Lemieux 2019b MiP2019

Altered mitochondrial metabolism in the diabetic heart.

Link: MiP2019

Makrecka-Kuka M, Liepinsh E, Murray AJ, Lemieux H, Dambrova M, Tepp K, Puurand M4 Kaambre T, Han WH, de Goede P, O’Brien KA, Turan B, Tuncay E, Olgar Y, Rolo AP, Palmeira CM, Boardman NT, Wuest RCI, Larsen TS (2019)

Event: MiP2019

Obesity-induced insulin resistance and type 2 diabetes mellitus can ultimately result in various complications, including diabetic cardiomyopathy. In this case, cardiac dysfunction is characterized by metabolic disturbances such as impaired glucose oxidation and an increased reliance on fatty acid oxidation. Mitochondrial dysfunction has often been associated with the altered metabolic function in the diabetic heart, and may result from fatty acid-induced lipotoxicity and uncoupling of oxidative phosphorylation. In this review, we address the metabolic changes in the diabetic heart, focusing on the loss of metabolic flexibility and cardiac mitochondrial function. We consider the alterations observed in mitochondrial substrate utilization, bioenergetics and dynamics, and highlight new areas of research which may improve our understanding of the cause and effect of cardiac mitochondrial dysfunction in diabetes. Finally, we explore how lifestyle (nutrition and exercise) and pharmacological interventions can prevent and treat metabolic and mitochondrial dysfunction in diabetes.

• Bioblast editor: Plangger M, Tindle-Solomon L

Labels: MiParea: Exercise physiology;nutrition;life style, Pharmacology;toxicology  Pathology: Diabetes 

Tissue;cell: Heart 

Affiliations

Makrecka-Kuka M(1), Liepinsh E(1), Murray AJ(2), Lemieux H(3), Dambrova M(1), Tepp K(4), Puurand M(4), Käämbre T(4), Han WH(5), de Goede P(6), O’Brien KA(2), Turan B(6), Tuncay E(7), Olgar Y(7), Rolo AP(8), Palmeira CM(8), Boardman NT(9), Wüst RCI(10), Larsen TS(9)

1. Latvian Inst Organic Synthesis, Riga, Latvia
2. Dept Physiology, Development Neuroscience, Univ Cambridge, UK
3. Fac Saint-Jean, Women Children's Health Research Inst, Dept Medicine, Univ Alberta, Canada
4. National Inst Chemical Physics Biophysics, Tallinn, Estonia
5. Fac Saint-Jean Univ Alberta, Canada
6. Lab Endocrinology, Amsterdam Univ Medical Center, Univ Amsterdam, Amsterdam Gastroenterology & Metabolism, Amsterdam, The Netherlands
7. Dept Biophysics, Fac Medicine, Ankara Univ, Ankara, Turkey
8. Dept Life Sciences, Univ Coimbra Center Neurosciences Cell Biology, Univ Coimbra, Portugal
9. Cardiovascular Research Group, Dept Medical Biology, UiT the Arctic Univ Norway
10. Lab Myology, Fac Behavioural Movement Sciences, Dept Human Movement Sciences, Amsterdam Movement Sciences, Vrije Univ Amsterdam, Amsterdam, The Netherlands