Morales-Rubio 2023 Sci Rep
| Morales-Rubio R, Bernal-Ramírez J, Rubio-Infante N, Luévano-Martínez LA, Ríos A, Escalante BA, García-Rivas G, Rodríguez González J (2023) Cellular shortening and calcium dynamics are improved by noisy stimulus in a model of cardiomyopathy. https://doi.org/10.1038/s41598-023-41611-6 |
» Sci Rep 13:14898. PMID: 37689752 Open Access
Morales-Rubio Russell, Bernal-Ramirez Judith, Rubio-Infante Nestor, Luevano-Martinez Luis A, Rios Amelia, Escalante Bruno A, Garcia-Rivas Gerardo, Rodriguez Gonzalez Jesus (2023) Sci Rep
Abstract: Noise is present in cell biology. The capability of cells to respond to noisy environment have become essential. This study aimed to investigate whether noise can enhance the contractile response and Ca2+ handling in cardiomyocytes from a cardiomyopathy model. Experiments were conducted in an experimental setup with Gaussian white noise, frequency, and amplitude control to stimulate myocytes. Cell shortening, maximal shortening velocity, time to peak shortening, and time to half relaxation variables were recorded to cell shortening. Ca2+ transient amplitude and raise rate variables were registered to measure Ca2+ transients. Our results for cell shortening, Ca2+ transient amplitude, and raise rate suggest that cell response improve when myocytes are noise stimulated. Also, cell shortening, maximal shortening velocity, Ca2+ transient amplitude, and raise improves in control cells. Altogether, these findings suggest novel characteristics in how cells improve their response in a noisy environment.
• Bioblast editor: Plangger M • O2k-Network Lab: MX San Pedro Garcia-Rivas G
Labels: MiParea: Respiration, Comparative MiP;environmental MiP
Pathology: Cardiovascular, Myopathy
Organism: Mouse Tissue;cell: Heart Preparation: Permeabilized cells
Regulation: Calcium Coupling state: LEAK, OXPHOS, ET Pathway: S, CIV HRR: Oxygraph-2k
2023-09
