Makrecka-Kuka 2019 Acta Physiol (Oxf)
| Makrecka-Kuka M, Liepinsh E, Murray AJ, Lemieux H, Dambrova M, Tepp K, Puurand M, Käämbre T, Han WH, de Goede P, O'Brien KA, Turan B, Tuncay E, Olgar Y, Rolo AP, Palmeira CM, Boardman NT, Wüst RCI, Larsen TS (2019) Altered mitochondrial metabolism in the insulin-resistant heart. Acta Physiol (Oxf) 228:e13430. |
Makrecka-Kuka M, Liepinsh E, Murray AJ, Lemieux H, Dambrova M, Tepp K, Puurand M, Kaambre T, Han WH, de Goede P, O'Brien KA, Turan B, Tuncay E, Olgar Y, Rolo AP, Palmeira CM, Boardman NT, Wuest RCI, Larsen TS (2019) Acta Physiol (Oxf)
Abstract: Obesity-induced insulin resistance and type 2 diabetes mellitus can ultimately result in various complications, including diabetic cardiomyopathy. In this case, cardiac dysfunction is characterized by metabolic disturbances such as impaired glucose oxidation and an increased reliance on fatty acid (FA) oxidation. Mitochondrial dysfunction has often been associated with the altered metabolic function in the diabetic heart, and may result from FA-induced lipotoxicity and uncoupling of oxidative phosphorylation. In this review, we address the metabolic changes in the diabetic heart, focusing on the loss of metabolic flexibility and cardiac mitochondrial function. We consider the alterations observed in mitochondrial substrate utilization, bioenergetics and dynamics, and highlight new areas of research which may improve our understanding of the cause and effect of cardiac mitochondrial dysfunction in diabetes. Finally, we explore how lifestyle (nutrition and exercise) and pharmacological interventions can prevent and treat metabolic and mitochondrial dysfunction in diabetes.
© 2019 The Authors. Acta Physiologica published by John Wiley & Sons Ltd on behalf of Scandinavian Physiological Society. • Keywords: Diabetes, Heart, Lipotoxicity, Mitochondria • Bioblast editor: Plangger M • O2k-Network Lab: LV Riga Makrecka-Kuka M, UK Cambridge Murray AJ, CA Edmonton Lemieux H, EE Tallinn Kaambre T, PT Coimbra Laranjinha J, NO Tromsoe Larsen TS, NL Amsterdam Wuest RC
Labels: MiParea: Respiration, mt-Structure;fission;fusion, Exercise physiology;nutrition;life style, Pharmacology;toxicology
Pathology: Diabetes
Stress:Oxidative stress;RONS
Tissue;cell: Heart
Enzyme: Supercomplex Regulation: Calcium, Fatty acid
Labels, 2020-02, MitoEAGLEPublication
