Lemieux 2010 J Gerontol A Biol Sci Med Sci

From Bioblast
Publications in the MiPMap
Lemieux H, Vazquez EJ, Fujioka H, Hoppel CL (2010) Decrease in mitochondrial function in rat cardiac permeabilized fibers correlates with the aging phenotype. J Gerontol A Biol Sci Med Sci 65:1157-64.

Β» PMID: 20801909 Open Access

Lemieux H, Vazquez EJ, Fujioka H, Hoppel CL (2010) J Gerontol A Biol Sci Med Sci

Abstract: We measured the loss of cardiac mitochondrial function related to aging in males of three rat strains presenting with different longevity and aging phenotypes: the Fischer 344 (F344), the Brown Norway (BN), and the hybrid F344Γ—BN. The F344 rat has a short life span and a ∼45% decrease in coupled mitochondrial oxidation in the cardiac permeabilized fibers from the old rats compared with the young rats. Citrate synthase activity in the permeabilized fibers (mitochondrial content) did not change significantly with aging. The BN live longer compared with the F344 and have a 15%-18% loss of mitochondrial respiration in the aged rats compared with the young rats. The differences are not significant. In hybrids, more resistant to aging than are the BN and the F344, mitochondrial function is preserved during aging. The difference in longevity of the different strains is correlated with mitochondrial dysfunction in the heart, suggesting the importance of mitochondria in cardiac aging. β€’ Keywords: Aging, Mitochondrial, Oxidative phosphorylation, Rat, Strains

β€’ O2k-Network Lab: CA Edmonton Lemieux H, US OH Cleveland Hoppel CL

Labels: Pathology: Aging;senescence 

Organism: Rat  Tissue;cell: Heart  Preparation: Permeabilized tissue 

HRR: Oxygraph-2k 

Cookies help us deliver our services. By using our services, you agree to our use of cookies.