MiPschool Tromso-Bergen 2018

MiPschool Tromso-Bergen 2018

Tromso-Bergen, NO. 2018 Oct 20-24, 11^th MitoEAGLE Training School - MiPschool 2018. From basics of mitochondrial physiology to cardiovascular health and disease.

» Mitochondrial Physiology Society

Mitochondrial Physiology Society (2018-10-20) MitoGlobal

Abstract: MiPschool, Tromso-Bergen, Norway 2018

Impressions MiPschool Tromso-Bergen 2018

Feedback

The evaluation of the present and previous training schools will be integrated into the programme of the MitoEAGLE/MiPschool 2019 in Coimbra, PT:

Abstracts selected for oral presentations (10+5 min) are retained - training for conference presentations with critical discussions.
Meet the expert sessions are emphasized - training in small groups, discussions on a large variety of topics.
Introductory lectures are extended, replacing conference-style presentations by invited lecturers. Three specific topics are introduced in detail:

(a) reproducibility of sample preparations;

(b) concepts of respirometric SUIT protocols;

(c) interpretation of results.

An entrance test will be the basis for providing grants to students.

Delegates feedback comments

I enjoyed the training school in Norway. The presentations were very nice and the location was remarkable. I have never been to a workshop or conference like this. Very unique for me. - Zobalova Renata
I would like to acknowledge the organizers for such a good programme. In addition, the proximity between researchers was very high. Everyone would talk about good science. I met real nice people with different interests at this point
MIPschool at a very special location, very much worth doing it again

Delegates feedback for future Training Schools

One of the questions raised during the round table was about the physiological consequences of mitochondrial dysfunction at the level of tissues and organisms. I think that this question is very important and that there should be a session aimed at summarizing the current knowledge about it and to develop common and standardized strategies to improve it.
I would definitely like to have disruptive works in different organs/systems. Mitochondria is such a complex subject that can go beyond the molecular part. Translational discussion should be more encouraged towards future applications. Finally, writing/grants/career paths could be added.
Maybe an poster session should be interesting

Local organizer

Larsen Terje

Faculty of Health Sciences, University of Tromsø

Lecturers

Harper Mary-Ellen (University of Ottawa, CA)
Hoppel Charles L (Case Western Reserve University, Cleveland, US)
Vendelin Marco (Tallin University of Technology, EE)
Gnaiger Erich (Medical University of Innsbruck, AT; Oroboros Instruments, AT)

Meet the expert

Larsen Terje (University of Tromsø, NO)
Makrecka-Kuka Marina (Latvian Institute of Organic Synthesis, LV)
Murray Andrew J (University of Cambridge, UK)
Schlattner Uwe (Université Grenoble Alpes, FR)
Wiesner Rudolf (Universtiy of Cologne, DE)
Wuest Rob (Academic Medical Center, NL)

Programme

Programme structure

Check-in will take place on Saturday, October 20 from 21:00-23:30 pm at Skarven Bar downtown Tromsø, and on the Coastal Express on Sunday from 00:15-01:30 am.

We will disembark on Wednesday, October 24 at 14:30 in Bergen.
The voyage from Tromsø to Bergen

The scientific sessions consist of introductory lectures, selected abstract presentations, and discussions in small groups in an open “meet the expert” format.

Sessions E1 - E3: Meet the expert - open MitoEAGLE topics - MitoEAGLE Early Career Investigator Forum

11 senior scientists will be available for discussions in small groups of about 6, dispersed on separate tables, without slide projection (but with paper and pencil). All participants can 'book' mentors in advance, and rotate after 20-30 min to another booked table. The topics are open, with some 'titles' mentioned in the programme. Students may raise the topic of their abstract for discussion, without formal presentation (you may bring along some printed material or A4-size copy of a poster). Mentors may join to form slightly enlarged groups as appropriate.

Session E4 – Open programme lectures: Programme decisions made during and by the MitoEAGLE/MiPschool

The Early Career Investigators (ECIs) will shape the programme for Session E4. The options range from topics selected for a round-table discussion, extended elaboration of any topic covered in the programme, selected summaries of Sessions E1 - E3, continuation of 'Meet the expert' sessions, parallel working group meetings on a list of selected topics, or other great ideas on which our ECIs will take a group decision.

Participants joined among the >460 coauthors

MitoEAGLE preprint on Mitochondrial respiratory states and rates (Last update 2018-10-25, Version 45) - »Bioblast link«
A hardcopy of Version 44 (40 pp.) was handed out at registration. Participants were invited to join as a coauthors during the MitoEAGLE/MiPschool.

Sessions with abstracts for oral presentations

   (Attendance list)

» Final programme for download

Sunday, October 21 – Morning

	A1. Mitochondrial physiology: pathways and coupling	Session
Gnaiger 2018 MiPschool Tromso A1	Mitochondrial states and rates: 1. Electron transfer pathways and respiratory control. 2. Coupling control.	Oral A1

	B1. Energy transfer and movement of molecules in cardiomyocytes	Session
Schlattner 2018 MiPschool Tromso B1	Mitochondrial kinases: key players in respiratory control and energy transfer.	B1 Oral
Vendelin 2018 MiPschool Tromso B1	Restrictions to intracellular diffusion of ATP and ADP in cardiomyocytes.	B1 Oral

Sunday, October 21 – Afternoon

	C1. Selected abstracts: Cardiac OXPHOS	Session
Pereira 2018 MiPschool Tromso C1	Obesity-induced mitochondrial hepatic changes during pregnancy.	Oral C1
Goncalo Teixeira 2018 MiPschool Tromso C1	Subchronic in vivo study for the evaluation of hepatic mitochondrial toxicity induced by silver nanoparticles.	Oral C1
Ma 2018 MiPschool Tromso C1	Cardiolipin synthesis in brown and beige fat mitochondria is essential for systemic energy homeostasis.	C1 Oral

	C2. Selected abstracts: Cardioprotection	Session
Kampa 2018 MiPschool Tromso C2	Cardioprotective flavoniods as a natural modulators of mitoBKCa channel.	C2 Oral
MartinsJD 2018 MiPschool Tromso C2	Sweetheart: Cardiac consequences of fetal exposure to maternal gestational diabetes on the offspring mitochondrial function.	C2 Oral
Tuncay 2018 MiPschool Tromso C2	MitoTEMPO ameliorates hyperglycemia induced mitochondrial damage in cardiomyocytes.	C2 Oral
Jansen 2018 MiPschool Tromso C2	Dietary and pharmacological treatment of diet-induced obese mice – impact on mitochondrial function.	C2 Oral

Monday, October 22 – Morning

	D1. Cardiovascular disease and mitochondrial medicine	Session
Harper 2018 MiPschool Tromso D1	OXPHOS efficiency in skeletal and cardiac muscles: Proton leaks, ROS and glutathione redox.	D1 Oral
Hoppel 2018 MiPschool Tromso D1	Two populations of muscle mitochondria: heart and skeletal muscle.	D1 Oral

	E1. MitoEAGLE Early Career Investigator Forum	Session
Harper 2018 MiPschool Tromso E1	Deacetylation acceleration of BAT thermogenesis.	E1
Iglesias-Gonzalez 2018 MiPschool Tromso E1	Oscillations in mitochondrial ROS production during the early cell cycles in Xenopus embryos.	E1
Makrecka-Kuka 2018 MiPschool Tromso E1	Cardiac fatty acid oxidation: from in vitro to in vivo.	E1
Murray 2018 MiPschool Tromso E1	OXPHOS protocols: understanding the patterns.	E1
Vendelin 2018 MiPschool Tromso E1	Introducing a platform for primary kinetics data analysis.	E1
Wiesner 2018 MiPschool Tromso E1	Aging-related accumulation of mitochondrial DNA deletions in skeletal muscle occurs preferentially in Type IIb fibers – high mitophagic flux protects Type I fibers.	E1

	E2. MitoEAGLE Early Career Investigator Forum - table discussions	Session
Alves 2018 MiPschool Tromso E2	Role for mitochondria on the response of highly proliferative and invasive bladder cancer cells to the combined inhibition of mTOR and SIRT1.	E2
Huete-Ortega 2018 MiPschool Tromso E2	High-resolution respirometry: new perspectives for the study of bioenergetics in algae and plants.	E2
Puurand 2018 MiPschool Tromso E2	Intracellular energy-transfer networks in health and disease – the results of oxygraphic studies.	E2
Kidere 2018 MiPschool Tromso E2	Cytoplasmic hybrid cells as a model to characterize the OXPHOS system: control sample with glutamate metabolism defect.	E2
Fischer 2018 MiPschool Tromso E2	Analysis of mitochondrial function in iron deficiency anemia and iron overload conditions.	E2
Siewiera 2018 MiPschool Tromso E2	Effect of metformin treatment on blood platelet bioenergetics and platelet function in STZ-diabetic and non-diabetic rats.	E2
MartinsAD 2018 MiPschool Tromso E2	Mitochondrial dynamics of human Sertoli cells under the effect of leptin and ghrelin.	E2
Garipi 2018 MiPschool Tromso E2	Phenotyping mitochondrial metabolism in Barrett’s metaplasia-dysplasia-adenocarcinoma sequence: respiratory capacity, extracelular proton flux and ROS production	E2
Cardoso 2018 MiPschool Tromso E2	Concomitant respiration and ATP production measurements to analyse P»/O₂ ratios at physiological normoxia.	E2
Storder 2018 MiPschool Tromso E2	Investigaton on the role of the mitochondiral deacetylase Sirtuin 3 in adipose tissue.	E2
Li Puma 2018 MiPschool Tromso E2	Fads2 exacerbates myocardial ischemia-reperfusion injury in mice: role of mitochondria.	E2
Krajcova 2018 MiPschool Tromso E2	High-resolution respirometry to assess function of mitochondria in native homogenates of human heart muscle.	E2

Monday, October 22 - Afternoon

	A2. Mitochondrial physiology: protonmotive force	Session
Gnaiger 2018 MiPschool Tromso A2	The protonmotive force and respiratory control. 1. Coupling of electron transfer reactions to vectorial translocation of protons. 2. From Einstein’s diffusion equation on gradients to Fick’s law on compartments.	Oral A2

	C3. Selected abstracts: Adipose and liver mitochondria	Session
Torp 2018 MiPschool Tromso C3	Intracellular complement factor 3 in the heart – a link to metabolism?	Oral C3
Isola 2018 MiPschool Tromso C3	AMPK deficiency elicits changes in OXPHOS in heart mitochondria.	Oral C3

Tuesday, October 23 - Morning

	D2. Cardiac mitochondrial physiology and pathology	Session
Vendelin 2018 MiPschool Tromso D2	Modeling actomyosin contraction in the heart muscle.	D2 Oral
Hoppel 2018 MiPschool Tromso D2	Mitochondrial function during ischemia/reperfusion injury.	D2 Oral

E3: MitoEAGLE Early Career Investigator Forum - meet the expert

Tuesday, October 23 – Afternoon

E4: Open programme lectures: Programme decisions made during and by the MitoEAGLE/MiPschool

	C4. Selected abstracts: Mitochondrial disorders, remodeling, and degenerative diseases	Session
Musiol 2018 MiPschool Tromso C4	Alpha-tomatine as a novel membrane-permeabilizing agent for mitochondrial respiration measurements.	C4 Oral
Bastos Sant'Anna Silva 2018 MiPschool Tromso C4	Role of succinate in prostate cancer cells: uptake and mitochondrial respiratory function.	C4 Oral
Vella 2018 MiPschool Tromso C4	Exome analysis sheds light on mitochondrial disorders.	C4 Oral
Crisostomo 2018 MiPschool Tromso C4	Mitochondrion at the crosstalk between metabolic disease and dysfunction in male fertility?	C4 Oral
Zdrazilova 2018 MiPschool Tromso C4	Bioenergetic characterization of skin fibroblasts from patients with congenital disorders of glycosylation.	C4 Oral
Vujacic-Mirski 2018 MiPschool Tromso C4	Development of analytical assays for the detection and quantification of reactive oxygen and nitrogen species in an animal model of type 1 diabetes - ROS formation involving mitochondrial and NADPH oxidase.	C4 Oral

Wednesday, October 24 - Morning

	D3. Mitochondrial function and cardioprotection	Session
Wuest 2018 MiPschool Tromso D3	Metabolic flexibility and mitochondrial function in the diabetic heart.	D3 Oral
Boardman 2018 MiPschool Tromso D3	High fat-load induces cardioprotection in hearts from obese mice.	Oral D3

Participants and abstracts - alphabetical order

	Presentation
Alves 2018 MiPschool Tromso E2	Role for mitochondria on the response of highly proliferative and invasive bladder cancer cells to the combined inhibition of mTOR and SIRT1.
Arago 2018 MiPschool Tromso	No abstract.
Armand 2018 MiPschool Tromso	No abstract.
Bajzikova 2018 MiPschool Tromso	No abstract.
Bastos Sant'Anna Silva 2018 MiPschool Tromso C4	Role of succinate in prostate cancer cells: uptake and mitochondrial respiratory function.
Bello 2018 MiPschool Tromso	No abstract.
Bergmeister 2018 MiPschool Tromso	No abstract.
Boardman 2018 MiPschool Tromso D3	High fat-load induces cardioprotection in hearts from obese mice.
Cardoso 2018 MiPschool Tromso E2	Concomitant respiration and ATP production measurements to analyse P»/O₂ ratios at physiological normoxia.
Crisostomo 2018 MiPschool Tromso C4	Mitochondrion at the crosstalk between metabolic disease and dysfunction in male fertility?
Dahdah 2018 MiPschool Tromso	No abstract.
Detraux 2018 MiPschool Tromso	No abstract.
Dubouchaud 2018 MiPschool Tromso	AMPK deficiency elicits changes in OXPHOS in heart mitochondria.
Ferreira 2018 MiPschool Tromso	No abstract.
Fischer 2018 MiPschool Tromso E2	Analysis of mitochondrial function in iron deficiency anemia and iron overload conditions.
Garipi 2018 MiPschool Tromso E2	Phenotyping mitochondrial metabolism in Barrett’s metaplasia-dysplasia-adenocarcinoma sequence: respiratory capacity, extracelular proton flux and ROS production
Gnaiger 2018 MiPschool Tromso A1	Mitochondrial states and rates: 1. Electron transfer pathways and respiratory control. 2. Coupling control.
Gnaiger 2018 MiPschool Tromso A2	The protonmotive force and respiratory control. 1. Coupling of electron transfer reactions to vectorial translocation of protons. 2. From Einstein’s diffusion equation on gradients to Fick’s law on compartments.
Goncalo Teixeira 2018 MiPschool Tromso C1	Subchronic in vivo study for the evaluation of hepatic mitochondrial toxicity induced by silver nanoparticles.
Handl 2018 MiPschool Tromso	No abstract.
Harper 2018 MiPschool Tromso D1	OXPHOS efficiency in skeletal and cardiac muscles: Proton leaks, ROS and glutathione redox.
Harper 2018 MiPschool Tromso E1	Deacetylation acceleration of BAT thermogenesis.
Heiestad 2018 MiPschool Tromso	No abstract.
Hoppel 2018 MiPschool Tromso D1	Two populations of muscle mitochondria: heart and skeletal muscle.
Hoppel 2018 MiPschool Tromso D2	Mitochondrial function during ischemia/reperfusion injury.
Huete-Ortega 2018 MiPschool Tromso E2	High-resolution respirometry: new perspectives for the study of bioenergetics in algae and plants.
Hyrossova 2018 MiPschool Tromso	No abstract.
Iglesias-Gonzalez 2018 MiPschool Tromso E1	Oscillations in mitochondrial ROS production during the early cell cycles in Xenopus embryos.
Isola 2018 MiPschool Tromso C3	AMPK deficiency elicits changes in OXPHOS in heart mitochondria.
Jansen 2018 MiPschool Tromso C2	Dietary and pharmacological treatment of diet-induced obese mice – impact on mitochondrial function.
Jaskiewicz 2018 MiPschool Tromso	No abstract.
Kampa 2018 MiPschool Tromso C2	Cardioprotective flavoniods as a natural modulators of mitoBKCa channel.
Kidere 2018 MiPschool Tromso E2	Cytoplasmic hybrid cells as a model to characterize the OXPHOS system: control sample with glutamate metabolism defect.
Krajcova 2018 MiPschool Tromso E2	High-resolution respirometry to assess function of mitochondria in native homogenates of human heart muscle.
Larsen 2018 MiPschool Tromso	Local organizer
Li Puma 2018 MiPschool Tromso E2	Fads2 exacerbates myocardial ischemia-reperfusion injury in mice: role of mitochondria.
Ma 2018 MiPschool Tromso C1	Cardiolipin synthesis in brown and beige fat mitochondria is essential for systemic energy homeostasis.
Majtnerova 2018 MiPschool Tromso	No abstract.
Makrecka-Kuka 2018 MiPschool Tromso E1	Cardiac fatty acid oxidation: from in vitro to in vivo.
Marstein 2018 MiPschool Tromso	No abstract.
MartinsAD 2018 MiPschool Tromso E2	Mitochondrial dynamics of human Sertoli cells under the effect of leptin and ghrelin.
MartinsJD 2018 MiPschool Tromso C2	Sweetheart: Cardiac consequences of fetal exposure to maternal gestational diabetes on the offspring mitochondrial function.
Murray 2018 MiPschool Tromso E1	OXPHOS protocols: understanding the patterns.
Musiol 2018 MiPschool Tromso C4	Alpha-tomatine as a novel membrane-permeabilizing agent for mitochondrial respiration measurements.
Pedersen 2018 MiPschool Tromso	No abstract.
Pereira 2018 MiPschool Tromso C1	Obesity-induced mitochondrial hepatic changes during pregnancy.
Puurand 2018 MiPschool Tromso E2	Intracellular energy-transfer networks in health and disease – the results of oxygraphic studies.
Schartner 2018 MiPschool Tromso
Schlattner 2018 MiPschool Tromso B1	Mitochondrial kinases: key players in respiratory control and energy transfer.
Schots 2018 MiPschool Tromso
Siewiera 2018 MiPschool Tromso E2	Effect of metformin treatment on blood platelet bioenergetics and platelet function in STZ-diabetic and non-diabetic rats.
Storder 2018 MiPschool Tromso E2	Investigaton on the role of the mitochondiral deacetylase Sirtuin 3 in adipose tissue.
Template 2018 MiPschool Tromso
Torp 2018 MiPschool Tromso C3	Intracellular complement factor 3 in the heart – a link to metabolism?
Truu 2018 MiPschool Tromso	No abstract.
Tuncay 2018 MiPschool Tromso C2	MitoTEMPO ameliorates hyperglycemia induced mitochondrial damage in cardiomyocytes.
Vella 2018 MiPschool Tromso C4	Exome analysis sheds light on mitochondrial disorders.
Vendelin 2018 MiPschool Tromso B1	Restrictions to intracellular diffusion of ATP and ADP in cardiomyocytes.
Vendelin 2018 MiPschool Tromso D2	Modeling actomyosin contraction in the heart muscle.
Vendelin 2018 MiPschool Tromso E1	Introducing a platform for primary kinetics data analysis.
Vieira Ligo Teixeira 2018 MiPschool Tromso	No abstract.
Vujacic-Mirski 2018 MiPschool Tromso C4	Development of analytical assays for the detection and quantification of reactive oxygen and nitrogen species in an animal model of type 1 diabetes - ROS formation involving mitochondrial and NADPH oxidase.
Wiesner 2018 MiPschool Tromso E1	Aging-related accumulation of mitochondrial DNA deletions in skeletal muscle occurs preferentially in Type IIb fibers – high mitophagic flux protects Type I fibers.
Wuest 2018 MiPschool Tromso D3	Metabolic flexibility and mitochondrial function in the diabetic heart.
Zdrazilova 2018 MiPschool Tromso C4	Bioenergetic characterization of skin fibroblasts from patients with congenital disorders of glycosylation.
Zobalova 2018 MiPschool Tromso	No abstract.

Support

MitoEAGLE Scholarships

Eligibility: Participants from all COST countries can apply - MitoEAGLE network.
Late registration: The COST MitoEAGLE grant is a financial support to cover part of the local costs (accommodation, meals).

» Notification of MitoEAGLE scholarships for late registrations until September 20.

Registration and further information

The maximum number of attendees for the MiP/MitoEAGLE Training School 2018 of 65 participants is reached.

closed

MitoEAGLE

The MitoEAGLE network aims to improve our knowledge on mitochondrial function in health and disease related to Evolution, Age, Gender, Lifestyle and Environment. Every study of mitochondrial (mt) function and disease is faced with EAGLE as the essential background conditions characterizing the individual patient, subject, study group, species, tissue or even cell line.

Membership in the MitoEAGLE network is open to all researchers sharing an interest in mitochondrial research and medicine

» Join the COST Action CA15203 MITOEAGLE

MiPsociety

The MiPsociety is an international organization, based in Europe and operating world-wide and has become a legal body in 2011 continuing a tradition of rigorous mitochondrial bioenergetics; integrating molecular, cellular and organismic physiology and pathology.

Membership is open to all researchers

» MiP membership

How to get there

There are daily flights in each direction between Oslo and Tromsø, flown by SAS and Norwegian (Please note that there are only a few flights on a Saturday)

The same companies also offer some direct flights from Stockholm Arlanda, Copenhagen, and London Gatwick, but these are seasonal (so do check yourselves if these routes are operating and of interest).

Arctic Airlink also offer direct flights to Tromsø from Luleå and Oulu. The nearest train station is Narvik.

It is 3 1/2 hours’ drive from Tromsø, and it is connected to the Swedish, not the Norwegian, rail network (sj.se). There is a bus link from Narvik, but usually, the train does not meet the last bus to Tromsø.

Training school participants arriving in Tromsø before October 20th can find accommodation on the official travel guide to Tromsø (https://www.visittromso.no/en/Troms%C3%B8%20Airport), which gives you an overview of the various hotels in the city, as well as transportation from the airport to the city center, and what to do in Tromsø.

On Saturday morning (from 10:00 h), we will organize a meeting place at the UiT Campus for training school participants arriving throughout the day (information desk and temporary luggage storage).

Here, you will also have access to Internet and, if needed, a quiet spot for work. Take a taxi from the airport to the university and ask the driver to stop at the main (west) entrance of the MH building (link to map). The meeting place will keep open until 21:00 h.

In the city, luggage lockers are available on the 1st floor in the harbour terminal (link to map). These are card-operated lockers, and cost NOK 60 for a 24-hour period. Available during the terminal opening hours: 05.30-02.00 h.

The registration desk opens at 21:00 h at Skarven Bar downtown Tromsø. This will be our assembly point until the Coastal Express arrives around midnight. We will walk from the bar to the harbor terminal, which is just a couple of minutes away (link to map).

Venue and accommodation

Hurtigruten

Bergen to Tromso

Norway

Impressions: Ship and Hurtigruten travel offers

Hurtigruten boat
Bergen, NO
Tromsoe, NO
Impression of the route
Restaurant
Seminar room

Support

This project has received funding from the European Union's Horizon 2020 research and innovation programme supported by COST (European Cooperation in Science and Technology) under grant agreement No OC-2015-2-19984.

Listed under MitoGlobal Events.

Labels:

2018, ORO, MitoEAGLE, MiP, MitoGlobal