป Mol Neurobiol [Epub ahead of print]. PMID: 36394711 Open Access

Spagnuolo Maria Stefania, Mazzoli Arianna,  Nazzaro Martina,  Troise Antonio Dario,  Gatto Cristina,  Tonini Claudia,  Colardo Mayra,  Segatto Marco,  Scaloni Andrea,  Pallottini Valentina,  Iossa Susanna,  Cigliano Luisa (2022) Mol Neurobiol

Abstract: The detrimental impact of fructose, a widely used sweetener in industrial foods, was previously evidenced on various brain regions. Although adolescents are among the highest consumers of sweet foods, whether brain alterations induced by the sugar intake during this age persist until young adulthood or are rescued returning to a healthy diet remains largely unexplored. To shed light on this issue, just weaned rats were fed with a fructose-rich or control diet for 3 weeks. At the end of the treatment, fructose-fed rats underwent a control diet for a further 3 weeks until young adulthood phase and compared with animals that received from the beginning the healthy control diet. We focused on the consequences induced by the sugar on the main neurotrophins and neurotransmitters in the frontal cortex, as its maturation continues until late adolescence, thus being the last brain region to achieve a full maturity. We observed that fructose intake induces inflammation and oxidative stress, alteration of mitochondrial function, and changes of brain-derived neurotrophic factor (BDNF) and neurotrophin receptors, synaptic proteins, acetylcholine, dopamine, and glutamate levels, as well as increased formation of the glycation end-products Nฮต-carboxymethyllysine (CML) and Nฮต-carboxyethyllysine (CEL). Importantly, many of these alterations (BDNF, CML, CEL, acetylcholinesterase activity, dysregulation of neurotransmitters levels) persisted after switching to the control diet, thus pointing out to the adolescence as a critical phase, in which extreme attention should be devoted to limit an excessive consumption of sweet foods that can affect brain physiology also in the long term. โ€ข Keywords: Adolescent rat, Brain-derived neurotrophic factor, Frontal cortex, Fructose diet, Inflammation, Mitochondria, Neurotransmitters โ€ข Bioblast editor: Plangger M โ€ข O2k-Network Lab: IT Naples Iossa S

Labels: MiParea: Respiration, Developmental biology, Exercise physiology;nutrition;life style 

Organism: Rat  Tissue;cell: Nervous system  Preparation: Homogenate 

Coupling state: LEAK, OXPHOS, ET  Pathway: N, S, NS, ROX  HRR: Oxygraph-2k