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MitoScore

From Bioblast

MitoScore - Evaluating Mitochondrial Stress in Health and Disease

Network for the Diagnosis of Acute and Latent Mitochondrial Dysfunction

Abstract

Mitochondria play multiple roles in health, nutrition, sport, aging, and degenerative diseases. To understand these roles better is a current need in the European research, medical and commercial communities. Therefore, MitoScore aims at developing sensitive tests of mitochondrial function and stress resistance, towards standardization of methods for evaluating and scoring acute and latent mitochondrial dysfunction, at baseline and in response to oxidative stress. As a result, interventions (nutrition, exercise, drugs, novel treatments) that potentially impact on mitochondrial health, can be evaluated objectively in different labs, hospitals and companies. By coordinating a critical mass of expertise, the network will address the problems that may have prevented so far the major break-though required for relating the quality of life and the severity of disease to a clinically standardized measure of mitochondrial function: the MitoScore – providing vital knowledge to improve health.

Keywords

mitochondrial physiology, oxidative stress, life style, nutrition, sports, aging, degenerative diseases, neurodegeneration, obesity, diabetes, cardiovascular diseases, cancer, latent mitochondrial dysfunction, stress resistance, respirometry, membrane potential, ROS production, redox regulation, isolated mitochondria, homogenate, cells, permeabilized cells, muscle fibres, tissues, model organisms

  • MitoScore aims at meeting current demands of the global research community to improve the data base on mitochondrial function/dysfunction in various tissues of humans and animal models, and to diagnose the mitochondrial implications in various pathologies, for development and evaluation of mitochondria-targeted therapies.
  • MitoScore opens the feedback loop between the primary problems of attack (mitochondrial roles in Fitness, Aging, Pathologies, Integrative Physiology) and the consequential models and methods employed.
  • MitoScore will generate the critical mass of partners required to address the complex conceptual and methodological problems that may have prevented so far the major break-though required for relating the quality of life and the severity of a disease to a clinically accessible functional mitochondrial score. A functional mitochondrial score will help to evaluate molecular mechanisms and the genetic background on an integrated systems level.
  • MitoScore is an initiative towards a broad but focussed project, to β€˜contribute substantially to the coordination and defragmentation of research efforts across Europe’.

Contact

Erich Gnaiger, Ao.Univ.-Prof., Ph.D.

Medical University of Innsbruck

Department of Visceral, Transplant and Thoracic Surgery

D. Swarovski Research Laboratory

Anichstr. 35

A-6020 Innsbruck, Austria



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