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Schlein 2021 Cell Rep

From Bioblast
Publications in the MiPMap
Schlein C, Fischer AW, Sass F, Worthmann A, Tödter K, Jaeckstein MY, Behrens J, Lynes MD, Kiebish MA, Narain NR, Bussberg V, Darkwah A, Jespersen NZ, Nielsen S, Scheele C, Schweizer M, Braren I, Bartelt A, Tseng YH, Heeren J, Scheja L (2021) Endogenous fatty acid synthesis drives brown adipose tissue involution. Cell Rep 34:108624.

» PMID: 33440156 Open Access

Schlein Christian, Fischer Alexander W, Sass Frederike, Worthmann Anna, Toedter Klaus, Jaeckstein Michelle Y, Behrens Janina, Lynes Matthew D, Kiebish Michael A, Narain Niven R, Bussberg Val, Darkwah Abena, Jespersen Zenius Naja, Nielsen Soeren, Scheele Camilla, Schweizer Michaela, Braren Ingke, Bartelt Alexander, Tseng Yu-Hua, Heeren Joerg, Scheja Ludger (2021) Cell Rep

Abstract: Thermoneutral conditions typical for standard human living environments result in brown adipose tissue (BAT) involution, characterized by decreased mitochondrial mass and increased lipid deposition. Low BAT activity is associated with poor metabolic health, and BAT reactivation may confer therapeutic potential. However, the molecular drivers of this BAT adaptive process in response to thermoneutrality remain enigmatic. Using metabolic and lipidomic approaches, we show that endogenous fatty acid synthesis, regulated by carbohydrate-response element-binding protein (ChREBP), is the central regulator of BAT involution. By transcriptional control of lipogenesis-related enzymes, ChREBP determines the abundance and composition of both storage and membrane lipids known to regulate organelle turnover and function. Notably, ChREBP deficiency and pharmacological inhibition of lipogenesis during thermoneutral adaptation preserved mitochondrial mass and thermogenic capacity of BAT independently of mitochondrial biogenesis. In conclusion, we establish lipogenesis as a potential therapeutic target to prevent loss of BAT thermogenic capacity as seen in adult humans. Keywords: ChREBP, Brown adipose tissue, Cardiolipins, De novo lipogenesis, Energy expenditure, Fatty acid synthesis, Fatty acids, Lipidome, Mitochondria, Mitophagy, Non-shivering thermogenesis, Phospholipids, Thermoneutrality, Triacylglycerols, Whitening Bioblast editor: Plangger M O2k-Network Lab: US MO St Louis Gross RW, DE Hamburg Heine M


Labels: MiParea: Respiration 





HRR: Oxygraph-2k 

2021-01