Schlattner Uwe

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BEC 2020.1 Mitochondrial physiology
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COST Action CA15203 (2016-2021): MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping

Schlattner Uwe

MitoPedia topics: EAGLE 

COST: Member


COST Mentor: Mentor

Training Schools Coordinator - Management Committee MitoEAGLE
Name Schlattner Uwe, Prof.


Uwe Schlattner
Laboratory of Fundamental and Applied Bioenergetics,


University Grenoble Alpes

Address Campus St. Martin d'Hères

2280 rue de la Piscine, 38041

City Grenoble Cedex 9
Country France
Email [email protected]
O2k-Network Lab FR Grenoble Schlattner U

Bioenergetics Communications

Keywords: energy homeostasis, cell signaling, mitochondrial stress, mitochondrial metabolism, AMPK, NME/NDPK, creatine kinase


        • Benefits for COST and for the COST Action MitoEAGLE
For the kind of work group, our expertise is certainly most on muscle tissue (skeletal and heart), although we also worked on all kinds of permeabilized cells (primary cells and cell lines). We also have expertise not only in classical respiratory physiology, but also in mitochondrial regulation of cell death (permeability transition pore), mitochondrial imaging etc. For all these, we have extended data sets, mainly rat, but also human, from diverse experimental setups (nutritional regimen, exercise, drugs ...). - Uwe Schlattner (2016).

Participated at



Delfinis 2022 JCI Insight2022Delfinis LJ, Bellissimo CA, Gandhi S, DiBenedetto SN, Garibotti MC, Thuhan AK, Tsitkanou S, Rosa-Caldwell ME, Rahman FA, Cheng AJ, Wiggs MP, Schlattner U, Quadrilatero J, Greene NP, Perry CG (2022) Muscle weakness precedes atrophy during cancer cachexia and is linked to muscle-specific mitochondrial stress.
BEC 2020.1 doi10.26124bec2020-0001.v12020Gnaiger E et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1.
Hughes 2019 J Physiol2019Hughes MC, Ramos SV, Turnbull PC, Edgett BA, Huber JS, Polidovitch N, Schlattner U, Backx PH, Simpson JA, Perry CGR (2019) Impairments in left ventricular mitochondrial bioenergetics precede overt cardiac dysfunction and remodelling in Duchenne muscular dystrophy. J Physiol 598:1377-92.
Klepinin 2016 J Bioenerg Biomembr2016Klepinin A, Ounpuu L, Guzun R, Chekulayev V, Timohhina N, Tepp K, Shevchuk I, Schlattner U, Kaambre T (2016) Simple oxygraphic analysis for the presence of adenylate kinase 1 and 2 in normal and tumor cells. J Bioenerg Biomembr 48:531-48.
Perspectives in Environmental and Systems Biology2015-04-13Grenoble FR, 2015 Apr 13-15. Perspectives in Environmental and Systems Biology, BEeSy.
Guzun 2015 Acta Physiol (Oxf)2015Guzun R, Kaambre T, Bagur R, Grichine A, Usson Y, Varikmaa M, Anmann T, Tepp K, Timohhina N, Shevchuk I, Chekulayev V, Boucher F, Dos Santos P, Schlattner U, Wallimann T, Kuznetsov AV, Dzeja P, Aliev M, Saks V (2015) Modular organization of cardiac energy metabolism:energy conversion, transfer and feedback regulation. Acta Physiol (Oxf) 213:84-106.
Ydfors 2015 J Physiol2015Ydfors M, Hughes MC, Laham R, Schlattner U, Norrbom J, Perry CG (2015) Modelling in vivo creatine/phosphocreatine in vitro reveal divergent adaptations in human muscle mitochondrial respiratory control by ADP after acute and chronic exercise. J Physiol 594:3127-40.
Li 2014 Mol Cell Biol2014Li S, Yao Y, Xu R, Pesenti S, Cottet-Rousselle C, Rieusset J, Tokarska-Schlattner M, Liao K, Schlattner U, Rousseau D (2014) ATAD3 is a limiting factor in mitochondrial biogenesis and adipogenesis of white adipocyte-like 3T3-L1 cells. Mol Cell Biol 37.
Guzun 2012 Biochim Biophys Acta2012Guzun R, Gonzalez-Granillo M, Karu-Varikmaa M, Grichine A, Usson Y, Kaambre T, Guerrero-Roesch K, Kuznetsov A, Schlattner U, Saks V (2012) Regulation of respiration in muscle cells in vivo by VDAC through interaction with the cytoskeleton and MtCK within Mitochondrial Interactosome. Biochim Biophys Acta 1818:1545-54.
Monge 2008 Mol Cell Biochem2008Monge C, Beraud N, Kuznetsov AV, Rostovtseva T, Sackett D, Schlattner U, Vendelin M, Saks V (2008) Regulation of respiration in brain mitochondria and synaptosomes: restrictions of ADP diffusion in situ, roles of tubulin, and mitochondrial creatine kinase. Mol Cell Biochem 318:147-65.
Tokarska-Schlattner 2007 Biochim Biophys Acta2007Tokarska-Schlattner M, Dolder M, Gerber I, Speer O, Wallimann T, Schlattner U (2007) Reduced creatine-stimulated respiration in doxorubicin challenged mitochondria: Particular sensitivity of the heart. Biochim Biophys Acta 1767:1276-84.
Brewer 2004 Mitochondrion2004Brewer GJ, Jones TT, Wallimann T, Schlattner U (2004) Higher respiratory rates and improved creatine stimulation in brain mitochondria isolated with anti-oxidants. Mitochondrion 4:49-57.
Dolder 2003 J Biol Chem2003Dolder M, Walzel B, Speer O, Schlattner U, Wallimann T (2003) Inhibition of the mitochondrial permeability transition by creatine kinase substrates. Requirement for microcompartmentation. J Biol Chem 278:17760-6.


Schlattner 2018 MiP20182018
Uwe Schlattner
Intramitochondrial nucleotide regeneration by NME/NDPK proteins – roles in mitochondrial dynamics, signaling and metastasis.
Isola 2018 MiPschool Tromso C32018
Raffaela Isola
AMPK deficiency elicits changes in OXPHOS in heart mitochondria.
Schlattner 2018 MiPschool Tromso B12018
Uwe Schlattner
Mitochondrial kinases: key players in respiratory control and energy transfer.
Dubouchaud 2018 MiPschool Tromso2018
Dubouchaud Herve
AMPK deficiency elicits changes in OXPHOS in heart mitochondria.
Dubouchaud 2017 Abstract MITOEAGLE Barcelona2017
Impact of high-fat diet or PUFAs consumption on the mitochondrial function.
Klepinin 2017 MiP20172017
Novel method to study the role of the adenylate kinase network in health and disease.
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